Behavioural Neurology最新文献

{"title":"Association between Ambient Illumination and Cognitive Impairment: A Population-Based Study of Older.","authors":"Tieyi Shi,&nbsp;Baozhong Chen","doi":"10.1155/2023/4131377","DOIUrl":"https://doi.org/10.1155/2023/4131377","url":null,"abstract":"<p><p>It is well-established that light therapy can alleviate cognitive impairment, and ambient illumination (AI) can quantify the amount of exposure to light. However, the relationship between AI and cognitive impairment has been largely understudied. <i>Objectives</i>. We aimed to examine the cross-sectional associations between AI and impaired cognition using data from the National Health and Nutrition Examination Survey (NHANES) (2011-2013) database. <i>Methods</i>. The correlation between AI and cognitive impairment was analyzed using multivariate logistic regression models. Nonlinear correlations were explored using curve fitting. <i>Results</i>. Multivariate logistic regression yielded an OR of 0.872 (95% CI 0.699, 1.088) for the association between AI and cognitive impairment after adjusting for covariates. Smooth curve fitting showed that the correlation was nonlinear, with an inflection point at 1.22. <i>Conclusions</i>. These results suggested that the level of AI may be linked to cognitive impairment. We found a nonlinear relationship of AI with cognitive impairment.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"4131377"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Functioning in Adults with Phenylketonuria in a Cohort of Spanish Patients.","authors":"P M Luna,&nbsp;J F López-Paz,&nbsp;M García,&nbsp;I Amayra,&nbsp;O Martínez,&nbsp;M Pérez,&nbsp;A A Rodríguez,&nbsp;P Pérez-Núñez,&nbsp;I Ceberio,&nbsp;N Mansilla,&nbsp;C Soria","doi":"10.1155/2023/9681740","DOIUrl":"https://doi.org/10.1155/2023/9681740","url":null,"abstract":"<p><p>The early introduction of a low phenylalanine (Phe) diet has been demonstrated to be the most successful treatment in subjects with phenylketonuria (PKU), especially for preventing severe cognitive and neurological damages. However, it still concerns that even if treated in the first months of life with supplements and following a diet, they can show slight scores below people without PKU in neuropsychological assignments. We investigated 20 adults with classical PKU aged 19-48 years (mean age 29 years) and 20 heathy controls matched by age, gender, and years of education. Patients and controls were assessed with an extended neuropsychological battery, as well as psychological aspects and quality of life, also the last Phe level result was obtained. Results showed that the most affected cognitive domains are processing speed, executive functioning, memory, and also theory of mind, but very well-preserved verbal fluency, language, and visuospatial functioning. In quality of life, some significant results were seen specially in anxiety of Phe levels, anxiety of Phe levels during pregnancy, guilt if poor adherence to supplements, and if dietary protein restriction not followed. No significant results were obtained for the psychological variables. In conclusion, it has been shown that a combination of a low Phe diet, supplement intake, and keeping Phe levels in a low range seems appropriate to have the most normal and alike cognitive performance to persons without PKU.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9681740"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management Practice and Clinical Outcomes of Dementia in Sub-Saharan Africa: A Systematic Review.","authors":"Dessale Abate Beyene,&nbsp;Alemseged Beyene Berha","doi":"10.1155/2023/2307443","DOIUrl":"https://doi.org/10.1155/2023/2307443","url":null,"abstract":"<p><strong>Background: </strong>Dementia is a severe neurodegenerative disorder and it is a group of acquired symptoms associated with impaired cognitive functions. In low-income settings particularly in Sub-Saharan Africa (SSA), it is often seen as part of normal aging. Environmental, behavioral, and lifestyle interventions have the potential to alter the disease course of dementia.</p><p><strong>Objective: </strong>This study is aimed to synthesize the literature/evidence(s) on the management practice and treatment outcomes of dementia in SSA.</p><p><strong>Method: </strong>Comprehensive literature was searched in PubMed database, Cochrane Library, and Google Scholar. Eligibility has been set, and based on the criteria, initially, a total of 442 results were obtained, and from those around 183 articles were duplicated. After examining titles and abstracts of records 26 articles were identified. Finally, five randomized clinical trials (RCT) and three prospective cohort studies that were reported on the management practice and treatment outcome of dementia in SSA were eligible for analysis. RCT and prospective cohort studies were used to strengthen the quality of evidence. The quality of the included RCT studies was assessed by using the Cochrane Risk of Bias Tool.</p><p><strong>Result: </strong>A total of 2781 patient data were included in the final analysis. Of these, 2354 patients were obtained from 5 RCTs and 427 patients from 3 prospective cohort studies, which were conducted in SSA countries. RCT studies were done on the feasibility and clinical effectiveness of cognitive stimulation therapy (CST) showed improvements in language memory domains and physical health. In addition, studies that focus on the management of human immunodeficiency virus-associated dementia (HIVAD) were reported to improve neurocognitively.</p><p><strong>Conclusion: </strong>CST is applicable in low-resource settings and it shows improvements in cognitive function and quality of life. Early initiation of combination antiretroviral therapy in resource-limited settings has been associated with improvement in the cognitive function of HIVAD.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"2307443"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: A Rapid Artificial Intelligence-Based Computer-Aided Diagnosis System for COVID-19 Classification from CT Images.","authors":"Behavioural Neurology","doi":"10.1155/2023/9876194","DOIUrl":"https://doi.org/10.1155/2023/9876194","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/2560388.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9876194"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Effects of Acupuncture and Rehabilitation Training on Limb Movement and Living Ability of Patients with Hemiplegia after Stroke.","authors":"Behavioural Neurology","doi":"10.1155/2023/9878720","DOIUrl":"https://doi.org/10.1155/2023/9878720","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/2032093.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9878720"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringin Protects against Tau Hyperphosphorylation in A<i>β</i> _25-35-Injured PC12 Cells through Modulation of ER, PI3K/AKT, and GSK-3<i>β</i> Signaling Pathways.","authors":"Qi Qiu,&nbsp;Xia Lei,&nbsp;Yueying Wang,&nbsp;Hui Xiong,&nbsp;Yanming Xu,&nbsp;Huifeng Sun,&nbsp;Hongdan Xu,&nbsp;Ning Zhang","doi":"10.1155/2023/1857330","DOIUrl":"https://doi.org/10.1155/2023/1857330","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common form of dementia and a significant social and economic burden. Estrogens can exert neuroprotective effects and may contribute to the prevention, attenuation, or even delay in the onset of AD; however, long-term estrogen therapy is associated with harmful side effects. Thus, estrogen alternatives are of interest for countering AD. Naringin, a phytoestrogen, is a key active ingredient in the traditional Chinese medicine Drynaria. Naringin is known to protect against nerve injury induced by amyloid beta-protein (A<i>β</i>) _25-35, but the underlying mechanisms of this protection are unclear. To investigate the mechanisms of naringin neuroprotection, we observed the protective effect on A<i>β</i> _25-35-injured C57BL/6J mice's learning and memory ability and hippocampal neurons. Then, an A<i>β</i> _25-35 injury model was established with adrenal phaeochromocytoma (PC12) cells. We examined the effect of naringin treatment on A<i>β</i> _25-35-injured PC12 cells and its relationship with estrogen receptor (ER), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), and glycogen synthase kinase (GSK)-3<i>β</i> signaling pathways. Estradiol (E₂) was used as a positive control for neuroprotection. Naringin treatment resulted in improved learning and memory ability, the morphology of hippocampal neurons, increased cell viability, and reduced apoptosis. We next examined the expression of ER<i>β</i>, p-AKT (Ser473, Thr308), AKT, p-GSK-3<i>β</i> (Ser9), GSK-3<i>β</i>, p-Tau (Thr231, Ser396), and Tau in PC12 cells treated with A<i>β</i> _25-35 and either naringin or E₂, with and without inhibitors of the ER, PI3K/AKT, and GSK-3<i>β</i> pathways. Our results demonstrated that naringin inhibits A<i>β</i> _25-35-induced Tau hyperphosphorylation by modulating the ER, PI3K/AKT, and GSK-3<i>β</i> signaling pathways. Furthermore, the neuroprotective effects of naringin were comparable to those of E₂ in all treatment groups. Thus, our results have furthered our understanding of naringin's neuroprotective mechanisms and indicate that naringin may comprise a viable alternative to estrogen therapy.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"1857330"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression.","authors":"Kai Guo,&nbsp;Lingling Fang,&nbsp;Mingjian Li,&nbsp;Aizheng Li,&nbsp;Na Liu","doi":"10.1155/2023/4190849","DOIUrl":"https://doi.org/10.1155/2023/4190849","url":null,"abstract":"<p><p>Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505. Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"4190849"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10698176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Ensemble Classification Approach for Sarcasm Detection.","authors":"Behavioural Neurology","doi":"10.1155/2023/9820206","DOIUrl":"https://doi.org/10.1155/2023/9820206","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/9731519.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9820206"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in the Treatment of Abnormal Muscle Tone in Children with Cerebral Palsy: A Meta-Analysis.","authors":"Yan Yuanjie,&nbsp;Xue Jianyi,&nbsp;Xu Jinyan,&nbsp;Huang Mao,&nbsp;Yan Siyang,&nbsp;Yin Zhenjin","doi":"10.1155/2023/4662788","DOIUrl":"https://doi.org/10.1155/2023/4662788","url":null,"abstract":"<p><strong>Objective: </strong>To analyse the clinical efficacy of acupuncture and routine treatment in improving dystonia in children with cerebral palsy.</p><p><strong>Method: </strong>The randomized controlled trials published from the establishment of the databases to August 2022 on acupuncture in the treatment of dystonia in children with cerebral palsy were collected and comprehensively searched in China national knowledge infrastructure (CNKI), weipu (VIP), Wanfang, SinoMed, PubMed, Excerpta medica database (EMBASE), and Cochrane Library. The literature was selected according to the established standards, the quality of the included studies was evaluated, the heterogeneity of the included studies was evaluated with the <i>I</i>² test, and the appropriate model was selected for analysis. Sensitivity analysis was used to evaluate the reliability of the results, and a funnel plot was used to evaluate the publication bias.</p><p><strong>Results: </strong>Fifteen studies were included in the meta-analysis. The control group was treated with routine treatment and acupuncture combined with routine treatment. The outcome index showed that the effect in the treatment group was better: Modified Ashworth Scale score: -0.52, 95% confidence interval (CI) (-0.62 to -0.41), <i>p</i> < 0.01. The treatment group showed reduced muscle tension to a greater extent (integral eletromyographic (iEMG) score: standard mean square deviation = -2.97, 95% CI (-4.87 to -1.06), <i>p</i> < 0.01). The effective rate in the control group was 74.2% and that in the treatment group was 91.5%, odds ratio = 3.70, 95% CI (2.02-6.78), <i>p</i> < 0.01. The funnel plot showed publication bias.</p><p><strong>Conclusion: </strong>Acupuncture combined with routine training could improve muscle tension abnormalities and improve the efficiency of clinical treatment.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"4662788"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters.","authors":"Mahdieh Anoush,&nbsp;Soroush Bijani,&nbsp;Fatemeh Moslemifar,&nbsp;Fatemeh Jahanpour,&nbsp;Ali Kalantari-Hesari,&nbsp;Mir-Jamal Hosseini","doi":"10.1155/2023/9652513","DOIUrl":"https://doi.org/10.1155/2023/9652513","url":null,"abstract":"<p><p>Alzheimer's disease (AD), as the main cause of dementia, has a progressive and neurodegenerative pattern with number of cases increasing over the next decades. Therefore, discovering an effective treatment with the ability to invert memory impairment and pathophysiological events of AD seems to be required. The present study performed to investigate the probable effects of Edaravone (EDV) in AD-like disorder induced by intracerebroventricular streptozotocin (ICV-STZ) administration in mice. This study also compares the two different methods of ICV-STZ in the memory impairment induction. NMRI male mice were administrated with 3 mg/kg of STZ for two times during 48 hours span, and after 24 hours, animals were treated with EDV (5 and 10 mg/kg), Donepezil, and Memantine for 14 days. After behavioral tests regarding memory and cognitive function, animals were sacrificed, and the hippocampi were utilized for further analyses. Our results demonstrated that administration of STZ induced memory impairment in the Morris water maze (MWM) test and decreased the discriminative factor in novel object recognition (NOR). The biochemical output shows a significant decrease in ferric reducing antioxidant power (FRAP) and glutathione (GSH) levels followed by increase in malondialdehyde (MDA) and protein carbonylation (PCO) levels. The output showed no difference between the patterns of AD-like disorder induction. Following our treatment groups, administration of EDV (5 and 10 mg/kg), Donepezil, and Memantine significantly improved memory performance and discriminatory behavior. Aforementioned treatments managed to improve FRAP and GSH content of hippocampus, while significantly attenuating MDA, PCO, and nitric oxide overproduction. In addition, no significant difference has been observed between the effect of 5 and 10 mg/kg EDV application. It was supposed that EDV managed to ameliorate memory dysfunction, discriminatory behavior, oxidative stress, and cellular antioxidant power in a dose-independent pattern in mice.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9652513"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9859751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}