Stress and Health最新文献

Association Between FABP7-5-HT Pattern and Anxiety or Depression in Patients With Psoriasis: A Cross-Sectional Study. 银屑病患者的 FABP7-5-HT 模式与焦虑或抑郁之间的关系：一项横断面研究

IF 3 2区心理学

Stress and Health Pub Date : 2024-11-05 DOI: 10.1002/smi.3498

Dawei Huang, Yuxiong Jiang, Min Wu, Rui Ma, Yingyuan Yu, Xiaoyuan Zhong, Ying Li, Jianhua Chen, Fei Tan, Jiajing Lu, Yuling Shi

{"title":"Association Between FABP7-5-HT Pattern and Anxiety or Depression in Patients With Psoriasis: A Cross-Sectional Study.","authors":"Dawei Huang, Yuxiong Jiang, Min Wu, Rui Ma, Yingyuan Yu, Xiaoyuan Zhong, Ying Li, Jianhua Chen, Fei Tan, Jiajing Lu, Yuling Shi","doi":"10.1002/smi.3498","DOIUrl":"https://doi.org/10.1002/smi.3498","url":null,"abstract":"Psoriasis exhibits a higher incidence of anxiety and depression. However, the diagnostic process heavily relies on subjective evaluation. Fatty acid-binding protein 7 (FABP7) and serotonin (5-HT) are considered as potential plasma biomarkers. We aimed to investigate the potentiality of plasma FABP7 and 5-HT as biomarkers for predicting anxiety and depression in psoriasis. Data were analysed from 140 patients with psoriasis in the Shanghai Psoriasis Effectiveness Evaluation CoHort (SPEECH). Unsupervised clustering was employed to group patients based on their FABP7 and 5-HT profiles. Subsequently, patients were categorised into Group 1 (lower FABP7 and higher 5-HT) or Group 2. Multivariate logistic regression was employed to investigate the correlation between the FABP7-5-HT pattern and anxiety or depression in psoriasis patients. Patients with psoriasis have a higher incidence of anxiety or depression, as well as higher levels of FABP7 and lower levels of 5-HT. After clustering patients using K-means clustering, Group 2 showed a higher body mass index, a higher incidence of hypertension, more severe psoriasis, and more significant anxiety and depression compared to Group 1. Multivariate logistic regression shows that adjusting for covariates except PASI, duration of psoriasis, and psoriatic arthritis, Group 2 had a higher risk of anxiety and depression compared to Group 1. Further adjustment for covariates yielded similar results. Pattern of FABP7-5-HT that may indicate an association with psoriasis accompanied by anxiety or depression.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the nature, predictors, and outcomes of work passion profiles: A generalisability study across distinct types of employees. 关于工作激情特征的性质、预测因素和结果：一项针对不同类型员工的通用性研究。

IF 3 2区心理学

Stress and Health Pub Date : 2024-11-05 DOI: 10.1002/smi.3495

Nicolas Gillet, Alexandre J S Morin, Stéphanie Brault, Margaux Becker, Iria Verbeke

{"title":"On the nature, predictors, and outcomes of work passion profiles: A generalisability study across distinct types of employees.","authors":"Nicolas Gillet, Alexandre J S Morin, Stéphanie Brault, Margaux Becker, Iria Verbeke","doi":"10.1002/smi.3495","DOIUrl":"https://doi.org/10.1002/smi.3495","url":null,"abstract":"Thus far, little research has adopted a person-centred approach to investigate the nature of work passion profiles. As a result, our understanding of the most commonly occurring combinations of harmonious passion (HP) and obsessive passion (OP) in the workplace remains limited. To achieve a more refined understanding of the nature of these work passion profiles, our first aim was thus to identify the configurations of HP and OP for work observed among five samples, including 11 subsamples, of employees (N = 7258). Then, we also considered the extent to which these profiles and their associations with theoretically-relevant predictors (work-home segmentation and organisational support) and outcomes (work engagement, work-family conflict, turnover intentions, presenteeism, and counterproductive work behaviours) generalised across all subsamples. We identified a total of five profiles with a structure that differed slightly across samples: High OP Dominant, High HP Dominant, Average HP Dominant, Low HP Dominant (i.e., low levels of passion dominated by higher levels of HP relative to OP), and Moderately Low Passion. The High OP Dominant profile was systematically the most prevalent (37.5%-54.1% of the sample), whereas the High HP Dominant was the least prevalent (2.1%-7.7%). Across all samples, work-home segmentation was related to a higher likelihood of membership into the profiles characterised by higher, relative to lower or moderate, levels of passion (HP and OP), whereas organisational support also helped employees to stay away from the High OP Dominant profile. Lastly, the least desirable outcomes were observed in the High OP Dominant profile, whereas the most desirable outcomes were observed in the High HP Dominant profile. Interestingly, work engagement levels where comparable in these two profiles. Beyond their theoretical implications for research on work passion, these results highlight how work passion has highly similar implications across contexts.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deployment stressors, mental health outcomes, and protective factors among wives of reserve soldiers during the Israel-Hamas War: A latent profile analysis approach. 以色列-哈马斯战争期间后备役士兵妻子的部署压力、心理健康结果和保护因素：潜在特征分析方法。

IF 3 2区心理学

Stress and Health Pub Date : 2024-11-01 DOI: 10.1002/smi.3497

Gadi Zerach

{"title":"Deployment stressors, mental health outcomes, and protective factors among wives of reserve soldiers during the Israel-Hamas War: A latent profile analysis approach.","authors":"Gadi Zerach","doi":"10.1002/smi.3497","DOIUrl":"https://doi.org/10.1002/smi.3497","url":null,"abstract":"Deployment to active conflict zones significantly affects military families, with spouses often experiencing heightened stress and mental health challenges. However, research on non-US military spouses, particularly those of reserve soldiers, who may face unique stressors compared to active-duty personnel, remains scarce. This study examined perceived stress profiles among Israeli spouses of reserve soldiers during the ongoing Israel-Hamas War, and their associations with deployment stressors, mental health outcomes, and psychological protective factors. A volunteer sample of Israeli spouses of reserve soldiers (n = 293) responded to self-report questionnaires in a cross-sectional study. Using latent profile analysis of the ratings of perceived stress, three distinct profiles were identified: low (35.1%), moderate (43.5%), and high (21.3%). Higher levels of deployment stressors (e.g., fear of spouse getting physically injured) predicted membership in the moderate and high-stress profiles, while better household management was associated with lower stress profiles. The high-stress profile reported significantly greater symptoms of depression and anxiety compared to the low and moderate stress profiles. In contrast, the low-stress profile exhibited higher levels of resilience, self-compassion, and perceived social support. These findings highlight the variability in spouses' stress responses during wartime deployment and identify key factors associated with psychological adjustment. Results suggest that deployment-related fears, household management abilities, and psychological resources are crucial in shaping stress profiles and mental health outcomes among military spouses.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A slow diaphragmatic breathing intervention for anxiety: How do respiration rate and inhalation/exhalation ratio influence self-reported anxiety? 针对焦虑的慢横膈膜呼吸干预：呼吸频率和吸气/呼气比如何影响自我报告的焦虑？

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-30 DOI: 10.1002/smi.3496

Marcin Czub, Marta Kowal, Rosa Esteve Zarazaga, Elena R Serrano-Ibáñez, Gema T Ruíz-Párraga, Carmen Ramírez-Maestre, Alicia E López-Martínez, Charles Paccione, Joanna Piskorz

{"title":"A slow diaphragmatic breathing intervention for anxiety: How do respiration rate and inhalation/exhalation ratio influence self-reported anxiety?","authors":"Marcin Czub, Marta Kowal, Rosa Esteve Zarazaga, Elena R Serrano-Ibáñez, Gema T Ruíz-Párraga, Carmen Ramírez-Maestre, Alicia E López-Martínez, Charles Paccione, Joanna Piskorz","doi":"10.1002/smi.3496","DOIUrl":"https://doi.org/10.1002/smi.3496","url":null,"abstract":"The primary aim was to investigate how respiration rate and inhalation/exhalation ratio influence self-reported state anxiety during a single slow diaphragmatic breathing exercise session. Eight hundred and twenty-eight participants completed the study at two separate geographical locations (Poland and Spain). Participants performed a 10-min online guided breathing exercise. Respiration rates were sampled from a continuous uniform distribution (ranging from 6 to 12 breaths/min). Similarly, inhalation/exhalation ratios were treated as continuous variables and sampled from a uniform distribution for each participant. An application programed for this experiment displayed visual and auditory cues adjusted for each participant. Before and after the breathing exercise, each participant filled in the Current Anxiety Level Measure questionnaire. Self-trait anxiety was measured with the Clinically Useful Anxiety Outcome Scale. A linear regression model showed that respiration rate, trait anxiety, pre-test anxiety, and nationality (Polish/Spanish) were positively related to post-test anxiety levels. Adding quadratic terms of respiration rate and inhalation/exhalation ratio did not improve model fit. Polish participants exhibited higher post-test anxiety levels compared with the Spanish subsample. Age was negatively associated with post-test anxiety. No significant relationships between inhalation/exhalation ratio and post-test anxiety level were found. Slower respiration rates during a single-session breathing exercise are linearly associated with lower post-test anxiety levels in a large and varied sample. This study is the largest to date and may offer further guidance for predicting expected effect sizes for the relationships between anxiety and respiratory dynamics.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns and transitions of posttraumatic stress symptoms and posttraumatic growth in trauma-exposed youth: A latent transition analysis. 受创伤青少年的创伤后应激症状和创伤后成长的模式与转变：潜在转变分析

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-23 DOI: 10.1002/smi.3494

Jiachen Wan, Chengqi Cao, Ruojiao Fang, Chen Chen, Li Wang

引用次数: 0

The actor-partner interdependence model of fertility stress and marital quality among couples undergoing in vitro fertilization and embryo transfer: The mediating role of dyadic coping. 体外受精和胚胎移植夫妇生育压力和婚姻质量的行为者-伴侣相互依存模型：夫妻应对措施的中介作用。

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-22 DOI: 10.1002/smi.3483

Xiaorun Song, Jing Zhao, Zhuoni Xiao, Hui Ye, ShiSi Dong, Lili Hu, Zhongxiang Cai

{"title":"The actor-partner interdependence model of fertility stress and marital quality among couples undergoing in vitro fertilization and embryo transfer: The mediating role of dyadic coping.","authors":"Xiaorun Song, Jing Zhao, Zhuoni Xiao, Hui Ye, ShiSi Dong, Lili Hu, Zhongxiang Cai","doi":"10.1002/smi.3483","DOIUrl":"10.1002/smi.3483","url":null,"abstract":"To explore the relationships among fertility stress, dyadic coping and marital quality in couples undergoing in vitro fertilization-embryo transfer (IVF-ET). Couples receiving IVF-ET treatment at the clinic of the reproductive medicine centre of a hospital in China from February 2023 to October 2023 were selected by convenience sampling. A general information questionnaire, the Infertility Fertility Stress Scale (COMP-FPSS-SF), the dyadic coping inventory, and the marital adjustment test were used to evaluate the results. AMOS24.0 software was used to construct an actor-partner interdependence model that extended to mediation to analyze the relationships among couples' fertility stress, dyadic coping, and marital quality. The fertility stress level of IVF-ET wives was significantly higher than that of their husbands (p < 0.05). Wives' levels of dyadic coping and marital quality were significantly lower than those of husbands (p < 0.05). Fertility stress, dyadic coping, and marital quality were positively correlated between IVF-ET couples (p < 0.01). In terms of the actor effect, the fertility stress of IVF-ET couples had a significant impact on their marital quality through their dyadic coping (β = -0.188, p < 0.05; β = -0.109, p < 0.05). In terms of partner effects, wives' fertility stress significantly affected their husbands' marital quality through their own or their husbands' dyadic coping (β = -0.055, p < 0.01; β = 0.157, p < 0.01). Dyadic coping mediates the relationship between fertility stress and marital quality in IVF-ET couples. Nurses can use husbands and wives as central individuals and dyadic coping as the starting point to formulate intervention measures to reduce fertility stress and improve marital quality.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burnout, working alliance, and ward atmosphere: A multisite study of mental health professionals and patients with schizophrenia. 职业倦怠、工作联盟和病房氛围：一项针对精神卫生专业人员和精神分裂症患者的多地点研究。

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-10 DOI: 10.1002/smi.3492

Miriam D'Addazio, Laura Poddighe, Renzo Bianchi, Stefano Calza, Martina Carnevale, Fabrizio Starace, Manuel Zamparini, Giovanni de Girolamo

{"title":"Burnout, working alliance, and ward atmosphere: A multisite study of mental health professionals and patients with schizophrenia.","authors":"Miriam D'Addazio, Laura Poddighe, Renzo Bianchi, Stefano Calza, Martina Carnevale, Fabrizio Starace, Manuel Zamparini, Giovanni de Girolamo","doi":"10.1002/smi.3492","DOIUrl":"https://doi.org/10.1002/smi.3492","url":null,"abstract":"This study examined the association between burnout, psychological distress, ward atmosphere, and working alliance (WA) among mental health workers treating patients with schizophrenia spectrum disorder (SSD). Data were collected from 345 patients with SSD and 151 mental health workers across 98 residential facilities (RFs) as part of the DiAPAson project from October 2020 to October 2021. Participants were excluded from the study if they exhibited patient-operator matching errors, dropped out, or had many missing Maslach Burnout Inventory (MBI) scores. The final sample included 282 patients and 155 healthcare workers. Burnout was assessed using the MBI. Psychological distress was evaluated with the 12-item version of the General Health Questionnaire. WA and ward atmosphere were evaluated with the WA Inventory and the Ward Atmosphere Scale, respectively, in both staff and patients. Sociodemographic and clinical data was also collected and analysed. Burnout was associated with a less supportive ward atmosphere, a weaker WA, and higher staff distress. Severe psychiatric symptoms evaluated with Brief Psychiatric Rating Scale in patients were also linked to staff burnout levels. Discrepancies in the perceptions of the ward atmosphere and the WA were observed between staff and patients, with patients reporting better perceptions in both domains. Our findings highlight the complex dynamics of well-being within psychiatric care settings, emphasizing the importance of role clarity, professional autonomy, and a positive ward atmosphere in mitigating burnout. Interventions focused on such factors may help support mental health professionals involved in SSD patient care. ISRCTN registry ID ISRCTN21141466.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-rumination and intrapersonal cognitive processes predict distress: Longitudinal evidence from the COVID-19 pandemic. 共同臆想和个人内部认知过程可预测痛苦：来自 COVID-19 大流行病的纵向证据。

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-08 DOI: 10.1002/smi.3490

Jennifer M Kowalsky, Amanda M Mitchell, Bradley M Okdie

{"title":"Co-rumination and intrapersonal cognitive processes predict distress: Longitudinal evidence from the COVID-19 pandemic.","authors":"Jennifer M Kowalsky, Amanda M Mitchell, Bradley M Okdie","doi":"10.1002/smi.3490","DOIUrl":"https://doi.org/10.1002/smi.3490","url":null,"abstract":"Perseverative thinking and catastrophizing have well established associations with fear and distress. However, less is known about the impact of interpersonal dynamics, such as co-rumination, on these intrapersonal cognitive processes and subsequent stress. The present study addresses this knowledge gap. A sample of 433 adults from across the United States was recruited online and completed measures of co-rumination, perseverative thinking, catastrophizing, and demographic characteristics early in the COVID-19 pandemic, and the COVID Stress Scales (CSS) at six month follow up. Co-rumination, perseverative thinking, catastrophizing, and CSS scores were correlated in the expected direction. Regression analyses revealed all three independently predicted CSS worry about the dangerousness of COVID-19 subscale. Co-rumination was the strongest predictor of CSS worry about the socioeconomic impact and CSS compulsive checking scales. Perseverative thinking and catastrophizing predicted CSS traumatic stress symptoms subscale. Finally, perseverative thinking was the strongest predictor of CSS xenophobia subscale. Structural equation modelling indicated that co-rumination had a significant indirect effect on CSS scores through perseverative thinking and catastrophizing. Interpersonal dynamics, such as co-rumination, are relevant for understanding stress and are promising targets for intervention research to prevent or attenuate fears and distress, in addition to traditional intrapersonal cognitive processes such as perseverative thinking and catastrophizing.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of individual differences in environmental sensitivity in teachers' stress and burnout at work. 环境敏感性的个体差异在教师工作压力和职业倦怠中的作用。

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-08 DOI: 10.1002/smi.3491

A Sperati, M E Persico, R Palumbo, M Fasolo, M Spinelli, M Pluess, G D'Urso, F Lionetti

{"title":"The role of individual differences in environmental sensitivity in teachers' stress and burnout at work.","authors":"A Sperati, M E Persico, R Palumbo, M Fasolo, M Spinelli, M Pluess, G D'Urso, F Lionetti","doi":"10.1002/smi.3491","DOIUrl":"https://doi.org/10.1002/smi.3491","url":null,"abstract":"School teachers are among workers most exposed to stress and burnout-a relevant occupational phenomenon leading to psychological and economic costs. The Environmental Sensitivity individual trait-as captured by the psychological marker of sensory processing sensitivity (SPS)-has been found to have a relevant role in stress and emotional exhaustion at work. Yet, little is still known about heightened SPS in the educational field and on underlying mechanisms occurring in the relationship between SPS, stress and burnout. The current work aimed to explore the association between SPS and burnout among teachers as well as the moderating role of perceived stress and school climate in this association. One hundred and ninety eight teachers (44.3 years; SD = 9.7, 94% F) reported on their levels of SPS, occupational burnout, perceived stress and school climate quality. In line with a vulnerability effect, we found heightened SPS largely associated with burnout. This was particularly evident in a context of high-perceived stress, suggesting that teachers high on SPS may experience more challenges in the face of elevated stress with the need of more support. When exposed to positive and supportive school climate, highly sensitive teachers showed a decrease in burnout, suggesting high SPS as a valuable strength for benefiting from positive experiences. Findings have the potential to inform the customisation of support programs, assisting both schools and work agencies in increasing their awareness of the role of individual differences in responding to both work-demand-related stress and to positive work environments.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction. 研究下丘脑-垂体-肾上腺轴基因变异对皮质醇和α-淀粉酶在明确的负面评价压力诱导过程中的反应性的影响。

IF 3 2区心理学

Stress and Health Pub Date : 2024-10-04 DOI: 10.1002/smi.3484

Alessandra R Grillo, Lisa R Starr, Suzanne Vrshek-Schallhorn

{"title":"Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction.","authors":"Alessandra R Grillo, Lisa R Starr, Suzanne Vrshek-Schallhorn","doi":"10.1002/smi.3484","DOIUrl":"https://doi.org/10.1002/smi.3484","url":null,"abstract":"Prior work consistently links additive genetic variation in the hypothalamic-pituitary-adrenal (HPA) axis-a multilocus genetic profile score (MGPS)-to depression risk in the context of stress exposure. However, despite that HPA MGPS variants were selected based on evidence that they elevate cortisol reactivity, there are surprisingly few tests of whether an HPA MGPS elevates cortisol reactivity to lab-based stress. Similarly, despite neurobiological connections and coordination between the HPA axis and the sympathetic nervous system (e.g., in the paraventricular nucleus and locus coeruleus), no work has tested whether an HPA MGPS influences sympathetic nervous system reactivity to stress. We investigated whether an HPA MGPS moderates the relation between lab-based stress and: (1) HPA activity indexed by cortisol, and/or (2) sympathetic activity indexed by salivary alpha-amylase, sAA. Emerging adults (N = 152; mean age = 19.5, largest subsample 44.4% Black/African American) were randomly assigned to one of two Trier Social Stress Test variations, a non-evaluative control, or an explicitly negative-evaluative condition. Participants provided DNA and repeated saliva samples for sAA and cortisol. The HPA MGPS did not significantly moderate the relationship between stress condition and cortisol or sAA reactivity, respectively; moreover, post-hoc tests highlight that individual polymorphisms showed non-significant effects in opposite directions from each other, cancelling out in aggregate. Findings suggest that the HPA MGPS's associations with cortisol reactivity are not as straightforward as initially believed. We speculate that the relationships of some HPA variants to biomarker reactivity may vary between modest lab-based stressors and the explicit negative-evaluative induction used here.","PeriodicalId":51175,"journal":{"name":"Stress and Health","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0