Anales De La Real Academia Nacional De Farmacia最新文献

{"title":"Evaluation of an immunoassay for the antithyroglobulin and antithyroperoxidase measuring","authors":"J. L. Martı́n-Calderón","doi":"10.53519/analesranf.2023.89.02.05","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.05","url":null,"abstract":"Introduction: The measuring of antibodies against thyroglobulin (ATG) and thyroperoxydase (ATPO) is useful for identifying patients with autoimmunethyroiditis. This study tries to assess an electrochemiluminescent immunoassay for ATG and ATPO, evaluating imprecision, linearity, analytic sensitivity, carry-over and the influence of endogenous interferents. Material and methods: Imprecision was assessed using three pools with different analytes concentrations, performing within run and between run 20 times. Fort the linearity study a sample containing high analyte concentration and a solvent devoid of analyte were combined, obtaining intermediates concentrations, which were analyzed by triplicate. The limit of detection was calculated analyzing 20 times a sample devoid of analyte. Carry-over was evaluated analyzing a sample with a high antibody concentration followed by other one containing low antibody concentration. The interference study was carried-out adding hemolyzed, Intralipid 30% and bilirubin into sera pool. Results: Total imprecision obtained (%) were 26.63, 9.53, and 14.9 for ATG and 21.19, 14.82, and 5.77 for ATPO. Linearity was defined for the following regression equations: Y=6.61+1.01X (ATG) and, Y=16.37+0.97X (ATPO). The limit of detection was 17.17 for ATG and 5 for ATPO. Carry-over was not significant. Hemolysis caused significant interference in both assays. Conclusions: Imprecision obtained were similar to the manufacturer declared ones. Analytic sensibility complies the manufacturer’s specifications. The behavior of both assays was linear and significant carry-over was not found. Hemolysis interferes in both assays.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of chronic statin use on the hydration status of older people","authors":"Sara López-Oliva, A. M. Puga, Carmela Maza-Albarrán, Ana M Montero-Bravo, M. L. Samaniego-Vaesken, Mar Ruperto, T. Partearroyo, G. Varela-Moreiras","doi":"10.53519/analesranf.2023.89.02.02","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.02","url":null,"abstract":"Introduction: Elderly people on chronic drug treatment are one of the population groups with the highest risk of developing alterations in hydration status. One of the drugs most consumed by this population group and that can trigger the onset of dehydration are statins. However, up to date, these interactions have not been studied in depth. Objective: The objective of this study was to evaluate the influence of chronic statin consumption on hydration status in elderly people attending the community pharmacy. Methods: A case-control study was conducted in volunteers aged between 60 and 79 years living in Madrid, chronic statin users (cases) and patients of the same age range, non-users of statin drugs. chronic form (controls). Results: Analysis of general population data revealed a high prevalence of overweight and obesity, as well as a high percentage of body fat. On the other hand, the urinalysis showed a better hydration status of women compared to men. Regarding the effect of statins on hydration status, it was observed that the different parameters analyzed in patients on chronic statin treatment were indicative of dehydration, compared to the adequate hydration status of patients without treatment. These results were confirmed by analyzing the prevalence of dehydration in the different groups. Conclusions: The importance of monitoring the chronic consumption of drugs, such as statins, in the elderly, to avoid the development of pathologies, including the appearance of dehydration and its associated complications, is concluded from the present study. Community pharmacists as expert professionals in the medication are the most suitable professionals to carry out this follow-up.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Drugs Recently Authorized by EMA and FDA (Q2, 2023)","authors":"Santiago Cuéllar Rodríguez","doi":"10.53519/analesranf.2023.89.02.10","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.10","url":null,"abstract":"EMA (EUROPEAN MEDICINES AGENCY): (A) TRACTO ALIMENTARIO Y METABOLISMO: Cipaglucosidasa Alfa (Pombiliti®): enfermedad de Pompe. Pegunigalsidasa Alfa (Elfabrio®): enfermedad de Fabry. Velmanasa Alfa (Lamzede®): alfa manosidosis. (B) SANGRE Y SISTEMA HEMATOPOYÉTICO: Vadadustat (Vafseo®): anemia por insuficiencia renal. (D) DERMATOLOGÍA: Ruxolitinib (Opzelura®): vitíligo. (J) ANTIINFECCIOSOS SISTÉMICOS: Vacuna COVID-19 recombinante (Bimervax®): COVID-19. Vacuna Virus Respiratorio Sincitial (Arexvy®): Virus respiratorio sincitial. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Ivosidenib (Tibsovo®): leucemia mieloide aguda. Mirikizumab (Omvoh®): Colitis ulcerosa.FDA (U.S. FOOD & DRUG ADMINISTRATION): (A) TRACTO ALIMENTARIO Y METABOLISMO: Esporas de microbiota fecal viva (Vowst®): recurrencia de infección por Clostridioides difficile . (B) SANGRE Y SISTEMA HEMATOPOYÉTICO: Efanesostocog alfa (Altuviiio®): hemofilia. Omidubicel (Omisirge®): trasplante de sangre de cordón umbilical. (D) DERMATOLOGÍA: Beremagene Geperpavec (Vyjuzek®): epidermolisis ampollosa. (G) SISTEMA GENITOURINARIO Y HORMONAS SEXUALES: Fezolinetant (Veozah®): sofocos asociados a menopausia. (J) ANTIINFECCIOSOS SISTÉMICOS: Rezafungina (Rezzayo®): candidiasis invasiva. Durlobactam/Sulbactam (Xacduro®): neumonía por Acinetobacter. (L) AGENTES ANTINEOPLÁSICOS E INMUNOMODULADORES: Ratifanlimab (Zynyz®): carcinoma de células de Merkel. Leniolisib (Joenja®): síndrome de PI3K-delta activado. Epcoritamab (Epkinly®): linfoma de células B. Glofitamab (Columvi®): linfoma de células B. (N) SISTEMA NERVIOSO: Tofersen (Qalsody®): esclerosis lateral amiotrófica. (S) ÓRGANOS SENSORIALES: Perfluorohexiloctano (Miebo®): ojo seco. (V) VARIOS: Flotufolastat F-18 (Posluma®): diagnóstico por imagen (PET).","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"191 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart medicines and medical devices: Opportunity or chimera?","authors":"Angel Concheiro Nine","doi":"10.53519/analesranf.2023.89.02.08","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.08","url":null,"abstract":"Medicines and medical devices capable of controlling the release of drugs and active substances in response to stimuli can significantly improve the therapeutic efficacy of treatments already implemented and open up new possibilities for advancing in the field of personalized medicine. Stimulus-responsive systems enable precise delivery of active substances at the right place and time and at the most convenient rate using lower doses than are required using conventional strategies. Advances in this field are directly linked to the evolution of materials science that makes it possible to have biomaterials and excipients that are not only bioactive but also modulators of the biological response. Activation-modulated and feedback-regulated controlled-release systems, based on bioinspired approaches, have already demonstrated their potential in the preclinical phases. The successful clinical use of some of them is an encouragement to continue advancing in this field.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active cannabinoid nanocarriers for the treatment of atherosclerosis","authors":"Lucía Martín-Navarro, Lucía Martín-Banderas, María Dolores Herrera","doi":"10.53519/analesranf.2023.89.02.06","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.06","url":null,"abstract":"In order to selectively deliver cannabinoid drugs (CB2 agonists) to the atherosclerotic plaque, biocompatible and biodegradable nanoparticles have been obtained. For this purpose, the PEGylated nanoparticles have been functionalized with a peptide capable of selectively binding to endothelial adhesion proteins overexpressed in the atherosclerotic plaque (vascular cell adhesion molecules 1, VCAM-1). The particles have been characterized physicochemically, in vitro in cell cultures and in vivo in an animal model of atherosclerosis (apolipoprotein E-deficient ApoE-/- mice), demonstrating optimal spatiotemporal control of cannabinoid release and superior pharmacological response. Given that CB2 agonist drugs present high lipophilicity and low availability, the introduction of selective nanosystems for the vehiculation of these antiatherogenic drugs would improve their bioavailability and efficacy. The work presented shows part of the results obtained from a previous project. These results have supported us for the award of a new funding grant to address a more advanced strategy involving the introduction of diagnostic elements and a phytocannabinoid.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichomonas vaginalis: diagnosis of a forgotten sexually transmitted infection","authors":"Judit Ester Méndez Izquierdo, Cristina Fonseca Berzal, Alexandra Ibáñez Escribano","doi":"10.53519/analesranf.2023.89.02.01","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.01","url":null,"abstract":"Trichomonas vaginalis is the protozoan parasite causative of one of the curable sexually transmitted infections that shows the highest annual incidence worldwide. However, the diagnostic methods most frequently used, are not sensitive enough and therefore, a large percentage of cases are not detected, especially in asymptomatic people. These traditional tests are not fast enough, and most of them are not suitable for carrying out diagnosis in men, with the consequent aggravation of the situation. In the last decades, new diagnostic techniques for trichomoniasis have been developed, which show much more acceptable sensitivity and specificity values, making it possible to reduce the time to diagnosis. Accordingly, their implementation could lead to a result in a few hours and thus, facilitate the start of treatment in those cases in which it is needed. In this framework, a bibliographic review of the most relevant techniques is carried out in the present work, including tests that are available for diagnosis in men, as well as for the detection of co-infections, highlighting their usefulness and both the advantages and disadvantages of each one.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A profession, a (bio)ethics. A conceptual vision","authors":"A. F. Pinto Marques","doi":"10.53519/analesranf.2023.89.02.04","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.04","url":null,"abstract":"The pharmaceutical profession has a unique scope of intervention in the area of health, where the pharmacist can be found in all domains related to access to health care, at its most varied levels. All this scope is based on a broad academic training, where scientific knowledge and expertise confer skills that are directly reflected on the pharmaceutical profession and practice. The professional practice of the pharmacist is very diverse and can be observed in various circumstances, from direct contact with the patient, with the person, as in community pharmacy, hospital pharmacy, clinical analysis laboratory, palliative or continuous care, in nursing homes, to in more reserved situations, such as in the laboratory or in scientific and clinical research. This wide range of activity of the pharmacist, supported by individual labor relations or integrated into multidisciplinary health teams, requires from him an assertive behavior and a (bio)ethical awareness that allows him to respond to the different demands he faces in his daily life. It is important, therefore, to reflect on the concepts and assumptions that ethics or bioethics have in the professional life of pharmacist, in the area of health and life sciences, and in the personal life of each one.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The “Academia de farmacia Santa María de España de la región de Murcia”: origin and history","authors":"S. Moreno Grau","doi":"10.53519/analesranf.2023.89.02.03","DOIUrl":"https://doi.org/10.53519/analesranf.2023.89.02.03","url":null,"abstract":"The founding of Regional Academies is a consequence of these regions assuming the constitutional authority to “foment culture and research.” The “Academia de Farmacia Santa María de España de la Región de Murcia” was founded in 2002 as a result of this authority. Its name calls to mind the military order founded in 1270 by Alfonso X el Sabio, who was closely connected to the Region of Murcia. The emblem of the Academy depicts two decorated shields. One of the shields has an eight-pointed star with Saint Mary holding Jesus in one arm and the bowl of Hygieia in the other. “Fechos allend mar” is written on the bottom and “strela do dia” on the top. The other shield has the name of the Academy in gold letters. Over the space between the two shields are seven crowns referring to the seven times Murcia was a kingdom. The Academy has inherited an Academic tradition related to the Health Sciences that has been present in Cartagena since the 17th century. This tradition includes the “Academia Médico Práctica”; the “Academia Médico-Farmacéutica” and the “Academia Médico-Quirúrgica”. The “Academia Médico Práctica” was established around 1740. Information about this Academy can be found in Anastasio Chinchilla’s work and, between 1786 and 1788, in the Semanario Literario y Curioso de Cartagena, which is an interesting publication we will refer to briefly. King Carlos IV authorized an Academy with the same name to be founded in 1803 by Royal Decree, and we have sporadic information about this Academy throughout the first half of the 19th century. In 1880, the “Academia Médico-Farmacéutica” of Cartagena was established as a restructuring of the Medical-Pharmaceutical Association founded in the city in 1874 after the devastation of the Cantonal Rebellion. This Academy was active until separate Medical and Pharmaceutical Associations were authorized in 1900 for Cartagena and La Unión. In 1929, the “Academia Médido-Quirúrgica” was created, maintaining ties with the Medical-Pharmaceutical Association. Both the “Academia Médico-Farmacéutica” and that of Physicians and Surgeons had their own publications. The “Academia Médico-Farmacéutica” published a journal called The Union of Medical Science in Cartagena between 1881 and 1887. The “Academia Médico-Quirúrgica” published Medical News in Murcia, where information about the Academy appeared in 1929 and 1930. As can be seen, the “Academia de Farmacia Santa María de España de la Región de Murcia” has inherited its vocation for science and dissemination from these Academies.","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Santiago Grisolía and Kansas City","authors":"M. Cascales Angosto","doi":"10.53519/analesranf.2022.88.04.01","DOIUrl":"https://doi.org/10.53519/analesranf.2022.88.04.01","url":null,"abstract":"","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47789569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Montecarlo Simulation for risk assessment in the Development of an analytical method according to the principles of quality by design (QbD)","authors":"Fernando Ferrándiz Vindel","doi":"10.53519/analesranf.2022.88.05.03","DOIUrl":"https://doi.org/10.53519/analesranf.2022.88.05.03","url":null,"abstract":"Montecarlo simulation is a powerful tool to identify influencing factors and intervals in which to carry out analytical development tests, although as it is a mathematical model, it must be experimentally confirmed. The results obtained and presented in the work confirm that this tool allows the previous analysis of the sources of analytical variability and its importance within the risk assessment phase. With this, the subsequent experimental confirmation must be mainly focused on the use of the variables revealed with the Montecarlo simulation, saving resources and time that do not add value to the global process of analytical development.\u0000\u0000Keywords: Montecarlo simulation; QbD; analytical method","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48992676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}