Evaluation of systemic Omega-3 PUFAs effect on orthodontic tooth movement in a rabbit model: RCT.

IF 3 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Angle Orthodontist Pub Date : 2023-07-01 DOI:10.2319/110222-750.1

Asser M Gad, Samia O Soliman

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引用次数: 0

Abstract

Objectives: To evaluate the effect of systemic administration of omega-3 fatty acids on orthodontic tooth movement (OTM) with histological analysis.

Materials and methods: OTM was induced in 20 adult albino New Zealand rabbits, divided into omega-3 and control groups, with nickel-titanium coil springs for 21 days. Omega-3 or saline was given every day via oral gavage during the experimental period. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling after 21 days of OTM.

Results: A significant difference in OTM amount was found in the third week of OTM with means of 1.445 ± 0.13 and 1.72 ± 0.15 for the experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant increase in osteoblastic activity in the omega-3 group after 3 weeks.

Conclusions: Strong evidence of the osteoclastic inhibitory effect of systemic omega-3 was found, which reduced the percentage and amount of OTM.

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评价全身性Omega-3 PUFAs对兔正畸牙齿运动的影响:随机对照试验。

目的:通过组织学分析评价欧米茄-3脂肪酸对正畸牙齿运动的影响。材料与方法:将20只成年白化新西兰兔进行OTM诱导，分为omega-3组和对照组，用镍钛线圈弹簧诱导21 d。实验期间每天灌胃Omega-3或生理盐水。处死动物进行骨移植21天后牙槽骨重塑的组织形态学分析。结果:实验组与对照组在第3周的OTM量差异有统计学意义，分别为1.445±0.13和1.72±0.15。组织形态学分析显示，3周后，omega-3组活跃骨吸收腔隙面积显著减少，成骨细胞活性显著增加。结论:系统性omega-3具有明显的破骨抑制作用，可降低OTM的百分比和数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angle Orthodontist 医学-牙科与口腔外科

CiteScore

6.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The Angle Orthodontist is the official publication of the Edward H. Angle Society of Orthodontists and is published bimonthly in January, March, May, July, September and November by The EH Angle Education and Research Foundation Inc. The Angle Orthodontist is the only major journal in orthodontics with a non-commercial, non-profit publisher -- The E. H. Angle Education and Research Foundation. We value our freedom to operate exclusively in the best interests of our readers and authors. Our website www.angle.org is completely free and open to all visitors.