Acta Endocrinologica-Bucharest最新文献_第4页

ROLE OF TYPE 2 DIABETES AND BODY MASS IN PROGRESSIVE OSTEOPENIA AND OSTEOPOROSIS. 2型糖尿病和体重在进行性骨质减少和骨质疏松症中的作用。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.544

Ali Abdul Hussein S Al-Janabi

{"title":"ROLE OF TYPE 2 DIABETES AND BODY MASS IN PROGRESSIVE OSTEOPENIA AND OSTEOPOROSIS.","authors":"Ali Abdul Hussein S Al-Janabi","doi":"10.4183/aeb.2024.544","DOIUrl":"10.4183/aeb.2024.544","url":null,"abstract":"Context: Osteopenia and osteoporosis are medical terms commonly used for a defect in compact bone. Diabetes has a complex effect on the degree of bone mineral density (BMD).Objective: Evaluation of the effect of type 2 diabetes mellitus (T2DM) on osteopenia and osteoporosis concerning body mass is the aim of this study.Design: A case-control study, including 400 patients with type 2 diabetes mellitus (T2DM) and 200 healthy individuals, was designed.Subjects and methods: BMD T-score measured by dual X-ray absorptiometry (DXA) was used as an indicator for osteopenia and osteoporosis, while body mass index (BMI) was used for determining obesity.Results: The BMD value of osteoporosis was observed in most females of both groups, compared to males with osteopenia with no supported by statistical analysis. The BMI value indicated that obese individuals are more likely to develop osteopenia in both groups, although there were no significant differences. Subjects aged 40 and over showed high osteopenia, which is associated with obesity.Conclusion: There is no significant effect of gender, diabetes, or obesity on the BMD. Osteopenia is more prevalent in age groups over 40. The obese women remain at risk of osteoporosis and men are at risk of osteopenia.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"544-550"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A NEW METHOD FOR INTRAOPERATIVE DEFINITIVE DIAGNOSIS OF INADVERTENT PARATHYROIDECTOMY DURING CENTRAL NECK DISSECTION. 中央颈部清扫术中不慎甲状旁腺切除术的新诊断方法。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.490

E Aysan, Y Y Korkmaz, E Hacihasanoglu

{"title":"A NEW METHOD FOR INTRAOPERATIVE DEFINITIVE DIAGNOSIS OF INADVERTENT PARATHYROIDECTOMY DURING CENTRAL NECK DISSECTION.","authors":"E Aysan, Y Y Korkmaz, E Hacihasanoglu","doi":"10.4183/aeb.2024.490","DOIUrl":"10.4183/aeb.2024.490","url":null,"abstract":"Background: The most serious complication of central neck dissection (CND) is inadvertent parathyroidectomy. There is no definitive method for intraoperative diagnosis of this complication.Method: We studied on CND indicated 17 thyroid cancer patients (14 female, 3 male, age range: 21-67, mean age: 43.4). The excised CND material was kept in 50 ml of normal saline for 30 minutes. A 2 ml sample was taken from this fluid and sent to biochemistry for rapid parathyroid hormone (PTH) measurement.Results: PTH values were <10pg/mL in 14 patients. PTH values of three patients were very high (112pg/mL, 167pg/mL, 210pg/mL respectively). When the excised tissue in these patients was evaluated intraoperatively with loop glasses, one parathyroid tissue was found in each of the three cases and these were autotransplanted intramuscularly. After this procedure we kept CND tissue material again in another normal saline of 50mL in 30 minutes and PTH was measured. The values came back as <10pg/mL. No parathyroid gland was found in any case in the postoperative routine histopathological evaluation. No patient had symptoms of hypocalcemia during the eight-weeks postoperative follow-up.Conclusion: Inadvertent parathyroidectomy due to CND is a serious complication. This complication can be prevented with the simple method we recommend here.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"490-493"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COULD THE RATE OF DECREASE IN INTRAOPERATIVE PARATHYROID HORMONE LEVEL BE A DETERMINANT OF SURGICAL TECHNIQUE IN TERTIARY HYPERPARATHYROIDISM? 术中甲状旁腺激素水平的降低率是否可以作为三期甲状旁腺功能亢进手术技术的决定因素？

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.471

G Güzel, D Sarıdemir Ünal, A Özen, Y E Saçın, N Yılmaz, A Boz, C Arıcı

{"title":"COULD THE RATE OF DECREASE IN INTRAOPERATIVE PARATHYROID HORMONE LEVEL BE A DETERMINANT OF SURGICAL TECHNIQUE IN TERTIARY HYPERPARATHYROIDISM?","authors":"G Güzel, D Sarıdemir Ünal, A Özen, Y E Saçın, N Yılmaz, A Boz, C Arıcı","doi":"10.4183/aeb.2024.471","DOIUrl":"10.4183/aeb.2024.471","url":null,"abstract":"Context: Intraoperative parathyroid hormone (IO PTH) monitoring has determinative role in surgery for tertiary hyperparathyroidism (tHPT).Objective: We tried to find out whether the extent of surgery to be performed can be dedicated via IO PTH monitoring in tHPT.Design: Renal transplantation (RTX) recipients who had been operated and followed up because of tHPT between 9/2014 and 5/2021 at our institution were retrospectively analysed.Subjects and methods: We analysed the pre-operative and postoperative data of 41 patients with tHPT.Results: Considering IO PTH monitoring; 70% and more decrease of the hormone level leaded us favourable results (89% surgical success) regardless of the PTX method (p<0.05). We obtained the same surgical success rate (75%) in patients in whom monitoring was done and was not done. We observed high success ratios (100%) in the latter group via subtotal PTX and total PTX plus autotransplantation (AT) (p<0.05).Conclusions: In surgery for tHPT, IO PTH monitoring should be maintained. When we observe 70% or more decline in the hormone level, we can decide to finish the operation regardless of the surgical technique. If hormone level decrease is below 70%, we have to continue exploration.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"471-476"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PERICARDIAL PARATHYROID ADENOMA. 心包甲状旁腺瘤。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.518

U Kesici, A Akan, M Duman, M Ayvazoglu, O Yalcin

{"title":"PERICARDIAL PARATHYROID ADENOMA.","authors":"U Kesici, A Akan, M Duman, M Ayvazoglu, O Yalcin","doi":"10.4183/aeb.2024.518","DOIUrl":"10.4183/aeb.2024.518","url":null,"abstract":"Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrine condition that presents with significant clinical symptoms. Ectopic adenomas commonly occur in the tracheo-esophageal groove, thymus, intrathyroidal, and mediastinum. While mediastinal ectopic adenomas are frequently observed, pericardial ectopic adenomas are only documented in case reports in the literature.Case report: We present a 65-year-old female patient who had persistent PHPT and underwent re-sternotomy and excision of a pericardial ectopic parathyroid adenoma. The typical treatment for PHPT has generally been conventional bilateral neck exploration without preoperative imaging. Conventional bilateral neck exploration has decreased in popularity because of the rise in the minimally invasive parathyroidectomy (MIP) procedure. The use of MIP is prevalent in surgical procedures, and it is crucial to have precise preoperative localization. Due to the ectopic localization of certain parathyroid adenomas, they are regarded as an important cause of the failure of primary surgery. Hence, particularly when dealing with persistent and recurrent PHPT, modern imaging techniques like 4D CT enhance the efficacy of surgical interventions. Therefore, particularly in cases of ectopic parathyroid adenomas located in the mediastinum, it is important to consider the possibility that if the adenoma cannot be found after surgery, it may be located in the pericardial region.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"518-521"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INNOVATIONS IN DIABETES MELLITUS MANAGEMENT: A REVIEW OF USFDA-APPROVED DRUGS AND PHASE 3 CLINICAL TRIALS. 糖尿病管理的创新：美国食品药品监督管理局批准的药物和3期临床试验的回顾。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.508

V Lasure, S Shankhapal, P Sonawane, P Sonawane, S Bansode, V Kashid

引用次数: 0

CURRENT INSIGHTS IN THE SCREENING OF SECONDARY HYPERTENSION: A CARDIOLOGIST'S PERSPECTIVE. 继发性高血压筛查的当前见解：心脏病专家的观点。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.551

R O Darabont

引用次数: 0

COMPARISON OF INTERMITTENT AND CONTINUOUS CALORIE RESTRICTION STRATEGIES IN OVERWEIGHT AND OBESE PATIENTS. 超重和肥胖患者间歇性和持续卡路里限制策略的比较。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.436

D B Esen Yiğit, B Aksakal, S Basat

{"title":"COMPARISON OF INTERMITTENT AND CONTINUOUS CALORIE RESTRICTION STRATEGIES IN OVERWEIGHT AND OBESE PATIENTS.","authors":"D B Esen Yiğit, B Aksakal, S Basat","doi":"10.4183/aeb.2024.436","DOIUrl":"10.4183/aeb.2024.436","url":null,"abstract":"Context: In this study we compared daily calorie restriction, and intermittent calorie restriction in overweight and class 1 obese patients. Findings are these diets correct metabolic parameters and intermittent calorie restriction diet regimen increases muscle strength.Aim: We investigated the effects on metabolic, anthropometric values and muscle in Intermittent Fasting (IF) and Continuous Calorie Restriction (CCR) groups in adult overweight and class 1 obese patients.Material and methods: The patients were randomly divided into 3 groups: IF group (n=23), CCR group (n=21), and control group (n=22). Fat mass, and basal metabolic rate were recorded. Fat-Free Mass Index (FFMI) was calculated. Handgrip strength was measured. Walking speed test was performed. The 'International Physical Activity Questionnaire' was administered to the patients. Weight, body mass index, fat mass, muscle mass, FFMI, waist circumference, right and left arm circumference, right and left calf circumference values decreased significantly and similarly compared to the beginning at the end of 6 months in the IF and CCR groups (p<0.05). A statistically significant increase was found in hand grip strength test measurements in the IF groups.Conclusions: IF and CCR diets enhance metabolic functions while reducing muscle mass. Despite this decrease, the IF diet increases muscular strength.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"436-443"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EARLY EFFECT OF ORLISTAT ON NONALCOHOLIC STEATOHEPATITIS AND ATHEROGENICITY ASSOCIATED INDICES IN OBESITY PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE. 奥利司他对肥胖合并非酒精性脂肪性肝病患者的非酒精性脂肪性肝炎及动脉粥样硬化相关指标的早期影响

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.494

B Menekşe, A Batman

{"title":"EARLY EFFECT OF ORLISTAT ON NONALCOHOLIC STEATOHEPATITIS AND ATHEROGENICITY ASSOCIATED INDICES IN OBESITY PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.","authors":"B Menekşe, A Batman","doi":"10.4183/aeb.2024.494","DOIUrl":"10.4183/aeb.2024.494","url":null,"abstract":"Objective: Obesity is a metabolic condition characterized by increased body fat mass. Increased prevalence of nonalcoholic steatohepatitis (NASH) and increased atherogenicity are closely associated with morbidity and mortality in obesity patients. In this study, we investigated the effect of orlistat, a gastrointestinal lipase inhibitor, on atherogenicity-related and NASH-related indexes in obese patients.Material and methods: This retrospective study was completed with a total of 139 class III obesity patients with NASH who were admitted to our hospital, creating an orlistat treatment group and a control group. NASH-related indices and atherogenicity indices were calculated at the beginning of the study. These parameters were repeated in the 12th week of the study. Statistical analyzes were performed on the entire patient population and in groups classified according to body mass index (BMI) (BMI <40 kg/m2 and BMI ≥40 kg/m2).Results: As a result of our 12-week study, in addition to the improvement in glycemic parameters and lipid profile, atherogenic indexes (Triglyceride-Glucose index and Triglyceride-Glucose-BMI index) and NASH-related indices (Nonalcoholic Fatty Liver Disease Fibrosis Score, Fibrosis-4 Index, Aspartate aminotransferase-Platelet Ratio Index) superior improvements were achieved compared to the control group (p<0.001). These improvements were similar in groups separated by BMI (p>0.05).Conclusion: In addition to its proven body weight loss effect, Orlistat may be beneficial in the treatment of atherogenicity and steatohepatitis.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"494-500"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MANAGEMENT STRATEGIES FOR NORMOTENSIVE PHEOCHROMOCYTOMA IN PREGNANCY. 妊娠期正常血压嗜铬细胞瘤的治疗策略。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.533

W W Parksook, K Panumatrassamee, V Phupong, T Snabboon

{"title":"MANAGEMENT STRATEGIES FOR NORMOTENSIVE PHEOCHROMOCYTOMA IN PREGNANCY.","authors":"W W Parksook, K Panumatrassamee, V Phupong, T Snabboon","doi":"10.4183/aeb.2024.533","DOIUrl":"10.4183/aeb.2024.533","url":null,"abstract":"Background: Managing pheochromocytoma during pregnancy presents significant challenges due to the absence of well-established guidelines. Early detection during prenatal care, together with timely medical and surgical interventions, is crucial for achieving favorable maternal and fetal outcomes.Case presentation: This report presents the case of a 35-year-old nulliparous woman with bilateral pheochromocytoma who became pregnant between the first and second stages of adrenalectomy. Preoperative management included α-adrenergic blockade and hydration, which was successfully implemented despite the patient being normotensive. The patient underwent a cortical-sparing tumor resection during the second trimester without complications and subsequently delivered a healthy full-term infant through normal labor.Conclusion: This case demonstrates that preoperative α-adrenergic blockade remains the recommended approach for managing pheochromocytoma during pregnancy, even in normotensive patients. Additionally, laparoscopic cortical-sparing adrenalectomy appears to be an effective surgical option for minimizing the risk of long-term adrenal insufficiency in cases of bilateral lesions.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"533-537"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPTIMIZING DIAGNOSTIC ACCURACY IN CUSHING SYNDROME USING 1 MG DEXAMETHASONE SUPPRESSION TEST CUT-OFFS. 利用1mg地塞米松抑制试验临界值优化库欣综合征的诊断准确性。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-10-01 Epub Date: 2025-10-03 DOI: 10.4183/aeb.2024.422

D S Yaman Kalender, Mehmet Çalan, Seçil Özışık, Dilek Cimrin, Fırat Bayraktar

{"title":"OPTIMIZING DIAGNOSTIC ACCURACY IN CUSHING SYNDROME USING 1 MG DEXAMETHASONE SUPPRESSION TEST CUT-OFFS.","authors":"D S Yaman Kalender, Mehmet Çalan, Seçil Özışık, Dilek Cimrin, Fırat Bayraktar","doi":"10.4183/aeb.2024.422","DOIUrl":"10.4183/aeb.2024.422","url":null,"abstract":"Introduction: Diagnosing Cushing Syndrome (CS) remains challenging due to its diverse symptoms and the complexity of its subtypes. This study aimed to optimize diagnostic cut-off values for differentiating CS subtypes using the 1 mg dexamethasone suppression test (DST) in a cohort of 237 patients.Materials and methods: Retrospective data from patients diagnosed with non-functional adrenal adenomas (NFA), mild autonomous cortisol secretion (MACS), adrenal CS, and pituitary CS at the Dokuz Eylül University Endocrinology and Metabolism Clinic (2005-2016) were analyzed. Sensitivity and specificity of morning cortisol levels after DST were evaluated using receiver operating characteristic (ROC) curve analysis.Results: The analysis identified optimal morning cortisol cut-off levels: 2.14 μg/dL (59.04 nmol/L) for MACS, 2.3 μg/dL (63.4 nmol/L) for adrenal CS, and 2.33 μg/dL (64.28 nmol/L) for pituitary CS.Conclusion: These optimized thresholds demonstrated high sensitivity and specificity, significantly improving diagnostic precision over the conventional threshold of 1.8 μg/dL (50 nmol/L). The findings underscore the importance of tailored cut-off values to address subtype-specific diagnostic challenges, reducing delays and mitigating long-term complications. Personalized diagnostic approaches, incorporating patient demographics and disease-specific characteristics, are essential for enhancing diagnostic accuracy and facilitating timely interventions.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 4","pages":"422-429"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0