Lancet Respiratory Medicine最新文献

{"title":"Management after combined BPA and medical therapy in CTEPH: time for cardiopulmonary exercise testing","authors":"Hakim Ghani, Joanna Pepke-Zaba","doi":"10.1016/s2213-2600(25)00216-4","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00216-4","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"712 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of riociguat on exercise following balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension in Japan (THERAPY-HYBRID-BPA): a multicentre, double-blind, randomised, controlled, phase 4 trial","authors":"Hiroto Shimokawahara, Mari Nishizaki, Takumi Inami, Kayoko Kubota, Yu Taniguchi, Ayane Miyagi, Hanako Kikuchi, Ayumi Goda, Sunao Miyanaga, Hiroya Hashimoto, Akiko M Saito, Masahiro Sekimizu, Hiromi Matsubara","doi":"10.1016/s2213-2600(25)00127-4","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00127-4","url":null,"abstract":"<h3>Background</h3>Balloon pulmonary angioplasty (BPA) and medical therapy are the most common treatment options for inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but their combined use has not been sufficiently studied. This study aimed to evaluate the efficacy during an exercise test and the safety of the continuation of riociguat post-BPA in patients with inoperable CTEPH and normalised haemodynamic variables.<h3>Methods</h3>This multicentre, double-blind, randomised, controlled, phase 4 trial was conducted at four high-volume CTEPH centres in Japan. Patients aged 18–85 years with a confirmed diagnosis of inoperable, WHO functional class II–IV CTEPH, and a resting mean pulmonary arterial pressure (mPAP) of 25 mm Hg or higher and pulmonary vascular resistance of 3·0 Wood units or higher on right-heart catheterisation, received riociguat and BPA at screening. Screened patients with a resting cardiac index of less than 5·0 L/min per m<sup>2</sup> and mPAP of less than 25 mm Hg 3 months after the final BPA procedure were randomly assigned (1:1) either to receive placebo three times daily for 16 weeks or to continue taking riociguat three times daily for 16 weeks at a dose established during the screening period, which varied per patient from 1·0 mg to 2·5 mg. Randomisation was done via an online system with a block size of 8 based on the allocation factors of medical institution and riociguat dose at allocation; patients and investigators were masked to treatment assignment. The primary endpoint was the change in peak cardiac index calculated using the direct Fick method during a cardiopulmonary exercise test (CPET) from baseline to week 16, and was measured in the full analysis set (ie, all randomly assigned patients apart from those who had withdrawn consent, had severe protocol violations, or had never taken the active drug or placebo) in all patients with available data. The safety analysis included all patients who had taken at least one dose of the active drug or placebo. The trial was registered with the Japan Registry of Clinical Trials (jRCTs041200052) and <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (<span><span>NCT04600492</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>) and is now closed.<h3>Findings</h3>Between Nov 25, 2020, and May 16, 2023, 74 patients (including 58 female patients and 16 male patients) were enrolled and randomly assigned, 36 to the riociguat-discontinuing group and 38 to the riociguat-continuing group. 32 patients in the riociguat-discontinuing group and 34 in the riociguat-continuing group were included in the primary analysis after exclus","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"23 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Respir Med 2025; published online June 24. https://doi.org/10.1016/S2213-2600(25)00213-9","authors":"","doi":"10.1016/s2213-2600(25)00266-8","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00266-8","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"673 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No plan B, no planet B: confronting the rising global burden of chronic respiratory diseases","authors":"Joan B Soriano, Bin Cao, Peter J Barnes","doi":"10.1016/s2213-2600(25)00255-3","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00255-3","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"18 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breathing barriers: bridging lung health, research, and awareness","authors":"Hendrik Pott, Dominic L Sykes, Jeremy Charriot, Lydia Finney, Freda Yang, Sanjay Ramakrishnan, Mustafa Abdo, Simon Couillard","doi":"10.1016/s2213-2600(25)00215-2","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00215-2","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"29 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Policy view: worldwide patterns of tobacco use with recommendations for tobacco control","authors":"Juliette McHardy, Adriana Blanco Marquizo, Douglas Bettcher, Emmanuela Gakidou","doi":"10.1016/s2213-2600(25)00172-9","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00172-9","url":null,"abstract":"The global epidemic of tobacco-related diseases continues to be a major health and economic issue. The WHO Framework Convention on Tobacco Control (WHO FCTC), adopted in 2003, is a legally binding treaty aimed at reducing the demand for and supply of tobacco products, with 183 Parties, comprising countries and the EU, covering more than 90% of the world's population. This Policy View presents an analysis of the global patterns of tobacco use, the effects of the WHO FCTC and measures implemented for tobacco control, barriers to progress, and the principal ways forward. Our paper focuses on the overarching challenge of uneven WHO FCTC and tobacco control implementation across countries and policy domains, as well as related implementation barriers of insufficient funding and tobacco industry interference in policy development and implementation. The necessary response is the concerted application of WHO FCTC Article 5.3 protections against the political and scientific practices of the tobacco industry and its affiliates. This response to industry's interference needs to be supported by efforts to increase funding and strengthen political will to act in favour of health. A further challenge is the aggressive commercial marketing—particularly to young people and with unproven health claims—of new tobacco products, such as heated tobacco products, and new nicotine products, such as e-cigarettes. This issue needs to be met with the extension of tobacco control measures to these newproducts and concerted efforts to prevent industry interference.","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"109 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden of COPD: epidemiology and effect of prevention strategies","authors":"Maria Montes de Oca, Rogelio Perez-Padilla, Bartolome Celli, Shawn D Aaron, Fernando C Wehrmeister, André F S Amaral, David Mannino, Jinping Zheng, Sundeep Salvi, Daniel Obaseki, A Sonia Buist, Ana Menezes","doi":"10.1016/s2213-2600(24)00339-4","DOIUrl":"https://doi.org/10.1016/s2213-2600(24)00339-4","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) affects more than 400 million people, continues to be the third cause of death worldwide, and has substantial regional variations in prevalence, risk factors, and temporal trends. COPD is associated with major socioeconomic and health consequences, with low-income and middle-income countries contributing the most to its growing burden. COPD prevalence among women is projected to increase, while that among men will decrease. This difference is possibly because tobacco consumption among women is decreasing at a slower rate than among men. Also, women are more likely to be exposed to other risk factors such as biomass combustion products. Most COPD cases are preventable given the role that smoking and environmental factors play in its development. Knowledge of the causes of COPD in different areas of the globe could provide new insights to address the geographical disparity of the disease and thus make COPD prevention a reality. It is important to implement preventive health policies that might mitigate the expected increase in COPD in women in low-income and middle-income countries and have already proven successful in some regions with high prevalence of the disease. In addition, a reduction in the huge burden of underdiagnosed COPD is necessary to offer effective secondary and tertiary preventive interventions.","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"677 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing the challenges in asthma care through innovation","authors":"","doi":"10.1016/s2213-2600(25)00257-7","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00257-7","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"27 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joan B Soriano—expert on asthma, COPD, and long COVID","authors":"Tony Kirby","doi":"10.1016/s2213-2600(25)00253-x","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00253-x","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"12 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities and challenges of COPD tertiary prevention","authors":"Annerika H M Slok, Loraine H L Peters, Valerie H J Debie, Onno C P van Schayck","doi":"10.1016/s2213-2600(25)00238-3","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00238-3","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"29 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}