Jan M Sargeant, Bhumika Deb, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Jennifer Dunn, Dapeng Hu, Carly Moody, Annette M O'Connor, Terri L O'Sullivan, Mark Reist, Chong Wang, Barbara Wilhelm, Charlotte B Winder
{"title":"Efficacy of bacterial vaccines to prevent respiratory disease in swine: a systematic review and network meta-analysis.","authors":"Jan M Sargeant, Bhumika Deb, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Jennifer Dunn, Dapeng Hu, Carly Moody, Annette M O'Connor, Terri L O'Sullivan, Mark Reist, Chong Wang, Barbara Wilhelm, Charlotte B Winder","doi":"10.1017/S1466252319000173","DOIUrl":"https://doi.org/10.1017/S1466252319000173","url":null,"abstract":"<p><p>A systematic review and network meta-analysis (MA) was conducted to address the question, 'What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?' Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Network MA was undertaken for morbidity, mortality, and the presence or absence of non-specific lung lesions. However, there was not a sufficient body of research evaluating the same interventions and outcomes to allow a meaningful synthesis of the comparative efficacy of the vaccines. To build this body of research, additional rigor in trial design and analysis, and detailed reporting of trial methods and results are warranted.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"274-290"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Catherine M Logue, Anastasia Novy, Annette M O'Connor, Mark Reist, Charlotte B Winder
{"title":"The efficacy of antibiotics to control colibacillosis in broiler poultry: a systematic review.","authors":"Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Catherine M Logue, Anastasia Novy, Annette M O'Connor, Mark Reist, Charlotte B Winder","doi":"10.1017/S1466252319000264","DOIUrl":"https://doi.org/10.1017/S1466252319000264","url":null,"abstract":"<p><p>The objective of this systematic review was to evaluate the efficacy of antibiotics to prevent or control colibacillosis in broilers. Studies found eligible were conducted controlled trials in broilers that evaluated an antibiotic intervention, with at least one of the following outcomes: mortality, feed conversion ratio (FCR), condemnations at slaughter, or total antibiotic use. Four electronic databases plus the gray literature were searched. Abstracts were screened for eligibility and data were extracted from eligible trials. Risk of bias was evaluated.Seven trials reported eligible outcomes in a format that allowed data extraction; all reported results for FCR and one also reported mortality. Due to the heterogeneity in the interventions and outcomes evaluated, it was not feasible to conduct meta-analysis.Qualitatively, for FCR, comparisons between an antibiotic and an alternative product did not show a significant benefit for either. Some of the comparisons between an antibiotic and a no-treatment placebo showed a numerical benefit to antibiotics, but with wide confidence intervals. The risk-of-bias assessment revealed concerns with reporting of key trial features.The results of this review do not provide compelling evidence for or against the efficacy of antibiotics for the control of colibacillosis.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"263-273"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A M O'Connor, D Hu, S C Totton, N Scott, C B Winder, B Wang, C Wang, J Glanville, H Wood, B White, R Larson, C Waldner, J M Sargeant
{"title":"A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot.","authors":"A M O'Connor, D Hu, S C Totton, N Scott, C B Winder, B Wang, C Wang, J Glanville, H Wood, B White, R Larson, C Waldner, J M Sargeant","doi":"10.1017/S1466252320000031","DOIUrl":"https://doi.org/10.1017/S1466252320000031","url":null,"abstract":"<p><p>We conducted a systematic review and network meta-analysis to determine the comparative efficacy of antibiotics used to control bovine respiratory disease (BRD) in beef cattle on feedlots. The information sources for the review were: MEDLINE®, MEDLINE In-Process and MEDLINE® Daily, AGRICOLA, Epub Ahead of Print, Cambridge Agricultural and Biological Index, Science Citation Index, Conference Proceedings Citation Index - Science, the Proceedings of the American Association of Bovine Practitioners, World Buiatrics Conference, and the United States Food and Drug Administration Freedom of Information New Animal Drug Applications summaries. The eligible population was weaned beef cattle raised in intensive systems. The interventions of interest were injectable antibiotics used at the time the cattle arrived at the feedlot. The outcome of interest was the diagnosis of BRD within 45 days of arrival at the feedlot. The network meta-analysis included data from 46 studies and 167 study arms identified in the review. The results suggest that macrolides are the most effective antibiotics for the reduction of BRD incidence. Injectable oxytetracycline effectively controlled BRD compared with no antibiotics; however, it was less effective than macrolide treatment. Because oxytetracycline is already commonly used to prevent, control, and treat BRD in groups of feedlot cattle, the use of injectable oxytetracycline for BRD control might have advantages from an antibiotic stewardship perspective.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"163-181"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252320000031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C B Winder, J M Sargeant, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, A M O'Connor
{"title":"Comparative efficacy of blanket versus selective dry-cow therapy: a systematic review and pairwise meta-analysis.","authors":"C B Winder, J M Sargeant, D F Kelton, S J Leblanc, T F Duffield, J Glanville, H Wood, K J Churchill, J Dunn, M D Bergevin, K Dawkins, S Meadows, A M O'Connor","doi":"10.1017/S1466252319000306","DOIUrl":"https://doi.org/10.1017/S1466252319000306","url":null,"abstract":"<p><p>A systematic review and meta-analysis were conducted to determine the efficacy of selective dry-cow antimicrobial therapy compared to blanket therapy (all quarters/all cows). Controlled trials were eligible if any of the following were assessed: incidence of clinical mastitis during the first 30 DIM, frequency of intramammary infection (IMI) at calving, or frequency of IMI during the first 30 DIM. From 3480 identified records, nine trials were data extracted for IMI at calving. There was an insufficient number of trials to conduct meta-analysis for the other outcomes. Risk of IMI at calving in selectively treated cows was higher than blanket therapy (RR = 1.34, 95% CI = 1.13, 1.16), but substantial heterogeneity was present (I2 = 58%). Subgroup analysis showed that, for trials using internal teat sealants, there was no difference in IMI risk at calving between groups, and no heterogeneity was present. For trials not using internal teat sealants, there was an increased risk in cows assigned to a selective dry-cow therapy protocol, compared to blanket treatment, with substantial heterogeneity in this subgroup. However, the small number of trials and heterogeneity in the subgroup without internal teat sealants suggests that the relative risk between treatments may differ from the determined point estimates based on other unmeasured factors.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"217-228"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, M A Godkin, K J Churchill, A M O'Connor
{"title":"Comparative efficacy of antimicrobials for treatment of clinical mastitis in lactating dairy cattle: a systematic review and network meta-analysis.","authors":"C B Winder, J M Sargeant, D Hu, C Wang, D F Kelton, M A Godkin, K J Churchill, A M O'Connor","doi":"10.1017/S1466252319000318","DOIUrl":"https://doi.org/10.1017/S1466252319000318","url":null,"abstract":"<p><p>A systematic review and network meta-analysis were conducted to assess the relative efficacy of antimicrobial therapy for clinical mastitis in lactating dairy cattle. Controlled trials in lactating dairy cattle with natural disease exposure were eligible if they compared an antimicrobial treatment to a non-treated control, placebo, or a different antimicrobial, for the treatment of clinical mastitis, and assessed clinical or bacteriologic cure. Potential for bias was assessed using a modified Cochrane Risk of Bias 2.0 tool. From 14775 initially identified records, 54 trials were assessed as eligible. Networks were established for bacteriologic cure by bacterial species group, and clinical cure. Disparate networks among bacteriologic cures precluded meta-analysis. Network meta-analysis was conducted for trials assessing clinical cure, but lack of precision of point estimates resulted in wide credibility intervals for all treatments, with no definitive conclusions regarding relative efficacy. Consideration of network geometry can inform future research to increase the utility of current and previous work. Replication of intervention arms and consideration of connection to existing networks would improve the future ability to determine relative efficacy. Challenges in the evaluation of bias in primary research stemmed from a lack of reporting. Consideration of reporting guidelines would also improve the utility of future research.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"229-246"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Dapeng Hu, Catherine M Logue, Shannon Meadows, Carly Moody, Anastasia Novy, Annette M O'Connor, Mark Reist, Yuko Sato, Chong Wang, Charlotte B Winder
{"title":"The efficacy of litter management strategies to prevent morbidity and mortality in broiler chickens: a systematic review and network meta-analysis.","authors":"Jan M Sargeant, Michele D Bergevin, Katheryn Churchill, Kaitlyn Dawkins, Bhumika Deb, Jennifer Dunn, Dapeng Hu, Catherine M Logue, Shannon Meadows, Carly Moody, Anastasia Novy, Annette M O'Connor, Mark Reist, Yuko Sato, Chong Wang, Charlotte B Winder","doi":"10.1017/S1466252319000227","DOIUrl":"https://doi.org/10.1017/S1466252319000227","url":null,"abstract":"<p><p>A systematic review and network meta-analysis (NMA) were conducted to address the question, 'What is the efficacy of litter management strategies to reduce morbidity, mortality, condemnation at slaughter, or total antibiotic use in broilers?' Eligible studies were clinical trials published in English evaluating the efficacy of litter management in broilers on morbidity, condemnations at slaughter, mortality, or total antibiotic use. Multiple databases and two conference proceedings were searched for relevant literature. After relevance screening and data extraction, there were 50 trials evaluating litter type, 22 trials evaluating litter additives, 10 trials comparing fresh to re-used litter, and six trials evaluating floor type. NMAs were conducted for mortality (61 trials) and for the presence or absence of footpad lesions (15 trials). There were no differences in mortality among the litter types, floor types, or additives. For footpad lesions, peat moss appeared beneficial compared to straw, based on a small number of comparisons. In a pairwise meta-analysis, there was no association between fresh versus used litter on the risk of mortality, although there was considerable heterogeneity among studies (I2 = 66%). There was poor reporting of key design features in many studies, and analyses rarely accounted for non-independence of observations within flocks.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"247-262"},"PeriodicalIF":2.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37663276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachael Vriezen, Jan M Sargeant, Ellen Vriezen, Mark Reist, Charlotte B Winder, Annette M O'Connor
{"title":"Systematic reviews and meta-analyses in animal health, performance, and on-farm food safety: a scoping review.","authors":"Rachael Vriezen, Jan M Sargeant, Ellen Vriezen, Mark Reist, Charlotte B Winder, Annette M O'Connor","doi":"10.1017/S1466252319000197","DOIUrl":"10.1017/S1466252319000197","url":null,"abstract":"<p><p>Systematic reviews and meta-analyses are used to summarize and interpret evidence for clinical decision-making in human health. The extent of the application of these methods in veterinary medicine and animal agriculture is unknown. The goal of this scoping study was to ascertain trends in the publication of systematic reviews and meta-analyses examining animal health, animal performance, and on-farm food safety. Online databases were searched for reviews published between 1993 and 2018 that focused on relevant outcomes in domestic livestock, companion animals, or wildlife species. In total 1787 titles and abstracts underwent data characterization. Dairy cattle, fish, and pigs were the most common target commodity groups. Few articles investigated both health and performance outcomes (only health: n = 418; only performance: n = 701; both health and performance: n = 103). Most of the reviews (67.6%, n = 1208/1787) described a meta-analysis but did not state in the title or abstract that a systematic review was also conducted, which is potentially problematic. Adherence to reporting guidelines is recommended for all systematic reviews and meta-analyses. For research areas with many reviews, an evidence repository is recommended. For less well-reviewed areas, additional investigation may be necessary to identify the reasons for the lack of synthesis research.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 2","pages":"116-127"},"PeriodicalIF":4.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37662735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of traditional and machine learning methods applied to animal breeding.","authors":"Shadi Nayeri, Mehdi Sargolzaei, Dan Tulpan","doi":"10.1017/S1466252319000148","DOIUrl":"https://doi.org/10.1017/S1466252319000148","url":null,"abstract":"<p><p>The current livestock management landscape is transitioning to a high-throughput digital era where large amounts of information captured by systems of electro-optical, acoustical, mechanical, and biosensors is stored and analyzed on a daily and hourly basis, and actionable decisions are made based on quantitative and qualitative analytic results. While traditional animal breeding prediction methods have been used with great success until recently, the deluge of information starts to create a computational and storage bottleneck that could lead to negative long-term impacts on herd management strategies if not handled properly. A plethora of machine learning approaches, successfully used in various industrial and scientific applications, made their way in the mainstream approaches for livestock breeding techniques, and current results show that such methods have the potential to match or surpass the traditional approaches, while most of the time they are more scalable from a computational and storage perspective. This article provides a succinct view on what traditional and novel prediction methods are currently used in the livestock breeding field, how successful they are, and how the future of the field looks in the new digital agriculture era.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 1","pages":"31-46"},"PeriodicalIF":2.5,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37506908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Dufour, Vincent Wellemans, Jean-Philippe Roy, Pierre Lacasse, Alfredo Ordonez-Iturriaga, David Francoz
{"title":"Non-antimicrobial approaches at drying-off for treating and preventing intramammary infections in dairy cows. Part 1. Meta-analyses of efficacy of using an internal teat sealant without a concomitant antimicrobial treatment.","authors":"Simon Dufour, Vincent Wellemans, Jean-Philippe Roy, Pierre Lacasse, Alfredo Ordonez-Iturriaga, David Francoz","doi":"10.1017/S1466252319000070","DOIUrl":"https://doi.org/10.1017/S1466252319000070","url":null,"abstract":"<p><p>Use of antimicrobial approaches at drying-off for preventing new intramammary infections (IMI) during the dry period in dairy cows could be replaced by non-antimicrobial approaches. Such approaches would be of interest not only for organic but also for conventional dairy producers. The objective of the current review was to quantify the effect of non-antimicrobial internal teat sealant (ITS)-based approaches at drying-off for treating and preventing IMI, when compared with no treatment or with an antimicrobial-based approach. The protocol for this review was published before initiating the review. A total of 18 trials from 16 articles could be used to investigate the effect of an ITS-based approach. With the available results, we conclude with a high level of confidence that non-antimicrobial ITS-based dry-off approaches are efficient for preventing new IMI during the dry period when compared with no treatment, and would reduce risk of new IMI by 52%. Moreover, we are relatively confident that a bismuth subnitrate-based ITS performed better than an antimicrobial for preventing new IMI during the dry period (a risk reduction of 23%). Similarly, we are relatively confident that an ITS-based approach would only slightly or not at all reduce the prevalence of IMI at calving compared with untreated quarters.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 1","pages":"86-97"},"PeriodicalIF":2.5,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37506315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren Wisnieski, Bo Norby, Steven J Pierce, Tyler Becker, Lorraine M Sordillo
{"title":"Prospects for predictive modeling of transition cow diseases.","authors":"Lauren Wisnieski, Bo Norby, Steven J Pierce, Tyler Becker, Lorraine M Sordillo","doi":"10.1017/S1466252319000112","DOIUrl":"https://doi.org/10.1017/S1466252319000112","url":null,"abstract":"<p><p>Transition cow diseases can negatively impact animal welfare and reduce dairy herd profitability. Transition cow disease incidence has remained relatively stable over time despite monitoring and management efforts aimed to reduce the risk of developing diseases. Dairy cattle disease risk is monitored by assessing multiple factors, including certain biomarker test results, health records, feed intake, body condition score, and milk production. However, these factors, which are used to make herd management decisions, are often reviewed separately without considering the correlation between them. In addition, the biomarkers that are currently used for monitoring may not be representative of the complex physiological changes that occur during the transition period. Predictive modeling, which uses data to predict future or current outcomes, is a method that can be used to combine the most predictive variables and their interactions efficiently. The use of an effective predictive model with relevant predictors for transition cow diseases will result in better targeted interventions, and therefore lower disease incidence. This review will discuss predictive modeling methods and candidate variables in the context of transition cow diseases. The next step is to investigate novel biomarkers and statistical methods that are best suited for the prediction of transition cow diseases.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":"20 1","pages":"19-30"},"PeriodicalIF":2.5,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252319000112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37506909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}