Facta Universitatis-Series Mechanical Engineering最新文献_第4页

PERFORMANCE OF UPLINK-NOMA WITH USER PAIRING AND DATA RATE-BASED POWER SCHEME 基于用户配对和数据速率功率方案的上行链路noma性能

2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-07-29 DOI: 10.22190/fuacr230324003p

Aleksandra Panajotović, Jelena Anastasov, Dejan Milić, Daniela Milović, Nikola Sekulović

引用次数: 0

CISPLATIN - AN OVERVIEW OF ITS EFFICIENCY AND TOXICITY 顺铂-其有效性和毒性的概述

2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-06-21 DOI: 10.22190/fumb230122002d

Marija Djordjević, Jovan Ilić, Nikola M. Stojanovic

{"title":"CISPLATIN - AN OVERVIEW OF ITS EFFICIENCY AND TOXICITY","authors":"Marija Djordjević, Jovan Ilić, Nikola M. Stojanovic","doi":"10.22190/fumb230122002d","DOIUrl":"https://doi.org/10.22190/fumb230122002d","url":null,"abstract":"Cisplatin is the first heavy metal compound that has been found to possess antineoplastic activity. It is effective in treating testicular, ovarian, head and neck, bladder, cervical, esophageal tumors, and small cell lung carcinoma. Approximately 1% of cisplatin that enters the cell interacts with DNA, forming DNA-cisplatin bonds. Both apoptosis and necrosis can be found in the same population of cells exposed to cisplatin, and the mode of cell death depends on the cisplatin concentration and metabolic state of the target cell. In the bloodstream, the platinum component of cisplatin binds to the blood's proteins (hemoglobin, albumin and transferrin), and other significant portion binds to the glutathione and other cysteine-rich biomolecules. Cisplatin impairs the mitochondrial and cell antioxidant defense system (decreases GSH, NADPH levels, GCH/GSSG ratio, and increases GSSG levels) leading to oxidative stress. There are three main mechanisms of cell resistance to cisplatin: (1) enhanced repair of cisplatin-induced DNA lesions, (2) decrease in uptake and/or increase in efflux and (3) inactivation of cisplatin intracellularly. The usage of cisplatin is limited due to its toxicity and side effects, which include neurotoxicity (numbness and tingling, paresthesia, reduced deep tendon reflexes), nephrotoxicity (renal insufficiency, hypomagnesemia), ototoxicity (tinnitus and bilateral high-frequency hearing loss), cardiotoxicity (changes in electric heart activity, congestive heart failure), gastrotoxicity (nausea, vomiting, and dyspepsia), etc. So far, there has been no effective, clinically administered, therapy for cisplatin-induced toxicity.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136355764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FREE VIBRATION INVESTIGATION ON RVE OF PROPOSED HONEYCOMB SANDWICH BEAM AND MATERIAL SELECTION OPTIMIZATION 蜂窝夹层梁的自由振动研究及材料选择优化

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume220806042s

B. Safaei, Emmanuel Chukwueloka Onyibo, Mehmet Goren, K. Kotrasová, Zhicheng Yang, Samaneh Arman, M.B.A Asmael

{"title":"FREE VIBRATION INVESTIGATION ON RVE OF PROPOSED HONEYCOMB SANDWICH BEAM AND MATERIAL SELECTION OPTIMIZATION","authors":"B. Safaei, Emmanuel Chukwueloka Onyibo, Mehmet Goren, K. Kotrasová, Zhicheng Yang, Samaneh Arman, M.B.A Asmael","doi":"10.22190/fume220806042s","DOIUrl":"https://doi.org/10.22190/fume220806042s","url":null,"abstract":"In this paper, free vibration, modal and stress state analyses of honeycomb sandwich structures with different boundary conditions was investigated and major factors affecting the sandwich frequencies and stiffness due to material or parameter changes were determined. The representative volume element (RVE) method used in this work were analytically and numerically validated by comparing the obtained results to those available in literature. Firstly, unit cell method was used to capture the entire effects of different parameters on the free vibration of honeycomb sandwich structure in ANSYS. This study analyzed the natural frequencies of honeycomb sandwich structures with different core materials combination. The effects of foil thickness, boundary conditions, materials selection, density and presence of crack on sandwich structure were taken into consideration and examined. The proposed core had an inbuilt shaped reinforcement with different materials for effective resonance, fatigue and deformation resistance at much higher frequency.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":"64 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90357657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

ELECTRO-MECHANICAL RESPONSE OF STRETCHABLE PDMS COMPOSITES WITH A HYBRID FILLER SYSTEM 混合填料体系可拉伸PDMS复合材料的机电响应

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume221205002k

Hae-Rim Kim, N. Qaiser, B. Hwang

引用次数: 5

SPRING BASED ON FLAT PERMANENT MAGNETS: DESIGN, ANALYSIS AND USE IN VARIABLE STIFFNESS ACTUATOR 基于扁平永磁体的弹簧:在变刚度执行器中的设计、分析和应用

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume210412055k

Bartłomiej Kozakiewicz, Tomasz Winiarski

{"title":"SPRING BASED ON FLAT PERMANENT MAGNETS: DESIGN, ANALYSIS AND USE IN VARIABLE STIFFNESS ACTUATOR","authors":"Bartłomiej Kozakiewicz, Tomasz Winiarski","doi":"10.22190/fume210412055k","DOIUrl":"https://doi.org/10.22190/fume210412055k","url":null,"abstract":"Modern robot applications benefit from including variable stiffness actuators (VSA) in the kinematic chain. In this paper, we focus on VSA utilizing a magnetic spring made of two coaxial rings divided into alternately magnetized sections. The torque generated between the rings is opposite to the angular deflection from equilibrium and its value increases as the deflection grows – within a specific range of angles that we call a stable range. Beyond the stable range, the spring exhibits negative stiffness what causes problems with prediction and control. In order to avoid it, it is convenient to operate within a narrower range of angles that we call a safe range. The magnetic springs proposed so far utilize few pairs of arc magnets, and their safe ranges are significantly smaller than the stable ones. In order to broaden the safe range, we propose a different design of the magnetic spring, which is composed of flat magnets, as well as a new arrangement of VSA (called ATTRACTOR) utilizing the proposed spring. Correctness and usability of the concept are verified in FEM analyses and experiments performed on constructed VSA, which led to formulating models of the magnetic spring. The results show that choosing flat magnets over arc ones enables shaping spring characteristics in a way that broadens the safe range. An additional benefit is lowered cost, and the main disadvantage is a reduced maximal torque that the spring is capable of transmitting. The whole VSA can be perceived as promising construction for further development, miniaturization and possible application in modern robotic mechanisms.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":"24 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85923930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

IMPROVEMENT OF SURFACE QUALITY OF Ti-6Al-4V ALLOY BY POWDER MIXED ELECTRICAL DISCHARGE MACHINING USING COPPER POWDER 采用铜粉混合电火花加工改善Ti-6Al-4V合金表面质量

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume201215042h

R. Haque, M. Sekh, G. Kibria, S. Haidar

{"title":"IMPROVEMENT OF SURFACE QUALITY OF Ti-6Al-4V ALLOY BY POWDER MIXED ELECTRICAL DISCHARGE MACHINING USING COPPER POWDER","authors":"R. Haque, M. Sekh, G. Kibria, S. Haidar","doi":"10.22190/fume201215042h","DOIUrl":"https://doi.org/10.22190/fume201215042h","url":null,"abstract":"Electrical Discharge Machining (EDM) is one of the most popular non-conventional machining processes that are being used in many high precision manufacturing industries. To increase the EDM performance, a hybrid technique, namely, powder mixed electrical discharge machining (EDM) (PMEDM) is generally used for getting more precise requirements. In this study, an experimental investigation is carried out in order to explore the machining performance of the PMEDM process on Ti-6Al-4V alloy using copper (Cu) powder in the EDM oil dielectric. Taguchi’s L18 orthogonal array design has been utilized for design of experiments and the analysis of variance (ANOVA) has been performed with the help of Minitab-19 software. The optimal parametric setting of Cu powder mixed EDM has been found utilizing the Taguchi - Grey Relational Analysis (GRA) integrated approach and also validation of optimal parametric setting is done through experimentation. It is a novel approach for machining Ti-6Al-4V alloy by this PMEDM technique in which the surface quality has been improved significantly with the addition of suitable amount of Cu powder into the dielectric medium.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":"8 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77117923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

DETECTION PROCESS OF ENERGY LOSS IN ELECTRIC RAILWAY VEHICLES 电气化轨道车辆能量损耗检测过程

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume221104046f

S. Fischer, Szabolcs Kocsis Szürke

{"title":"DETECTION PROCESS OF ENERGY LOSS IN ELECTRIC RAILWAY VEHICLES","authors":"S. Fischer, Szabolcs Kocsis Szürke","doi":"10.22190/fume221104046f","DOIUrl":"https://doi.org/10.22190/fume221104046f","url":null,"abstract":"The paper deals with the detection process of energy loss in electric railway hauling vehicles. The importance of efficient energy use in railways and cost-effective rail transport tendency toward regenerative braking energy are considered. In addition, the current situation and improvement opportunities to achieve efficient energy use are examined. Seven measurement series were performed with scheduled Railjet trains between Hegyeshalom and Győr railway stations in Hungary. This railway section is related to the Hungarian State Railways' No. 1 main railway line (between Budapest-Kelenföld and Hegyeshalom state board), which is a part of the international railway line between Budapest and Vienna (capitals of Hungary and Austria, respectively). This double-track, electrified railway line with traditional ballasted superstructures and continuously welded rail tracks is important due to the international passenger and freight transport between Germany, Austria, and Hungary. The value of the regenerative braking energy can be even 20-30% of the total consumed energy. This quite enormous untapped energy can be used for several aims, e.g., for comfort energy demand (air conditioning, heating-cooling, lighting, etc.) or energy-intensive starts. The article also investigates the optimization of regenerative braking energy by seeking the energy-waste locations and the reasons for the significant consumption. The train operator's driving style and habit have been identified as one of the main reasons. Furthermore, train driver assistance systems are recommended to save energy, which is planned for future research.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":"63 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90655505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

ACCURACY ANALYSIS OF THE CURVED PROFILE MEASUREMENT WITH CMM: A CASE STUDY 用三坐标测量机测量曲面轮廓的精度分析:以实例为例

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume210507063m

T. Mazur, M. Rucki, Yuriy Gutsalenko

引用次数: 2

REVIEW OF BONE SCAFFOLD DESIGN CONCEPTS AND DESIGN METHODS 骨支架设计概念与设计方法综述

IF 7.9 2区工程技术

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-04-10 DOI: 10.22190/fume200328038m

J. Milovanovic, M. Stojković, M. Trifunovic, N. Vitković

引用次数: 2

A GOOD INITIAL GUESS FOR APPROXIMATING NONLINEAR OSCILLATORS BY THE HOMOTOPY PERTURBATION METHOD 用同伦摄动法近似非线性振子的一个很好的初始猜想