Advances in Parasitology最新文献_第5页

An update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings: The time is now. 关于女性和男性生殖器血吸虫病的最新情况，并呼吁综合努力，在流行和非流行环境中提高诊断、治疗和认识:现在是时候了。

3区医学

Advances in Parasitology Pub Date : 2022-01-01 DOI: 10.1016/bs.apar.2021.12.003

A. Bustinduy, Bodo Randriansolo, Amy S Sturt, S. Kayuni, Peter D.C. Leustcher, B. Webster, L. van Lieshout, J. Stothard, H. Feldmeier, M. Gyapong

引用次数: 19

The microscopic five of the big five: Managing zoonotic diseases within and beyond African wildlife protected areas. 大五项中的微观五项:管理非洲野生动物保护区内外的人畜共患病。

3区医学

Advances in Parasitology Pub Date : 2022-01-01 DOI: 10.1016/bs.apar.2022.05.001

Anya V Tober, Danny Govender, Isa-Rita M Russo, Jo Cable

{"title":"The microscopic five of the big five: Managing zoonotic diseases within and beyond African wildlife protected areas.","authors":"Anya V Tober, Danny Govender, Isa-Rita M Russo, Jo Cable","doi":"10.1016/bs.apar.2022.05.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2022.05.001","url":null,"abstract":"African protected areas strive to conserve the continent's great biodiversity with a targeted focus on the flagship 'Big Five' megafauna. Though often not considered, this biodiversity protection also extends to the lesser-known microbes and parasites that are maintained in these diverse ecosystems, often in a silent and endemically stable state. Climate and anthropogenic change, and associated diversity loss, however, are altering these dynamics leading to shifts in ecological interactions and pathogen spill over into new niches and hosts. As many African protected areas are bordered by game and livestock farms, as well as villages, they provide an ideal study system to assess infection dynamics at the human-livestock-wildlife interface. Here we review five zoonotic, multi-host diseases (bovine tuberculosis, brucellosis, Rift Valley fever, schistosomiasis and cryptosporidiosis)-the 'Microscopic Five'-and discuss the biotic and abiotic drivers of parasite transmission using the iconic Kruger National Park, South Africa, as a case study. We identify knowledge gaps regarding the impact of the 'Microscopic Five' on wildlife within parks and highlight the need for more empirical data, particularly for neglected (schistosomiasis) and newly emerging (cryptosporidiosis) diseases, as well as zoonotic disease risk from the rising bush meat trade and game farm industry. As protected areas strive to become further embedded in the socio-economic systems that surround them, providing benefits to local communities, One Health approaches can help maintain the ecological integrity of ecosystems, while protecting local communities and economies from the negative impacts of disease.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"117 ","pages":"1-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10609571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improving translational power in antischistosomal drug discovery. 提高抗血吸虫药物发现的翻译能力。

3区医学

Advances in Parasitology Pub Date : 2022-01-01 DOI: 10.1016/bs.apar.2022.05.002

Alexandra Probst, Stefan Biendl, Jennifer Keiser

引用次数: 1

Current research on naturally transmitted Plasmodium knowlesi 自然传播诺氏疟原虫的研究现状

3区医学

Advances in Parasitology Pub Date : 2021-01-01 DOI: 10.1016/s0065-308x(21)x0005-x

引用次数: 0

Models in parasite and pathogen evolution: Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in parasitic protozoa, yeasts and bacteria. 寄生虫和病原体进化的模型:基因组分析揭示了寄生原生动物、酵母和细菌在所有进化尺度上的主要克隆性和渐进进化。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 Epub Date: 2021-01-11 DOI: 10.1016/bs.apar.2020.12.001

Michel Tibayrenc, Francisco J Ayala

{"title":"Models in parasite and pathogen evolution: Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in parasitic protozoa, yeasts and bacteria.","authors":"Michel Tibayrenc, Francisco J Ayala","doi":"10.1016/bs.apar.2020.12.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.12.001","url":null,"abstract":"The predominant clonal evolution (PCE) model of pathogenic microorganisms postulates that the impact of genetic recombination in those pathogens' natural populations is not enough to erase a persistent phylogenetic signal at all evolutionary scales from microevolution till geological times in the whole ecogeographical range of the species considered. We have tested this model with a set of representative parasitic protozoa, yeasts and bacteria in the light of the most recent genomic data. All surveyed species, including those that were considered as highly recombining, exhibit similar PCE patterns above and under the species level, from macro- to micro-evolutionary scales (Russian doll pattern), suggesting gradual evolution. To our knowledge, it is the first time that such a strong common evolutionary feature among very diverse pathogens has been evidenced. The implications of this model for basic biology and applied research are exposed. These implications include our knowledge on the pathogens' reproductive mode, their population structure, the possibility to type strain and to follow up epidemics (molecular epidemiology) and to revisit pathogens' taxonomy through a flexible use of the phylogenetic species concept (Cracraft, 1983).","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"111 ","pages":"75-117"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38849575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Survival of metazoan parasites in fish: Putting into context the protective immune responses of teleost fish. 鱼体内后生寄生虫的存活:硬骨鱼的保护性免疫反应。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 Epub Date: 2021-04-29 DOI: 10.1016/bs.apar.2021.03.001

Bahram Sayyaf Dezfuli, Luisa Giari, Giampaolo Bosi

{"title":"Survival of metazoan parasites in fish: Putting into context the protective immune responses of teleost fish.","authors":"Bahram Sayyaf Dezfuli, Luisa Giari, Giampaolo Bosi","doi":"10.1016/bs.apar.2021.03.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2021.03.001","url":null,"abstract":"Defence mechanisms of fish can be divided into specific and non-specific that act in concert and are often interdependent. Most fish in both wild and cultured populations are vulnerable to metazoan parasites. Endoparasitic helminths include several species of digeneans, cestodes, nematodes, and acanthocephalans. Although they may occur in large numbers, helminth infections rarely result in fish mortality. Conversely, some ectoparasites cause mass mortality in farmed fish. Given the importance of fish innate immunity, this review addresses non-specific defence mechanisms of fish against metazoan parasites, with emphasis on granulocyte responses involving mast cells, neutrophils, macrophages, rodlet cells, and mucous cells. Metazoan parasites are important disease agents that affect wild and farmed fish and can induce high economic loss and, as pathogen organisms, deserve considerable attention. The paper will provide our light and transmission electron microscopy data on metazoan parasites-fish innate immune and neuroendocrine systems. Insights about the structure and functions of the cell types listed above and a brief account of the effects and harms of each metazoan taxon to specific fish apparati/organs will be presented.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"112 ","pages":"77-132"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2021.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38927750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Towards global control of parasitic diseases in the Covid-19 era: One Health and the future of multisectoral global health governance. 2019冠状病毒病时代实现全球寄生虫病控制:同一个健康和多部门全球卫生治理的未来。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 DOI: 10.1016/bs.apar.2021.08.007

Lawson Ung, J Russell Stothard, Revati Phalkey, Andrew S Azman, James Chodosh, William P Hanage, Claire J Standley

{"title":"Towards global control of parasitic diseases in the Covid-19 era: One Health and the future of multisectoral global health governance.","authors":"Lawson Ung, J Russell Stothard, Revati Phalkey, Andrew S Azman, James Chodosh, William P Hanage, Claire J Standley","doi":"10.1016/bs.apar.2021.08.007","DOIUrl":"https://doi.org/10.1016/bs.apar.2021.08.007","url":null,"abstract":"Human parasitic infections-including malaria, and many neglected tropical diseases (NTDs)-have long represented a Gordian knot in global public health: ancient, persistent, and exceedingly difficult to control. With the coronavirus disease (Covid-19) pandemic substantially interrupting control programmes worldwide, there are now mounting fears that decades of progress in controlling global parasitic infections will be undone. With Covid-19 moreover exposing deep vulnerabilities in the global health system, the current moment presents a watershed opportunity to plan future efforts to reduce the global morbidity and mortality associated with human parasitic infections. In this chapter, we first provide a brief epidemiologic overview of the progress that has been made towards the control of parasitic diseases between 1990 and 2019, contrasting these fragile gains with the anticipated losses as a result of Covid-19. We then argue that the complementary aspirations of the United Nations Sustainable Development Goals (SDGs) and the World Health Organization (WHO)'s 2030 targets for parasitic disease control may be achieved by aligning programme objectives within the One Health paradigm, recognizing the interdependence between humans, animals, and the environment. In so doing, we note that while the WHO remains the preeminent international institution to address some of these transdisciplinary concerns, its underlying challenges with funding, authority, and capacity are likely to reverberate if left unaddressed. To this end, we conclude by reimagining how models of multisectoral global health governance-combining the WHO's normative and technical leadership with greater support in allied policy-making areas-can help sustain future malaria and NTD elimination efforts.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"114 ","pages":"1-26"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10363009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Molecular epidemiology and population genomics of Plasmodium knowlesi. 诺氏疟原虫的分子流行病学和种群基因组学。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 Epub Date: 2021-09-21 DOI: 10.1016/bs.apar.2021.08.003

Paul C S Divis, Balbir Singh, David J Conway

{"title":"Molecular epidemiology and population genomics of Plasmodium knowlesi.","authors":"Paul C S Divis, Balbir Singh, David J Conway","doi":"10.1016/bs.apar.2021.08.003","DOIUrl":"https://doi.org/10.1016/bs.apar.2021.08.003","url":null,"abstract":"Molecular epidemiology has been central to uncovering P. knowlesi as an important cause of human malaria in Southeast Asia, and to understanding the complex nature of this zoonosis. Species-specific parasite detection and characterization of sequences were vital to show that P. knowlesi was distinct from the human parasite species that had been presumed to cause all malaria. With established sensitive and specific molecular detection tools, surveys subsequently indicated the distribution of P. knowlesi infections in humans, wild primate reservoir host species, and mosquito vector species. The importance of studying P. knowlesi genetic polymorphism was indicated initially by analysing a few nuclear gene loci as well as the mitochondrial genome, and subsequently by multi-locus microsatellite analyses and whole-genome sequencing. Different human infections generally have unrelated P. knowlesi genotypes, acquired from the diverse local parasite reservoirs in macaques. However, individual human infections are usually less genetically complex than those of wild macaques which experience more frequent superinfection with different P. knowlesi genotypes. Multi-locus analyses have revealed deep population subdivisions within P. knowlesi, which are structured both geographically and in relation to different macaque reservoir host species. Simplified genotypic discrimination assays now enable efficient large-scale surveillance of the sympatric P. knowlesi subpopulations within Malaysian Borneo. The whole-genome sequence analyses have also identified loci under recent positive natural selection in the P. knowlesi genome, with evidence that different loci are affected in different populations. These provide a foundation to understand recent adaptation of the zoonotic parasite populations, and to track and interpret future changes as they emerge.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"113 ","pages":"191-223"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology. 诺氏疟疾:人类危险因素、临床谱和病理生理学。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 Epub Date: 2021-08-28 DOI: 10.1016/bs.apar.2021.08.001

Nicholas M Anstey, Matthew J Grigg, Giri S Rajahram, Daniel J Cooper, Timothy William, Steven Kho, Bridget E Barber

{"title":"Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology.","authors":"Nicholas M Anstey, Matthew J Grigg, Giri S Rajahram, Daniel J Cooper, Timothy William, Steven Kho, Bridget E Barber","doi":"10.1016/bs.apar.2021.08.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2021.08.001","url":null,"abstract":"Plasmodium knowlesi is endemic across Southeast Asia, and is the commonest cause of zoonotic malaria. The spectrum of clinical disease from P. knowlesi infection ranges from asymptomatic infection, through to severe malaria and death. Over 90% of clinical disease occurs in adults, mostly living in forest edge areas undergoing intensive land use change. With a 24-h asexual life cycle in humans, high parasite counts are possible, but most clinical cases of knowlesi malaria are uncomplicated with low parasitaemia. In co-endemic areas, median parasitaemia in knowlesi malaria is lower than that seen in vivax and falciparum malaria, suggesting a lower fever threshold. Severe malaria occurs in 6-9% of symptomatic adults. Manifestations of severe malaria from P. knowlesi are similar to those seen with falciparum malaria, with the notable absence of coma. Age, parasitaemia, cardiovascular comorbidities and delayed diagnosis are risk factors for severe disease and death, which are only seen in adults. Thrombocytopenia is near-universal in adults, likely related to platelet-red cell binding and clearance. Mechanisms underlying the microvascular sludging seen in fatal disease in non-natural primate hosts and the microvascular accumulation of parasites in fatal human disease are not clear. Marked reductions in deformability of both infected and uninfected red blood cells are associated with disease severity in both humans and other non-natural primate hosts, likely contributing to impaired microvascular perfusion and organ dysfunction. Endothelial activation, endothelial dysfunction, glycocalyx degradation and haemolysis are also associated with, and likely contribute to, severe disease and organ dysfunction, particularly acute kidney injury.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"113 ","pages":"1-43"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299579/pdf/nihms-1821604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Clinical management of Plasmodium knowlesi malaria. 诺氏疟原虫疟疾的临床管理。

3区医学

Advances in Parasitology Pub Date : 2021-01-01 Epub Date: 2021-09-01 DOI: 10.1016/bs.apar.2021.08.004

Bridget E Barber, Matthew J Grigg, Daniel J Cooper, Donelly A van Schalkwyk, Timothy William, Giri S Rajahram, Nicholas M Anstey

{"title":"Clinical management of Plasmodium knowlesi malaria.","authors":"Bridget E Barber, Matthew J Grigg, Daniel J Cooper, Donelly A van Schalkwyk, Timothy William, Giri S Rajahram, Nicholas M Anstey","doi":"10.1016/bs.apar.2021.08.004","DOIUrl":"https://doi.org/10.1016/bs.apar.2021.08.004","url":null,"abstract":"The zoonotic parasite Plasmodium knowlesi has emerged as an important cause of human malaria in parts of Southeast Asia. The parasite is indistinguishable by microscopy from the more benign P. malariae, but can result in high parasitaemias with multiorgan failure, and deaths have been reported. Recognition of severe knowlesi malaria, and prompt initiation of effective therapy is therefore essential to prevent adverse outcomes. Here we review all studies reporting treatment of uncomplicated and severe knowlesi malaria. We report that although chloroquine is effective for the treatment of uncomplicated knowlesi malaria, artemisinin combination treatment is associated with faster parasite clearance times and lower rates of anaemia during follow-up, and should be considered the treatment of choice, particularly given the risk of administering chloroquine to drug-resistant P. vivax or P. falciparum misdiagnosed as P. knowlesi malaria in co-endemic areas. For severe knowlesi malaria, intravenous artesunate has been shown to be highly effective and associated with reduced case-fatality rates, and should be commenced without delay. Regular paracetamol may also be considered for patients with severe knowlesi malaria or for those with acute kidney injury, to attenuate the renal damage resulting from haemolysis-induced lipid peroxidation.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"113 ","pages":"45-76"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299581/pdf/nihms-1821601.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39519462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12