Current Problems in Cardiology最新文献

{"title":"Editor’s Message","authors":"","doi":"10.1016/S0146-2806(25)00115-X","DOIUrl":"10.1016/S0146-2806(25)00115-X","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 7","pages":"Article 103093"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “The effect of individualized nutrition training of children with congenital heart disease (CHD) on their growth and development a randomized controlled trial” [Current Problems in Cardiology 49(2024 102567]","authors":"Emel Yuruk Phd, Senay Cetinkaya Phd","doi":"10.1016/j.cpcardiol.2025.103078","DOIUrl":"10.1016/j.cpcardiol.2025.103078","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103078"},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symphony of crossfire: Aneurysm, dual vessel occlusion, and lymphoma’s hypercoagulable crescendo a case report","authors":"Said Al-Najjar ,&nbsp;Noor Abu Hantash ,&nbsp;Dana Bader","doi":"10.1016/j.cpcardiol.2025.103079","DOIUrl":"10.1016/j.cpcardiol.2025.103079","url":null,"abstract":"<div><div>Occult asymptomatic myocardial infarction in patients with malignancy (lymphoma), advanced age, and multiple comorbidities may present atypically, complicating the diagnosis of presumed recurrent infarction. We present a highly complex case of a 66-year-old male with lymphoma and multiple comorbidities who collapsed with diffuse ST-segment elevation on electrocardiography (ECG). The diagnostic challenge required concurrent percutaneous coronary intervention (PCI) and echocardiography to identify the thrombotic occlusions in two coronary vessels. Empirical placement of stents in the right coronary artery and left circumflex artery resolved the acute occlusions, while retrograde imaging revealed a previously undiagnosed anteroapical left ventricular aneurysm. This case underscores the importance of integrating multimodal imaging in oncological patients with atypical cardiovascular presentations.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103079"},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmic mitral valve prolapse: In which patients should primary prevention of sudden cardiac death be considered and how should it be implemented?","authors":"Juan M. Iroulart,&nbsp;Rocío Blanco,&nbsp;Ana L. Miceli,&nbsp;Rodrigo P. Bagnati,&nbsp;Maria C. Bartolomé Roca,&nbsp;Mariano G. Bergier,&nbsp;Juan G. Krauss,&nbsp;Florencia Parcerisa,&nbsp;Pablo F. Oberti,&nbsp;Mariano L. Falconi,&nbsp;Rodolfo Pizarro","doi":"10.1016/j.cpcardiol.2025.103083","DOIUrl":"10.1016/j.cpcardiol.2025.103083","url":null,"abstract":"<div><div>Mitral valve prolapse (MVP) affects 2–3 % of the population and is generally benign. However, a subgroup presents severe complications such as ventricular arrhythmias and sudden cardiac death (SCD). Arrhythmogenic mitral valve prolapse (AMVP) combines MVP with frequent or complex ventricular arrhythmias in the absence of other causes. Although SCD in AMVP patients is rare (0.2–0.4 %, annual), it exceeds the general population rate and is associated with specific high arrhythmic risk features, such as mitral annular disjunction (MAD), bileaflet prolapse, Pickelhaube sign, abnormal T waves on the electrocardiogram, and rapid non-sustained ventricular tachycardia. Primary prevention is crucial but challenged by the lack of standardized guidelines. AMVP requires a multidisciplinary and cost-effective evaluation to stratify risk and prevent SCD in a predominantly young and healthy population.</div><div>The objective of this review is to describe the variables with the highest arrhythmogenic risk in patients with MVP and the possible primary prevention strategies for sudden cardiac death.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103083"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness after atrial shunt device in patients with heart failure:A systematic review and Meta-Analysis","authors":"Lihua Gao,&nbsp;Zhenze Yu,&nbsp;Pengfei Wang,&nbsp;Zihan Zhao","doi":"10.1016/j.cpcardiol.2025.103080","DOIUrl":"10.1016/j.cpcardiol.2025.103080","url":null,"abstract":"<div><h3>Background</h3><div>Limited data are available regarding the atrial shunt device (ASD), making it challenging to provide definitive recommendations for patients with heart failure (HF). We conducted a meta-regression analysis to identify individuals who may derive greater benefit from this device.</div></div><div><h3>Methods</h3><div>We conducted a search across PubMed, EMBASE, and Cochrane databases, including 8 studies for meta-analysis. Estimated endpoints were derived using random-effects proportional meta-analysis. Additionally, meta-regression analysis was performed to elucidate the potential impact of key covariates on these endpoints.</div></div><div><h3>Results</h3><div>A total of 522 patients were included. The pooled analysis revealed an estimated mortality rate of 1.9 % for patients who underwent ASD. Additionally, the proportion of patients who remained in NYHA III to IV was reduced to 22.5 %. Furthermore, there was an improvement of 35.1 meters in the 6-minute walk distance (6MWD) and a 16.2-point improvement in the KCCQ score. Meta-regression analysis indicated that NYHA III to IV status was found to be directly proportional to age (β= 2.799), hypertension (β= 0.782), diabetes (β= 0.951), and atrial fibrillation (β= 0.778). Hypertension and a high level of left ventricular ejection fraction (LVEF) were associated with less improvement in 6MWD and KCCQ score, whereas a higher NT-proBNP level was associated with better improvement in 6MWD and KCCQ score.</div></div><div><h3>Conclusions</h3><div>ASD emerges as a safe choice for HF patients aiming to alleviate symptoms. Specifically, individuals with reduced EF or elevated NT-proBNP levels, and without concomitant hypertension, diabetes, or atrial fibrillation, appear to achieve more substantial symptom relief.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103080"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of electrocardiographic patterns of ventricular hypertrophy in cardiac amyloidosis and other cardiomyopathies","authors":"Juan Pablo Costabel,&nbsp;Ramiro Espinosa,&nbsp;Ana Spaccavento,&nbsp;Franco Nicolas Ballari,&nbsp;Marcia Cortés,&nbsp;Diego Gabriel Conde,&nbsp;Pablo Fernando Elissamburu","doi":"10.1016/j.cpcardiol.2025.103074","DOIUrl":"10.1016/j.cpcardiol.2025.103074","url":null,"abstract":"<div><h3>Introduction</h3><div>The early identification of conditions that lead to increased myocardial wall thickness, such as transthyretin amyloid cardiomyopathy (ATTR-CM), severe aortic stenosis (AS), hypertrophic cardiomyopathy (HCM), and hypertensive heart disease (HHD), is challenging due to overlapping features. Delayed diagnosis can postpone appropriate treatment and worsen prognosis. This study aimed to evaluate the frequency of key electrocardiographic patterns in these conditions, with a specific emphasis on differentiating ATTR-CM from other causes of wall thickening.</div></div><div><h3>Methods</h3><div>Electrocardiograms (ECGs) from the medical records of 400 patients over 60 years old were analyzed, divided into four groups (ATTR-CM, HCM, HHD, and AS) with confirmed diagnoses and septal thickening (≥12 mm). Specific electrocardiographic patterns, including left ventricular hypertrophy, left atrial enlargement, low voltage, pseudoinfarction, and left ventricular pressure overload, were assessed. Multiple chi-square tests with Bonferroni adjustment were used to detect significant differences between groups.</div></div><div><h3>Results</h3><div>The Sokolow-Lyon criteria was absent in all ATTR-CM cases, compared to 13 % in other conditions (p = 0.001). Additionally, ATTR-CM showed a higher prevalence of low voltage (45 % vs. 18.3 %, p = 0.001) and pseudoinfarction pattern (32 % vs. 22 %, p = 0.007), but a lower prevalence of left atrial enlargement (8 % vs. 30 %, p = 0.005). Absence of the Sokolow criteria was the best predictor of ATTR-CM (sensitivity 100 %, NPV 100 %, PPV 27 %), followed by the presence of low voltage and pseudoinfarction.</div></div><div><h3>Conclusions</h3><div>Significant differences were observed in the prevalence of electrocardiographic patterns between ATTR-CM and other wall thickening phenotypes. These findings may aid in the early detection and diagnosis of ATTR-CM, allowing for more timely intervention.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 7","pages":"Article 103074"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine applications in dilated cardiomyopathy: Advancing personalized care","authors":"Elina Khattab ,&nbsp;Michael M Myrianthefs ,&nbsp;Stefanos Sakellaropoulos ,&nbsp;Kyriakos Alexandrou ,&nbsp;Andreas Mitsis MD, MSc, PhD(c)","doi":"10.1016/j.cpcardiol.2025.103076","DOIUrl":"10.1016/j.cpcardiol.2025.103076","url":null,"abstract":"<div><div>Dilated cardiomyopathy (DCM) is a prevalent cardiac disorder affecting 1 in 250–500 individuals, characterized by ventricular dilation and impaired systolic function, leading to heart failure and increased mortality, including sudden cardiac death. DCM arises from genetic and environmental factors, such as drug-induced, inflammatory, and viral causes, resulting in diverse yet overlapping phenotypes. Advances in precision medicine are revolutionizing DCM management by leveraging genetic and molecular profiling for tailored diagnostic and therapeutic approaches. This review highlights comprehensive diagnostic evaluations, genetic discoveries, and multi-omics approaches integrating genomic, transcriptomic, proteomic, and metabolomic data to enhance understanding of DCM pathophysiology. Innovative risk stratification methods, including machine learning, are improving predictions of disease progression. Despite these advancements, the current one-size-fits-all management strategy contributes to persistently high morbidity and mortality. Emerging targeted therapies, such as CRISPR/Cas9 genome editing, aetiology-specific interventions, and pharmacogenomics, are reshaping treatment paradigms. Precision medicine holds promise for optimizing DCM diagnosis, treatment, and outcomes, aiming to reduce the burden of this debilitating condition.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 7","pages":"Article 103076"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of positive stress echocardiography and its relationship with invasive coronary angiography: Rationale and design of the multicenter stress echo trial – AMPHIPOLIS","authors":"Nikolaos PE Kadoglou ,&nbsp;Constantinos H. Papadopoulos ,&nbsp;Vasilios Sahpekidis ,&nbsp;Konstantinos G. Papadopoulos ,&nbsp;Nearchos Kassinos ,&nbsp;Anastasios Theodosis-Georgilas","doi":"10.1016/j.cpcardiol.2025.103075","DOIUrl":"10.1016/j.cpcardiol.2025.103075","url":null,"abstract":"<div><div>Introduction/aim: Stress echocardiography (SE) is a first-line, non-invasive and well-validated technique for the diagnosis and decision making of coronary artery disease (CAD). The introduction of echocardiographic contrast agents, the growing usage of exercise on supine bike as a stressor and the recent technological advances have considerably improved the sensitivity of SE. Despite those advantages, SE remains an operator-dependent technique, and its association with CAD prognosis is based on limited evidence from old studies. Our aim is a) to assess the positive prognostic value of SE in patients with established or suspected CAD and b) to evaluate the relationship between SE findings and invasive coronary angiography (ICA) findings.</div><div>Methods: We describe the rationale and design of Amphipolis trial, a prospective, multicentre, self-controlled, open-label trial from 22 labs in Greece and Cyprus. We plan to enrol 390 consecutive adults with a positive SE based on echocardiographic findings, fulfilling specific selection criteria. All participants will undergo ICA within 6 weeks from positive SE. Then, we will be followed up them for at least 12 months for major adverse cardiovascular events (MACE) such as cardiovascular death, acute coronary syndrome (ACS), revascularization interventions (re-stenosis or new cases of myocardial ischemia), or the development of symptoms (angina relapse or new onset).</div><div>Conclusions: Amphipolis trial will test the prognostic role of SE, and its implementation in clinical practice along with anatomical findings from ICA.</div></div>","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103075"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcomes of acute myocardial infarction with arrhythmic onset: A retrospective cohort study","authors":"Marisa Varrenti ,&nbsp;Giorgio Solfanelli ,&nbsp;Davide Bernasconi ,&nbsp;Matteo Regazzetti ,&nbsp;Michele Galasso ,&nbsp;Alberto Preda ,&nbsp;Marco Carbonaro ,&nbsp;Matteo Baroni ,&nbsp;Lorenzo Gigli ,&nbsp;Fabrizio Guarracini ,&nbsp;Sara Vargiu ,&nbsp;Giulia Colombo ,&nbsp;Giovanni Tavecchia ,&nbsp;Giovanna Viola ,&nbsp;Luca Villanova ,&nbsp;Jacopo Oreglia ,&nbsp;Cristina Giannattasio ,&nbsp;Fabrizio Oliva ,&nbsp;Patrizio Mazzone ,&nbsp;Alice Sacco","doi":"10.1016/j.cpcardiol.2025.103077","DOIUrl":"10.1016/j.cpcardiol.2025.103077","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with acute coronary syndrome (ACS) have concomitant ventricular arrhythmic events (VA). Literature data are conflicting regarding short- and long-term prognosis. International guidelines do not recommend defibrillator (ICD) implantation in the first 40 days after a myocardial infarction. However, some patients may have an increased arrhythmic risk and deserve closer monitoring.</div></div><div><h3>Purpose</h3><div>The aim of our study was to define the incidence of arrhythmic events in a population of patients admitted for ACS to the Cardiac Intensive Care Unit (CICU) of a tertiary center and to determine the short- and long-term prognosis in patients with arrhythmic onset compared with patients without arrhythmic onset.</div></div><div><h3>Methods</h3><div>This is a single-center retrospective cohort data analysis of 1587 consecutive patients admitted with a diagnosis of ACS to the CICU of Niguarda Hospital of Milan, from 2014 to 2022. We classified the patients into two groups according to the arrhythmias at presentation: VA (sustained VT or VF) and no-VA. Kaplan–Meier (KM) estimated the probability of remaining event free in the time after ACS and were compared between VA and no-VA groups, using the log-rank test. Cox regression analysis was used to explore the association of specific variables with the occurrence of cardiac events in univariate and multivariate analysis. Statistical analyses were performed with R 42.0 statistical package (R Core Team, Vienna, Austria).</div></div><div><h3>Results</h3><div>Among 1587 ASC patients, 4.6 % had arrhythmic onset (4.0 had a diagnosis of VF and 0.6 % of VT). Patients with VA were significantly younger (63 y. vs 67 y., p = 0.026) and had a lower incidence of cardiovascular risk factors, such as hypertension and dyslipidemia, compared with no-VA group. VA group had a higher risk of arrhythmias during the hospitalization (9.6 % vs 1.3 %, p &lt; 0.001) and had a clinical course characterized by a significantly higher use of mechanical support with intra-aortic balloon pumps (IABP, 35.6 % vs. 6.8 %, p &lt; 0.001) and a greater use of inotropic drugs (34 % vs. 9 %, p &lt; 0.001). We observed in VA group a six-fold increase in-hospital mortality (23 % vs 4 %, p &lt; 0.001), identifying arrhythmic presentation as a marker of worse in-hospital prognosis in patients admitted with ACS. Likewise, mortality at 40 days after the acute event was higher in the VA group than in the no-VA group (22 % vs. 5 %, p &lt; 0.001). Conversely, during a median follow-up of 5.9 years, VA onset did not affect long-term mortality in patients discharged alive.</div></div><div><h3>Conclusion</h3><div>In this long-term follow-up retrospective registry involving a large cohort of patients with ACS admitted to the CICU, concomitant VA at admission was found to be linked with an increase in in-hospital arrhythmic complications and in-hospital mortality. The mortality rate at 40 days post-ACS was ","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 8","pages":"Article 103077"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The blind spot in cardiotoxicity: Reassessing right ventricular dysfunction in the era of SGLT2 inhibitors","authors":"Paschalis Karakasis MD, MSc (PhD candidate)","doi":"10.1016/j.cpcardiol.2025.103073","DOIUrl":"10.1016/j.cpcardiol.2025.103073","url":null,"abstract":"","PeriodicalId":51006,"journal":{"name":"Current Problems in Cardiology","volume":"50 7","pages":"Article 103073"},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}