Wellcome Open Research最新文献

{"title":"The genome sequence of the Red-clover Case-bearer, Coleophora deauratella Zeller, 1846","authors":"Liam M. Crowley, Denise C. Wawman","doi":"10.12688/wellcomeopenres.22581.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22581.1","url":null,"abstract":"We present a genome assembly from an individual female Coleophora deauratella (the Red-clover Case-bearer; Arthropoda; Insecta; Lepidoptera; Coleophoridae). The genome sequence is 518.4 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.76 kilobases in length.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of an ichneumonid wasp, Netelia fuscicornis (Holmgren, 1860)","authors":"Benjamin W. Price, Gavin R. Broad","doi":"10.12688/wellcomeopenres.22578.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22578.1","url":null,"abstract":"We present a genome assembly from an individual female Netelia fuscicornis (an ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 324.7 megabases in span. Most of the assembly is scaffolded into six chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 17.7 kilobases in length.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":"14 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the OPUF approach to create a value set for the EQ-HWB-S: An exploratory feasibility study","authors":"PP Schneider, Kristina Ludwig, Ole Marten, E. McDool, T. Peasgood, Nancy Devlin, Koonal Shah, John Brazier, Wolfgang Greiner, C. Mukuria","doi":"10.12688/wellcomeopenres.21408.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21408.1","url":null,"abstract":"Objectives The EQ-HWB-S (EQ Health and Wellbeing Short version) is a new generic measure of health, social care and carer related quality of life, specifically developed to generate utility values. However, its nine dimensions pose a challenge for creating value sets using traditional elicitation techniques, such as time trade-off. A promising alternative method, called Online elicitation of Personal Utility Functions (OPUF) has recently been proposed. The aim of this study was to test the feasibility of using OPUF to create a value set for the EQ-HWB-S. Methods We adapted the OPUF tool for the EQ-HWB-S, and piloted it in convenience samples from the UK and Germany. We then conducted an explorative valuation study in both countries in March 2023. We recruited a total of 658 respondents, in four samples: UK (n=328) and German (n=110) general population, and German rheumatic disease (n=110) and diabetes (n=110) patients. Feasibility was assessed based on completion times, data quality, logical consistency, and respondents’ feedback. A demo version of the English OPUF survey is available at: https://valorem.health/eqen-demo Results The OPUF approach was found to be feasible. Most respondents completed the survey in around 15 minutes and found it easy to complete. We derived well-ordered value set coefficients. Pain, mobility, and daily activities were the three most important dimensions in all four samples. The OPUF-derived UK value set differed in several notable ways from a UK value set derived using traditional elicitation methods. Conclusion This study has demonstrated the feasibility of using OPUF to create a value set for the EQ-HWB-S in four relatively small samples including two patient groups. While further validation is needed, our results suggest that OPUF might be a viable alternative or supplement to the traditional valuation techniques for eliciting health state preferences.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":"20 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of Reeves’ muntjac, Muntiacus reevesi (Ogilby, 1839)","authors":"Nick Ewart, Denise C. Wawman","doi":"10.12688/wellcomeopenres.22608.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22608.1","url":null,"abstract":"We present a genome assembly from an individual female Muntiacus reevesi (the Reeves’ muntjac; Chordata; Mammalia; Artiodactyla; Cervidae). The genome sequence is 2,656.2 megabases in span. Most of the assembly is scaffolded into 23 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.35 kilobases in length.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":"26 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaps in Long COVID treatments research: A scoping review","authors":"Stephanie Newton, Laura Davidson, Alice Norton, Anjum Memon, Louise Sigfrid","doi":"10.12688/wellcomeopenres.21766.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21766.1","url":null,"abstract":"Background Long COVID affects 6 to 10% of people following SARS-CoV-2 infection. It has been documented worldwide, with over 200 symptoms reported. This scoping review assesses the evidence on Long COVID treatments to identify gaps in the evidence-base to inform research prioritisation. Methods We searched four databases (MEDLINE, Embase, Cochrane’s Trial register, Epistemonikos) supplemented by a grey literature search up to April 2023. Two reviewers screened articles and extracted data. Data were analysed using a thematic approach. Results Of 3675 records identified, 26 studies were included. Most were in high-income countries (92%), with two in upper-middle-income countries (8%). None reported inclusion of children, nor pregnant women and only 37.5% included adults over 64 years. Five (20.8%) presented ethnicity data, of these 92.9% of participants were of white ethnicity. Treatments included nutritional supplements (46%), conventional medicines (38%), hyperbaric medicine (8%), COVID-19 vaccination (4%) and complementary, alternative medicine (4%). Conclusion This scoping review highlights that more than four years after the start of the pandemic, research gaps remain for Long COVID treatments. There is a lack of research in low-income countries, despite trials being best placed locally to reflect different population demographics. There is a lack of inclusion of population sub-groups, particularly children, pregnant women and ethnic minority groups. Inclusion of these groups in future research is important given they may be at a higher risk of adverse outcomes of COVID-19, and a lack of appropriate treatments for Long COVID may contribute to the widening of health inequalities.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":"28 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New frontiers for Biosocial Birth Cohort Research: interdisciplinary approaches to exposure, harmonisation and collaboration","authors":"S. Gibbon, Elizabeth, F. S. Roberts, Rebecca Hardy, D. Behague, Martha, M. Téllez Rojo, Ana Goncalves-Soares, Rosie Mathers, Michael Penkler, Silvia Fraga, Andrew Wooyoung Kim, Michelle Pentecost, Evie Tabor, Robbin Jeffries-Hein, Martine Lappé, Catherine Borra, Sophia Rossmann, Stephanie Lloyd, A. Filipe, Susana Silva","doi":"10.12688/wellcomeopenres.21734.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21734.1","url":null,"abstract":"In this Open Letter we bring together researchers from the Biosocial Birth Cohort Research (BBCR) network to reflect on interdisciplinary research and methods within birth cohorts and to draw attention to social science approaches to this field, which we argue are underutilized. A more comprehensive and consistent integration of social science approaches would expand the scope and value of research with birth cohorts. We critically engage three specific areas of birth cohort research that provide significant opportunities for exchange across disciplines; how exposure is defined and measured in birth cohorts, the harmonisation of data within and between birth cohorts and the broader experience of interdisciplinary collaboration in birth cohorts and birth cohort research. By reflecting on these three areas, we highlight the need for more in-depth dialogue between life and social sciences in the design of birth cohorts, the measures that are used, and the research made possible. We argue that improving the methodological tools for measuring social and biological exposures, incorporating the complexity of participant experience, and ensuring that longitudinal studies are recognised by a wider range of disciplines are essential for collaborative biosocial research with the goal of mitigating health disparities in global and public health.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fRAmework of the DetermInants of Arts aNd Cultural Engagement (RADIANCE): integrated insights from ecological, behavioural and complex adaptive systems theories","authors":"D. Fancourt, Katey Warran","doi":"10.12688/wellcomeopenres.21625.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.21625.1","url":null,"abstract":"Background Arts and cultural engagement (ACEng) is ubiquitous across every human culture since palaeolithic times, but in contemporary society, ACEng is unevenly distributed, demographically, socio-economically, geographically and politically. But what are the “determinants” of ACEng (i.e., the facilitators or barriers to people’s engagement) and how can they be optimised? Despite a large body of theory and evidence on individual determinants, this work has largely occurred in disciplinary silos, which has led variously to contrasting discourses and approaches, criticism, and inconsistent findings. What we lack is a rigorous comprehensive understanding of these determinants (both those already theorised and those that have been little recognised as determinants to date) that goes beyond descriptively showing inequalities, instead explaining why these inequalities exist and how they can be overcome. This paper explores the currently recognised determinants of ACEng, and existing theoretical approaches to these determinants. Methods Drawing on the theoretical bases of ecological systems theory, ecosocial theory and complex adaptive systems science, we conducted a review and iterative theorising process. Results We propose a new theoretical framework of the determinants of arts and cultural engagement (RADIANCE) developed through cross-disciplinary literature reviewing, domain mapping, and consensus building. Conclusions Overall, we identified 35 different factors that can act as determinants of ACEng across micro, meso, exo, macro and chrono levels. We broadly categorised these as social (i.e. a primary feature being the interaction of people), tangible (i.e. a primary feature involving physical assets or resources or the production of physical assets), and intangible (i.e. constructs that do not have a primary physical basis but instead have a virtual or imaginary basis). The relevance and implications of this framework for broader research, policy, and practice and case studies of it in use are presented.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Barred Chestnut moth, Diarsia dahlii (Hübner, 1813)","authors":"David C. Lees","doi":"10.12688/wellcomeopenres.22587.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22587.1","url":null,"abstract":"We present a genome assembly from an individual female Diarsia dahlii (the Barred Chestnut; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 683.0 megabases in span. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.36 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,177 protein coding genes.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of the Smooth Rustic moth, Hoplodrina blanda ([Denis & Schiffermüller], 1775)","authors":"David C. Lees, I. Sims","doi":"10.12688/wellcomeopenres.22588.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22588.1","url":null,"abstract":"We present a genome assembly from an individual male Hoplodrina blanda (the Smooth Rustic; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 464.0 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.49 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,860 protein coding genes.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":" 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genome sequence of a hoverfly, Xylota segnis (Linnaeus, 1758)","authors":"Liam M. Crowley, Katie J. Woodcock","doi":"10.12688/wellcomeopenres.22582.1","DOIUrl":"https://doi.org/10.12688/wellcomeopenres.22582.1","url":null,"abstract":"We present a genome assembly from an individual male Xylota segnis (a hoverfly; Arthropoda; Insecta; Diptera; Syrphidae). The genome sequence is 422.9 megabases in span. Most of the assembly is scaffolded into 5 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.86 kilobases in length.","PeriodicalId":508490,"journal":{"name":"Wellcome Open Research","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}