Iranian Journal of Public Health最新文献_第2页

Trend Analysis of Suicide Mortality and Years of Life Lost from 2016 to 2021 in Southern Iran 2016 年至 2021 年伊朗南部自杀死亡率和生命损失年数趋势分析

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15594

Iman ShakibkhahShakibkhah, H. Azarbakhsh, M. Peyravi, M. Marzaleh, Mitra Rafiei Boldaji

{"title":"Trend Analysis of Suicide Mortality and Years of Life Lost from 2016 to 2021 in Southern Iran","authors":"Iman ShakibkhahShakibkhah, H. Azarbakhsh, M. Peyravi, M. Marzaleh, Mitra Rafiei Boldaji","doi":"10.18502/ijph.v53i5.15594","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15594","url":null,"abstract":"Background: Suicide as the commonest psychiatric emergency imposes a heavy burden on communities. We aimed to evaluate the years of life lost (YLLs) due to premature death from suicide in Kohgiluyeh and Boyer-Ahmad Province, Iran. \u0000Methods: Data regarding suicidal deaths were extracted from the Forensic Medicine Organization. The YLL of each year were calculated among gender and age groups. The YLL calculation was performed using the 2015 WHO excel calendars template. The Join Point Regression method was used to examine the trend of the crude mortality rate, the standardized mortality rate, and the YLL rate. \u0000Results: Overall, 572 people died by suicide between 2016 and 2021 (63.5% in males and 36. 5% in females). The main method of death in most cases was hanging (52.8%). The total YLL due to premature death in the 6 year– period was 9248 (4.2 per 1000 persons) in males, 5602 (2.6 per 1000 persons) in females. Hanging (7909) compromised the largest YLL category between different methods of suicide. According to the joinpoint regression analysis, the 6-year trend of YLL rate due to premature mortality was increasing in males: the annual percent change (APC) was 4.8% (95% CI 1.0 to 8.7, P=0.024) and stable trend for females. \u0000Conclusion: The YLL was higher in men than in women. Effective training interventions should be designed and implemented to reduce the incidence of suicide.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Problems and Solutions to Facilitate the Payment and Receipt of Health Taxes 研究方便缴纳和收取卫生税的问题和解决方案

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15596

Mahdi Kooshkebaghi, Hossein Dargahi, Sara Emamgholipour

{"title":"Examining the Problems and Solutions to Facilitate the Payment and Receipt of Health Taxes","authors":"Mahdi Kooshkebaghi, Hossein Dargahi, Sara Emamgholipour","doi":"10.18502/ijph.v53i5.15596","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15596","url":null,"abstract":"Background: In addition to creating significant health gains, taxation can be used to increase public health funding. However, achieving the goals of health-related taxes faces many barriers and problems. We aimed to examine the barriers and solutions to facilitate the payment and receipt of health taxes. \u0000Methods: The present descriptive and analytical study was conducted in 2021-2022. The first part of the research was the questionnaire's design and validation, and the second part was using the designed questionnaire to collect and analyze data. The validity of the questionnaire was measured using the content validity, and the reliability of the questionnaire was measured using Cronbach's alpha. Then, the questionnaires were distributed in person at the workplace of 430 professors, managers, and experts in economics and health, and the collected data were reviewed and analyzed. \u0000Results: Barriers and problems related to structure and infrastructure, evasion, avoidance, and tax exemption, and coordination and cooperation are the most important problems related to health taxes. Moreover, evasion, avoidance and tax exemption, cultural and social issues, and coordination and cooperation are the most important solutions to overcome the problems of health taxes. \u0000Conclusion: To dispel the barriers and facilitate the payment and receipt of health-related taxes and achieve the goals of the health sectors, it is very important to deal with tax evasion, build a culture, and close cooperation with related organizations.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"57 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141232418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using of Hot Red Bean Bag on the Symptoms of Depression, Sleep, and Fatigue in Stroke Patients 使用热红豆袋对中风患者的抑郁、睡眠和疲劳症状的影响

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15589

Ye Seul Choi, M. Gu, S. Sok

{"title":"Using of Hot Red Bean Bag on the Symptoms of Depression, Sleep, and Fatigue in Stroke Patients","authors":"Ye Seul Choi, M. Gu, S. Sok","doi":"10.18502/ijph.v53i5.15589","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15589","url":null,"abstract":"Background: Symptoms of depression, sleep, and fatigue in stroke patients are associated with each other, and intervention development for improving of these symptoms is needed. This study aimed to examine the effects of hot red bean bag on depression, sleep state, sleep satisfaction, and fatigue among Korean stroke patients. \u0000Methods: A quasi-experimental pretest-posttest control group design was employed. The study participants included 57 stroke patients (Intervention: n=28, Control: n=29) in a hospital in Seoul, South Korea from Aug 2017 to Mar 2018. Hot red bean bag, as an intervention, was heated in a 2,450 MHz microwave oven for 3 min, and applied for 30 min at 41±6 ℃ in the lower limbs of the intervention group for 5 days. \u0000Results: There were statistically significant differences on depression (P<0.001), sleep state (P<0.001), sleep satisfaction (P<0.001), and total fatigue (P<0.001) between the two groups. \u0000Conclusion: Hot red bean bag was an effective intervention for decreasing depression and total/subcategories fatigue, and for improving sleep state and sleep satisfaction of Korean stroke patients. Research on complementary and alternative therapies for stroke patients needs be studied continuously.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"84 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Intervention Strategies-Based on Positive Psychology on the Emotional Cognition, Mental Health, and Recovery of Speech Function in Speech Disabilities 基于积极心理学的干预策略对言语残疾者的情感认知、心理健康和言语功能恢复的影响

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15588

Zhixiang Luo, Ningfang Wang

{"title":"Effects of Intervention Strategies-Based on Positive Psychology on the Emotional Cognition, Mental Health, and Recovery of Speech Function in Speech Disabilities","authors":"Zhixiang Luo, Ningfang Wang","doi":"10.18502/ijph.v53i5.15588","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15588","url":null,"abstract":"Background: Compared with able-bodied people, speech disabilities are more prone to various mental health problems. We aimed to explore the impact of positive psychology-based intervention strategies on emotional cognition, mental health, and recovery of speech function in speech disabilities. \u0000Methods: In May 2023, 306 cases of speech disabilities were selected from 112 village committees and 129 neighborhood committees in Jingmen City, China. The control group was given routine speech rehabilitation training, and the observation group was given an intervention strategies-based on positive psychology based on the above training. The Symptom Checklist-90 (SCL-90), Chinese Facial Emotion Test (CFET), Comprehensive Function Assessment for Disabled Children (CFADC), and Boston Diagnostic Aphasia Examination (BDAE) were used to evaluate the two groups of patients before and after intervention. \u0000Results: After the intervention, the mental state scores (psychotic, obsessive-compulsive symptoms, somatization, paranoia, terror, hostility, anxiety, and depression) of the observation group were lower than those of the control group (P<0.05). The correct emotional scores in the observation group were higher than those in the control group were. However, the remote error scores of the observation group were lower than those of the control group were. The difference was also statistically significant (P<0.05). The cognitive function score, speech function score, and BDAE score (retelling, writing, fluency, and reading comprehension) of the observation group were all higher than those of the control group (P<0.05). \u0000Conclusion: The intervention strategies-based on positive psychology could promote the improvement of health problems and speech function in speech disabilities.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"37 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short Chain Fatty Acid Sodium Butyrate Increases miR-21, miR-143 and miR-145 Expression in Human Colorectal Cancer HCT-116 Cell Line 短链脂肪酸丁酸钠能增加人结直肠癌 HCT-116 细胞系中 miR-21、miR-143 和 miR-145 的表达

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15598

Parastoo Mohammadi, Flora Forouzesh, Fatemeh Kouhkan

{"title":"Short Chain Fatty Acid Sodium Butyrate Increases miR-21, miR-143 and miR-145 Expression in Human Colorectal Cancer HCT-116 Cell Line","authors":"Parastoo Mohammadi, Flora Forouzesh, Fatemeh Kouhkan","doi":"10.18502/ijph.v53i5.15598","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15598","url":null,"abstract":"Background: Sodium butyrate (NaBu) is a short-chain fatty acid; it is one of the histone deacetylase inhibitors, which can alter both genetic and epigenetic expressions. The present study aimed to elucidate the effect of NaBu on the expression of miR-21, miR-143, and miR-145 in human colorectal cancer HCT-116 cell lines. \u0000Methods: This study was done in Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. HCT-116 cell line was treated with diverse concentrations of NaBu (6.25 mM to 200 mM) at 24, 48, and 72 h. MTT assay was used for assessing the cytotoxicity. Quantitative Real-Time-PCR was performed to investigate the gene expression of miR-21, miR-143, and miR-145. \u0000Results: IC50 values were evaluated by MTT assay. IC50 for HCT-116 was 50 mM, 12.5 mM, and 6.25 mM for 24, 48, and 72 h of incubation, respectively. According to the Real-Time-PCR results, 50 mM NaBu after 24 h caused a significant up-regulation in the expression of the miR-21, miR-143, and miR-145 (P<0.05). In 48 h, incubation, 12.5 mM NaBu caused a significant up-regulation in the expression of the miR-21, miR-143, and miR-145 (P<0.05). In treated cells with 6.25 mM NaBu after 72 h of incubation caused a significant up-regulation in the expression of the miR-21, miR-143, and miR-145 compared with untreated cells (P<0.05). \u0000Conclusion: The upregulation of miR-21, miR-143, and miR-145 expression are mediated by transcriptional regulation and the activation of this miR promoter is modulated by histone acetylation. The employment of NaBu may represent a promising approach for improving HDACi drug-based therapies for colon cancers.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Microbial Contamination and Metabolite Expo-sure in Cosmetic Products Used in Women's Beauty Salons 评估妇女美容院使用的化妆品中的微生物污染和代谢物含量

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15599

Maryam Ghias, Leila Fozouni

{"title":"Assessment of Microbial Contamination and Metabolite Expo-sure in Cosmetic Products Used in Women's Beauty Salons","authors":"Maryam Ghias, Leila Fozouni","doi":"10.18502/ijph.v53i5.15599","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15599","url":null,"abstract":"Background: An important route of microbial transmission is the shared use of these products in beauty salons. We aimed to investigate level of contamination with microorganisms and their metabolites in shared-use cosmetics in several women's beauty salons. \u0000Methods: Bacterial and fungal strains from 320 opened/used cosmetic samples were identified according to the Iranian standards for microbial quality of cosmetic products in Golestan Province (North of Iran) during Jul-Sep 2021. In order to assess production of toxins and protease by the predominant bacterial and fungal isolates, multiplex-polymerase chain reaction and the Lowry protein assay were performed, respectively. \u0000Results: Microbial contamination was detected in 180 samples (56.5%), and the highest and lowest rates of microbial contamination were related to skin products (63.88%) and eye beauty products (20%), respectively. The highest level of S. aureus contamination (> 4,000 colony-forming units/g) was found in toner and face wash samples, and the highest level of C. albicans contamination was seen in lipstick samples (>20,000 colony-forming units/g). Only one (2%) S. aureus isolate produced staphylococcal enterotoxin B, while 3 out of 12 (25%) C. albicans isolates were able to produce protease. \u0000Conclusion: The shared-used health and beauty products, face products, in the study area are heavily contaminated. Therefore, it is essential to store used cosmetics in dry and cool places, establish strict inspection regulations for cosmetic products before and after entering the market, and increase awareness of beauty salon workers regarding the appropriate use, sanitary control, and maintenance of health and beauty products.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"133 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glia Maturation Factor Beta: A Novel Neuro-Impairment Prediction Factor in Toxoplasmosis 胶质细胞成熟因子β：弓形虫病中的一种新型神经损伤预测因子

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15602

Mohammad Matini, Razieh Amini, F. Foroughi-Parvar

{"title":"Glia Maturation Factor Beta: A Novel Neuro-Impairment Prediction Factor in Toxoplasmosis","authors":"Mohammad Matini, Razieh Amini, F. Foroughi-Parvar","doi":"10.18502/ijph.v53i5.15602","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15602","url":null,"abstract":"Background: Toxoplasma gondii, a neurotropic protozoan, infects up one to third of the world population. The parasite can invade a wide variety of nucleated cells but preferably glial cells. Glia maturation factor β (GMFβ), a 17KD protein expressed at high levels in the central nervous system is predominantly related to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Multiple sclerosis. We aimed to determine the expression level of GMFβ and its relation to other pro-inflammatory factors (IL33, SDF1, and CCL2) on T. gondii infected human neuroblastoma cell line. \u0000Methods: The human neuroblastoma (SK_NMC C535) cell line was infected by 5Í106 (1:1 ratio). The supernatant was collected after cell lysis and centrifugation. Total RNA was extracted using the Yekta Tajhiz RNA extraction kit. cDNA was synthesized based on RevertAid First Strand cDNA Synthesis Kit manufacturer`s protocol (Parstous, cDNA synthesis kit, Iran). The specificity of each primer pair (GMFβ, IL33, SDF1, and CCL2) was provided by NCBI BLAST. Gene expression level was measured using Real-Time PCR. All experiments were conducted at the Hamadan University of Medical Sciences, western Iran in 2022. \u0000Results: The GMFβ increased significantly up to 1.35-fold (P=0.007). The increase in GMFβ expression in neuroblastoma cells was consistent with the increase in pro-inflammatory factors (CCL2 (0.47), IL33 (0.152) and, SDF1 (1.33)). \u0000Conclusion: GMFβ upregulation can be a novel indicator of the destruction of nerve cells.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"54 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Formula Based on Simple Blood Indices to Differentiate Beta Thalassemia Trait from Iron Deficiency Anemia 基于简单血液指标的新公式，用于区分地中海贫血特质和缺铁性贫血

Iranian Journal of Public Health Pub Date : 2024-06-01 DOI: 10.18502/ijph.v53i5.15601

Parviz Shahmirzalou, Morteza Seyyed Hamze, H. Sadagheyani

{"title":"A New Formula Based on Simple Blood Indices to Differentiate Beta Thalassemia Trait from Iron Deficiency Anemia","authors":"Parviz Shahmirzalou, Morteza Seyyed Hamze, H. Sadagheyani","doi":"10.18502/ijph.v53i5.15601","DOIUrl":"https://doi.org/10.18502/ijph.v53i5.15601","url":null,"abstract":"Background: Thalassemia is an inherited blood disorder with a defect in the sufficient production of a protein called hemoglobin. We aimed to investigate the simple blood indices of patients with Beta Thalassemia Trait (BTT) and Iron Deficiency Anemia (IDA) to propose a new formula using logistic regression for differentiate two characteristics from each other. \u0000Methods: Among the 702 records of the BTT Counseling Center (Khoy, Iran-2022), 292 cases (219 iron deficiency anemia (IDA) and 73 BTT) were eligible for the study. Blood indices such as RBC, HGB, HbA2 described and used to diagnose two types of participants. Blood indices had high multicollinearity that was modified. Logistic regression for blood indices fitted and goodness of fit indices with Area Under ROC curve (AUC) estimated. \u0000Results: The average age of the participants was 24.56 yr. The status of Multicollinearity between independent variables was modified. The HGB, MCV, HbA2, and HbA variables were used in the model and only HbA2 status was significant (P<0.001). According to the output of the model, for each unit increase in HbA2, the chance of having BTT was about 8.5 times higher than IDA. The sensitivity, specificity, AUC curve, and accuracy of the final model were estimated to be 97, 72, 84, and 93%, respectively. A regression formula to differentiate BTT from IDA proposed. \u0000Conclusion: In studies related to the differentiation of the BTT from IDA, the presence of the HbA2 index in the model and prediction is very necessary. \u0000 ","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"46 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Detection of Toxoplasma gondii Oocytes in Soil Samples from Guilan Province, Northern Iran 伊朗北部吉兰省土壤样本中弓形虫卵母细胞的分子检测

Iranian Journal of Public Health Pub Date : 2024-03-13 DOI: 10.18502/ijph.v53i3.15147

Hossien Hassani Lafmejan Pour, M. Tavalla, Hossien Keshavarz Valian, Mehdi Mohebali, Saeedeh Hashemi Hafshejani, Ali Latifi, M. Salimi, Aref Teimouri, S. Shojaee

{"title":"Molecular Detection of Toxoplasma gondii Oocytes in Soil Samples from Guilan Province, Northern Iran","authors":"Hossien Hassani Lafmejan Pour, M. Tavalla, Hossien Keshavarz Valian, Mehdi Mohebali, Saeedeh Hashemi Hafshejani, Ali Latifi, M. Salimi, Aref Teimouri, S. Shojaee","doi":"10.18502/ijph.v53i3.15147","DOIUrl":"https://doi.org/10.18502/ijph.v53i3.15147","url":null,"abstract":"Background: Soil is an appropriate substrate for the storage and transmission of oocytes of Toxoplasma gondii. Ingestion of soil contaminated with T. gondii oocysts is a major transmission route of human and animal toxoplasmosis. The present study was carried out to investigate soil contamination with T. gondii oocysts in urban and rural areas of Guilan Province, northern Iran. \u0000Methods: Overall, 208 soil samples were collected from 16 cities and villages in Guilan Province, northern Iran from Oct 2020 to Nov 2021. Soil samples were investigated using modified sucrose flotation technique. Real-time polymerase chain reaction was used to detect presence of T. gondii DNAs in the samples. Positive samples were further analyzed using nested polymerase chain reaction for GRA6 gene. Moreover, six selected positive samples were used for amplifying and sequencing of the GRA6 gene. \u0000Results: Overall, 31 samples were positive for T. gondii with frequency of 14.9% and ranging from 10.9% in rural areas to 16.3% in urban areas. Statistical analysis showed significant differences between the seasons (P=0.003). The phylogenetic analysis illustrated that our six sequences were similar and closely related to Type I strain of T. gondii. \u0000Conclusion: Results showed relatively high levels (14.9%) of T. gondii oocytes in soil samples of Guilan Province, northern Iran, which provided essential data for the effective prevention and control of toxoplasmosis in the region.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140393242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Immunohistochemical Expression of Survivin and its Correlation with qRT-PCR Results as a Useful Diagnostic Marker in Gastric Cancer 评估 Survivin 的免疫组化表达及其与 qRT-PCR 结果的相关性，以此作为胃癌的有效诊断标记物

Iranian Journal of Public Health Pub Date : 2024-02-19 DOI: 10.18502/ijph.v53i2.14931

Khadijeh Fanaei, Fereshteh Ameli, Iman Salahshourifar, Shiva Irani, Mohsen Esfandbod

{"title":"Evaluation of Immunohistochemical Expression of Survivin and its Correlation with qRT-PCR Results as a Useful Diagnostic Marker in Gastric Cancer","authors":"Khadijeh Fanaei, Fereshteh Ameli, Iman Salahshourifar, Shiva Irani, Mohsen Esfandbod","doi":"10.18502/ijph.v53i2.14931","DOIUrl":"https://doi.org/10.18502/ijph.v53i2.14931","url":null,"abstract":"Background: Today, survivin is known as one of the most specific cancer proteins; provide unique and practical study opportunities. Clinical value of survivin in gastric cancer (GC) is not yet appointed. To establish the expression level of survivin and its diagnosis value in Iranian patients with GC, we evaluated the association of survivin expression with clinicopathologic factors. \u0000Methods: Overall, 60 matched-normal controls with 60 GC samples including 30 cases with evidence of metastasis at time of our study and 30 cases without evidence of metastasis were recruited, in Tehran, Iran during 2008 to 2018. Survivin expression was evaluated by quantitative Real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) study. \u0000Results: Increased expression of survivin at mRNA and protein levels was found in 86.7% and 71.6% of cases, respectively. Evidence indicated a significant difference in survivin mRNA expression level between tumor and non-tumoral (marginal) tissues (P<0.001). The difference in expression of survivin mRNA was not significant between metastatic and non-metastatic tumor tissues (P=0.171). Positive immunoreactivity of survivin was observed to be predominantly in the nucleus of tumor cells. A significant difference in survivin protein expression was detected between tumor and non-tumoral tissues (P<0.001) and between metastatic and non-metastatic tumor tissues (P<0.001). There was no significant association between survivin mRNA expression and clinicopathological variables. However, survivin protein expression was significantly correlated with perineural involvement (P<0.018). \u0000Conclusion: This data could be supportive of using survivin as a useful diagnostic marker in GC. Although, more research is needed in this area.","PeriodicalId":510223,"journal":{"name":"Iranian Journal of Public Health","volume":"83 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0