{"title":"Evaluation of systemic Omega-3 PUFAs effect on orthodontic tooth movement in a rabbit model: RCT.","authors":"Asser M Gad, Samia O Soliman","doi":"10.2319/110222-750.1","DOIUrl":"https://doi.org/10.2319/110222-750.1","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of systemic administration of omega-3 fatty acids on orthodontic tooth movement (OTM) with histological analysis.</p><p><strong>Materials and methods: </strong>OTM was induced in 20 adult albino New Zealand rabbits, divided into omega-3 and control groups, with nickel-titanium coil springs for 21 days. Omega-3 or saline was given every day via oral gavage during the experimental period. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling after 21 days of OTM.</p><p><strong>Results: </strong>A significant difference in OTM amount was found in the third week of OTM with means of 1.445 ± 0.13 and 1.72 ± 0.15 for the experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant increase in osteoblastic activity in the omega-3 group after 3 weeks.</p><p><strong>Conclusions: </strong>Strong evidence of the osteoclastic inhibitory effect of systemic omega-3 was found, which reduced the percentage and amount of OTM.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"476-481"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294573/pdf/i1945-7103-93-4-476.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does YouTube offer high-quality ınformation? Evaluation of patient experience videos after orthognathic surgery.","authors":"Elif Albayrak, Muhammed Hilmi Büyükçavuş","doi":"10.2319/042522-315.1","DOIUrl":"https://doi.org/10.2319/042522-315.1","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the content, reliability, and quality of videos of patient experiences after orthognathic surgery on YouTube.</p><p><strong>Materials and methods: </strong>Fifty videos that met the inclusion criteria were analyzed. The demographic characteristics of the videos were determined, and 13 points were used to classify poor and rich-content videos. The quality of the videos was evaluated using the Video Information and Quality Index (VIQI), Global Quality Score (GQS), and DISCERN. The Mann-Whitney U-test, Spearman correlation, and linear regression analysis were used for statistical analysis.</p><p><strong>Results: </strong>When poor- and rich-content videos were evaluated, there were statistically significant differences in video duration, number of likes, number of comments, and interaction index (P < .05). Compared to the poor-content video group, the GQS score, DISCERN, total content, and VIQI score of the rich-content video group were significantly higher. The interaction index and video duration and video information content quality showed a positive relationship.</p><p><strong>Conclusions: </strong>Although the quality of the videos shared by patients on YouTube was generally moderate, the content of the information was generally poor. Nevertheless, it should be considered that YouTube videos can be a source of information for patients who want to have surgery, which can affect the process.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"409-416"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294570/pdf/i1945-7103-93-4-409.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9723821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of anterior open bite and an ankylosed incisor by applying multiloop edgewise archwire, mini-implants, and dentoalveolar distraction.","authors":"Tae-Woo Kim, Soon Jung Hwang, Tingxi Wu","doi":"10.2319/070122-472.1","DOIUrl":"https://doi.org/10.2319/070122-472.1","url":null,"abstract":"<p><p>An 18.7-year-old female patient with an anterior open bite and an ankylosed left maxillary central incisor was referred from a private orthodontic clinic. Canine relationships were Class II and molar relationships were Class I. The open bite was closed with the multiloop edgewise archwire and up-and-down elastics. The maxillary left central incisor was extruded by dentoalveolar distraction assisted with mini-implants. Active treatment took 2 years and 1 month, and the treatment result remained stable 14 months after debonding.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"482-492"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294582/pdf/i1945-7103-93-4-482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A coupled-lines system to determine the anteroposterior position of maxillary central incisors for smiling profile esthetics.","authors":"Bin Li, Xiang Xiang, Gao Huang, Peiqi Wang, Chaoran Xue, Xianglong Han, Ding Bai, Hui Xu","doi":"10.2319/073022-529.1","DOIUrl":"https://doi.org/10.2319/073022-529.1","url":null,"abstract":"OBJECTIVES\u0000To develop a coupled-lines system to determine the anteroposterior position of maxillary central incisors (U1) for smiling profile esthetics.\u0000\u0000\u0000MATERIALS AND METHODS\u0000Thirty Asian females with ordinary and good facial harmony were selected as the study sample and the control sample, respectively. Three-dimensional facial images and 45°- and 90°-angled profiles were collected. The anteroposterior relationships between U1 and upper- and mid-facial soft tissue landmarks were measured. By morphing photos of the study sample, two artificial images were created to represent the well-balanced 45°- and 90°-angled profiles and were further processed with combined variations of soft tissue subnasale (SSn)-Glabella and the mid-point of facial axial points of the bilateral central incisor (mFA)-SSn distances. Esthetic assessments were performed on these images by layperson (n = 94) and orthodontist (n = 94) raters.\u0000\u0000\u0000RESULTS\u0000Both upper- and mid-facial soft tissue landmarks were indispensable in assessing anteroposterior positions of U1 for well-balanced smiling profiles. As assessed in 45°- and 90°-angled profiles, the most esthetically sensitive parameters were mFA-Glabella and mFA-SSn distances. A coupled-lines system was constructed, comprising the Glabella and SSn vertical lines. In smiling profiles with optimal esthetics, the mFA point was at 2 to 5 mm posterior to the Glabella vertical and concomitantly 4 to 7 mm posterior to the SSn vertical, as perceived by orthodontists. Laypersons gave a wider range for mFA-Glabella distances, at 2 to 6 mm.\u0000\u0000\u0000CONCLUSIONS\u0000The coupled-lines system could serve as a reliable reference for determining esthetically optimal anteroposterior positions of U1 for female facial profiles.","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"447-457"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294574/pdf/i1945-7103-93-4-447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-ligating brackets do not reduce discomfort or pain when compared to conventional orthodontic appliances in Class I patients: a clinical study.","authors":"Gracia Costa Lopes, Gilson Kazuo Watinaga, Antônio Sérgio Guimarães, Lidia Audrey Rocha Valadas, Juliana Ramacciato","doi":"10.2319/050822-346.1","DOIUrl":"https://doi.org/10.2319/050822-346.1","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the intensity, location, and short-term impact of the periodontal discomfort/pain, as well as the related functional parameters of bite force and masticatory efficiency, between self-ligating and conventional orthodontic appliances.</p><p><strong>Materials and methods: </strong>In 20 patients referred for orthodontic treatment, samples were collected from the gingival sulcus to evaluate the level of substance P using enzyme-linked immunosorbent assay. Orthodontic devices were randomly bonded, with self-ligating appliances on one side and conventional brackets on the contralateral side. Pain threshold (PT), maximal bite force (MBF), and masticatory efficiency (ME) were assessed using standard validated techniques at the beginning of the treatment and 24 hours post-orthodontic activation with an 0.016-inch nickel-titanium wire.</p><p><strong>Results: </strong>There were no significant differences (P > .05) in the substance P levels, PT, MBF, and ME between the self-ligating and conventional orthodontic appliances.</p><p><strong>Conclusions: </strong>There was no difference between conventional and self-ligating appliances in the parameters of pain: substance P and pressure. Functional aspects, such as pain, discomfort, and masticatory efficiency, should not be considered when making a therapeutic decision regarding the use of self-ligating vs conventional orthodontic appliances.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"398-402"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294580/pdf/i1945-7103-93-4-398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alan Yee, Wendy Chu, Pramod Sinha, Amir Mohajeri, Man Hung, Donna Kritz-Silverstein
{"title":"Effects of perceived vs actual frequency of rewards on orthodontic patient attitudes and compliance.","authors":"Alan Yee, Wendy Chu, Pramod Sinha, Amir Mohajeri, Man Hung, Donna Kritz-Silverstein","doi":"10.2319/060122-403.1","DOIUrl":"https://doi.org/10.2319/060122-403.1","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the longitudinal association of different reward schedules on patient compliance (as measured by oral hygiene assessments). The cross-sectional associations of actual vs perceived rewards frequency on patient attitudes were also examined.</p><p><strong>Materials and methods: </strong>138 patients undergoing treatment at a university orthodontic clinic were surveyed to collect information on perceived frequency of rewards, likelihood of making patient referrals, and attitudes toward reward programs and orthodontic treatment. Oral hygiene assessment from the most recent appointment and actual frequency of rewards were obtained from patient charts.</p><p><strong>Results: </strong>Among participants, 44.9% were male, age ranged from 11 to 18 (mean = 14.9 ± 1.7) years; treatment time ranged from 9 to 56 (mean = 23.2 ± 9.8) months. Mean perceived frequency of rewards was 48% while actual frequency of rewards was 19.6%. There were no significant differences in attitudes by actual reward frequency (P > .10). However, those who perceived always receiving rewards were significantly more likely to have more positive opinions of reward programs (P = .004 and P = .024). Age- and treatment-time adjusted analyses showed that always receiving actual rewards was associated with odds of good oral hygiene 3.8 times (95% CI = 1.13, 13.09) higher than those never/rarely receiving actual rewards, but there was no association between perceived rewards and odds of good oral hygiene. Actual and perceived reward frequencies were significantly and positively correlated (r = 0.40, P < .001).</p><p><strong>Conclusions: </strong>It is beneficial to give rewards to patients as often as possible to maximize compliance (as shown by hygiene ratings) and foster positive attitudes.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"433-439"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294581/pdf/i1945-7103-93-4-433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient perceptions and attitudes regarding post-orthodontic treatment changes.","authors":"Nurver Karslı, Irmak Ocak, Burak Gülnar, Tamer Tüzüner, Simon J Littlewood","doi":"10.2319/100222-677.1","DOIUrl":"https://doi.org/10.2319/100222-677.1","url":null,"abstract":"<p><strong>Objectives: </strong>To determine patient perceptions and attitudes regarding posttreatment changes at least 2 years after completion of orthodontic treatment.</p><p><strong>Materials and methods: </strong>A total of 125 patients (75 females, 50 males, aged 22.93 ± 2.98 years) were enrolled at least 2 years after debonding. Participants had either vacuum-formed retainers (VFRs) or bonded retainers (BRs). Posttreatment changes were evaluated digitally by comparing tooth positions at debonding and at least 2 years after debonding. A questionnaire was used to assess patient attitudes. Retainer usage, awareness of relapse, satisfaction with their current occlusion, and whether posttreatment changes were severe enough for them to consider retreatment were investigated.</p><p><strong>Results: </strong>All patients showed some posttreatment changes in irregularity. Only 74% of patients wearing VFRs and 47.1% of patients wearing BRs were aware of posttreatment changes. Patients were more likely to notice posttreatment changes if there was an increase in mandibular irregularity of 1-3 mm. Awareness of posttreatment changes in the upper arch was higher in both groups. The majority of participants were satisfied with the results even if they noticed some minor posttreatment changes (VFR, 69.4%; BR, 76.5%). Dissatisfaction with posttreatment changes did not necessarily mean that a patient wanted retreatment.</p><p><strong>Conclusions: </strong>A total of 26% of patients wearing VFRs and 52.9% of patients wearing BRs were unaware of posttreatment changes. Approximately half of the patients who noticed posttreatment changes were still satisfied with the result 2 years after debonding. Even patients dissatisfied with the effect of posttreatment changes do not necessarily want retreatment.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"440-446"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294576/pdf/i1945-7103-93-4-440.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comparison of maxillary canine retraction into healed and recent extraction sites using cone beam computed tomography: a randomized clinical trial.","authors":"Salam Ghazwan Almaasarani, Nada Rajeh","doi":"10.2319/110522-757.1","DOIUrl":"https://doi.org/10.2319/110522-757.1","url":null,"abstract":"<p><strong>Objectives: </strong>To compare maxillary canine retraction between healed and recent extraction sites by assessing movement rate, canine dentoalveolar changes, molar rotation, and anchorage loss using cone-beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>Twenty-eight patients (16-26 years old) who had bimaxillary protrusion and orthodontic treatment planned with extraction of first premolars were randomly distributed into two groups and treated using a straight wire appliance. In the recent group (RG), the upper first premolars were extracted 2 weeks before the initiation of canine retraction (after tooth alignment). In the healed group (HG), the upper first premolars were extracted before tooth alignment. Movement rate, canine dentoalveolar changes, molar rotation, and anchorage loss were assessed using CBCT.</p><p><strong>Results: </strong>Movement rate, canine alveolar bone dimensions, canine rotation, and rotation and mesial movement of the first molar were not significantly different between groups (P > .05). Canine tipping was greater in RG (P = .001).</p><p><strong>Conclusions: </strong>Retracting canines into recent extraction sites compared with healed sites showed greater distal tipping of the canine with no differences in movement rate, canine alveolar bone dimensions, canine rotation, molar rotation, and anchorage loss.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"382-389"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294575/pdf/i1945-7103-93-4-382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of orthodontic camouflage treatment vs orthodontic-orthognathic surgical treatment on condylar stability in Class II hyperdivergent patients with severe temporomandibular joint osteoarthrosis: a retrospective observational study.","authors":"Yajing Tian, Bochun Mao, Shengjie Cui, Yanning Guo, Ningrui Zhao, Yidan Zhang, Yanheng Zhou, Xuedong Wang","doi":"10.2319/090622-622.1","DOIUrl":"https://doi.org/10.2319/090622-622.1","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the differences in profile changes and stability of the condyles between orthodontic camouflage treatment assisted by vertical control and that accomplished via orthognathic surgery in Class II hyperdivergent patients with TMJ osteoarthrosis (TMJOA).</p><p><strong>Materials and methods: </strong>This study included 27 Class II hyperdivergent TMJOA patients (54 condyles) who received orthodontic camouflage treatment (13 patients) or orthognathic surgery (14 patients) Cone-beam computerized tomography (CBCT) scans were taken before treatment (T1) and 1 year after treatment (T2). Cephalometric and TMJ measurement analyses were conducted to evaluate the change in profile and condyles from T1 to T2 using independent samples t-test and paired t-test. Three-dimensional (3D) deviation analysis was also performed to evaluate the stability of condyles from T1 to T2.</p><p><strong>Results: </strong>Both groups showed significant profile improvement from T1 to T2. The changes in Z angle and ANB angle were larger in the surgical group than in the orthodontic group. Condylar width, length, and height remained stable after treatment in the orthodontic group (P > .05), while they reduced by 0.67 ± 0.85 mm, 1.14 ± 1.10 mm, and 1.07 ± 1.34 mm, respectively, in the surgical group (P < .05). Superior, posterior, medial, and lateral joint spaces were significantly reduced in the orthodontic group (P < .05). 3D deviations intuitively showed that condylar bone in the orthodontic group was more stable than that in the surgical group.</p><p><strong>Conclusions: </strong>For Class II hyperdivergent patients with severe TMJOA, orthodontic camouflage treatment with vertical control can effectively maintain the stability of condyles while significantly improving the profile. Surgical treatment yields a better profile but may increase the risk of condyle resorption.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"458-466"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294572/pdf/i1945-7103-93-4-458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhenxing Tang, Weichang Chen, Li Mei, Ehab A Abdulghani, Zhihe Zhao, Yu Li
{"title":"Relative anchorage loss under reciprocal anchorage in mandibular premolar extraction cases treated with clear aligners.","authors":"Zhenxing Tang, Weichang Chen, Li Mei, Ehab A Abdulghani, Zhihe Zhao, Yu Li","doi":"10.2319/102222-727.1","DOIUrl":"https://doi.org/10.2319/102222-727.1","url":null,"abstract":"<p><strong>Objectives: </strong>To compare mandibular relative anchorage loss (RAL) under reciprocal anchorage between first and second premolar extraction cases in bimaxillary protrusion mild crowding cases treated using clear aligner therapy (CAT).</p><p><strong>Materials and methods: </strong>Adult patients who met the following criteria were included: treated using CAT with bilateral mandibular premolar extractions and space closure using intra-arch reciprocal anchorage. RAL was defined as the percent molar mesial movement relative to the sum of molar mesial plus canine distal movement. Movements of the mandibular central incisor (L1), canine (L3), and first molar (L6) were measured based on superimposition of the pre- and post-treatment dentition and jaw models.</p><p><strong>Results: </strong>Among the 60 mandibular extraction quadrants, 38 had lower first premolar (L4) and 22 had lower second premolar (L5) extracted. L6 mesial movement was 2.01 ± 1.11 mm with RAL of 25% in the L4 extraction group vs 3.25 ± 1.19 mm with RAL of 40% in the L5 extraction group (P < .001). Tooth movement efficacy was 43% for L1 occlusogingival movement, 75% for L1 buccolingual inclination, 60% for L3 occlusogingival movement, and 53% for L3 mesiodistal angulation. L1 had unwanted extrusion and lingual crown torquing whereas L3 had unwanted extrusion and distal crown tipping, on which the power ridges or attachments had little preventive effect.</p><p><strong>Conclusions: </strong>The average mandibular reciprocal RAL is 25% or 40% for extraction of L4 or L5, respectively, in CAT cases. A RAL-based treatment planning workflow is proposed for CAT extraction cases.</p>","PeriodicalId":50790,"journal":{"name":"Angle Orthodontist","volume":"93 4","pages":"375-381"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294577/pdf/i1945-7103-93-4-375.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}