Altex-Alternatives To Animal Experimentation最新文献_第6页

No more monkey business: Advancing personalized medicine with animal-free research - Animalfree Research Forum 2023. 不再有猴子通过无动物研究推进个性化医疗 - 2023 年无动物研究论坛。

IF 5.6 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2311171

Miriam A Zemanova, Silvia Frey

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Summer school for systematic reviews of animal studies: Fostering evidence-based and rigorous animal research. 动物研究系统综述暑期班：促进循证和严格的动物研究。

IF 5.6 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2310251

Marianna Rosso, Simona E Doneva, David W Howells, Cathalijn Hc Leenaars, Benjamin V Ineichen

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Heads on! Designing a Qualification Framework for Organ-on-Chip. 迎头赶上！设计芯片上器官的资格认证框架。

IF 5.6 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 Epub Date: 2024-01-23 DOI: 10.14573/altex.2401231

Monica Piergiovanni, Milena Mennecozzi, Stavroula Sampani, Maurice Whelan

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Non-animal models: Complexity for interactions…Connecting science. 非动物模型：相互作用的复杂性......连接科学。

IF 4.5 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2407181

Francesca Caloni, Alessandra Cazzaniga, Arno C Gutleb, Thomas Hartung, Helena Kandarova, Giulia Ranaldi, Hassan Rashidi, Doris Wilflingseder, Saliha Moutaharrik

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Role of standards and funding in accelerating the development and use of microphysiological systems. 标准和资金在加速开发和使用微观生理系统方面的作用。

IF 4.5 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2407061

Surat Parvatam, Harshita Mittal, Francesca Pistollato, Kasturi Mahadik, Lorna Ewart, Abhijit Majumder, Y K Gupta, Sonja Beken, Rajeshwari Adheseshan, Glyn Stacey, Vishal Gandhi, Dhiraj Kumar, Helder Constantino, Goutami Nayak, Tejaswini Ghurde, Mousumi Gupta, Alokparna Sengupta, Troy Seidle

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Corrigendum to Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment. 将新方法纳入监管性非临床药物安全性评估的更正。

IF 4.5 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2408291

Jan Turner, Pandora Pound, Carla Owen, Isobel Hutchinson, Marina Hop, David Y S Chau, Lady V Barrios Silva, Mike Coleman, Audrey Dubourg, Lorna W Harries, Victoria Hutter, J Gerry Kenna, Volker M Lauschke, Winfried Neuhaus, Clive Roper, Paul B Watkins, Jonathan Welch, Laura Rego Avarez, Katy Taylor

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3 Days for 3Rs 2023: Refinement, reduction, replacement. 2023 年 3R 的 3 天：改进、减少、替代。

IF 5.6 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2402121

Augusto Vitale, Maurilio Calleri, Francesca Caloni, Cristina M Failla, Paola Granata, Laura Gribaldo, Urte Jaeh, Michela Kuan, Stefano Lorenzetti, Francesco Nevelli, Giulia Ranaldi, Irene Ruspantini, Orsola R Salva, Lena Smirnova, Julia Steitz, Luigia Trabace, Zoe Windsor, Isabella De Angelis

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Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review. 污染物暴露和心肌损伤:毒理学系统制图审查的方案和进展报告。

IF 4.5 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 Epub Date: 2023-11-20 DOI: 10.14573/altex.2304111

Tom Roos, Cathalijn Leenaars, Alexandra Schaffert, Martin Paparella, Sivakumar Murugadoss, Birgit Mertens, Nunzia Linzalone, Gabriele Donzelli, Merel Ritskes-Hoitinga, Ronette Gehring

{"title":"Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.","authors":"Tom Roos, Cathalijn Leenaars, Alexandra Schaffert, Martin Paparella, Sivakumar Murugadoss, Birgit Mertens, Nunzia Linzalone, Gabriele Donzelli, Merel Ritskes-Hoitinga, Ronette Gehring","doi":"10.14573/altex.2304111","DOIUrl":"10.14573/altex.2304111","url":null,"abstract":"An increasing body of evidence identifies pollutant exposure as a risk factor for cardiovascular disease (CVD), while CVD incidence is rising steadily with the aging population. Although numerous experimental studies are now available, the mechanisms through which lifetime exposure to environmental pollutants can result in CVD are not fully understood. To comprehensively describe and understand the pathways through which pollutant exposure leads to cardiotoxicity, a systematic mapping review of the available toxicological evidence is needed. This protocol outlines a step-by-step framework for conducting this review. Using the National Toxicology Program (NTP) Health Assessment and Translation (HAT) approach for conducting toxicological systematic reviews, we selected 362 out of 8110 in vitro (17%), in vivo (67%), and combined (15%) studies for 129 potential cardiotoxic environmental pollutants, including heavy metals (29%), air pollutants (16%), pesticides (27%), and other chemicals (28%). The internal validity of included studies is being assessed with HAT and SYRCLE risk of bias tools. Tabular templates are being used to extract key study elements regarding study setup, methodology, techniques, and (qualitative and quantitative) outcomes. Subsequent synthesis will consist of an explorative meta-analysis of possible pollutant-related cardiotoxicity. Evidence maps and interactive knowledge graphs will illustrate evidence streams, cardiotoxic effects, and associated quality of evidence, helping researchers and regulators to efficiently identify pollutants of interest. The evidence will be integrated in novel adverse outcome pathways to facilitate regulatory acceptance of non-animal methods for cardiotoxicity testing. The current article describes the progress of the steps made in the systematic mapping review process.","PeriodicalId":51231,"journal":{"name":"Altex-Alternatives To Animal Experimentation","volume":" ","pages":"248-259"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro-replace systems. 微型替换系统

IF 4.5 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 DOI: 10.14573/altex.2407021

Marita Meurer, Manasa Nandimandalam, Maren von Köckritz-Blickwede, André Bleich

引用次数: 0

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment. 基因共表达网络的定性和定量浓度反应模型，为下一代化学品安全评估揭示肝毒性机制。

IF 5.6 2区医学

Altex-Alternatives To Animal Experimentation Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI: 10.14573/altex.2309201

Steven J Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water

{"title":"Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.","authors":"Steven J Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water","doi":"10.14573/altex.2309201","DOIUrl":"10.14573/altex.2309201","url":null,"abstract":"Next generation risk assessment of chemicals revolves around the use of mechanistic information without animal experimentation. In this regard, toxicogenomics has proven to be a useful tool to elucidate the underlying mechanisms of adverse effects of xenobiotics. In the present study, two widely used human in vitro hepatocyte culture systems, namely primary human hepatocytes (PHH) and human hepatoma HepaRG cells, were exposed to liver toxicants known to induce liver cholestasis, steatosis or necrosis. Benchmark concentration-response modelling was applied to transcriptomics gene co-expression networks (modules) to derive benchmark concentrations (BMCs) and to gain mechanistic insight into the hepatotoxic effects. BMCs derived by concentration-response modelling of gene co-expression modules recapitulated concentration-response modelling of individual genes. Although PHH and HepaRG cells showed overlap in deregulated genes and modules by the liver toxicants, PHH demonstrated a higher responsiveness, based on the lower BMCs of co-regulated gene modules. Such BMCs can be used as transcriptomics point of departure (tPOD) for assessing module-associated cellular (stress) pathways/processes. This approach identified clear tPODs of around maximum systemic concentration (Cmax) levels for the tested drugs, while for cosmetics ingredients the BMCs were 10-100-fold higher than the estimated plasma concentrations. This approach could serve next generation risk assessment practice to identify early responsive modules at low BMCs, that could be linked to key events in liver adverse outcome pathways. In turn, this can assist in delineating potential hazards of new test chemicals using in vitro systems and used in a risk assessment when BMCs are paired with chemical exposure assessment.","PeriodicalId":51231,"journal":{"name":"Altex-Alternatives To Animal Experimentation","volume":" ","pages":"213-232"},"PeriodicalIF":5.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0