Advances in Microbial Physiology最新文献_第9页

Mechanism and Role of Globin-Coupled Sensor Signalling. 珠蛋白耦合传感器信号传导的机制和作用。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-07-06 DOI: 10.1016/bs.ampbs.2017.05.003

Johnnie A Walker, Shannon Rivera, Emily E Weinert

引用次数: 19

Manganese in Marine Microbiology. 海洋微生物学中的锰。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-03-14 DOI: 10.1016/bs.ampbs.2017.01.005

Colleen M Hansel

{"title":"Manganese in Marine Microbiology.","authors":"Colleen M Hansel","doi":"10.1016/bs.ampbs.2017.01.005","DOIUrl":"https://doi.org/10.1016/bs.ampbs.2017.01.005","url":null,"abstract":"The importance of manganese in the physiology of marine microbes, the biogeochemistry of the ocean and the health of microbial communities of past and present is emerging. Manganese is distributed widely throughout the global ocean, taking the form of an essential antioxidant (Mn2+), a potent oxidant (Mn3+) and strong adsorbent (Mn oxides) sequestering disproportionately high levels of trace metals and nutrients in comparison to the surrounding seawater. Manganese is, in fact, linked to nearly all other elemental cycles and intricately involved in the health, metabolism and function of the ocean's microbiome. Here, we briefly review the diversity of microbes and pathways responsible for the transformation of Mn within the three Mn pools and their distribution within the marine environment. Despite decades of interrogation, we still have much to learn about the players, mechanisms and consequences of the Mn cycle, and new and exciting discoveries are being made at a rapid rate. What is clear is the dynamic and ever-inspiring complexity of reactions involving Mn, and the acknowledgement that microorganisms are the catalytic engine driving the Mn cycle.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35013937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Preface. 前言。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 DOI: 10.1016/S0065-2911(17)30018-8

Robert K Poole

引用次数: 0

Metal-Based Combinations That Target Protein Synthesis by Fungi. 以真菌合成蛋白质为目标的金属基组合。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-02-11 DOI: 10.1016/bs.ampbs.2017.01.001

Cindy Vallières, Simon V Avery

{"title":"Metal-Based Combinations That Target Protein Synthesis by Fungi.","authors":"Cindy Vallières, Simon V Avery","doi":"10.1016/bs.ampbs.2017.01.001","DOIUrl":"https://doi.org/10.1016/bs.ampbs.2017.01.001","url":null,"abstract":"A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent need for new antifungal treatments. Certain metals have been used for decades as efficient fungicides in agriculture. However, concerns over metal toxicity have escalated over this time. Recent studies have revealed that metals like copper and chromate can impair functions required for the fidelity of protein synthesis in fungi. This occurs through different mechanisms, based on targeting of iron-sulphur cluster integrity or competition for uptake with amino acid precursors. Moreover, chromate at least acts synergistically with other agents known to target translation fidelity, like aminoglycoside antibiotics, causing dramatic and selective growth inhibition of several fungal pathogens of humans and plants. As such synergy allows the application of decreased amounts of metals for effective inhibition, it lessens concerns about nonspecific toxicity and opens new possibilities for metal applications in combinatorial fungicides targeting protein synthesis.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35014477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Copper and Antibiotics: Discovery, Modes of Action, and Opportunities for Medicinal Applications. 铜和抗生素:发现、作用方式和医药应用机会。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-03-18 DOI: 10.1016/bs.ampbs.2017.01.007

Alex G Dalecki, Cameron L Crawford, Frank Wolschendorf

{"title":"Copper and Antibiotics: Discovery, Modes of Action, and Opportunities for Medicinal Applications.","authors":"Alex G Dalecki, Cameron L Crawford, Frank Wolschendorf","doi":"10.1016/bs.ampbs.2017.01.007","DOIUrl":"10.1016/bs.ampbs.2017.01.007","url":null,"abstract":"Copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable for many cellular functions. However, these same properties can be highly detrimental to prokaryotes and eukaryotes when not properly controlled, damaging many biomolecules including DNA, lipids, and proteins. To restrict free copper concentrations, all bacteria have developed mechanisms of resistance, sequestering and effluxing labile copper to minimize its deleterious effects. This weakness is actively exploited by phagocytes, which utilize a copper burst to destroy pathogens. Though administration of free copper is an unreasonable therapeutic antimicrobial itself, due to insufficient selectivity between host and pathogen, small-molecule ligands may provide an opportunity for therapeutic mimicry of the immune system. By modulating cellular entry, complex stability, resistance evasion, and target selectivity, ligand/metal coordination complexes can synergistically result in high levels of antibacterial activity. Several established therapeutic drugs, such as disulfiram and pyrithione, display remarkable copper-dependent inhibitory activity. These findings have led to development of new drug discovery techniques, using copper ions as the focal point. High-throughput screens for copper-dependent inhibitors against Mycobacterium tuberculosis and Staphylococcus aureus uncovered several new compounds, including a new class of inhibitors, the NNSNs. In this review, we highlight the microbial biology of copper, its antibacterial activities, and mechanisms to discover new inhibitors that synergize with copper.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.01.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35013934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Haem-Based Sensors of O₂: Lessons and Perspectives. 基于血液的O2传感器:经验教训和观点。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-07-06 DOI: 10.1016/bs.ampbs.2017.05.001

Eduardo H S Sousa, Marie-Alda Gilles-Gonzalez

引用次数: 13

Metal Resistance and Its Association With Antibiotic Resistance. 金属耐药性及其与抗生素耐药性的关系。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-04-03 DOI: 10.1016/bs.ampbs.2017.02.001

Chandan Pal, Karishma Asiani, Sankalp Arya, Christopher Rensing, Dov J Stekel, D G Joakim Larsson, Jon L Hobman

{"title":"Metal Resistance and Its Association With Antibiotic Resistance.","authors":"Chandan Pal, Karishma Asiani, Sankalp Arya, Christopher Rensing, Dov J Stekel, D G Joakim Larsson, Jon L Hobman","doi":"10.1016/bs.ampbs.2017.02.001","DOIUrl":"https://doi.org/10.1016/bs.ampbs.2017.02.001","url":null,"abstract":"Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development of antibiotic resistance is considered to be the use, misuse and overuse of antibiotics in humans and animals. Nonantibiotic compounds, such as antibacterial biocides and metals, may also contribute to the promotion of antibiotic resistance through co-selection. This may occur when resistance genes to both antibiotics and metals/biocides are co-located together in the same cell (co-resistance), or a single resistance mechanism (e.g. an efflux pump) confers resistance to both antibiotics and biocides/metals (cross-resistance), leading to co-selection of bacterial strains, or mobile genetic elements that they carry. Here, we review antimicrobial metal resistance in the context of the antibiotic resistance problem, discuss co-selection, and highlight critical knowledge gaps in our understanding.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35013935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 231

Nutritional Immunity and Fungal Pathogenesis: The Struggle for Micronutrients at the Host-Pathogen Interface. 营养免疫和真菌发病机制:在宿主-病原体界面争夺微量营养素。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-02-16 DOI: 10.1016/bs.ampbs.2017.01.006

Dhara Malavia, Aaron Crawford, Duncan Wilson

引用次数: 40

Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. 化脓性链球菌和肺炎链球菌的过渡金属稳态。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-02-20 DOI: 10.1016/bs.ampbs.2017.01.002

Andrew G Turner, Cheryl-Lynn Y Ong, Mark J Walker, Karrera Y Djoko, Alastair G McEwan

{"title":"Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae.","authors":"Andrew G Turner, Cheryl-Lynn Y Ong, Mark J Walker, Karrera Y Djoko, Alastair G McEwan","doi":"10.1016/bs.ampbs.2017.01.002","DOIUrl":"https://doi.org/10.1016/bs.ampbs.2017.01.002","url":null,"abstract":"Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions including proper innate immune function. The host immune system has complicated and coordinated mechanisms in place to either starve and/or overload invading pathogens with various metals to combat the infection. Here, we discuss the roles of Fe, Mn and Zn in terms of nutritional immunity, and also the roles of Cu and Zn in metal overload in relation to the physiology and pathogenesis of two human streptococcal species, Streptococcus pneumoniae and Streptococcus pyogenes. S. pneumoniae is a major human pathogen that is carried asymptomatically in the nasopharynx by up to 70% of the population; however, transition to internal sites can cause a range of diseases such as pneumonia, otitis media, meningitis and bacteraemia. S. pyogenes is a human pathogen responsible for diseases ranging from pharyngitis and impetigo, to severe invasive infections. Both species have overlapping capacity with respect to metal acquisition, export and regulation and how metal homeostasis relates to their virulence and ability to invade and survive within the host. It is becoming more apparent that metals have an important role to play in the control of infection, and with further investigations, it could lead to the potential use of metals in novel antimicrobial therapies.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35014479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

The Role of Intermetal Competition and Mis-Metalation in Metal Toxicity. 金属间竞争和错金属化在金属毒性中的作用。

2区生物学

Advances in Microbial Physiology Pub Date : 2017-01-01 Epub Date: 2017-02-13 DOI: 10.1016/bs.ampbs.2017.01.003

Anna Barwinska-Sendra, Kevin J Waldron

{"title":"The Role of Intermetal Competition and Mis-Metalation in Metal Toxicity.","authors":"Anna Barwinska-Sendra, Kevin J Waldron","doi":"10.1016/bs.ampbs.2017.01.003","DOIUrl":"https://doi.org/10.1016/bs.ampbs.2017.01.003","url":null,"abstract":"The metals manganese, iron, cobalt, nickel, copper and zinc are essential for almost all bacteria, but their precise metal requirements vary by species, by ecological niche and by growth condition. Bacteria thus must acquire each of these essential elements in sufficient quantity to satisfy their cellular demand, but in excess these same elements are toxic. Metal toxicity has been exploited by humanity for centuries, and by the mammalian immune system for far longer, yet the mechanisms by which these elements cause toxicity to bacteria are not fully understood. There has been a resurgence of interest in metal toxicity in recent decades due to the problematic spread of antibiotic resistance amongst bacterial pathogens, which has led to an increased research effort to understand these toxicity mechanisms at the molecular level. A recurring theme from these studies is the role of intermetal competition in bacterial metal toxicity. In this review, we first survey biological metal usage and introduce some fundamental chemical concepts that are important for understanding bacterial metal usage and toxicity. Then we introduce a simple model by which to understand bacterial metal homeostasis in terms of the distribution of each essential metal ion within cellular 'pools', and dissect how these pools interact with each other and with key proteins of bacterial metal homeostasis. Finally, using a number of key examples from the recent literature, we look at specific metal toxicity mechanisms in model bacteria, demonstrating the role of metal-metal competition in the toxicity mechanisms of diverse essential metals.","PeriodicalId":50953,"journal":{"name":"Advances in Microbial Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.ampbs.2017.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35013936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37