Journal of Geriatric Cardiology最新文献

{"title":"Intravascular lithotripsy successfully open recurrent in-stent chronic occlusion lesion combined with circular calcification.","authors":"Yu Zhao, Xue-Qing Dong, Jun-Jie Li, Ji Qiu, Jia-Hui Liu, Hui-Juan Li, Ying Liu, Meng-Ying Wang, Hai-Yan Wang, Wen-Hui Fan, Yuan-Yang Jia, Jing Bai","doi":"10.26599/1671-5411.2024.10.004","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.004","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"997-1002"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory index as a predictive marker for the severity of coronary artery disease in individuals with chronic kidney disease.","authors":"Meng-Qi Zhao, Yang Zhang, Xin Huang, Jian-Jun Peng","doi":"10.26599/1671-5411.2024.10.002","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the correlation between the inflammatory intensity, as indicated by the systemic inflammatory index (SII), and the severity of coronary artery disease (CAD) in patients with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A total of 280 CKD patients who underwent coronary angiography were enrolled. CAD was evaluated using the Gensini score (GS). Patients were divided into the low, medium and high SII groups according to the tertiles of the SII values. Logistic regression analysis was conducted to analyze the relationship between SII and GS. The cutoff points for the sensitivity and specificity of SII in predicting GS were estimated by performing the receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>Patients in the higher SII group had a higher prevalence of CAD (<i>P</i> = 0.013). In addition, the high SII group had more patients with complex CAD (triple-vessel disease and/or left main coronary artery stenosis) and chronic total occlusion lesions, and more patients required revascularization (<i>P</i> < 0.05). Correlation analysis suggested a positive relationship between SII and GS, and in comparison to neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, SII displayed a stronger correlation with GS (<i>r</i> = 0.332, <i>P</i> < 0.001). Multifactorial logistic regression analysis revealed that SII is independently associated with the severity of CAD (adjusted OR = 1.14, 95% CI: 1.08-1.21, <i>P</i> < 0.01), particularly among elderly patients (age ≥ 65 years). Receiver operating characteristic curve analysis indicated that the optimal cutoff value for SII in predicting severe coronary artery stenosis (GS > 60) was 6.01 (sensitivity: 76.30%, specificity: 53.50%), with an area under the curve (AUC) of 0.705 (95% CI: 0.642-0.768, <i>P</i> < 0.001), which was statistically significantly better than platelet-to-lymphocyte ratio (AUC = 0.646, 95% CI: 0.579-0.713, <i>P</i> < 0.001) and neutrophil-to-lymphocyte ratio (AUC = 0.643, 95% CI: 0.574-0.712, <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>In patients with CKD, SII is independently associated with the severity of CAD, especially in individuals aged 65 years or older. Furthermore, SII functions as a predictive marker for the severity of coronary lesions.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"962-971"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of multimodality imaging in calcified valves with infective endocarditis.","authors":"Aker Amir, Alexander Fuks, Salim Adawi, Yuval Avidan, Vsevolod Tabachnikov, Amnon Eitan, Avinoam Shiran","doi":"10.26599/1671-5411.2024.09.006","DOIUrl":"10.26599/1671-5411.2024.09.006","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"927-930"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a 6-gene signature derived from RNA modification-associated genes for the diagnosis of Acute Stanford Type A Aortic Dissection.","authors":"Ting-Ting Zhang, Qun-Gen Li, Zi-Peng Li, Wei Chen, Chang Liu, Hai Tian, Jun-Bo Chuai","doi":"10.26599/1671-5411.2024.09.007","DOIUrl":"10.26599/1671-5411.2024.09.007","url":null,"abstract":"<p><strong>Background: </strong>Acute Stanford Type A Aortic Dissection (ATAAD) is a critical medical emergency characterized by significant morbidity and mortality. This study aims to identify specific gene expression patterns and RNA modification associated with ATAAD.</p><p><strong>Methods: </strong>The GSE153434 dataset was obtained from the Gene Expression Omnibus (GEO) database. Differential expression analysis was conducted to identify differential expression genes (DEGs) associated with ATAAD. To validate the involvement of RNA modification in ATAAD, RNA modification-related genes (M6A, M1A, M5C, APA, A-to-I) were acquired from GeneCards, following by Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis. A gene prediction signature consisting of key genes was established, and Real-time PCR was used to validate the gene expression in clinical samples. The patients were then divided into high and low-risk groups, and subsequent enrichment analysis, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA), and assessments of immune infiltration. A co-expression network analysis (WGCNA) was performed to explore gene-phenotype relationships and identify key genes.</p><p><strong>Results: </strong>A total of 45 RNA modification genes were acquired. Six gene signatures (YTHDC1, WTAP, CFI, ADARB1, ADARB2, TET3) were developed for ATAAD diagnosis and risk stratification. Enrichment analysis suggested the potential involvement of inflammation and extracellular matrix pathways in the progression of ATAAD. The incorporation of pertinent genes from the GSE147026 dataset into the six-gene signature further validated the model's effectiveness. A significant upregulation in WTAP, ADARB2, and TET3 expression, whereas YTHDC1 exhibited a noteworthy downregulation in the ATAAD group.</p><p><strong>Conclusion: </strong>Six-gene signature could serve as an efficient model for predicting the diagnosis of ATAAD.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"884-898"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental disorders after myocardial infarction: potential mediator role for chemokines in heart-brain interaction?","authors":"Parth Patel, Feiyan Yang, Dumitru A Iacobas, Lei Xi","doi":"10.26599/1671-5411.2024.09.004","DOIUrl":"10.26599/1671-5411.2024.09.004","url":null,"abstract":"<p><p>Acute myocardial infarction (MI) remains one of the leading causes of mortality and morbidity in the global communities. A prevailing topic that has attracted increasing attentions over the past few decades is the so-called heart-brain interaction, in particular following a major traumatic event such as MI. Increased prevalence of depression and other mental disorders has been recognized in cardiac patients after MI, coronary catheterization, or cardiothoracic surgeries. In this review, we focus on the potential pathogenic mechanisms and pre-clinical transcriptomic evidence for identifying potential mediators of post-MI depression. We first summarize the conventional mechanistic understanding that leads to the current clinical management of post-MI depression with the use of selective serotonin reuptake inhibitors (SSRIs) and cognitive behavior and exercise therapies. We further envisage a possible role played by certain chemokines, e.g., Chemokine (C-X-C motif) ligand 12 (CXCL12) and Chemokine (C-C motif) ligand 2 (CCL22), in serving as signaling molecules to connect the MI-induced heart damage to the pro-depressive changes in brain during the post-MI period. Future in-depth investigations into this chemokine hypothesis will be instrumental in developing new chemokine-targeted therapies for better management of the cardiac patients suffering from post-MI depression.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"913-926"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians: evidence from China Hainan Centenarian Cohort Study.","authors":"Qiao Li, Sheng-Shu Wang, Guang-Dong Liu, Jian-Hua Wang, Ya-Li Zhao, Miao Liu, Yao He, Shan-Shan Yang","doi":"10.26599/1671-5411.2024.09.009","DOIUrl":"10.26599/1671-5411.2024.09.009","url":null,"abstract":"<p><strong>Objectives: </strong>To conduct a comprehensive analysis in Hainan centenarians on the link between sleep status and their blood pressure status. Furthermore, the study also aims to explore how inflammatory indicators may mediate the relationship.</p><p><strong>Methods: </strong>The China Hainan Centenarians Cohort Study (CHCCS) collected baseline data on sleep status, inflammatory indicators, and blood pressure data. The study used a mediation model to investigate how inflammatory indicators mediate the relationship between sleep status and blood pressure status.</p><p><strong>Result: </strong>In this study, a total of 967 centenarians were included. The prevalence of hypertension among the centenarians was 71.4%. The analysis showed that centenarians with poor sleep quality had a 43% higher risk of hypertension compared to those with normal sleep quality (OR = 1.43, 95% CI: 1.03-1.97). Additionally, centenarians with nighttime sleep durations of ≤ 6 h or > 9 h had higher proportions of high pulse pressure (PP), with OR values of 1.76 (95% CI: 1.18-2.63) and 2.07 (95% CI: 1.34-3.19), respectively. Mediation analysis illustrated that complement C3 played a mediating role in the relationship between sleep quality and hypertension, with an effect ratio of 2.4%. Similarly, lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII) were identified as mediating factors in the association between nighttime sleep duration and high PP, with effect ratios of 91.22%, 36.93%, and 0.20%, respectively.</p><p><strong>Conclusion: </strong>In centenarians, poor sleep quality raises the risk of hypertension, with complement C3 as a mediator. Additionally, nighttime sleep durations of ≤ 6 h or > 9 h increases the risk of high PP, mediated by lymphocyte count, NLR, and SII.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"874-883"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve implantation versus surgery: 4-year survival according to life expectancy.","authors":"Vittoria Lodo, Enrico G Italiano, Edoardo Zingarelli, Claudio Pietropaolo, Stefano Pidello, Gabriella Buono, Paolo Centofanti","doi":"10.26599/1671-5411.2024.09.005","DOIUrl":"10.26599/1671-5411.2024.09.005","url":null,"abstract":"<p><strong>Background: </strong>In the last years, transcatheter aortic valve implantation (TAVI) indication has expanded to younger and lower risk patients. Consequently, interest in mid and long-term follow up and in the role of life expectancy, as a key factor for selecting the most tailored treatment, has grown. The aim of this retrospective study is to compare the 4-year survival of patients who underwent aortic valve replacement (AVR) <i>vs</i>. TAVI at our department.</p><p><strong>Methods: </strong>From September 2017 to December 2020, 673 consecutive patients with severe aortic valve stenosis were enrolled for AVR (<i>n</i> = 283) or TAVI (<i>n</i> = 390). Inclusion criteria was isolated severe aortic stenosis, while exclusion criteria were redo surgery, valve-in-valve procedure and the need for concomitant surgical procedures. Based on the Lee index, patients were divided into four groups according to their 4-year life expectancy. Four-year survival was assessed and reported using the Kaplan-Meier method. A multivariate regression analysis of risk factors for 4-year mortality was performed.</p><p><strong>Results: </strong>Four years survival is always superior in the AVR patients (89.8% <i>vs.</i> 75.6%, <i>P</i> < 0.001). Surgery is associated with a higher incidence of acute kidney injury (23% <i>vs.</i> 5.1%, <i>P</i> < 0.001), while TAVI is related to a higher incidence of new onset left bundle branch block (0 <i>vs.</i> 23.8%, <i>P</i> < 0.001), pace-maker implantation (2.5% <i>vs.</i> 11.8%, <i>P</i> = 0,02) and mild-to-moderate paravalvular leak (0.3% <i>vs.</i> 5.4%, <i>P</i> < 0.001). The independent risk factors for 4-years mortality are post-procedural AKI, poor mobility and transcatheter procedure.</p><p><strong>Conclusion: </strong>In our analysis, 4 years survival is always superior in the AVR patients. Life expectancy is a key factor for selecting the most appropriate approach for each patient. A longer follow up is mandatory before extending TAVI indication to patients with a long-life expectancy.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"846-854"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual cause of myocardial infarction in an elderly man.","authors":"Shing Ching, Chiu Sun Yue","doi":"10.26599/1671-5411.2024.08.008","DOIUrl":"10.26599/1671-5411.2024.08.008","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 8","pages":"826-827"},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative review of latest research progress about robotic percutaneous coronary intervention.","authors":"Zhen-Yu Liu, Guang-Yao Zhai","doi":"10.26599/1671-5411.2024.08.004","DOIUrl":"10.26599/1671-5411.2024.08.004","url":null,"abstract":"<p><p>Robotic percutaneous coronary intervention (R-PCI) is a novel technology in which operators can manipulate guidewires and catheter devices in interventional cardiology. This approach provides great benefits to interventional cardiologists in terms of reducing both radiation exposure and orthopedic injuries. Several large, high-quality cohort studies have confirmed the short-term safety and high technical success rate of R-PCI. However, randomized long-term data are still needed before adopting them as part of standard coronary interventions. Furthermore, tele-stenting for complex coronary lesions has significant potential for R-PCI. We need to overcome the present relevant challenges for its application such as inherent delays, bedside care for unstable patients from R-PCIs to manual PCIs (M-PCIs), incompatibility for a thrombus aspiration catheter and heavily calcified lesions. There is a great future in laboratory workflow teams, 3D-printed anatomical models and multiple joint collaborative control algorithms. This narrative review summarizes the latest developments in R-PCI, with a focus on developments in robotic technology, and discusses the current and future potential use of R-PCI in clinical practice globally.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 8","pages":"816-825"},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999-2014.","authors":"Yu-Jun Zhang, Jing-Jing Song, Jian-Hao Zhan, Chu-Lin Zhou, Ao Li, Mao-Qi Wang, Ben-Jie Li, Cong-Cong Ding, Yi-Wei Zhang, Zi-Heng Tan, Zai-Hua Cheng, Xiao Huang","doi":"10.26599/1671-5411.2024.08.002","DOIUrl":"10.26599/1671-5411.2024.08.002","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress is closely associated with hypertensive outcomes. The oxidative balance score (OBS) measures oxidative stress exposure from dietary and lifestyle elements. The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.</p><p><strong>Methods: </strong>This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) 1999-2014. Several models, including Cox regression, restricted cubic splines (RCS), Kaplan‒Meier survival analysis, subgroup, and sensitivity analyses, were exploited to investigate the relationship between OBS and the risk of mortality.</p><p><strong>Results: </strong>Controlling for all potential confounders, a significantly inverse association was observed between elevated OBS and all-cause [hazard ratio (HR) = 0.90, 95% CI: 0.85-0.95] and cardiovascular mortality (HR = 0.85, 95% CI: 0.75-0.95). With adjustment for covariates, significant associations between lifestyle OBS and mortality risks diminished, whereas associations between dietary OBS and these mortality risks remained robust (all-cause mortality: HR = 0.91, 95% CI: 0.86-0.96; cardiovascular mortality: HR = 0.85, 95% CI: 0.76-0.96). RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk (<i>P</i> _nonlinear = 0.088 and <i>P</i> _nonlinear = 0.447, respectively). Kaplan‒Meier curves demonstrated that the mortality rate was lower with a high OBS (<i>P</i> < 0.001). The consistency of the association was demonstrated in subgroup and sensitivity analyses. RCS after stratification showed that among current drinkers, those with higher OBS had a lower risk of mortality compared with former or never drinkers.</p><p><strong>Conclusions: </strong>In hypertensive individuals, there was a negative association between OBS and all-cause and cardiovascular mortality. Encouraging hypertensive individuals, especially those currently drinking, to maintain high levels of OBS may be beneficial in improving their prognosis.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 8","pages":"779-790"},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}