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Systemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions 皮肤癌患者和良性病变患者的全身氧化应激参数

Stresses Pub Date : 2023-11-29 DOI: 10.3390/stresses3040054

E. Karampinis, P. Nechalioti, Konstantina Eirini Georgopoulou, George Goniotakis, Angeliki Viktoria Roussaki Schulze, E. Zafiriou, Demetrios Kouretas

{"title":"Systemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions","authors":"E. Karampinis, P. Nechalioti, Konstantina Eirini Georgopoulou, George Goniotakis, Angeliki Viktoria Roussaki Schulze, E. Zafiriou, Demetrios Kouretas","doi":"10.3390/stresses3040054","DOIUrl":"https://doi.org/10.3390/stresses3040054","url":null,"abstract":"Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or red blood cells have been found to be elevated in many diseases, including skin cancer. UV radiation (UVR) induces damage to biomolecules that enter the bloodstream, reinforcing systemic oxidative stress. On the other hand, pre-existing systemic oxidative stress does not supply the skin with the adequate micronutrients and antioxidant resources to ameliorate the skin’s antioxidant defense against UVR. In both scenarios, skin cancer patients are exposed to oxidative conditions. In the case of warts, oxidation is linked to chronic inflammation, while impaired cutaneous antioxidant defense could ineffectively deal with possible oxidative stimuli from viral agents, such as HPV. Therefore, the aim of our study is to evaluate the existing data on systemic oxidative stress in skin diseases such as non-melanoma skin cancer (NMSC), basal-cell carcinoma (BCC), squamous-cell carcinoma (SCC), and melanoma as well as benign lesions such as actinic keratosis (AK), sebaceous keratosis (SK), and warts. Previous studies have demonstrated that patients with NMSC, melanoma, AK, and warts (both genital and non-genital) are subjected to severe oxidative stress, indicated by disturbed antioxidant enzyme levels, accumulated oxidized proteins and lipid products, and, to a lesser extent, lower concentrations of micronutrients. Interestingly, medical history of NMSC or melanoma as well as stage of skin cancer and treatment approach were found to affect systemic oxidative stress parameters. In the case of warts (both genital and non-genital), high oxidative stress levels were also detected, and they were found to be aligned with their recalcitrant character.","PeriodicalId":508968,"journal":{"name":"Stresses","volume":"192 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Composition, Antioxidant, and Anti-Diabetic Activities of Scorzonera phaeopappa Boiss Scorzonera phaeopappa Boiss 的化学成分、抗氧化和抗糖尿病活性

Stresses Pub Date : 2023-11-19 DOI: 10.3390/stresses3040053

Leina El Hosry, Souad Al Ayash, Jocelyne Matar Boumosleh, Elias Bou-Maroun

{"title":"Chemical Composition, Antioxidant, and Anti-Diabetic Activities of Scorzonera phaeopappa Boiss","authors":"Leina El Hosry, Souad Al Ayash, Jocelyne Matar Boumosleh, Elias Bou-Maroun","doi":"10.3390/stresses3040053","DOIUrl":"https://doi.org/10.3390/stresses3040053","url":null,"abstract":"Wild edible plants have attracted increasing interest from researchers because of their richness in biologically active phytochemicals. These are found to be a potential remedy for oxidative-stress-mediated diseases such as diabetes mellitus. In this study, total phenol, total terpene, and total flavonoid content as well as antioxidant and antidiabetic activities of Scorzonera phaeopappa Boiss from Lebanon were determined. Using dichloromethane, dichloromethane ammonia, methanol, acetone, and ethanol, extracts were prepared from the edible leaves. The antioxidant activity and the antidiabetic activity were determined by 2,2-diphenyl-1-picrylhydrazyl scavenging, Fe2+-chelating and α-amylase/α-glucosidase inhibitory assays, respectively. Dichloromethane ammonia was found to have the highest extraction capacity on phenols (2.73 mg GAE /100 mg extract) and terpenes (232.42 mg LE/100 mg extract). Methanol was found to have the highest extraction capacity on total flavonoids (63.05 mg QE/100 mg extract). The methanol extract exhibited the highest DPPH scavenging activity (IC50 0.07 mg/mL) and the highest chelating activity as compared to other extracts (0.08 mg/mL, chelating activity 50%). The acetone extract was two times more active than acarbose against α-amylase enzyme and was the most active against α-glucosidase (6.3 mg/mL). Significant positive correlations were observed between total phenol content and α-glucosidase inhibitory assay and total terpene content and α-glucosidase inhibitory assay.","PeriodicalId":508968,"journal":{"name":"Stresses","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139260417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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