Journal of Geriatric Cardiology最新文献

{"title":"Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia: a case report.","authors":"Wei Chen, Kun Huang, Wei-Wei Guo, Fan Zhou, De-Ning Liao","doi":"10.26599/1671-5411.2024.02.007","DOIUrl":"10.26599/1671-5411.2024.02.007","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 2","pages":"242-245"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese expert consensus on the clinical application of drug-coated balloon (2^nd Edition).","authors":"Jun-Bo Ge, Yun-Dai Chen","doi":"10.26599/1671-5411.2024.02.001","DOIUrl":"10.26599/1671-5411.2024.02.001","url":null,"abstract":"<p><p>Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and improved patient prognosis, making drug-eluting stents the mainstream interventional treatment for coronary artery disease. In recent years, drug-coated balloons (DCBs) have become a new treatment strategy for coronary artery disease, and the drugs used in the coating and the coating technology have progressed in the past years. Without permanent implant, a DCB delivers antiproliferative drugs rapidly and uniformly into the vessel wall via the excipient during a single balloon dilation. Many evidence suggests that DCB angioplasty is an effective measure for dealing with in-stent restenosis and <i>de novo</i> lesions in small coronary vessels. As more clinical studies are published, new evidence is emerging for the use of DCB angioplasty in a wide range of coronary diseases, and the indications are expanding internationally. Based on the latest research from China and elsewhere, the Expert Writing Committee of the Chinese Expert Consensus on Clinical Applications of Drug-Coated Balloon has updated the previous DCB consensus after evidence-based discussions and meetings in terms of adequate preparation of in-stent restenosis lesions, expansion of the indications for coronary <i>de novo</i> lesions, and precise guidance of DCB treatment by intravascular imaging and functional evaluation.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 2","pages":"135-152"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal cardiac imaging assisted tumor characterization and surgical planning of a patient with rare primary cardiac paraganglioma.","authors":"Shu-Yu Meng, Li-Qun Wang, Hao-Dan Dang, Lin Zhang, Sheng-Li Jiang, Bo-Han Liu","doi":"10.26599/1671-5411.2024.02.006","DOIUrl":"10.26599/1671-5411.2024.02.006","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 2","pages":"246-250"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Factors in China.","authors":"Sheng-Shou Hu","doi":"10.26599/1671-5411.2024.02.008","DOIUrl":"10.26599/1671-5411.2024.02.008","url":null,"abstract":"<p><p>The <i>Annual Report on Cardiovascular Health and Diseases in China</i> (2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China, with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia, have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in China, with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in China.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 2","pages":"153-199"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma metabolites and risk of myocardial infarction: a bidirectional Mendelian randomization study.","authors":"Dong-Hua Li, Qiang Wu, Jing-Sheng Lan, Shuo Chen, You-Yi Huang, Lan-Jin Wu, Zhi-Qing Qin, Ying Huang, Wan-Zhong Huang, Ting Zeng, Xin Hao, Hua-Bin Su, Qiang Su","doi":"10.26599/1671-5411.2024.02.002","DOIUrl":"10.26599/1671-5411.2024.02.002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Myocardial infarction (MI) is a critical cardiovascular event with multifaceted etiology, involving several genetic and environmental factors. It is essential to understand the function of plasma metabolites in the development of MI and unravel its complex pathogenesis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study employed a bidirectional Mendelian randomization (MR) approach to investigate the causal relationships between plasma metabolites and MI risk. We used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice versa. In addition, the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite (1400 metabolites) and MI (20,917 individuals with MI and 440,906 individuals without MI) susceptibility. Inverse variance weighted was the primary method for estimating causal effects. MR estimates are expressed as beta coefficients or odds ratio (OR) with 95% CI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We identified 14 plasma metabolites associated with the occurrence of MI (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), among which 8 plasma metabolites [propionylglycine levels (OR = 0.922, 95% CI: 0.881-0.965, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), gamma-glutamylglycine levels (OR = 0.903, 95% CI: 0.861-0.948, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), hexadecanedioate (C16-DC) levels (OR = 0.941, 95% CI: 0.911-0.973, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), pentose acid levels (OR = 0.923, 95% CI: 0.877-0.972, &lt;i&gt;P&lt;/i&gt; = 0.002), X-24546 levels (OR = 0.936, 95% CI: 0.902-0.971, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), glycine levels (OR = 0.936, 95% CI: 0.909-0.964, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), glycine to serine ratio (OR = 0.930, 95% CI: 0.888-0.974, &lt;i&gt;P&lt;/i&gt; = 0.002), and mannose to trans-4-hydroxyproline ratio (OR = 0.912, 95% CI: 0.869-0.958, &lt;i&gt;P&lt;/i&gt; &lt; 0.001)] were correlated with a decreased risk of MI, whereas the remaining 6 plasma metabolites [1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels (OR = 1.051, 95% CI: 1.018-1.084, &lt;i&gt;P&lt;/i&gt; = 0.002), behenoyl dihydrosphingomyelin (d18:0/22:0) levels (OR = 1.076, 95% CI: 1.027-1.128, &lt;i&gt;P&lt;/i&gt; = 0.002), 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) levels (OR = 1.067, 95% CI: 1.027-1.109, &lt;i&gt;P&lt;/i&gt; = 0.001), alpha-ketobutyrate levels (OR = 1.108, 95% CI: 1.041-1.180, &lt;i&gt;P&lt;/i&gt; = 0.001), 5-acetylamino-6-formylamino-3-methyluracil levels (OR = 1.047, 95% CI: 1.019-1.076, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and N-acetylputrescine to (N (1) + N (8))-acetylspermidine ratio (OR = 1.045, 95% CI: 1.018-1.073, &lt;i&gt;P&lt;/i&gt; &lt; 0.001)] were associated with an increased risk of MI. Furthermore, we also observed that the mentioned relationships were unaffected by horizontal pleiotropy (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). On the contrary, MI did not lead to significant alterations in the levels of the aforementioned 14 plasma metabolites (&lt;i&gt;P&lt;/i&gt; &gt; 0.05 for each comparison).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our bidirectional MR study identified 14 plasma metabolites associated with th","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 2","pages":"219-231"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity.","authors":"Viacheslav A Korepanov, Tariel A Atabekov, Tatiana Yu Rebrova, Roman E Batalov, Sergey A Afanasiev","doi":"10.26599/1671-5411.2024.01.002","DOIUrl":"10.26599/1671-5411.2024.01.002","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 1","pages":"130-134"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates of developments in interventional therapy for elderly patients with cardiovascular diseases.","authors":"Hua Shen, Xun-Xun Feng, Qian-Yun Guo, Yu-Jie Zhou","doi":"10.26599/1671-5411.2024.01.010","DOIUrl":"10.26599/1671-5411.2024.01.010","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 1","pages":"1-3"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis.","authors":"Yong-Gang Sui, Cheng Yang, Chang-Dong Guan, Yan-Lu Xu, Na-Qiong Wu, Wei-Xian Yang, Yong-Jian Wu, Ke-Fei Dou, Yue-Jin Yang, Shu-Bin Qiao, Wei Yu, Bo Xu, Sheng-Xian Tu, Jie Qian","doi":"10.26599/1671-5411.2024.01.003","DOIUrl":"10.26599/1671-5411.2024.01.003","url":null,"abstract":"<p><strong>Background: </strong>The recently introduced ultrasonic flow ratio (UFR), is a novel fast computational method to derive fractional flow reserve (FFR) from intravascular ultrasound (IVUS) images. In the present study, we evaluate the diagnostic performance of UFR in patients with intermediate left main (LM) stenosis.</p><p><strong>Methods: </strong>This is a prospective, single center study enrolling consecutive patients with presence of intermediated LM lesions (diameter stenosis of 30%-80% by visual estimation) underwent IVUS and FFR measurement. An independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area (MLA) in a blinded fashion.</p><p><strong>Results: </strong>Both UFR and FFR were successfully achieved in 41 LM patients (mean age, 62.0 ± 9.9 years, 46.3% diabetes). An acceptable correlation between UFR and FFR was identified (<i>r</i> = 0.688, <i>P</i> < 0.0001), with an absolute numerical difference of 0.03 (standard difference: 0.01). The area under the curve (AUC) in diagnosis of physiologically significant coronary stenosis for UFR was 0.94 (95% CI: 0.87-1.01), which was significantly higher than angiographic identified stenosis > 50% (AUC = 0.66, <i>P</i> < 0.001) and numerically higher than IVUS-derived MLA (AUC = 0.82; <i>P</i> = 0.09). Patient level diagnostic accuracy, sensitivity and specificity for UFR to identify FFR ≤ 0.80 was 82.9% (95% CI: 70.2-95.7), 93.1% (95% CI: 82.2-100.0), 58.3% (95% CI: 26.3-90.4), respectively.</p><p><strong>Conclusion: </strong>In patients with intermediate LM diseases, UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard reference. The present study supports the use of UFR for functional evaluation of intermediate LM stenosis.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 1","pages":"34-43"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between systemic iron parameters and left ventricular structure and function in the preserved ejection fraction population: a two-sample bidirectional Mendelian randomization study.","authors":"Xiong-Bin Ma, Yong-Ming Liu, Yan-Lin Lv, Lin Qian","doi":"10.26599/1671-5411.2024.01.006","DOIUrl":"10.26599/1671-5411.2024.01.006","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular (LV) remodeling and diastolic function in people with heart failure (HF) are correlated with iron status; however, the causality is uncertain. This Mendelian randomization (MR) study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.</p><p><strong>Methods: </strong>Transferrin saturation (TSAT), total iron binding capacity (TIBC), and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies. Individuals without myocardial infarction history, HF, or LV ejection fraction (LVEF) < 50% (<i>n</i> = 16,923) in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset. The dataset included LV end-diastolic volume, LV end-systolic volume, LV mass (LVM), and LVM-to-end-diastolic volume ratio (LVMVR). We used a two-sample bidirectional MR study with inverse variance weighting (IVW) as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.</p><p><strong>Results: </strong>In the IVW analysis, one standard deviation (SD) increased in TSAT significantly correlated with decreased LVMVR (β = -0.1365; 95% confidence interval [CI]: -0.2092 to -0.0638; <i>P</i> = 0.0002) after Bonferroni adjustment. Conversely, no significant relationships were observed between other iron and LV parameters. After Bonferroni correction, reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT (β = -0.0699; 95% CI: -0.1087 to -0.0311; <i>P</i> = 0.0004). No heterogeneity or pleiotropic effects evidence was observed in the analysis.</p><p><strong>Conclusions: </strong>We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 1","pages":"64-80"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cytochrome P450 2C19 (CYP2C19) gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI.","authors":"Cheng-Yan Hu, Yan-Ling Wang, Zhen-Xing Fan, Xi-Peng Sun, Shuai Wang, Zhi Liu","doi":"10.26599/1671-5411.2024.01.004","DOIUrl":"10.26599/1671-5411.2024.01.004","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with long-term clinical outcome in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>In total, 675 patients were enrolled. Based on the platelet inhibition rate, patients were categorized into two groups: clopidogrel low responsiveness (CLR) and normal clopidogrel responsiveness (NCR). The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up treatment. Patients were classified into three groups (normal metabolizer, intermediate metabolizer, and poor metabolizer) based on the CYP2C19 genotype. We aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity. The cumulative rates of 12-month all-cause deaths, major adverse cardiovascular events (MACCEs), and bleeding events were calculated.</p><p><strong>Results: </strong>CLR was observed in 44.4% of the overall population. Significant differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes (<i>P</i> < 0.05). At the 12-month follow-up, 13 patients (1.9%) died and 96 patients (14.2%) experienced MACCEs. Patients with CLR (9.6% <i>vs</i>. 11.7% <i>vs</i>. 22.1%, <i>P</i> < 0.05) or poor metabolizer (10.7% <i>vs</i>. 16.4% <i>vs</i>. 22.6%, <i>P</i> = 0.026) experienced a higher rate of MACCEs. A MACCEs risk score between zero and two was calculated. The highest incidence of MACCEs significantly increased with the 2-positive results, and the area under the curve (AUC) was 0.712 (95% CI: 0.650-0.774, <i>P</i> < 0.05). There was no significant difference between the group with a score of one and the occurrence of MACCEs (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene polymorphism. CYP2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI, which is better than either test alone.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 1","pages":"90-103"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}