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IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-07-01 DOI: 10.1016/s0021-9258(24)02086-6
{"title":"Cover","authors":"","doi":"10.1016/s0021-9258(24)02086-6","DOIUrl":"https://doi.org/10.1016/s0021-9258(24)02086-6","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"277 1‐2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferroptosis regulation by Cap’n’collar family transcription factors Cap'n'collar家族转录因子对铁蛋白沉积的调控
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-07-01 DOI: 10.1016/j.jbc.2024.107583
Magdalena B. Murray, Scott J. Dixon
{"title":"Ferroptosis regulation by Cap’n’collar family transcription factors","authors":"Magdalena B. Murray, Scott J. Dixon","doi":"10.1016/j.jbc.2024.107583","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107583","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"52 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classical and non-classical effects of angiotensin converting enzyme: how increased ACE enhances myeloid immune function. 血管紧张素转换酶的经典和非经典效应：血管紧张素转换酶的增加如何增强骨髓免疫功能。
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107388
Kenneth E. Bernstein, Duo-Yao Cao, Tomohiro Shibata, Suguru Saito, E. Bernstein, Erika Nishi, Michifumi Yamashita, Warren G. Tourtellotte, Tuantuan V. Zhao, Zakir Khan
{"title":"Classical and non-classical effects of angiotensin converting enzyme: how increased ACE enhances myeloid immune function.","authors":"Kenneth E. Bernstein, Duo-Yao Cao, Tomohiro Shibata, Suguru Saito, E. Bernstein, Erika Nishi, Michifumi Yamashita, Warren G. Tourtellotte, Tuantuan V. Zhao, Zakir Khan","doi":"10.1016/j.jbc.2024.107388","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107388","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"13 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-translational control of NLRP3 inflammasome signaling NLRP3 炎症小体信号的翻译后控制
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107386
Meghan E. O’Keefe, George Dubyak, Derek W. Abbott
{"title":"Post-translational control of NLRP3 inflammasome signaling","authors":"Meghan E. O’Keefe, George Dubyak, Derek W. Abbott","doi":"10.1016/j.jbc.2024.107386","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107386","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"27 16","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consensus, controversies, and conundrums of P4-ATPases: the emerging face of eukaryotic lipid flippases P4-ATP 酶的共识、争议和难题：真核生物脂质翻转酶的新面貌
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107387
H. Duan, Huilin Li
{"title":"Consensus, controversies, and conundrums of P4-ATPases: the emerging face of eukaryotic lipid flippases","authors":"H. Duan, Huilin Li","doi":"10.1016/j.jbc.2024.107387","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107387","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"165 3","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141050309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient kinetics reveal the mechanism of competitive inhibition of the neutral amino acid transporter ASCT2 瞬时动力学揭示了中性氨基酸转运体 ASCT2 的竞争性抑制机制
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107382
Yang Dong, Jiali Wang, Christof Grewer
{"title":"Transient kinetics reveal the mechanism of competitive inhibition of the neutral amino acid transporter ASCT2","authors":"Yang Dong, Jiali Wang, Christof Grewer","doi":"10.1016/j.jbc.2024.107382","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107382","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"18 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. ERG激活了具有混合基底腔特征的前列腺上皮细胞的干样增殖-分化程序。
2区 生物学
Journal of Biological Chemistry Pub Date : 2024-04-06 DOI: 10.1101/2023.05.15.540839
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa de Stanchina, Yu Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
{"title":"ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity.","authors":"Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa de Stanchina, Yu Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers","doi":"10.1101/2023.05.15.540839","DOIUrl":"10.1101/2023.05.15.540839","url":null,"abstract":"<p><p>To gain insight into how ERG translocations cause prostate cancer, we performed single cell transcriptional profiling of an autochthonous mouse model at an early stage of disease initiation. Despite broad expression of ERG in all prostate epithelial cells, proliferation was enriched in a small, stem-like population with mixed-luminal basal identity (called intermediate cells). Through a series of lineage tracing and primary prostate tissue transplantation experiments, we find that tumor initiating activity resides in a subpopulation of basal cells that co-express the luminal genes <i>Tmprss2</i> and <i>Nkx3.1</i> (called Basal<sup>Lum</sup>) but not in the larger population of classical <i>Krt8</i>+ luminal cells. Upon ERG activation, Basal<sup>Lum</sup> cells give rise to the highly proliferative intermediate state, which subsequently transitions to the larger population of Krt8+ luminal cells characteristic of ERG-positive human cancers. Furthermore, this proliferative population is characterized by an ERG-specific chromatin state enriched for NFkB, AP-1, STAT and NFAT binding, with implications for TF cooperativity. The fact that the proliferative potential of ERG is enriched in a small stem-like population implicates the chromatin context of these cells as a critical variable for unmasking its oncogenic activity.</p>","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10996491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77892864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A minimum functional form of the E. coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro 由 BamADE 构成的大肠杆菌 BAM 复合物在体外组装外膜蛋白的最小功能形式
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107324
Zhe Wang, Yindi Chu, Qingrong Li, Xiaochen Han, Leyi Zhao, Hanqing Zhang, Kun Cai, Xuyan Zhang, Xingyuan Wang, Youcai Qin, Enguo Fan
{"title":"A minimum functional form of the E. coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro","authors":"Zhe Wang, Yindi Chu, Qingrong Li, Xiaochen Han, Leyi Zhao, Hanqing Zhang, Kun Cai, Xuyan Zhang, Xingyuan Wang, Youcai Qin, Enguo Fan","doi":"10.1016/j.jbc.2024.107324","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107324","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"115 12","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing RNA Structure and Dynamics using Nanopore and Next Generation Sequencing 利用纳米孔和新一代测序技术探测 RNA 结构和动力学
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107317
Emma Bose, Shengwei Xiong, Alisha N. Jones
{"title":"Probing RNA Structure and Dynamics using Nanopore and Next Generation Sequencing","authors":"Emma Bose, Shengwei Xiong, Alisha N. Jones","doi":"10.1016/j.jbc.2024.107317","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107317","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"495 ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The types and numbers of kinesins and dyneins transporting endocytic cargoes modulate their motility and response to tau 运输内吞货物的驱动蛋白和动力蛋白的类型和数量可调节其运动性和对 tau 的反应
IF 4.8 2区 生物学
Journal of Biological Chemistry Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107323
Daniel Beaudet, Christopher L. Berger, Adam G. Hendricks
{"title":"The types and numbers of kinesins and dyneins transporting endocytic cargoes modulate their motility and response to tau","authors":"Daniel Beaudet, Christopher L. Berger, Adam G. Hendricks","doi":"10.1016/j.jbc.2024.107323","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107323","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"29 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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