Theodora K Tsouloufi, Louise M Donnison, Karen L Smyth, Andrew R Peters
{"title":"Development of a systematic mapping review protocol for the most recent evidence on ruminant infectious disease frequency and disease-associated mortality: Ethiopia as a case study.","authors":"Theodora K Tsouloufi, Louise M Donnison, Karen L Smyth, Andrew R Peters","doi":"10.1017/S1466252319000203","DOIUrl":"10.1017/S1466252319000203","url":null,"abstract":"<p><p>Almost 19% of the GDP of Ethiopia results from livestock production. Ruminants, in particular, form the majority of the national herd and are a critical source of income for smallholder farmers. Infectious diseases have been identified as a major cause of reduced livestock productivity in low- and middle-income countries (LMICs); therefore, a sound and comprehensive understanding of the relevant evidence would be beneficial in order to enable decision making on disease control policies. However, livestock disease data from sub-Saharan Africa is variable and disparate, which poses a challenge for evidence synthesis. This paper describes a protocol for a systematic mapping review of the recent available evidence on ruminant disease prevalence and associated mortality in Ethiopia. Literature sources will be identified using database search strategies. The titles, abstracts and, subsequently, full texts will be screened for inclusion based on predefined eligibility criteria. Specific data will be extracted and a preliminary qualitative assessment of the evidence will be performed using predefined indicators. The planned systematic map will be the first to provide a large-scale overview of the available ruminant disease evidence in Ethiopia; the final output will be an interactive dashboard tool to inform critical stakeholders in policy and research.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"21 1","pages":"96-102"},"PeriodicalIF":4.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38349293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lee V Wisener, Jan M Sargeant, Annette M O'Connor, Terri L O'Sullivan, Scott A McEwen, Andrea Nwosu, Tanya M Rossi
{"title":"Non-antibiotic approaches for disease prevention and control in beef and veal production: a scoping review.","authors":"Lee V Wisener, Jan M Sargeant, Annette M O'Connor, Terri L O'Sullivan, Scott A McEwen, Andrea Nwosu, Tanya M Rossi","doi":"10.1017/S1466252319000252","DOIUrl":"10.1017/S1466252319000252","url":null,"abstract":"<p><p>Livestock producers are encouraged to reduce the use of antibiotics belonging to classes of medical importance to humans. We conducted a scoping review on non-antibiotic interventions in the form of products or management practices that could potentially reduce the need for antibiotics in beef and veal animals living under intensive production conditions. Our objectives were to systematically describe the research on this broad topic, identify specific topics that could feasibly support systematic reviews, and identify knowledge gaps. Multiple databases were searched. Two reviewers independently screened and charted the data. From the 13,598 articles screened, 722 relevant articles were charted. The number of relevant articles increased steadily from 1990. The Western European research was dominated by veal production studies whereas the North American research was dominated by beef production studies. The interventions and outcomes measured were diverse. The four most frequent interventions included non-antibiotic feed additives, vaccinations, breed type, and feed type. The four most frequent outcomes were indices of immunity, non-specific morbidity, respiratory disease, and mortality. There were seven topic areas evaluated in clinical trials that may share enough commonality to support systemic reviews. There was a dearth of studies in which interventions were compared to antibiotic comparison groups.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"128-142"},"PeriodicalIF":4.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachael Vriezen, Jan M Sargeant, Ellen Vriezen, Charlotte B Winder, Annette M O'Connor
{"title":"Quality assessment of systematic reviews and meta-analyses that examine preventive antibiotic uses and management practices designed to prevent disease in livestock.","authors":"Rachael Vriezen, Jan M Sargeant, Ellen Vriezen, Charlotte B Winder, Annette M O'Connor","doi":"10.1017/S146625231900029X","DOIUrl":"https://doi.org/10.1017/S146625231900029X","url":null,"abstract":"<p><p>To implement effective stewardship in food animal production, it is essential that producers and veterinarians are aware of preventive interventions to reduce illness in livestock. Systematic reviews and meta-analyses (SR/MA) provide transparent, replicable, and quality-assessed overviews. At present, it is unknown how many SR/MA evaluate preventive antibiotic use or management practices aimed at reducing disease risk in animal agriculture. Further, the quality of existing reviews is unknown. Our aim was to identify reviews investigating these topics and to provide an assessment of their quality. Thirty-eight relevant reviews were identified. Quality assessment was based on the AMSTAR 2 framework for the critical appraisal of systematic reviews. The quality of most of the reviews captured was classified as critically low (84.2%, n = 32/38), and only a small percentage of the evaluated reviews did not contain critical weaknesses (7.9%, n = 3/38). Particularly, a small number of reviews reported the development of an a priori protocol (15.8%, n = 6/38), and few reviews stated that key review steps were conducted in duplicate (study selection/screening: 26.3%, n = 10/38; data extraction: 15.8%, n = 6/38). The development of high-quality reviews summarizing evidence on approaches to antibiotic reduction is essential, and thus greater adherence to quality conduct guidelines for synthesis research is crucial.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"305-318"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S146625231900029X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Hu, A M O'Connor, C B Winder, J M Sargeant, C Wang
{"title":"How to read and interpret the results of a Bayesian network meta-analysis: a short tutorial.","authors":"D Hu, A M O'Connor, C B Winder, J M Sargeant, C Wang","doi":"10.1017/S1466252319000343","DOIUrl":"https://doi.org/10.1017/S1466252319000343","url":null,"abstract":"<p><p>In this manuscript we use realistic data to conduct a network meta-analysis using a Bayesian approach to analysis. The purpose of this manuscript is to explain, in lay terms, how to interpret the output of such an analysis. Many readers are familiar with the forest plot as an approach to presenting the results of a pairwise meta-analysis. However when presented with the results of network meta-analysis, which often does not include the forest plot, the output and results can be difficult to understand. Further, one of the advantages of Bayesian network meta-analyses is in the novel outputs such as treatment rankings and the probability distributions are more commonly presented for network meta-analysis. Our goal here is to provide a tutorial for how to read the outcome of network meta-analysis rather than how to conduct or assess the risk of bias in a network meta-analysis.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"106-115"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Dapeng Hu, Carly Moody, Annette M O'Connor, Terri L O'Sullivan, Mark Reist, Chong Wang, Barbara Wilhelm, Charlotte B Winder
{"title":"A systematic review of the efficacy of antibiotics for the prevention of swine respiratory disease.","authors":"Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Dapeng Hu, Carly Moody, Annette M O'Connor, Terri L O'Sullivan, Mark Reist, Chong Wang, Barbara Wilhelm, Charlotte B Winder","doi":"10.1017/S1466252319000185","DOIUrl":"https://doi.org/10.1017/S1466252319000185","url":null,"abstract":"<p><p>Prevention and control of respiratory disease is a major contributor to antibiotic use in swine. A systematic review was conducted to address the question, 'What is the comparative efficacy of antimicrobials for the prevention of swine respiratory disease?' Eligible studies were controlled trials published in English evaluating prophylactic antibiotics in swine, where clinical morbidity, mortality, or total antibiotic use was assessed. Four databases and the gray literature were searched for relevant articles. Two reviewers working independently screened titles and abstracts for eligibility followed by full-text articles, and then extracted data and evaluated risk of bias for eligible trials. There were 44 eligible trials from 36 publications. Clinical morbidity was evaluated in eight trials where antibiotics were used in nursery pigs and 10 trials where antibiotics were used in grower pigs. Mortality was measured in 22 trials in nursery pigs and 12 trials in grower pigs. There was heterogeneity in the antibiotic interventions and comparisons published in the literature; thus, there was insufficient evidence to allow quantification of the efficacy, or relative efficacy, of antibiotic interventions. Concerns related to statistical non-independence and quality of reporting were noted in the included trials.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"291-304"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A M O'Connor, D Hu, S C Totton, N Scott, C B Winder, B Wang, C Wang, J Glanville, H Wood, B White, R Larson, C Waldner, J M Sargeant
{"title":"A systematic review and network meta-analysis of bacterial and viral vaccines, administered at or near arrival at the feedlot, for control of bovine respiratory disease in beef cattle.","authors":"A M O'Connor, D Hu, S C Totton, N Scott, C B Winder, B Wang, C Wang, J Glanville, H Wood, B White, R Larson, C Waldner, J M Sargeant","doi":"10.1017/S1466252319000288","DOIUrl":"https://doi.org/10.1017/S1466252319000288","url":null,"abstract":"<p><p>Vaccination against putative causal organisms is a frequently used and preferred approach to controlling bovine respiratory disease complex (BRD) because it reduces the need for antibiotic use. Because approximately 90% of feedlots use and 90% of beef cattle receive vaccines in the USA, information about their comparative efficacy would be useful for selecting a vaccine. We conducted a systematic review and network meta-analysis of studies assessing the comparative efficacy of vaccines to control BRD when administered to beef cattle at or near their arrival at the feedlot. We searched MEDLINE, MEDLINE In-Process, MEDLINE Daily Epub Ahead of Print, AGRICOLA, Cambridge Agricultural and Biological Index, Science Citation Index, and Conference Proceedings Citation Index - Science and hand-searched the conference proceedings of the American Association of Bovine Practitioners and World Buiatrics Congress. We found 53 studies that reported BRD morbidity within 45 days of feedlot arrival. The largest connected network of studies, which involved 17 vaccine protocols from 14 studies, was included in the meta-analysis. Consistent with previous reviews, we found little compelling evidence that vaccines used at or near arrival at the feedlot reduce the incidence of BRD diagnosis.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"143-162"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan M Sargeant, Annette M O'Connor, Charlotte B Winder
{"title":"Editorial: Systematic reviews reveal a need for more, better data to inform antimicrobial stewardship practices in animal agriculture.","authors":"Jan M Sargeant, Annette M O'Connor, Charlotte B Winder","doi":"10.1017/S1466252319000240","DOIUrl":"https://doi.org/10.1017/S1466252319000240","url":null,"abstract":"<p><p>This editorial summarizes the key observations from a special issue of Animal Health Research Reviews comprising 14 articles related to the efficacy of antimicrobial and non-antimicrobial approaches to reduce disease in beef, dairy cattle, swine, and broiler chickens. The articles used evidence-based methods, including scoping reviews, systematic reviews, meta-analyses, and network meta-analyses. Despite finding evidence of efficacy for some of the interventions examined, across the body of research, there was a lack of replication and inconsistency in outcomes among the included trials, and concerns related to completeness of reporting and trial design and execution. There is an urgent need for more and better data to inform antimicrobial stewardship practices in animal agriculture.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"103-105"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, B Deb, M Reist, C Moody, A M O'Connor
{"title":"Comparative efficacy of teat sealants given prepartum for prevention of intramammary infections and clinical mastitis: a systematic review and network meta-analysis.","authors":"C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, B Deb, M Reist, C Moody, A M O'Connor","doi":"10.1017/S1466252319000276","DOIUrl":"https://doi.org/10.1017/S1466252319000276","url":null,"abstract":"<p><p>A systematic review and network meta-analysis were conducted to assess the relative efficacy of internal or external teat sealants given at dry-off in dairy cattle. Controlled trials were eligible if they assessed the use of internal or external teat sealants, with or without concurrent antimicrobial therapy, compared to no treatment or an alternative treatment, and measured one or more of the following outcomes: incidence of intramammary infection (IMI) at calving, IMI during the first 30 days in milk (DIM), or clinical mastitis during the first 30 DIM. Risk of bias was based on the Cochrane Risk of Bias 2.0 tool with modified signaling questions. From 2280 initially identified records, 32 trials had data extracted for one or more outcomes. Network meta-analysis was conducted for IMI at calving. Use of an internal teat sealant (bismuth subnitrate) significantly reduced the risk of new IMI at calving compared to non-treated controls (RR = 0.36, 95% CI 0.25-0.72). For comparisons between antimicrobial and teat sealant groups, concerns regarding precision were seen. Synthesis of the primary research identified important challenges related to the comparability of outcomes, replication and connection of interventions, and quality of reporting of study conduct.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"182-198"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AHR volume 20 issue 2 Cover and Front matter","authors":"","doi":"10.1017/s1466252320000055","DOIUrl":"https://doi.org/10.1017/s1466252320000055","url":null,"abstract":"","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 1","pages":"f1 - f2"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s1466252320000055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45502019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, B Deb, M Reist, C Moody, A M O'Connor
{"title":"Comparative efficacy of antimicrobial treatments in dairy cows at dry-off to prevent new intramammary infections during the dry period or clinical mastitis during early lactation: a systematic review and network meta-analysis.","authors":"C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, B Deb, M Reist, C Moody, A M O'Connor","doi":"10.1017/S1466252319000239","DOIUrl":"https://doi.org/10.1017/S1466252319000239","url":null,"abstract":"<p><p>A systematic review and network meta-analysis were conducted to assess the relative efficacy of antimicrobial therapy given to dairy cows at dry-off. Eligible studies were controlled trials assessing the use of antimicrobials compared to no treatment or an alternative treatment, and assessed one or more of the following outcomes: incidence of intramammary infection (IMI) at calving, incidence of IMI during the first 30 days in milk (DIM), or incidence of clinical mastitis during the first 30 DIM. Databases and conference proceedings were searched for relevant articles. The potential for bias was assessed using the Cochrane Risk of Bias 2.0 algorithm. From 3480 initially identified records, 45 trials had data extracted for one or more outcomes. Network meta-analysis was conducted for IMI at calving. The use of cephalosporins, cloxacillin, or penicillin with aminoglycoside significantly reduced the risk of new IMI at calving compared to non-treated controls (cephalosporins, RR = 0.37, 95% CI 0.23-0.65; cloxacillin, RR = 0.55, 95% CI 0.38-0.79; penicillin with aminoglycoside, RR = 0.42, 95% CI 0.26-0.72). Synthesis revealed challenges with a comparability of outcomes, replication of interventions, definitions of outcomes, and quality of reporting. The use of reporting guidelines, replication among interventions, and standardization of outcome definitions would increase the utility of primary research in this area.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"199-216"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}