Surgical Oncology-Oxford最新文献

{"title":"Prevention in non-oncologic intent sarcoma surgery","authors":"Clare E. Wise , Chris Le , Nicole S. Pham , Christin New , Deborah Ellen Kenney , Raffi Avedian , David Mohler , Robert Steffner","doi":"10.1016/j.suronc.2025.102273","DOIUrl":"10.1016/j.suronc.2025.102273","url":null,"abstract":"<div><h3>Background</h3><div>Non-oncologic resection of soft tissue sarcomas (STS) continue to be a common referral to multidisciplinary sarcoma centers. While previous literature has reported tumor characteristics and outcomes related to non-oncologic resections, little is known regarding the surgical specialties most likely to excise such a mass and the non-oncological manner in which they do so. Such information can facilitate preventative strategies.</div></div><div><h3>Purpose</h3><div>The goals of this study are: 1) Investigate the surgical specialties that most often perform unplanned excisions and their diagnostic imaging approach, 2) Identify the frequency of non-oncological techniques utilized in initial unplanned excisions, and 3) Define indications for the use of radiation (XRT) in patients with initial non-oncologic resections of STS.</div></div><div><h3>Methods</h3><div>Patient data were collected from a large tertiary referral sarcoma center between 2005 and 2022. Eligible patients had a diagnosis of soft tissue sarcoma that was excised at an outside institution in a non-oncologic manner and subsequently underwent tumor bed re-excision using wide resection. Data regarding the index procedures at outside hospitals were obtained from referral documents and tumor bed re-excisions, along with follow-up care. A total of 124 patients were identified.</div></div><div><h3>Results</h3><div>Forty-three percent of referrals for non-oncologic resection of soft tissue sarcomas (STS) involved tumors located deep to the fascia. The majority of these referrals originated from General Surgery (N = 54, 44 %), Orthopedic Surgery (N = 35, 28 %), and Plastic Surgery (N = 11, 9 %). Preoperative imaging was conducted in 59 % of cases. General surgeons were less likely to obtain preoperative imaging (p = 0.009) and perform MRI scans (p = 0.013) than orthopaedic surgeons. The proper orientation of the incision based on location was incorrect for general surgeons in 26 % (N = 20) of cases. General surgeons were less likely to make an appropriate incision (p = 0.052) and to use a tourniquet during the initial procedure (p < 0.001). There were no differences among surgical subspecialties in the use of local anesthetic, drain use, or excision type regarding the initial non-oncologic resection. Residual disease following tumor bed re-excision was linked to masses removed in the clinic (p = 0.030) and initial stage IIIB tumors (p = 0.019). Our institutional use of radiation therapy (XRT) correlated with large initial size, high-grade histology, location deep to fascia, and tumors that were re-excised with staged coverage by plastic surgery.</div></div><div><h3>Conclusion</h3><div>Most referrals for initial non-oncologic resection of STS come from general surgery followed by orthopaedic surgery. Indications for pre-operative MRI imaging, incision orientation, and tourniquet use are education targets for general surgeons in training. Interpretation of MRI scans","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102273"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal heterogeneity in apparent diffusion coefficient map of magnetic resonance imaging in resectable pancreatic cancer: a new prognostic factor for biological borderline resectable pancreatic cancer","authors":"Michinori Matsumoto,&nbsp;Masashi Tsunematsu,&nbsp;Kenei Furukawa,&nbsp;Koichiro Haruki,&nbsp;Yoshihiro Shirai,&nbsp;Shinji Onda,&nbsp;Tadashi Uwagawa,&nbsp;Takeshi Gocho,&nbsp;Mitsuru Yanagaki,&nbsp;Toru Ikegami","doi":"10.1016/j.suronc.2025.102270","DOIUrl":"10.1016/j.suronc.2025.102270","url":null,"abstract":"<div><h3>Background</h3><div>s: This study aimed to identify recurrence and prognostic factors in patients with resectable pancreatic cancer (RPC) that may define biological borderline resectable pancreatic cancer (BRPC).</div></div><div><h3>Methods</h3><div>This retrospective study included 162 patients with R/BRPC who underwent upfront surgery. Univariate and multivariate analyses were performed to assess the relationship between preoperative factors and disease-free survival (DFS) and overall survival (OS) for RPC. The cutoff value for the coefficient of variation of apparent diffusion coefficient (CV_ADC) on preoperative magnetic resonance imaging was determined using receiver operating characteristic curve analysis. Surgical outcomes of patients with RPC were stratified by a score, with each independent prognostic factor assigned 1 point. The outcomes of R/BRPC patients were compared according to the score.</div></div><div><h3>Results</h3><div>Of the patients, 145 had RPC, and 17 had BRPC. In RPC patients, serum CA19-9 &gt;500 U/mL (<em>p</em> = 0.03) and CV_ADC ≥ 0.1 (<em>p</em> = 0.003) were independent recurrence factors, while serum CA19-9 &gt;500 U/mL (<em>p</em> = 0.03), superior mesenteric vein/portal vein contact &lt;180° (<em>p =</em> 0.03), and CV_ADC ≥ 0.1 (<em>p &lt;</em> 0.001) were independent prognostic factors. RPC patients with a score of 0 had significantly better prognoses than those with scores of 1 or 2–3, and BRPC patients (median DFS: 35.0, 9.8, 9.0, and 7.0 months; median OS: 80.7, 26.5, 16.8, and 17.6 months, respectively). No significant difference in prognosis was found between BRPC patients and RPC patients with scores of 1 or 2–3.</div></div><div><h3>Conclusions</h3><div>Preoperative CV_ADC in RPC may be a new recurrence and prognostic factor defining biological BRPC.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102270"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Qaly study: Quality of life and lower extremity lymphedema in 174 patients after inguinal lymphadenectomy","authors":"Brett A. Hahn ,&nbsp;Alieske Kleeven ,&nbsp;Milan C. Richir ,&nbsp;Arjen J. Witkamp ,&nbsp;Anke M.J. Kuijpers ,&nbsp;Kristien B.M.I. Keymeulen ,&nbsp;J. Henk Coert ,&nbsp;Shan Shan Qiu ,&nbsp;David D. Krijgh","doi":"10.1016/j.suronc.2025.102257","DOIUrl":"10.1016/j.suronc.2025.102257","url":null,"abstract":"<div><h3>Background</h3><div>Lower extremity lymphedema (LEL) can develop in patients who undergo inguinal lymph node dissection (ILND) in the treatment of gynecologic, genitourinary, and skin and soft tissue malignancies. While LEL can negatively impact quality of life, the poorly documented prevalence and severity of lymphedema-related symptoms complicates the ability to identify high-risk patients and improve the selection of candidates for emerging microsurgical interventions.</div></div><div><h3>Methods</h3><div>This multicenter, cross-sectional study included patients who underwent ILND between 1990 and 2022 across three medical centers in the Netherlands. Retrospective clinical data, including demographic, surgical, and postoperative variables, were abstracted from medical records. Lymphedema prevalence and severity were assessed using the Lymph-ICF-LL questionnaire, while additional patient-reported outcome measures (PROMs) evaluated quality of life and lower extremity function. Statistical analyses included multivariate logistic and linear regression to identify predictors of lymphedema-related symptoms and their impact on PROMs.</div></div><div><h3>Results</h3><div>Among 174 patients who underwent ILND, 77 % reported lymphedema-related symptoms, which were associated with significantly lower quality of life. Multivariable analysis identified that younger age at time of surgery, medical history of cardiovascular disease, and postoperative complications such as surgical site infections (SSI) and prolonged wound healing were significant predictors of developing lymphedema-related symptoms. Additionally, the presence of lymphedema was strongly linked to poorer physical and mental health PROMs, with malignancy type and surgical factors influencing these outcomes.</div></div><div><h3>Conclusion</h3><div>This study emphasizes the significant burden of lymphedema-related symptoms following ILND, while highlighting the potential role of reconstructive microsurgery in reducing morbidity for high-risk patients.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102257"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend shift from autologous to implant-based breast reconstruction","authors":"Ekaterina Nedeoglo ,&nbsp;Philipp Moog ,&nbsp;Jun Jiang ,&nbsp;Inessa Suhova ,&nbsp;Hans-Günther Machens ,&nbsp;Kai Megerle ,&nbsp;Haydar Kükrek","doi":"10.1016/j.suronc.2025.102256","DOIUrl":"10.1016/j.suronc.2025.102256","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer is the most common type of cancer in women and advances in treatment have shifted the focus towards improving quality of life. Breast reconstruction plays a crucial role in preserving body image for patients undergoing mastectomy. However, significant variations exist in breast reconstruction choices across different countries. Understanding national trends can help optimize patient-centered care.</div></div><div><h3>Methods</h3><div>Using data from quality reports, we analyzed breast reconstruction trends in Germany from 2012 to 2021. The study examined overall reconstruction rates, the distribution of reconstruction methods (implant-based vs. autologous), and differences between surgical departments.</div></div><div><h3>Results</h3><div>Breast reconstruction rates in Germany have steadily increased, with up to 38 % of mastectomy patients undergoing reconstruction. The number of implant-based reconstructions rose significantly by nearly 70 % during this period. Most reconstructions were performed in gynecology departments, where the highest increase in implant-based procedures was observed.</div></div><div><h3>Conclusion</h3><div>The reasons for the shift towards implant-based reconstruction are speculative. The increase in contralateral prophylactic mastectomies, the lack of collaboration with plastic surgery departments and the complexity of autologous breast reconstruction could all be plausible explanations for this observation. Further analysis and critical evaluation of current trends are essential to ensure an individualized, patient-centered approach to breast reconstruction surgery.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102256"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Tilmanocept based lymphoscintigraphy measure up against colloid-based lymphoscintigraphy for sentinel node biopsy in melanoma and early oral squamous cell cancer?","authors":"Giuleta Jamsari ,&nbsp;Eva Wong ,&nbsp;Gopi Elango ,&nbsp;Michael Veness ,&nbsp;Bradley Camden ,&nbsp;David Farlow ,&nbsp;Muzib Abdul-Razak","doi":"10.1016/j.suronc.2025.102258","DOIUrl":"10.1016/j.suronc.2025.102258","url":null,"abstract":"<div><h3>Objective</h3><div>Sentinel lymph node biopsy (SLNB) is crucial in cutaneous melanoma and oral cavity squamous cell carcinoma (OCSCC) as it directs the need for systemic therapy. There has been growing interest in Technetium-99m-labeled Tilmanocept (TL) due to its specific binding capability. This study compares the efficacy of TL to ^99mTc-antimony sulphide colloid (ASC), in these two biologically distinct cancers.</div></div><div><h3>Design</h3><div>In this prospective cross-sectional study, 40 patients were included in each radiotracer group. The primary outcomes measured SN identification rate on lymphoscintigraphy and surgical node retrieval rate. Secondary outcomes include pathological status of lymph nodes, false negative rates (FNR), and nodal recurrence.</div></div><div><h3>Result</h3><div>TL had comparable outcome to ASC with a 100 % SN detection and retrieval rate. Both radiotracers had 100 % lymph nodal tissue specificity with an FNR rate of 0 % for both radiotracers in CM and 25 % for TL in OCSCC. There were significant differences between the SN detection and retrieval rates in ASC in CM and OCSCC but not TL, reflecting its superior binding capability.</div></div><div><h3>Conclusion</h3><div>Our study is the first to demonstrate the superior molecular binding capability of TL with minimal migration to the second echelon nodes.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102258"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear wave elastography combined with high-frequency ultrasound for predicting the presence of occult carcinoma contralateral to unilateral papillary thyroid cancer","authors":"Shu-ni Jia ,&nbsp;Dong Wang ,&nbsp;Zhe-xia Zhao ,&nbsp;Ting-ting Xue","doi":"10.1016/j.suronc.2025.102267","DOIUrl":"10.1016/j.suronc.2025.102267","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the correlation between high-frequency ultrasound (US) signs and shear wave elastography (SWE) parameters of papillary thyroid carcinoma (PTC) in a unilateral lobe and the contralateral lobe occult PTC, and to evaluate the value of SWE in combination with high-frequency US in predicting contralateral occult carcinoma of the thyroid gland preoperatively, to provide clinicians with assistance in the selection of preoperative surgical approaches.</div></div><div><h3>Methods</h3><div>We collected a total of 552 preoperatively diagnosed patients with unilateral thyroid carcinoma and postoperatively pathologically confirmed PTC. High-frequency US and SWE were performed before surgery. Based on the pathologic findings, they were divided into the contralateral occult PTC positive group and the negative group. To investigate the association between the ultrasonographic features of unilateral PTC and the presence of contralateral occult carcinoma by univariate and multivariate analyses, and comparing the accuracy of high-frequency US alone, SWE alone, and SWE combined with high-frequency US in predicting contralateral occult PTC.</div></div><div><h3>Results</h3><div>Univariate analysis showed that the differences between the two groups of extrathyroidal extension (ETE), ipsilateral multifocality, the combination of Hashimoto's thyroiditis (HT), the combination of lymph node metastasis, and Emax and Emean values of the primary tumors were statistically significant (<em>P</em> &lt; 0.05). The multifactorial binary logistic regression model showed that the differences between the two groups of extrathyroidal extension, ipsilateral multifocality, lymph node metastasis, HT and high Emax value were all independent predictors of contralateral occult PTC. The ROC curve analysis showed no statistically significant difference between high-frequency ultrasound and SWE in predicting the AUC of contralateral occult PTC (0.739 vs 0.699,<em>P</em> = 0.185). The AUC for predicting contralateral occult PTC using high-frequency US combined with SWE was significantly higher than the AUC predicted using high-frequency US and SWE alone (0.794 vs 0.739, <em>P</em> = 0.005; 0.794 vs 0.699,<em>P</em> &lt; 0.001)</div></div><div><h3>Conclusion</h3><div>SWE combined with high-frequency US improves the prediction of contralateral occult PTC, and the presence of contralateral occult PTC is more likely in the presence of extrathyroidal extension of a unilateral lobe lesion of the thyroid gland, ipsilateral multifocality, metastasis to cervical lymph nodes, high Emax, and the combination of HT.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102267"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery versus immunotherapy in locally advanced cutaneous carcinoma of the external ear: A multicenter study","authors":"Francesco Mattioli ,&nbsp;Matteo Miglio ,&nbsp;Margherita Basso ,&nbsp;Giacomo Papi ,&nbsp;Roberto Tonelli ,&nbsp;Giulio Martinelli ,&nbsp;Massimo Dominici ,&nbsp;Daniele Marchioni ,&nbsp;Roberta Depenni","doi":"10.1016/j.suronc.2025.102271","DOIUrl":"10.1016/j.suronc.2025.102271","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Immunotherapy is a promising therapeutic strategy for cutaneous carcinoma in locally advanced and advanced stages. This study aims to compare the survival outcomes between patients treated with surgery and those treated with cemiplimab. Secondly, we evaluated how adjuvant treatment, tumor stage, and margins status may influence the oncological outcomes in the surgical group.</div></div><div><h3>Methods</h3><div>The study included 77 patients with locally advanced cutaneous carcinoma of the external ear treated between 2015 and 2023 with surgery, either followed or not by adjuvant therapy, or treated with cemiplimab.</div></div><div><h3>Results</h3><div>Immunotherapy demonstrated a benefit in the disease-specific survival both at 24 months (HR = 0.09, p = 0.02) and at 60 months (HR = 0.11, p = 0.04) when compared to patients treated by surgery, with an estimated 5-year survival of 80 % and 55.9 %, respectively (log-rank = 0.03). Conversely, surgery showed a more favorable trend for disease-free survival than cemiplimab (HR 0.58, p = 0.08), with a median survival of 25.6 and 14.2 months. Stage IV, compared to stage III, tended to have a worse survival rate when stratified by treatment strategy. The addition of adjuvant therapy improved median disease-specific survival from 12 to 40 months for stage IV. On the other hand, adjuvant radiotherapy did not significantly affect outcomes when stratified by margin status, especially when resection margins were clear (p = 0.36).</div></div><div><h3>Conclusions</h3><div>Cutaneous carcinoma of the external ear represents a rare entity, affecting elderly patients and still associated with high complication rates. Emerging therapeutic strategies, which may serve as alternatives to surgery, offer a basis for future adjustments of treatment algorithms for these neoplasms.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102271"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of antiviral treatment for hepatitis C virus on long-term outcomes in patients undergoing resection for hepatocellular carcinoma","authors":"Hiroyuki Hakoda,&nbsp;Yoshikuni Kawaguchi,&nbsp;Yujiro Nishioka,&nbsp;Yuichiro Mihara,&nbsp;Akihiko Ichida,&nbsp;Takeshi Takamoto,&nbsp;Nobuhisa Akamatsu,&nbsp;Kiyoshi Hasegawa","doi":"10.1016/j.suronc.2025.102255","DOIUrl":"10.1016/j.suronc.2025.102255","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis C virus infection is a risk factor for hepatocellular carcinoma (HCC). The effect of direct-acting antivirals on prognoses remains unclear. We assessed the prognosis of patients receiving direct-acting antiviral and interferon treatment after the initial resection of hepatitis C virus-related HCC.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients who underwent initial hepatitis C virus-related HCC resection at The University of Tokyo Hospital between June 2009 and December 2022. Recurrence-free survival (RFS) and overall survival (OS) were assessed using the log-rank test. Cox proportional hazards model analysis was performed to identify the risk factors for RFS and OS.</div></div><div><h3>Results</h3><div>Of 756 patients who underwent HCC resection, 142 had hepatitis C virus-related HCC. Among them, the 5-year OS was significantly better in those receiving antiviral treatment than in those without antiviral treatment (72.2 % vs. 48.9 %, P &lt; 0.001); however, RFS did not differ between the groups (P = 0.35). RFS and OS did not differ significantly between patients who received direct-acting antivirals and those who received interferon (P = 0.09 and P = 0.47, respectively). RFS and OS did not differ significantly between patients receiving antiviral treatment before surgery and those after surgery (P = 0.11 and P = 0.23, respectively).</div></div><div><h3>Conclusions</h3><div>Antiviral treatment improved postoperative prognosis; however, the prognosis did not differ between the types of antiviral treatment in patients with hepatitis C virus-related hepatocellular carcinoma.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102255"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the completeness of cytoreductive surgery on the prognostic role of the KELIM score in patients treated for ovarian peritoneal metastasis","authors":"Charif Khaled ,&nbsp;Lise Sogalow ,&nbsp;Laura Polastro ,&nbsp;Maxime Fastrez ,&nbsp;Michel Moreau ,&nbsp;C. Florin Pop ,&nbsp;Isabelle Veys ,&nbsp;Vincent Donckier ,&nbsp;Gabriel Liberale","doi":"10.1016/j.suronc.2025.102272","DOIUrl":"10.1016/j.suronc.2025.102272","url":null,"abstract":"<div><h3>Introduction</h3><div>The two major treatment related prognostic factors for peritoneal metastasis of ovarian cancer (PMOC) are chemosensitivity and completeness of cytoreduction (CC). Chemosensitivity can be assessed by the CA-125 elimination rate constant K (KELIM) score, based on CA-125 kinetics. CC is evaluated by residual macroscopic disease. The aim of this study was to evaluate the prognostic impact of KELIM score versus CC, in a population who underwent complete (CC-0) and near-complete (CC-1) debulking.</div></div><div><h3>Materials and methods</h3><div>Monocentric retrospective study including patients with primary PMOC treated with curative intent between January 2010 and December 2021. The Biomarker Kinetics website (CA-125 KELIM Calculator) was used to calculate the KELIM score. Univariate and multivariate analysis were performed to assess the impact of CC and KELIM score on PFS and OS.</div></div><div><h3>Results</h3><div>A total of 111 patients were included in the study. Kaplan-Meier analysis showed that PFS and OS were significantly influenced by KELIM, CC, PCI, and BRCA mutation (p &lt; 0.05). Multivariate Cox analysis showed that PFS was significantly influenced by CC (HR = 0.481, p = 0.0027), while OS was influenced by KELIM (HR 0.561, p = 0.0408).</div></div><div><h3>Conclusion</h3><div>These results suggest that PFS is more impacted by the completeness of the surgery than the KELIM score and the KELIM score influences OS more than the completeness of surgery.</div></div>","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102272"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The expression of stem cell protein Piwil2 and piR-932 in breast cancer” [Surg. Oncol. (2013) 22(4) 217-23]","authors":"Hao Zhang ,&nbsp;Yuan Ren ,&nbsp;Huanming Xu ,&nbsp;Deyan Pang ,&nbsp;Chao Duan ,&nbsp;Caigang Liu","doi":"10.1016/j.suronc.2025.102214","DOIUrl":"10.1016/j.suronc.2025.102214","url":null,"abstract":"","PeriodicalId":51185,"journal":{"name":"Surgical Oncology-Oxford","volume":"62 ","pages":"Article 102214"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}