Jessica M Hampton, Elizabeth C Ward, Lynette Morrison, Kellie Sosnowski, James Banham, Marilia Libera, Chanelle Louwen, Hayden White, Rachael Watson, Melissa A Day
{"title":"The development and feasibility of a psychologist-led screening and modular-based psychological intervention in an Australian intensive care unit: A pilot study.","authors":"Jessica M Hampton, Elizabeth C Ward, Lynette Morrison, Kellie Sosnowski, James Banham, Marilia Libera, Chanelle Louwen, Hayden White, Rachael Watson, Melissa A Day","doi":"10.1016/j.aucc.2025.101301","DOIUrl":"https://doi.org/10.1016/j.aucc.2025.101301","url":null,"abstract":"<p><strong>Background: </strong>Psychological distress is common among intensive care unit (ICU) patients and can lead to long-term adverse psychological sequelae. While early psychological interventions may help mitigate these effects, their feasibility within critical care settings remains largely unexplored. Additionally, the role of psychologists in delivering such interventions in Australia remains unclear, particularly given inconsistencies in workforce availability and integration into standard care.</p><p><strong>Aims/objectives: </strong>The aim of this study was to (i) outline the development of a psychologist-led screening and intervention protocol in an Australian ICU and (ii) evaluate its preliminary feasibility. It also examined the suitability of a potential outcome measure to inform future trial design.</p><p><strong>Methods: </strong>The Medical Research Council's framework for developing complex interventions in health was applied. The intervention was designed for an Australian metropolitan ICU. It consisted of a modular-based psychological intervention tailored to the patient's level of psychological distress. A single-arm prospective pilot study was conducted, and 30 patients were recruited. Feasibility was assessed based on recruitment rates, patient engagement, and outcome measure completion.</p><p><strong>Results: </strong>Recruitment challenges were observed, with a low eligibility screening rate. Staffing constraints and consent-related barriers further limited recruitment. Intervention engagement was high, with 96% of consenting participants completing at least one intervention component. Outcome measure completion rates supported the feasibility of a larger trial, with preliminary findings suggesting a significant reduction in negative emotional affect over time. Consistent with the Medical Research Council's framework, refinements to the intervention are recommended.</p><p><strong>Conclusions: </strong>The findings support the feasibility of a psychologist-led intervention in the ICU, though refinements are necessary to improve recruitment, streamline delivery, and enhance engagement. This study highlights the potential of early psychological interventions to improve patients' emotional well-being. Addressing staffing limitations and consent barriers could enhance accessibility and effectiveness in future trials.</p><p><strong>Registration: </strong>This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12623000619640), with the first participant recruited on 4/07/2023.</p>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 6","pages":"101301"},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Ding MD , Chunfeng Yang MD , Yanling Qin MN , Yumei Li PhD
{"title":"Risk factors and 6-month outcomes of paediatric intensive care unit–acquired weakness","authors":"Min Ding MD , Chunfeng Yang MD , Yanling Qin MN , Yumei Li PhD","doi":"10.1016/j.aucc.2025.101294","DOIUrl":"10.1016/j.aucc.2025.101294","url":null,"abstract":"<div><h3>Background</h3><div>Intensive care unit–acquired weakness results in adverse prognosis, healthcare costs, and resources. Little is known about paediatric intensive care unit–acquired weakness (PICU-AW).</div></div><div><h3>Objective</h3><div>The goal of this study was to determine risk factors and 6-month outcomes after discharge of patients with PICU-AW.</div></div><div><h3>Methods</h3><div>From May 2021 to December 2022, a prospective observational study was conducted in a single centre from China. Children aged 7–18 years were divided into two groups with and without PICU-AW at discharge. A predesigned data form was used to collect patients' characteristics. Risk factors were analysed by univariate and multivariate logistic analyses. Outcomes such as muscle strength, functional status, and health-related quality of life (HRQOL) were assessed at 1, 3, and 6 months after discharge.</div></div><div><h3>Results</h3><div>A total of 172 patients were assessed for eligibility at discharge, and 44 children (25.6%) were diagnosed with PICU-AW. The presence of systemic inflammatory response syndrome on admission (odds ratio [OR]: 6.482, 95% confidence interval [CI]: 2.245–18.712, p = 0.001), higher Pediatric Logistic Organ Dysfunction 2 score on admission (OR: 1.337, 95% CI: 1.011–1.767, p = 0.041), and longer length of stay in the PICU (OR: 1.222, 95% CI: 1.133–1.318, p < 0.001) were significantly associated with PICU-AW. PICU-AW was an independent risk factor for decreased HRQOL at 1 month (OR: 5.215, 95% CI: 1.147–23.715, p = 0.033) and 3 months (OR: 5.318, 95% CI: 1.759–16.077, p = 0.003) after discharge. PICU-AW was not associated with functional status within 6 months after discharge.</div></div><div><h3>Conclusions</h3><div>The presence of systemic inflammatory response syndrome on admission, organ dysfunction on admission, and longer PICU stays were independent risk factors for PICU-AW. PICU-AW was found to be the independent risk factor for decreased HRQOL at 1 and 3 months after discharge. Children with normal baseline function were more likely to recover their functional status after discharge.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A cluster double-crossover trial of early versus delayed aperient use in mechanically ventilated, enterally fed patients","authors":"Yaodong Tang MMed FCICM , Glenn Eastwood RN PHD , Nuanprae Kitisin MD , Nuttapol Pattamin MD , Yukiko Hikasa MD , Jonathan Nübel MD , Alessandro Caroli MD , Stephen Warrillow PHD FRACP FCICM , Rinaldo Bellomo PHD FRACP FCICM , Ary Serpa Neto PHD FCICM","doi":"10.1016/j.aucc.2025.101300","DOIUrl":"10.1016/j.aucc.2025.101300","url":null,"abstract":"<div><h3>Background</h3><div>Aperient use in enterally fed, intubated, invasively mechanically ventilated intensive care unit (ICU) patients remains controversial and is associated with diarrhoea. The aim of this study was to assess whether the timing of aperient administration impacts the incidence and timing of diarrhoea and related complications in such patients.</div></div><div><h3>Methods</h3><div>We conducted a cluster, double-crossover, randomised trial in mechanically ventilated, enterally fed adults. We compared “delayed” aperient use (started on day 6 of enteral feeding) to “early” aperient use (started on day 1 of enteral feeding). The primary outcome was the occurrence of diarrhoea. Secondary outcomes included time until first defecation, rate of faecal management device insertion, rate of ileus, ICU length of stay, and mortality. Data were analysed using a Bayesian analysis.</div></div><div><h3>Results</h3><div>Of the 177 patients included, 42.4% in the delayed aperient group and 44.9% in early group developed diarrhoea (odds ratio: 0.91 [95% credible interval: 0.52 to 1.61]; probability of benefit: 62.4%). Diarrhoea, however, occurred later in patients in the delayed aperient group. Moreover, the occurrence of diarrhoea after day 6 was less in the delayed aperients group (21.2% vs. 44.9%; odds ratio: 0.37 [95% credible interval: 0.20 to 0.68]; probability of benefit: 99.9%). Other secondary outcomes including rate of ileus, ICU length of stay, and mortality did not show significant difference.</div></div><div><h3>Conclusion</h3><div>The timing of aperient administration did not impact the occurrence of diarrhoea or other patient-centred outcomes but delayed its onset. These findings suggest that delaying aperients has limited impact on diarrhoea.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101300"},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving satisfaction with intensive care nursing: Perspectives of nurses and patients","authors":"Marta Romero-García RN, PhD , Pilar Delgado-Hito RN, PhD , Llúcia Benito-Aracil RN, PhD , Elisabet Gallart Vivé RN, PhD , Rocío Tabernero-Gallego RN, MSc , M. Pilar Muñoz-Rey RN, MSc , Laura Martinez Rodríguez RN, PhD , Isidro Alcalá-Jiménez RN, PhD","doi":"10.1016/j.aucc.2025.101295","DOIUrl":"10.1016/j.aucc.2025.101295","url":null,"abstract":"<div><h3>Background</h3><div>Interest in measuring patient satisfaction as an indicator of the quality of nursing care has led to the development of various measurement instruments. However, to date there are no studies that propose multidimensional strategies to improve satisfaction with intensive care nursing from the perspective of both nurses and patients.</div></div><div><h3>Objectives</h3><div>The objective of this study was to describe strategies to improve satisfaction with nursing care identified by nurses and critically ill patients.</div></div><div><h3>Methods</h3><div>This was a qualitative descriptive study. This multicentre study was conducted in intensive care units in Spain. The population consisted of discharged patients and critical care nurses, and the sample was recruited using convenience sampling. Four online focus groups were held with patients and nurses until theoretical saturation of the data was reached. The focus groups were led by a moderator, recorded on video after obtaining informed consent, and then transcribed. Next, content was analysed, and the information was triangulated. Guba and Lincoln's criteria of trustworthiness and authenticity were followed.</div></div><div><h3>Results</h3><div>The strategies identified were (i) strategies for holistic care; (ii) strategies related to forms of communication; (iii) strategies related to professional behaviours; and (iv) strategies related to the infrastructure of the unit. The most frequently mentioned strategies were continuously monitoring pain, documenting pain, promoting patient autonomy, fostering patient privacy, showing empathy, listening attentively, using medication for rest, meeting recreational needs, using simple language, making eye contact, receiving communication training, practicing interdisciplinary communication, and using clinical judgement. Reporting complied with Consolidated Criteria for Reporting Qualitative Research.</div></div><div><h3>Conclusion</h3><div>Nurses and patients identified similar strategies to improve satisfaction with the nursing care received during intensive care unit admission. Implementing and evaluating the identified strategies will support the ongoing improvement of humanised care, driven by the commitment of healthcare professionals.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101295"},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Gutting MD , A. Brobeil BSc , L. Strach BSc , E. Stricker , M. Boxberger MD , B. Trierweiler-Hauke BSc , C. Heine , P. Michl Prof. Dr. , S. Luntz MD , B. Robert MSc , F. Göbel MD , C. Weis MSc , A. Pfützner Prof. Dr.
{"title":"Sealing efficiency and safety of a polyurethane-based fecal management system in intensive care—Results from a real-world study","authors":"T. Gutting MD , A. Brobeil BSc , L. Strach BSc , E. Stricker , M. Boxberger MD , B. Trierweiler-Hauke BSc , C. Heine , P. Michl Prof. Dr. , S. Luntz MD , B. Robert MSc , F. Göbel MD , C. Weis MSc , A. Pfützner Prof. Dr.","doi":"10.1016/j.aucc.2025.101296","DOIUrl":"10.1016/j.aucc.2025.101296","url":null,"abstract":"<div><h3>Objective</h3><div>Fecal management systems (FMSs) are critical for preventing skin irritations and anal dermatitis in intensive care. A polyurethane-based system (hygh-tec® [Advanced Medical Balloons]) has been introduced in the European Union and United States. This real-world observational study aimed to evaluate the sealing efficiency and safety of the system in routine care.</div></div><div><h3>Methods</h3><div>Thirty-nine patients were included in the descriptive analysis (18 females and 21 males; mean age: 66.4 ± 10.5 years; body mass index: 28.8 ± 11.7 kg/m<sup>2</sup>). Intensive care nurses documented findings related to sealing efficiency, anal lesions, and adverse events during their shifts.</div></div><div><h3>Results</h3><div>Sealing efficiency was assessed from 1110 shift reports. The mean device usage duration was 10.8 days (range: 3–31 days). No visible perianal contamination was noted in 76.0% of shift reports (n = 844). Relevant leakage was documented in 10.7% of cases and was independent of body mass index, anal sphincter muscle tone, and reason for admission. Stool consistency and patient vigilance had minimal influence. There were no device-related adverse events, and the incidence of anal lesions was 0.8% over 31 days of use.</div></div><div><h3>Conclusion</h3><div>The polyurethane-based FMS demonstrated excellent sealing efficiency, tolerability, and safety. Controlled studies are needed to confirm these findings and evaluate economic implications. FMSs can improve both work quality and patient safety.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101296"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheryl Power RN, MN Adv Prac, Kylie O’Neill RN, MN, Shu-Kay Ng BSc, PhD, Edward Berry RN, BN, Adelene Luong BMedSc, MD, Melissa J. Bloomer RN, PhD, Life Member ACCCN
{"title":"Re: Enhancing communication equity in critical care: Multimodal and technological approaches to overcome language barriers","authors":"Cheryl Power RN, MN Adv Prac, Kylie O’Neill RN, MN, Shu-Kay Ng BSc, PhD, Edward Berry RN, BN, Adelene Luong BMedSc, MD, Melissa J. Bloomer RN, PhD, Life Member ACCCN","doi":"10.1016/j.aucc.2025.101299","DOIUrl":"10.1016/j.aucc.2025.101299","url":null,"abstract":"","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101299"},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meredith Heily RN, MEd , Marie Gerdtz RN, PhD , Rebecca J. Jarden RN, PhD , Celene Y.L. Yap BPharm, PhD , Rinaldo Bellomo AO MBBS, PhD, FRACP, FCICM
{"title":"Prevalence and complications of agitation between intensive care unit admission and tracheal extubation in adult cardiac surgery patients: A single-centre observational study","authors":"Meredith Heily RN, MEd , Marie Gerdtz RN, PhD , Rebecca J. Jarden RN, PhD , Celene Y.L. Yap BPharm, PhD , Rinaldo Bellomo AO MBBS, PhD, FRACP, FCICM","doi":"10.1016/j.aucc.2025.101293","DOIUrl":"10.1016/j.aucc.2025.101293","url":null,"abstract":"<div><h3>Background</h3><div>Some patients admitted to the intensive care unit (ICU) after adult cardiac surgery develop agitation prior to tracheal extubation. The prevalence and consequences of such agitation remain unknown.</div></div><div><h3>Objectives</h3><div>The objectives were to study the prevalence and complications of agitation that occurs between ICU admission and prior to tracheal extubation.</div></div><div><h3>Methods</h3><div>A single-centre observational study was conducted from March 2021 to December 2023. Data were retrieved from the medical records of all adult patients with sedation ceased for tracheal extubation < 24 hours after ICU admission. Agitation prior to tracheal extubation was defined as a Richmond Agitation-Sedation Scale score ≥+2. Comparisons were made between agitated and nonagitated groups. All variables underwent descriptive analysis. For time-to-event outcomes, Cox regression was performed, while dichotomous outcomes were analysed using logistic regression.</div></div><div><h3>Results</h3><div>Seven hundred patient records were analysed. Agitation was identified in 204 (29%) patients. Patients with agitation had prolonged mechanical ventilation (mean: 25.7 hours, standard deviation [SD]: 41.1) compared to non-agitated patients (mean: 11.6 hours, SD: 15.6, hazard ratio: 0.50, 95% confidence interval [CI]: 0.42–0.59), and prolonged ICU stay (72.9 hours, SD: 66.1 compared to nonagitated patients (52.4 hours, SD: 60.7, hazard ratio: 0.68, 95% CI: 0.58–0.80). Sixty-four (31.4%) patients with agitation were referred to specialist pain services compared to 92 (18.5%) nonagitated patients (odds ratio [OR]: 2.00, 95% CI: 1.38–2.91). Delirium in the ICU developed in 48 (23.5%) patients with agitation, compared to 61 (12.3%) nonagitated patients (OR: 2.19, 95% CI: 1.44–3.34). After transfer to the ward, 70 (34.5%) patients with agitation and 114 (23%) nonagitated patients were diagnosed with delirium (OR: 0.57, 95% CI: 0.40–0.82).</div></div><div><h3>Conclusion</h3><div>Patients frequently developed agitation before extubation. All patients received mechanical ventilation, but the duration was prolonged in agitated patients, who also stayed in the ICU for longer, received more specialist pain services, and had a higher likelihood of delirium.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101293"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mana Egawa , Souichi Oka PhD , Yoshiyasu Takefuji PhD
{"title":"Re-evaluating structural equation modelling in nursing research: Insights from compassion fatigue and empowerment in Chinese intensive care units","authors":"Mana Egawa , Souichi Oka PhD , Yoshiyasu Takefuji PhD","doi":"10.1016/j.aucc.2025.101292","DOIUrl":"10.1016/j.aucc.2025.101292","url":null,"abstract":"","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101292"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Rojas-Suarez MSc , Iveth Vanegas MD , Oscar Lavalle MD , Miguel Aguilar-Schotborgh MD , Amilkar Almanza-Hurtado MD , Diana Borre-Naranjo MD , Francisco Camargo MD , Yasaira Pajaro-Cantillo MD , Carmelo Dueñas-Castell MD
{"title":"Acid–base imbalances in critically ill obstetric patients: A multicentre retrospective cohort study","authors":"José Rojas-Suarez MSc , Iveth Vanegas MD , Oscar Lavalle MD , Miguel Aguilar-Schotborgh MD , Amilkar Almanza-Hurtado MD , Diana Borre-Naranjo MD , Francisco Camargo MD , Yasaira Pajaro-Cantillo MD , Carmelo Dueñas-Castell MD","doi":"10.1016/j.aucc.2025.101297","DOIUrl":"10.1016/j.aucc.2025.101297","url":null,"abstract":"<div><h3>Background</h3><div>Acid–base imbalances are critical indicators of clinical outcomes in intensive care settings, yet their specific impact on critically ill pregnant obstetric patients remains underexplored. This lack of knowledge is particularly concerning given the potential for severe outcomes in this vulnerable population.</div></div><div><h3>Aim/objective</h3><div>The aim of this study was to assess acid–base abnormalities and their association with severe outcomes, including mortality.</div></div><div><h3>Methods</h3><div>We conducted a retrospective multicentre cohort study between 2006 and 2019 across six high-complexity hospitals in Colombia (two obstetric centres and four general hospitals with intensive care units that admit obstetric patients). Arterial blood gas was evaluated for acid–base balance at admission, and its association with clinical outcomes, including maternal death, mechanical ventilation, and vasopressor use, was assessed.</div></div><div><h3>Results</h3><div>The study included 798 patients: 768 survivors and 30 nonsurvivors. Our findings revealed that respiratory alkalosis was the most common imbalance (491/798 [61.5%]). Its presence is linked to better survival rates. Conversely, mixed metabolic and respiratory acidosis significantly increased the risk of mortality (18/768 [2.3%] in survivors vs. 7/30 [23.3%] in nonsurvivors, p < 0.001). After adjusting for confounders, lower potential hydrogen (pH) and bicarbonate (HCO<sub>3</sub>) levels were associated with higher in-hospital mortality.</div></div><div><h3>Conclusions</h3><div>Most critically ill obstetric patients presented with baseline respiratory alkalosis, and the inability to maintain it was strongly associated with increased mortality. Further controlled studies are needed to confirm these findings and explore the impact of interventions to sustain respiratory alkalosis on outcomes.</div></div>","PeriodicalId":51239,"journal":{"name":"Australian Critical Care","volume":"38 5","pages":"Article 101297"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}