Rachel A Millstein, Loren Winters, Carol Sullivan, Stephanie Eisenstat, Emily Sorg, Amy Comander
{"title":"Implementing a Multidisciplinary Lifestyle Medicine Clinic for Cancer Survivorship.","authors":"Rachel A Millstein, Loren Winters, Carol Sullivan, Stephanie Eisenstat, Emily Sorg, Amy Comander","doi":"10.46883/2024.25921030","DOIUrl":"10.46883/2024.25921030","url":null,"abstract":"<p><strong>Background: </strong>Lifestyle medicine (LM) is increasingly recognized in cancer survivorship guidelines. The 6 LM pillars are physical activity, a predominantly plant diet, restorative sleep, stress management, avoiding risky substance use, and social connections. Through a multidisciplinary LM clinic in oncology, we describe 2 illustrative cases and the implications for broader implementation and dissemination of this clinic model.</p><p><strong>Methods: </strong>In the multidisciplinary LM clinic in oncology, patients meet with an American College of Lifestyle Medicine (ACLM) board-certified physician or nurse practitioner, a registered dietitian, and, as needed, a clinical psychologist, a psychiatrist, an obesity medicine physician, a physical therapist, and/or a rehabilitation medicine physician.</p><p><strong>Results: </strong>Patient 1 met with the physician, the registered dietitian, the psychologist, and an affiliated cancer center psychiatrist. Patient 2 met with the nurse practitioner and the registered dietitian. The 2 cases presented illustrate the diversity of LM pillars and strategies to increase health and well-being post cancer treatment.</p><p><strong>Conclusion: </strong>This paper details the model of implementation of a novel oncology-focused multidisciplinary LM clinic and the clinical focuses of 2 diverse patients. The LM needs of cancer survivors seeking lifestyle consultation are growing, and awareness of the benefits of LM for this population can enhance the quality of life for patients who are survivors of cancer.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 11","pages":"421-425"},"PeriodicalIF":1.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Casting a Wide NET: When Is the Optimal Time for 177Lu-Dotatate Treatment?","authors":"Natasha Bahri, Christiana Crook, Daneng Li Md","doi":"10.46883/2024.25921029","DOIUrl":"https://doi.org/10.46883/2024.25921029","url":null,"abstract":"<p><p>The incidence of neuroendocrine tumors (NETs) in the US is rising, with 8.3 cases per 100,000 individuals diagnosed in 2018 compared with 6.98 cases per 100,000 individuals diagnosed in 2012. 1,2 Most patients with NETs are diagnosed with metastatic disease, at which point curative surgery is no longer a treatment option. 3 Prior to 2017, available treatments for advanced NETs included somatostatin analogues (lanreotide [Somatuline] and octreotide [Sandostatin]), targeted therapy (everolimus [Afinitor] and sunitinib [Sutent]), and chemotherapy. 4-7 In 2017, the World Health Organization added a classification for well-differentiated grade 3 NETs (Ki67 > 20% and ≤ 55%). 8 Previously these tumors were placed under the umbrella of poorly differentiated neuroendocrine carcinomas. Given that well-differentiated grade 3 NETs are relatively new, standard-of-care treatment options are undefined.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 11","pages":"442-443"},"PeriodicalIF":1.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fnu Fatima, Faryal Arif, Muhammad Hamza Gul, Neha Siddiqui, Muhammad Zulqarnain, Abdul Baseer Wardak
{"title":"The Hidden Danger Unveiling the Connection Between Multiple Myeloma and Pleural Effusion.","authors":"Fnu Fatima, Faryal Arif, Muhammad Hamza Gul, Neha Siddiqui, Muhammad Zulqarnain, Abdul Baseer Wardak","doi":"10.46883/2024.25921028","DOIUrl":"https://doi.org/10.46883/2024.25921028","url":null,"abstract":"<p><p>We present a 65-year-old man with multiple myeloma who developed a rare complication of pleural effusion. Initial laboratory results showed elevated creatinine, calcium, and protein electrophoresis with an M spike. A bone marrow biopsy confirmed 80% plasma cells. Despite the rarity of pleural effusion in patients with multiple myeloma, our patient demonstrated significant improvement with targeted therapy and palliative care. This case highlights the importance of early recognition and management of pleural effusion in patients with multiple myeloma and underscores the need for further research into optimal management strategies and underlying mechanisms.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 11","pages":"410-412"},"PeriodicalIF":1.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Luis Rodríguez-Olivares, Héctor Raúl González-Sánchez, Evelyn Lilian Beas-Lozano, Jazmin Arteaga-Vázquez, Elaine T Lam Md, María T Bourlon
{"title":"Hereditary Renal Tumor Syndromes and the Use of mTOR Inhibitors.","authors":"José Luis Rodríguez-Olivares, Héctor Raúl González-Sánchez, Evelyn Lilian Beas-Lozano, Jazmin Arteaga-Vázquez, Elaine T Lam Md, María T Bourlon","doi":"10.46883/2024.25921027","DOIUrl":"10.46883/2024.25921027","url":null,"abstract":"<p><p>The Case A 47-year-old woman with a history of drug-resistant epilepsy during childhood presented to the emergency department with sudden dyspnea and chest pain. Upon admission, her oxygen saturation was 88%. A chest CT scan revealed pulmonary cystic lesions consistent with lymphangioleiomyomatosis and a right spontaneous pneumothorax, which resolved with the placement of a chest tube. Physical examination revealed a hypopigmented macule on the skin of the lumbar region, facial angiofibromas, and periungual fibromas. An abdominal MRI documented multiple bilateral renal tumors that were hypointense on T2-weighted imaging and showed a black boundary artifact, suggestive of fat-poor angiomyolipomas (AMLs). Subsequent percutaneous biopsy of the largest renal tumor confirmed the diagnosis of angiomyolipoma (positive for HMB-45 on immunohistochemistry). The brain MRI revealed subependymal nodules. The pulmonary function tests showed a mild obstructive pattern. Germline genetic testing confirmed the suspected diagnosis, and the patient started oral systemic treatment with everolimus (Afinitor) 10 mg once daily, along with dexamethasone rinses for prophylaxis.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 10","pages":"376-380"},"PeriodicalIF":1.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multidisciplinary Team Meetings: Barriers to Implementation in Cancer Care.","authors":"Carl He","doi":"10.46883/2024.25921026","DOIUrl":"10.46883/2024.25921026","url":null,"abstract":"<p><p>The multidisciplinary team meeting has become a fundamental component of cancer care across most of Europe, North America, and Australia. In certain institutions, it holds a mandatory role in the treatment planning of all patients with cancer. Although the multidisciplinary team meeting has demonstrated improved adherence to clinical protocols in the oncology field and serves as a valuable educational tool for clinicians, it is difficult to truly gauge its impact on clinical outcomes due to the wide heterogeneity in interinstitutional meeting practices and the varied data reporting clinical outcomes. This literature review will provide an overview of the history and contextual role of the multidisciplinary team meeting in cancer management and discuss the barriers to its implementation, offering means to navigate these barriers. This review will also explore the barriers to adherence to treatment recommendations offered by the multidisciplinary team meeting in cancer care, through the lens of the patient and health care provider.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 9","pages":"339-344"},"PeriodicalIF":1.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Hamza Gul, Aisha Rehman Siddiqui, Farwa Zehra, Malaika Rehmani, Faraz Waheed, Natasha Masood, Maleeha Saqib, Mahnoor Keen, Sharan Siddharth Keshetty, Maham Maqsood, Siddharth Arjun Atwal, Muhammad Hamza Sikandari, Abdul Baseer Wardak
{"title":"Navigating a Paradigm Shift Venetoclax Treatment Redefines Landscape of Acute Myeloid Leukemia.","authors":"Muhammad Hamza Gul, Aisha Rehman Siddiqui, Farwa Zehra, Malaika Rehmani, Faraz Waheed, Natasha Masood, Maleeha Saqib, Mahnoor Keen, Sharan Siddharth Keshetty, Maham Maqsood, Siddharth Arjun Atwal, Muhammad Hamza Sikandari, Abdul Baseer Wardak","doi":"10.46883/2024.25921025","DOIUrl":"10.46883/2024.25921025","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the accumulation of malignant myeloid progenitor hematopoietic cells in the bone marrow and peripheral blood. Recent studies have shown promising results with the use of small molecule inhibitors and targeted therapy in the treatment of patients with AML. One such molecule is venetoclax, which has been approved in AML by the FDA in combination with hypomethylating agents or low-dose cytarabine. We thoroughly searched electronic literature related to venetoclax and its role in AML, using databases such as MEDLINE, PubMed, Google Scholar, and PsychInfo, through April 2024. We applied population, intervention, comparison, and outcome criteria, specifically focusing on studies with a population using venetoclax from review articles and clinical trials. All selected studies were required to be in English, and any study that did not involve the use of venetoclax was excluded. A meticulous literature review was conducted to consolidate the current knowledge and new combination therapies on AML. In our review article, we focused on the latest advances in the treatment of patients with AML. Based on the literature, we recommend that physicians prioritize the use of venetoclax in the management of this deadly disease because it has been shown to significantly impact the course of the disease.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 8","pages":"311-314"},"PeriodicalIF":1.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios Evangelou, Ioannis Vamvakaris, Irene Konstantopoulou, Konstantinos Syrigos
{"title":"Neoadjuvant Capecitabine Plus Temozolomide in Atypical Lung NETs.","authors":"Georgios Evangelou, Ioannis Vamvakaris, Irene Konstantopoulou, Konstantinos Syrigos","doi":"10.46883/2024.25921024","DOIUrl":"10.46883/2024.25921024","url":null,"abstract":"<p><p>Neoadjuvant and adjuvant treatment in lung neuroendocrine tumors (NETs) is a field that has not been explored in-depth, with little information on the impact on disease-free survival. This case study highlights the effectiveness of neoadjuvant treatment with capecitabine plus temozolomide (CAPTEM) in a woman with well-differentiated atypical carcinoid. The patient was asymptomatic at diagnosis and was referred to the outpatient NET clinic at Sotiria Hospital in Athens, following an incidental finding on a chest x-ray. 18F-fluorodeoxyglucose (FDG) PET/CT and 68Ga-Dotatoc PET/CT revealed another mass in the pancreas, with avidity in both imaging studies. The patient underwent treatment for 6 months with CAPTEM with a response in the lung NET and mediastinal lymph nodes. However, the mass in the pancreas slightly increased and was removed with a central pancreatectomy. The patient continued treatment with CAPTEM for 6 more months. There was further response according to RECIST 1.1 criteria (partial response in the mediastinal lymph nodes and a 21% regression in the primary tumor size). Pathology report after lobectomy with lymph node dissection showed a pathologic complete response in the mediastinal lymph nodes. Twenty-four months after surgery, the patient remains disease-free and has a good quality of life. Although large clinical trials are needed, this case study underlines the value of preoperative chemotherapy in atypical carcinoids.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 7","pages":"264-268"},"PeriodicalIF":1.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Q Trinh, Shristi Upadhyay Banskota, Alissa S Marr
{"title":"A Rare Case of Metastatic Spiradenocarcinoma With CDKN2A Mutation.","authors":"Jonathan Q Trinh, Shristi Upadhyay Banskota, Alissa S Marr","doi":"10.46883/2024.25921022","DOIUrl":"10.46883/2024.25921022","url":null,"abstract":"<p><p>Spiradenocarcinomas are rare malignant skin adnexal tumors. We describe a novel case of a patient with an aggressive CDKN2A-mutated spiradenocarcinoma who responded to a CDK4/6 inhibitor. This case highlights the unique nature of spiradenocarcinomas as well as the potential benefit of targeted therapy.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 6","pages":"230-231"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Continued Success of Venetoclax in t(11;14) Multiple Myeloma Despite Negative Trials.","authors":"Zachary M Avigan, Joshua Richter Md","doi":"10.46883/2024.25921023","DOIUrl":"10.46883/2024.25921023","url":null,"abstract":"<p><p>The June Hot Topics focuses on the challenges venetoclax regimens have faced in multiple myeloma trials.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 6","pages":"239-241"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AI Use in Prostate Cancer: Potential Improvements in Treatments and Patient Care.","authors":"James B Yu Md Mhs Fastro, Julian C Hong","doi":"10.46883/2024.25921021","DOIUrl":"10.46883/2024.25921021","url":null,"abstract":"<p><p>Artificial intelligence use in prostate cancer encompasses 4 main areas including diagnostic imaging, prediction of outcomes, histopathology, and treatment planning.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 5","pages":"208-209"},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}