Tomography最新文献

{"title":"Skeletal Muscle Segmentation at the Level of the Third Lumbar Vertebra (L3) in Low-Dose Computed Tomography: A Lightweight Algorithm.","authors":"Xuzhi Zhao, Yi Du, Haizhen Yue","doi":"10.3390/tomography10090111","DOIUrl":"https://doi.org/10.3390/tomography10090111","url":null,"abstract":"<p><strong>Background: </strong>The cross-sectional area of skeletal muscles at the level of the third lumbar vertebra (L3) measured from computed tomography (CT) images is an established imaging biomarker used to assess patients' nutritional status. With the increasing prevalence of low-dose CT scans in clinical practice, accurate and automated skeletal muscle segmentation at the L3 level in low-dose CT images has become an issue to address. This study proposed a lightweight algorithm for automated segmentation of skeletal muscles at the L3 level in low-dose CT images.</p><p><strong>Methods: </strong>This study included 57 patients with rectal cancer, with both low-dose plain and contrast-enhanced pelvic CT image series acquired using a radiotherapy CT scanner. A training set of 30 randomly selected patients was used to develop a lightweight segmentation algorithm, and the other 27 patients were used as the test set. A radiologist selected the most representative axial CT image at the L3 level for both the image series for all the patients, and three groups of observers manually annotated the skeletal muscles in the 54 CT images of the test set as the gold standard. The performance of the proposed algorithm was evaluated in terms of the Dice similarity coefficient (DSC), precision, recall, 95th percentile of the Hausdorff distance (HD95), and average surface distance (ASD). The running time of the proposed algorithm was recorded. An open source deep learning-based AutoMATICA algorithm was compared with the proposed algorithm. The inter-observer variations were also used as the reference.</p><p><strong>Results: </strong>The DSC, precision, recall, HD95, ASD, and running time were 93.2 ± 1.9% (mean ± standard deviation), 96.7 ± 2.9%, 90.0 ± 2.9%, 4.8 ± 1.3 mm, 0.8 ± 0.2 mm, and 303 ± 43 ms (on CPU) for the proposed algorithm, and 94.1 ± 4.1%, 92.7 ± 5.5%, 95.7 ± 4.0%, 7.4 ± 5.7 mm, 0.9 ± 0.6 mm, and 448 ± 40 ms (on GPU) for AutoMATICA, respectively. The differences between the proposed algorithm and the inter-observer reference were 4.7%, 1.2%, 7.9%, 3.2 mm, and 0.6 mm, respectively, for the averaged DSC, precision, recall, HD95, and ASD.</p><p><strong>Conclusion: </strong>The proposed algorithm can be used to segment skeletal muscles at the L3 level in either the plain or enhanced low-dose CT images.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1513-1526"},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic Analysis of Treatment Effect for Patients with Radiation Necrosis Treated with Pentoxifylline and Vitamin E.","authors":"Jimmy S Patel, Elahheh Salari, Xuxin Chen, Jeffrey Switchenko, Bree R Eaton, Jim Zhong, Xiaofeng Yang, Hui-Kuo G Shu, Lisa J Sudmeier","doi":"10.3390/tomography10090110","DOIUrl":"https://doi.org/10.3390/tomography10090110","url":null,"abstract":"<p><strong>Background: </strong>The combination of oral pentoxifylline (Ptx) and vitamin E (VitE) has been used to treat radiation-induced fibrosis and soft tissue injury. Here, we review outcomes and perform a radiomic analysis of treatment effects in patients prescribed Ptx + VitE at our institution for the treatment of radiation necrosis (RN).</p><p><strong>Methods: </strong>A total of 48 patients treated with stereotactic radiosurgery (SRS) had evidence of RN and had MRI before and after starting Ptx + VitE. The radiation oncologist's impression of the imaging in the electronic medical record was used to score response to treatment. Support Vector Machine (SVM) was used to train a model of radiomics features derived from radiation necrosis on pre- and 1st post-treatment T1 post-contrast MRIs that can classify the ultimate response to treatment with Ptx + VitE.</p><p><strong>Results: </strong>A total of 43.8% of patients showed evidence of improvement, 18.8% showed no change, and 25% showed worsening RN upon imaging after starting Ptx + VitE. The median time-to-response assessment was 3.17 months. Nine patients progressed significantly and required Bevacizumab, hyperbaric oxygen therapy, or surgery. Patients who had multiple lesions treated with SRS were less likely to show improvement (<i>p</i> = 0.037). A total of 34 patients were also prescribed dexamethasone, either before (7), with (16), or after starting (11) treatment. The use of dexamethasone was not associated with an improved response to Ptx + VitE (<i>p</i> = 0.471). Three patients stopped treatment due to side effects. Finally, we were able to develop a machine learning (SVM) model of radiomic features derived from pre- and 1st post-treatment MRIs that was able to predict the ultimate treatment response to Ptx + VitE with receiver operating characteristic (ROC) area under curve (AUC) of 0.69.</p><p><strong>Conclusions: </strong>Ptx + VitE appears safe for the treatment of RN, but randomized data are needed to assess efficacy and validate radiomic models, which may assist with prognostication.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1501-1512"},"PeriodicalIF":2.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Joint Classification Method for COVID-19 Lesions Based on Deep Learning and Radiomics.","authors":"Guoxiang Ma, Kai Wang, Ting Zeng, Bin Sun, Liping Yang","doi":"10.3390/tomography10090109","DOIUrl":"https://doi.org/10.3390/tomography10090109","url":null,"abstract":"<p><p>Pneumonia caused by novel coronavirus is an acute respiratory infectious disease. Its rapid spread in a short period of time has brought great challenges for global public health. The use of deep learning and radiomics methods can effectively distinguish the subtypes of lung diseases, provide better clinical prognosis accuracy, and assist clinicians, enabling them to adjust the clinical management level in time. The main goal of this study is to verify the performance of deep learning and radiomics methods in the classification of COVID-19 lesions and reveal the image characteristics of COVID-19 lung disease. An MFPN neural network model was proposed to extract the depth features of lesions, and six machine-learning methods were used to compare the classification performance of deep features, key radiomics features and combined features for COVID-19 lung lesions. The results show that in the COVID-19 image classification task, the classification method combining radiomics and deep features can achieve good classification results and has certain clinical application value.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1488-1500"},"PeriodicalIF":2.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Machine-Learning Derived Radiomic Analysis of CT and PET Imaging to Investigate Atherosclerotic Cardiovascular Disease.","authors":"Arshpreet Singh Badesha, Russell Frood, Marc A Bailey, Patrick M Coughlin, Andrew F Scarsbrook","doi":"10.3390/tomography10090108","DOIUrl":"10.3390/tomography10090108","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease affects the carotid arteries, coronary arteries, aorta and the peripheral arteries. Radiomics involves the extraction of quantitative data from imaging features that are imperceptible to the eye. Radiomics analysis in cardiovascular disease has largely focused on CT and MRI modalities. This scoping review aims to summarise the existing literature on radiomic analysis techniques in cardiovascular disease.</p><p><strong>Methods: </strong>MEDLINE and Embase databases were searched for eligible studies evaluating radiomic techniques in living human subjects derived from CT, MRI or PET imaging investigating atherosclerotic disease. Data on study population, imaging characteristics and radiomics methodology were extracted.</p><p><strong>Results: </strong>Twenty-nine studies consisting of 5753 patients (3752 males) were identified, and 78.7% of patients were from coronary artery studies. Twenty-seven studies employed CT imaging (19 CT carotid angiography and 6 CT coronary angiography (CTCA)), and two studies studied PET/CT. Manual segmentation was most frequently undertaken. Processing techniques included voxel discretisation, voxel resampling and filtration. Various shape, first-order, second-order and higher-order radiomic features were extracted. Logistic regression was most commonly used for machine learning.</p><p><strong>Conclusion: </strong>Most published evidence was feasibility/proof of concept work. There was significant heterogeneity in image acquisition, segmentation techniques, processing and analysis between studies. There is a need for the implementation of standardised imaging acquisition protocols, adherence to published reporting guidelines and economic evaluation.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1455-1487"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance-Guided Cancer Therapy Radiomics and Machine Learning Models for Response Prediction.","authors":"Jesutofunmi Ayo Fajemisin, Glebys Gonzalez, Stephen A Rosenberg, Ghanim Ullah, Gage Redler, Kujtim Latifi, Eduardo G Moros, Issam El Naqa","doi":"10.3390/tomography10090107","DOIUrl":"https://doi.org/10.3390/tomography10090107","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is known for its accurate soft tissue delineation of tumors and normal tissues. This development has significantly impacted the imaging and treatment of cancers. Radiomics is the process of extracting high-dimensional features from medical images. Several studies have shown that these extracted features may be used to build machine-learning models for the prediction of treatment outcomes of cancer patients. Various feature selection techniques and machine models interrogate the relevant radiomics features for predicting cancer treatment outcomes. This study aims to provide an overview of MRI radiomics features used in predicting clinical treatment outcomes with machine learning techniques. The review includes examples from different disease sites. It will also discuss the impact of magnetic field strength, sample size, and other characteristics on outcome prediction performance.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1439-1454"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Biomarkers of Muscle.","authors":"Usha Sinha, Shantanu Sinha","doi":"10.3390/tomography10090106","DOIUrl":"https://doi.org/10.3390/tomography10090106","url":null,"abstract":"<p><p>This review is focused on the current status of quantitative MRI (qMRI) of skeletal muscle. The first section covers the techniques of qMRI in muscle with the focus on each quantitative parameter, the corresponding imaging sequence, discussion of the relation of the measured parameter to underlying physiology/pathophysiology, the image processing and analysis approaches, and studies on normal subjects. We cover the more established parametric mapping from T1-weighted imaging for morphometrics including image segmentation, proton density fat fraction, T2 mapping, and diffusion tensor imaging to emerging qMRI features such as magnetization transfer including ultralow TE imaging for macromolecular fraction, and strain mapping. The second section is a summary of current clinical applications of qMRI of muscle; the intent is to demonstrate the utility of qMRI in different disease states of the muscle rather than a complete comprehensive survey.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1411-1438"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposing the Public BraTS Dataset for Postoperative Brain Tumour Treatment Response Monitoring.","authors":"Peter Jagd Sørensen, Claes Nøhr Ladefoged, Vibeke Andrée Larsen, Flemming Littrup Andersen, Michael Bachmann Nielsen, Hans Skovgaard Poulsen, Jonathan Frederik Carlsen, Adam Espe Hansen","doi":"10.3390/tomography10090105","DOIUrl":"https://doi.org/10.3390/tomography10090105","url":null,"abstract":"<p><p>The Brain Tumor Segmentation (BraTS) Challenge has been a main driver of the development of deep learning (DL) algorithms and provides by far the largest publicly available expert-annotated brain tumour dataset but contains solely preoperative examinations. The aim of our study was to facilitate the use of the BraTS dataset for training DL brain tumour segmentation algorithms for a postoperative setting. To this end, we introduced an automatic conversion of the three-label BraTS annotation protocol to a two-label annotation protocol suitable for postoperative brain tumour segmentation. To assess the viability of the label conversion, we trained a DL algorithm using both the three-label and the two-label annotation protocols. We assessed the models pre- and postoperatively and compared the performance with a state-of-the-art DL method. The DL algorithm trained using the BraTS three-label annotation misclassified parts of 10 out of 41 fluid-filled resection cavities in 72 postoperative glioblastoma MRIs, whereas the two-label model showed no such inaccuracies. The tumour segmentation performance of the two-label model both pre- and postoperatively was comparable to that of a state-of-the-art algorithm for tumour volumes larger than 1 cm³. Our study enables using the BraTS dataset as a basis for the training of DL algorithms for postoperative tumour segmentation.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1397-1410"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Therapeutic Approach to Thoracic Outlet Syndrome.","authors":"Stefania Rizzo, Cammillo Talei Franzesi, Andrea Cara, Enrico Mario Cassina, Lidia Libretti, Emanuele Pirondini, Federico Raveglia, Antonio Tuoro, Sara Vaquer, Sara Degiovanni, Erica Michela Cavalli, Andrea Marchesi, Alberto Froio, Francesco Petrella","doi":"10.3390/tomography10090103","DOIUrl":"https://doi.org/10.3390/tomography10090103","url":null,"abstract":"<p><p>Thoracic outlet syndrome (TOS) is a group of symptoms caused by the compression of neurovascular structures of the superior thoracic outlet. The knowledge of its clinical presentation with specific symptoms, as well as proper imaging examinations, ranging from plain radiographs to ultrasound, computed tomography and magnetic resonance imaging, may help achieve a precise diagnosis. Once TOS is recognized, proper treatment may comprise a conservative or a surgical approach.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1365-1378"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Presurgical Cortical Gray Matter Volumetry and Cerebral Perfusion Improves the Efficacy of Predicting Postoperative Cognitive Impairment of Elderly Patients.","authors":"Weijian Zhou, Binbin Zhu, Yifei Weng, Chunqu Chen, Jiajing Ni, Wenqi Shen, Wenting Lan, Jianhua Wang","doi":"10.3390/tomography10090104","DOIUrl":"https://doi.org/10.3390/tomography10090104","url":null,"abstract":"<p><strong>Background: </strong>Postoperative cognitive dysfunction (POCD) is a common complication of the central nervous system in elderly surgical patients. Structural MRI and arterial spin labelling (ASL) techniques found that the grey matter volume and cerebral perfusion in some specific brain areas are associated with the occurrence of POCD, but the results are inconsistent, and the predictive accuracy is low. We hypothesised that the combination of cortical grey matter volumetry and cerebral blood flow yield higher accuracy than either of the methods in discriminating the elderly individuals who are susceptible to POCD after abdominal surgery.</p><p><strong>Materials and methods: </strong>Participants underwent neuropsychological testing before and after surgery. Postoperative cognitive dysfunction (POCD) was defined as a decrease in cognitive score of at least 20%. ASL-MRI and T1-weighted imaging were performed before surgery. We compared differences in cerebral blood flow (CBF) and cortical grey matter characteristics between POCD and non-POCD patients and generated receiver operating characteristic curves.</p><p><strong>Results: </strong>Out of 51 patients, 9 (17%) were diagnosed with POCD. CBF in the inferior frontal gyrus was lower in the POCD group compared to the non-POCD group (<i>p</i> < 0.001), and the volume of cortical grey matter in the anterior cingulate gyrus was higher in the POCD group (<i>p</i> < 0.001). The highest AUC value was 0.973.</p><p><strong>Conclusions: </strong>The combination of cortical grey matter volumetry and cerebral perfusion based on ASL-MRI has improved efficacy in the early warning of POCD to elderly abdominal surgical patients.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1379-1396"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-Fluoroazomycin Arabinoside (FAZA) PET/MR as a Biomarker of Hypoxia in Rectal Cancer: A Pilot Study.","authors":"Ur Metser, Andres Kohan, Catherine O'Brien, Rebecca K S Wong, Claudia Ortega, Patrick Veit-Haibach, Brandon Driscoll, Ivan Yeung, Adam Farag","doi":"10.3390/tomography10090102","DOIUrl":"https://doi.org/10.3390/tomography10090102","url":null,"abstract":"<p><p>Tumor hypoxia is a negative prognostic factor in many tumors and is predictive of metastatic spread and poor responsiveness to both chemotherapy and radiotherapy. <b>Purpose:</b> To assess the feasibility of using ¹⁸F-Fluoroazomycin arabinoside (FAZA) PET/MR to image tumor hypoxia in patients with locally advanced rectal cancer (LARC) prior to and following neoadjuvant chemoradiotherapy (nCRT). The secondary objective was to compare different reference tissues and thresholds for tumor hypoxia quantification. <b>Patients and Methods:</b> Eight patients with histologically proven LARC were included. All patients underwent ¹⁸F-FAZA PET/MR prior to initiation of nCRT, four of whom also had a second scan following completion of nCRT and prior to surgery. Tumors were segmented using T₂-weighted MR. Each voxel within the segmented tumor was defined as hypoxic or oxic using thresholds derived from various references: ×1.0 or ×1.2 SUVmean of blood pool [BP] or left ventricle [LV] and SUVmean +3SD for gluteus maximus. Correlation coefficient (CoC) between HF and tumor SUVmax/reference SUVmean TRR for the various thresholds was calculated. Hypoxic fraction (HF), defined as the % hypoxic voxels within the tumor volume was calculated for each reference/threshold. <b>Results:</b> For all cases, baseline and follow-up, the CoCs for gluteus maximus and for BP and LV (×1.0) were 0.241, 0.344, and 0.499, respectively, and HFs were (median; range) 16.6% (2.4-33.8), 36.8% (0.3-72.9), and 30.7% (0.8-55.5), respectively. For a threshold of ×1.2, the CoCs for BP and LV as references were 0.611 and 0.838, respectively, and HFs were (median; range) 10.4% (0-47.6), and 4.3% (0-20.1%), respectively. The change in HF following nCRT ranged from (-18.9%) to (+54%). <b>Conclusions:</b> Imaging of hypoxia in LARC with ¹⁸F-FAZA PET/MR is feasible. Blood pool as measured in the LV appears to be the most reliable reference for calculating the HF. There is a wide range of HF and variable change in HF before and after nCRT.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 9","pages":"1354-1364"},"PeriodicalIF":2.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}