Journal of Applied Biomaterials & Biomechanics最新文献

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Flow investigation of second grade micropolar nanofluid with porous medium over an exponentially stretching sheet 二级微极性纳米流体在多孔介质上的流动研究
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-04-01 DOI: 10.1177/22808000221089782
Aamir Abbas Khan, Muhammad Naveed Khan, N. A. Ahammad, Muhammad Ashraf, Kamel Guedri, A. Galal
{"title":"Flow investigation of second grade micropolar nanofluid with porous medium over an exponentially stretching sheet","authors":"Aamir Abbas Khan, Muhammad Naveed Khan, N. A. Ahammad, Muhammad Ashraf, Kamel Guedri, A. Galal","doi":"10.1177/22808000221089782","DOIUrl":"https://doi.org/10.1177/22808000221089782","url":null,"abstract":"This article mainly focuses on the influence of heat and mass transportation of micropolar second grade nanofluid toward porous medium of an exponentially stretched surface. The significance of activation energy and viscous dissipation with magnetic effect are taken into deliberated. Furthermore, to analyze the heat and mass transport scrutiny the concentration and thermal slip boundary conditions are assessed on the surface of the sheet. The convenient similarity variables are adopted to transfer the non-linear governing PDEs into the dimensionless ODEs and their corresponding boundary conditions also transformed. The nonlinear coupled ODEs are numerically solved by the usage of BVP4C MATLAB technique. The obtained numerical estimations are displayed graphically to display the significance of the various parameters against the velocity, temperature, microrotation, concentration distributions. It is noticed that larger estimations of micropolar and second grade parameter improves the fluid velocity consequently, while opposite trend is found for the higher estimation of porous medium parameter. Further, it is observed that the skin friction rate is boosted by the increment of ε and β , whereas opposite trend is noted against the mass transfer rate and heat transfer rate.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42473262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Influence different polishing systems on roughness and colour stability of chairside CAD/CAM blocks with laminate veneer thickness 影响不同抛光系统对椅边CAD/CAM块的粗糙度和颜色稳定性
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221086493
R. Sasany, Göknil Ergün Kunt, Mehmet Faruk Koca
{"title":"Influence different polishing systems on roughness and colour stability of chairside CAD/CAM blocks with laminate veneer thickness","authors":"R. Sasany, Göknil Ergün Kunt, Mehmet Faruk Koca","doi":"10.1177/22808000221086493","DOIUrl":"https://doi.org/10.1177/22808000221086493","url":null,"abstract":"Objective: The aim of this study was to evaluate the effect of different polishing systems on the colour stability of different laminate veneer blocks for chair-side CAD-CAM after ultraviolet (UV) ageing. Methods: About 240 sample (13 × 13 × 0.7) were prepared from four different CAD-CAM blocks IPS e.max CAD (IP), IPS Empress CAD (IE), Mark II (M) and Lava Ultimate (LU)) with A1 shade. Each group was divided into five subgroups (n = 12) according to the control (C) and four different polishing system: Sof-Lex (S), Edenta (E), Identoflex (I) and Zircon Brite (Z). Surface roughnesses (Ra) were measured by a profilometer before and after polishing. The baseline colour values were recorded according to the CIELab system. The colour coordinates (L*, a* and b*) of the samples were measured before and after UV ageing, and colour differences (ΔE00) were calculated by using the CIEDE2000 colour difference formula. A two-way ANOVA and Tukey test methods were used to analyse the data (α = 0.05). Results: A significant interaction was observed between CAD-CAM blocks and polishing system (p < 0.001). The higher Ra and colour difference was calculated in LU in the Z group after polished and the lower Ra and colour difference was calculated in the IP in the S group after polished. For the IP group, the glazing procedure showed higher Ra and ΔE values with Z group than polished S system, whereas there is no statistical differences. Conclusion: It is concluded that polishing with the Sof-Lex system improves significantly smoothness and colour stability. However, there is no success in using the Zircon Brite polishing system.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46256918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Commercially pure titanium modification to enhance corrosion behavior and osteoblast response by ECAP for biomedical applications 商业纯钛改性增强腐蚀行为和成骨细胞反应的ECAP生物医学应用
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221095234
P. Hashemi, E. Borhani, M. Nourbakhsh
{"title":"Commercially pure titanium modification to enhance corrosion behavior and osteoblast response by ECAP for biomedical applications","authors":"P. Hashemi, E. Borhani, M. Nourbakhsh","doi":"10.1177/22808000221095234","DOIUrl":"https://doi.org/10.1177/22808000221095234","url":null,"abstract":"When it comes to using bio-metals, the chemical and biocompatibility properties of titanium led to its widespread use in biomedical implants. However, pure titanium possesses lower mechanical properties than Ti alloys containing cytotoxic elements. Severe plastic deformation (SPD) techniques were able to cause a significant strength increase, corrosion behavior improvement, and the release of the alloying elements. In this study, the ECAP process was performed on commercially pure titanium with a square cross-section at two and four passes, which resulted in a finer grain size and a more uniform microstructure. In order to improve cell behaviors, etch treatment was performed to produce nano-rough and nano-texture surfaces for all Ti samples. The effect of surface etching on corrosion, surface roughness, and cell behaviors on ECAP and untreated samples was also investigated. Optical/Field Emission Scanning Electron Microscopy, Atomic Force Microscopy, and X-Ray Diffraction were used to study the microstructural characterizations of samples. In addition, the impact of grain structure on the contact angle, electrochemical corrosion behavior, osteoblast response, and cell viability was investigated. The titanium that was ECAPed four times provided finer grains (200 nm) than the unprocessed sample (25 µm). The potentiodynamic polarization test revealed that corrosion resistance of ECAPed samples was enhanced, which was associated with grain refinement, affecting the passive film formation. Corrosion resistance and wettability experienced an apparent increase after each ECAP pass. In conclusion, improvement of grain size and surface roughness was due to the simultaneous effect of ECAP and etching treatment that led to the osteoblast response and cellular activity of samples.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46142640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A Copper nanoparticles-based polymeric spray coating: Nanoshield against Sars-Cov-2 一种基于铜纳米颗粒的聚合物喷涂涂层:针对严重急性呼吸系统综合征冠状病毒2型的纳米防护
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221076326
I. Foffa, P. Losi, Paola Quaranta, Alice Cara, T. Al Kayal, M. D’Acunto, G. Presciuttini, M. Pistello, G. Soldani
{"title":"A Copper nanoparticles-based polymeric spray coating: Nanoshield against Sars-Cov-2","authors":"I. Foffa, P. Losi, Paola Quaranta, Alice Cara, T. Al Kayal, M. D’Acunto, G. Presciuttini, M. Pistello, G. Soldani","doi":"10.1177/22808000221076326","DOIUrl":"https://doi.org/10.1177/22808000221076326","url":null,"abstract":"Face masks are an effective protection tool to prevent bacterial and viral transmission. However, commercial face masks contain filters made of materials that are not capable of inactivating either SARS-CoV-2. In this regard, we report the development of an antiviral coating of polyurethane and Copper nanoparticles on a face mask filter fabricated with a spray technology that is capable of inactivating more than 99% of SARS-CoV-2 particles in 30 min of contact.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45365532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Swirling flow of fluid containing (SiO2) and (MoS2) nanoparticles analyze via Cattaneo-Christov theory 用Cattaneo-Christov理论分析含(SiO2)和(MoS2)纳米颗粒流体的旋流
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221094685
Juan Zhang, Awais Ahmed, Muhammad Naveed Khan, Fuzhang Wang, Shaimaa A M Abdelmohsen, H. Tariq
{"title":"Swirling flow of fluid containing (SiO2) and (MoS2) nanoparticles analyze via Cattaneo-Christov theory","authors":"Juan Zhang, Awais Ahmed, Muhammad Naveed Khan, Fuzhang Wang, Shaimaa A M Abdelmohsen, H. Tariq","doi":"10.1177/22808000221094685","DOIUrl":"https://doi.org/10.1177/22808000221094685","url":null,"abstract":"Investigation of heat transport mechanism in swirling flow of viscous fluid containing silicon dioxide ( S i O 2 ) and molybdenum disulfide ( M o S 2 ) nanoparticles is performed. The flow is engendered due to stretchable rotating cylinder which immersed in infinite fluid. The boundary layer assumption is applied to simplify the governing equations of the problem. The theory of Cattaneo-Christov for thermal energy transportation is employed in the present phenomenon under the heat and mass constraints. The flow is also influenced by Lorentz force. The results for flow field, temperature, and concentration field are produced by employing the bvp4c numerical technique to the similar differential equations. According to the observations, it is noted that in the presence of Lorentz force the reduction in velocity field of the nanofluid occurs. The thermal and solutal relaxation phenomena also declines the energy transport in nanofluid flow. The outcomes are validated through the comparison with previous published studies.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48262332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration 矿化度增加对成骨前细胞对天然胶原纤维支架骨组织修复和再生的影响
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221104000
Brendan H Grue, Samuel P. Veres
{"title":"Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration","authors":"Brendan H Grue, Samuel P. Veres","doi":"10.1177/22808000221104000","DOIUrl":"https://doi.org/10.1177/22808000221104000","url":null,"abstract":"With limited availability of auto- and allografts, there is increasing demand for alternative bone repair and regeneration materials. Inspired by a mimetic approach, the utility of producing engineered native protein scaffolds is being increasingly realized, demonstrating the need for continued research in this field. In previous work, we detailed a process for producing mineralized collagen scaffolds using tendon to create collagen templates of highly aligned, natively crosslinked collagen fibrils. The process produced mineral phase closely matching that of native bone, and integration of mineral with the collagen template was demonstrated to be easily controlled, allowing scaffolds to be mechanically tuned. In the current study, we have extended this work to investigate how variation in the mineralization level of these scaffolds affects the osteogenic response of pre-osteoblastic cells. Scaffolds were produced under three treatment groups, where collagen templates underwent 0, 5, or 20 mineralization cycles. Scaffolds in each treatment group were cultured with MC3T3-E1 cells for 1, 7, or 14 days. Morphologic assessment under SEM indicated decreased attachment to the mineralized scaffolds, supported by DNA results showing a significant drop between culture days 1 and 7 for mineralized scaffolds only. For adherent cells, increasing scaffold mineralization also delayed cell spreading. While mineralization presented a barrier to cell coverage of scaffolds, it increased osteogenic activity, with cells on the mineralized scaffolds showing significantly greater alkaline phosphatase activity and osteocalcin production. Understanding how increasing collagen mineralization effects pre-osteoblast function may enable design of more advanced mineralized collagen scaffolds for bone repair and regeneration.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47408044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
β-TCP/DCPD-PHBV (40%/60%): Biomaterial made from bioceramic and biopolymer for bone regeneration; investigation of intrinsic properties β-TCP/DCPD-HBV(40%/60%):由生物陶瓷和生物聚合物制成的用于骨再生的生物材料;内在性质研究
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221088950
Trimeche Monia
{"title":"β-TCP/DCPD-PHBV (40%/60%): Biomaterial made from bioceramic and biopolymer for bone regeneration; investigation of intrinsic properties","authors":"Trimeche Monia","doi":"10.1177/22808000221088950","DOIUrl":"https://doi.org/10.1177/22808000221088950","url":null,"abstract":"In this study, a detailed physical, chemical, and mechanical investigation of bone substitute (β-TCP/DCPD-PHBV) was carried out. In fact, it is composed of biocompatible materials such as ceramic phosphocalcic, consisting of tricalcium phosphate (β-TCP) and dihydrated dicalcium phosphate (DCPD) and 3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) polymer having a weight fraction 40%/60%. For these analyses, diverse techniques were used, including SEM-EDS, mercury porosimeter, Fourier Transform Infrared Spectroscopy, and, finally, uniaxial compression test machine. A morphological investigation of biomaterials using MEB revealed uneven particle shape and size, as well as a rough surface with a porous and microcracked structure. In fact, this architecture promotes the development of bone within biomaterials. Compositional studies applying FTIR technology, also, revealed the existence of chemical components, comparable to those found in the mineral phase of bone (Ca2+, PO43−, and HPO42−). The following compounds prove the bioactivity of β-TCP/DCPD-PHBV. Furthermore, mechanical investigations revealed that this biomaterial has a satisfying mechanical strength (195.21 MPa), closer to bone. Nevertheless, another significant benefit of combining the two biocompatible materials used in this work is that the ductility of PHBV restricts the brittleness of β-TCP/DCPD-PHBV, compared to pure β-TCP/DCPD. The obtained results demonstrate the beneficial properties of β-TCP/DCPD-PHBV and approve the possibility of using this biomaterial as a viable material for future implantology applications.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41334509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Comparative modal analysis on fishing rod made of functionally graded composite material using finite element analysis 用有限元方法对功能梯度复合材料鱼竿进行模态比较分析
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221089774
S. Asiri
{"title":"Comparative modal analysis on fishing rod made of functionally graded composite material using finite element analysis","authors":"S. Asiri","doi":"10.1177/22808000221089774","DOIUrl":"https://doi.org/10.1177/22808000221089774","url":null,"abstract":"The use of smart and advanced composite materials instead of conventional metals is foreseen in material sciences due to the development of novel manufacturing techniques. In this regard, a novel type of composite materials “functionally graded materials (FGM)” has attained great attention owing to their intrinsic mechanical characteristics. FGM have been the focus for researchers for analytical formulation, static structural (large deformation, material nonlinearity) analysis as well as for dynamic analysis on simple beams and on structure having non-uniform tapered rectangular profile considering different boundary conditions. No focus is made to thin structure having non-uniform circular cross-sections. This study aims to deal with analyzing the “dynamic behavior of thin circular non-uniform truncated conical section” which is mostly used for manufacturing of fishing rod. This works primarily compares the static, modal, and harmonic analysis under the application of loads of 50 N acting on fishing rod made up of conventional steel, composite (carbon fiber) steel, and functionally graded material (FGM) with the help of ANSYS®. Firstly, static analysis performed to analyze the structural behavior under the application of static loadings. After that modal analysis performed and first five modes selected for Steel; from 0 to 600 Hz, for Carbon Fiber; from 0 to 850 Hz and for FGM; from 0 to 900 Hz for harmonic analysis. Maximum defection at resonance for steel is 7.94 mm, for composite is 74.4 mm, and for FGM is just 0.032 mm. The comparison of these results clearly depicts that FGM is having excellent vibration suppression performance as compared to other two materials under consideration. This confirms that thin structure (non-uniform circular profile) made of FGM can be used efficiently for the intended applications in future.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47662330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodegradation behaviors of magnesium(Mg)-based alloy nails in autologous bone grafts: In vivo study in rabbit skulls 镁基合金钉在兔颅骨内的生物降解行为研究
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221095230
Yuta Yanagisawa, Y. Shimizu, T. Mukai, Yuya Sano, Kenji Odashima, N. Ikeo, H. Saito, K. Yamauchi, Tetsu Takahashi, H. Kumamoto
{"title":"Biodegradation behaviors of magnesium(Mg)-based alloy nails in autologous bone grafts: In vivo study in rabbit skulls","authors":"Yuta Yanagisawa, Y. Shimizu, T. Mukai, Yuya Sano, Kenji Odashima, N. Ikeo, H. Saito, K. Yamauchi, Tetsu Takahashi, H. Kumamoto","doi":"10.1177/22808000221095230","DOIUrl":"https://doi.org/10.1177/22808000221095230","url":null,"abstract":"Objective: In this study, autologous bone grafts using bone-fixing nails made of magnesium-zinc-calcium ternary alloys were performed using rabbit skulls. Material and methods: Two types of nails for bone fixation were prepared: 2.5 mm width, 3 mm length and 2.5 mm width, 2 mm length. A disk-shaped bone with a diameter of 5 mm was resected from the parietal bone and fixed with a 3 mm long nail. As a control group, a 2 mm long nail was driven into the existing bone. The rabbits were sacrificed at 1, 4, 12, and 24 weeks after surgery. The resected samples were observed with micro X-ray CT, and embedded in methyl methacrylate to prepare non-decalcified specimens. The in vivo localization of elements was examined using energy-dispersive X-ray spectroscopy (EDS). Results: Micro X-ray CT images of samples showed volume reduction due to degradation in both the bone graft and control groups. No significant difference in the amount of degradation between the two groups was observed, however characteristic degradation processes were observed in each group. The samples stained with alizarin red S showed amorphous areas around the nails, which were considered as corrosion products and contacted directly with the newly formed bones. EDS analysis showed that corrosion products were mainly composed of magnesium and oxygen at an early stage, while calcium and phosphorus were detected on the surface layer during the long-term observation. Conclusions: The degradation speed of the magnesium alloy nails varied depending on the shapes of the nails and surrounding tissue conditions. A calcium phosphate layer was formed on the surface of magnesium alloy nails, suggesting that the degradation rate of the nail was slow.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48434820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and properties of N-glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings 伤口敷料用n -糖基化壳聚糖/聚乙烯醇水凝胶的制备及性能研究
Journal of Applied Biomaterials & Biomechanics Pub Date : 2022-01-01 DOI: 10.1177/22808000221101809
Y. Yi, Ting Huang, Yunxia Xu, Jianfeng Mei, Yanlu Zhang, Xudong Wang, Jianshu Chen, Guoqing Ying
{"title":"Preparation and properties of N-glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings","authors":"Y. Yi, Ting Huang, Yunxia Xu, Jianfeng Mei, Yanlu Zhang, Xudong Wang, Jianshu Chen, Guoqing Ying","doi":"10.1177/22808000221101809","DOIUrl":"https://doi.org/10.1177/22808000221101809","url":null,"abstract":"Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48776769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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