Behavioural Neurology最新文献

{"title":"<i>Cucurbita maxima</i> Seeds Reduce Anxiety and Depression and Improve Memory.","authors":"Shahana Wahid,&nbsp;Ali Alqahtani,&nbsp;Rafeeq Alam Khan","doi":"10.1155/2023/7509937","DOIUrl":"10.1155/2023/7509937","url":null,"abstract":"<p><p>The current study was planned to assess the neuropharmacological benefits of the <i>Cucurbita maxima</i> seed. These seeds have been conventionally used for the nutritional as well as amelioration of various diseases. However, there was a need to provide a pharmacological basis for such use. Four central nervous system-related functions, that is, anxiety, depression, memory, and motor coordination, were evaluated, and the levels of brain biogenic amines were also assessed. Anxiety was evaluated through selected experimental models, such as light and dark apparatus, elevated plus maze, head dip, and open field test. The head dip test was mainly used to assess exploratory behavior. Depression was assessed by two animal models, that is, the forced swim test and tail suspension test. Memory and learning ability were assessed by the passive avoidance test, stationary rod apparatus, and Morris's water maze test. Motor skilled learning was assessed by stationary rod and rotarod apparatus. Reversed phase high-pressure liquid chromatography was used to determine biogenic amine levels. Results reveal that <i>C. maxima</i> exhibited anxiolytic and antidepressant effects with memory improvement. There was a reduction in the weight of the animal following chronic administration. Furthermore, no remarkable effects were observed on motor coordination. Norepinephrine was found elevated, which may be linked to its antidepressant effects. These biological effects of <i>C. maxima</i> may be due to the presence of secondary metabolites, such as cucurbitacin, beta-sitosterol, polyphenolic compounds, citrulline, kaempferol, arginine, <i>β</i>-carotene, quercetin, and other antioxidants. The outcomes of the present study authenticate that the chronic use of <i>C. maxima</i> seeds reduces the intensity of neurological problems like anxiety and depression.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"7509937"},"PeriodicalIF":2.8,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9609097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of Clinically Relevant Executive Functions Tests Performance after COVID-19.","authors":"Boris B Velichkovsky, Anna Y Razvaliaeva, Alena A Khlebnikova, Piruza A Manukyan, Vladimir N Kasatkin, Artem V Barmin","doi":"10.1155/2023/1094267","DOIUrl":"10.1155/2023/1094267","url":null,"abstract":"<p><p>It is widely known that COVID-19 has a number of prolonged effects on general health, wellbeing, and cognitive functioning. However, studies using differentiated performance measures of cognitive functions are still not widely spread making it hard to assess the exact functions that get impaired. Taking into account the similarities between post-COVID 'brain fog' and chemofog, we hypothesized that executive functions (EF) would be impaired. Literature search yielded six studies with 14 effect sizes of interest; pooled effect size was small to medium (<i>d</i> = -0.35). Combined with a narrative synthesis of six studies without a comparison group, these results show that EF get impaired after COVID-19; although, in most cases the impairment is transient and does not seem to be severe. These results specify the picture of 'brain fog' and may help to discover its mechanisms and ways of helping people with long COVID.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"1094267"},"PeriodicalIF":2.7,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Customer Experience towards the Product during a Coronavirus Outbreak.","authors":"Behavioural Neurology","doi":"10.1155/2023/9842478","DOIUrl":"https://doi.org/10.1155/2023/9842478","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/4279346.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9842478"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigallocatechin Gallate Ameliorates Nicotine Withdrawal Conditions-Induced Somatic and Affective Behavior Changes in Mice and Its Molecular Mechanism.","authors":"Mahardian Rahmadi,&nbsp;Ahmad D Nurhan,&nbsp;Retno I A Rahmawati,&nbsp;Theresia F Damayanti,&nbsp;Djoko A Purwanto,&nbsp;Junaidi Khotib","doi":"10.1155/2023/5581893","DOIUrl":"https://doi.org/10.1155/2023/5581893","url":null,"abstract":"<p><p>In nicotine withdrawal (NW) conditions, molecular changes, such as increasing corticotropin-releasing factor (CRF) in the amygdala, and melanocortin signaling in the hypothalamus, can occur in the brain, leading to increased feeding behavior and body weight as somatic changes as well as high anxiety-like behavior as an affective changes. Therefore, this research aimed to investigate the effect of epigallocatechin gallate (EGCG), the largest component in green tea, on CRF, pro-opiomelanocortin (POMC), and melanocortin four receptor gene expression in the brain under NW conditions. The 24 Balb/c male mice used were randomly divided into four groups. The doses used included normal saline 1.0 mL/kg as a control group, and nicotine 3.35 mg/kg that was administered subcutaneously three times a day. After NW conditions, EGCG 50 mg/kg was administered intraperitoneally two times a day. Behavior evaluation was performed to measure somatic and affective changes, and the animal was sacrificed for molecular analysis. The results showed that NW conditions significantly increased food intake, body weight, and anxiety-like behavior compared with the normal group. Meanwhile, EGCG significantly decreased food intake, body weight, and anxiety-like behavior compared with NW conditions in mice without EGCG. The polymerase chain reaction results also showed that EGCG decreased the CRF mRNA expression in the amygdala and increased the POMC. This indicated that EGCG improved somatic and affective behavior in NW conditions by decreasing CRF mRNA expression in the amygdala and increasing POMC mRNA expression in the hypothalamus.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"5581893"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Ambient Illumination and Cognitive Impairment: A Population-Based Study of Older.","authors":"Tieyi Shi,&nbsp;Baozhong Chen","doi":"10.1155/2023/4131377","DOIUrl":"https://doi.org/10.1155/2023/4131377","url":null,"abstract":"<p><p>It is well-established that light therapy can alleviate cognitive impairment, and ambient illumination (AI) can quantify the amount of exposure to light. However, the relationship between AI and cognitive impairment has been largely understudied. <i>Objectives</i>. We aimed to examine the cross-sectional associations between AI and impaired cognition using data from the National Health and Nutrition Examination Survey (NHANES) (2011-2013) database. <i>Methods</i>. The correlation between AI and cognitive impairment was analyzed using multivariate logistic regression models. Nonlinear correlations were explored using curve fitting. <i>Results</i>. Multivariate logistic regression yielded an OR of 0.872 (95% CI 0.699, 1.088) for the association between AI and cognitive impairment after adjusting for covariates. Smooth curve fitting showed that the correlation was nonlinear, with an inflection point at 1.22. <i>Conclusions</i>. These results suggested that the level of AI may be linked to cognitive impairment. We found a nonlinear relationship of AI with cognitive impairment.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"4131377"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Functioning in Adults with Phenylketonuria in a Cohort of Spanish Patients.","authors":"P M Luna,&nbsp;J F López-Paz,&nbsp;M García,&nbsp;I Amayra,&nbsp;O Martínez,&nbsp;M Pérez,&nbsp;A A Rodríguez,&nbsp;P Pérez-Núñez,&nbsp;I Ceberio,&nbsp;N Mansilla,&nbsp;C Soria","doi":"10.1155/2023/9681740","DOIUrl":"https://doi.org/10.1155/2023/9681740","url":null,"abstract":"<p><p>The early introduction of a low phenylalanine (Phe) diet has been demonstrated to be the most successful treatment in subjects with phenylketonuria (PKU), especially for preventing severe cognitive and neurological damages. However, it still concerns that even if treated in the first months of life with supplements and following a diet, they can show slight scores below people without PKU in neuropsychological assignments. We investigated 20 adults with classical PKU aged 19-48 years (mean age 29 years) and 20 heathy controls matched by age, gender, and years of education. Patients and controls were assessed with an extended neuropsychological battery, as well as psychological aspects and quality of life, also the last Phe level result was obtained. Results showed that the most affected cognitive domains are processing speed, executive functioning, memory, and also theory of mind, but very well-preserved verbal fluency, language, and visuospatial functioning. In quality of life, some significant results were seen specially in anxiety of Phe levels, anxiety of Phe levels during pregnancy, guilt if poor adherence to supplements, and if dietary protein restriction not followed. No significant results were obtained for the psychological variables. In conclusion, it has been shown that a combination of a low Phe diet, supplement intake, and keeping Phe levels in a low range seems appropriate to have the most normal and alike cognitive performance to persons without PKU.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9681740"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management Practice and Clinical Outcomes of Dementia in Sub-Saharan Africa: A Systematic Review.","authors":"Dessale Abate Beyene,&nbsp;Alemseged Beyene Berha","doi":"10.1155/2023/2307443","DOIUrl":"https://doi.org/10.1155/2023/2307443","url":null,"abstract":"<p><strong>Background: </strong>Dementia is a severe neurodegenerative disorder and it is a group of acquired symptoms associated with impaired cognitive functions. In low-income settings particularly in Sub-Saharan Africa (SSA), it is often seen as part of normal aging. Environmental, behavioral, and lifestyle interventions have the potential to alter the disease course of dementia.</p><p><strong>Objective: </strong>This study is aimed to synthesize the literature/evidence(s) on the management practice and treatment outcomes of dementia in SSA.</p><p><strong>Method: </strong>Comprehensive literature was searched in PubMed database, Cochrane Library, and Google Scholar. Eligibility has been set, and based on the criteria, initially, a total of 442 results were obtained, and from those around 183 articles were duplicated. After examining titles and abstracts of records 26 articles were identified. Finally, five randomized clinical trials (RCT) and three prospective cohort studies that were reported on the management practice and treatment outcome of dementia in SSA were eligible for analysis. RCT and prospective cohort studies were used to strengthen the quality of evidence. The quality of the included RCT studies was assessed by using the Cochrane Risk of Bias Tool.</p><p><strong>Result: </strong>A total of 2781 patient data were included in the final analysis. Of these, 2354 patients were obtained from 5 RCTs and 427 patients from 3 prospective cohort studies, which were conducted in SSA countries. RCT studies were done on the feasibility and clinical effectiveness of cognitive stimulation therapy (CST) showed improvements in language memory domains and physical health. In addition, studies that focus on the management of human immunodeficiency virus-associated dementia (HIVAD) were reported to improve neurocognitively.</p><p><strong>Conclusion: </strong>CST is applicable in low-resource settings and it shows improvements in cognitive function and quality of life. Early initiation of combination antiretroviral therapy in resource-limited settings has been associated with improvement in the cognitive function of HIVAD.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"2307443"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: A Rapid Artificial Intelligence-Based Computer-Aided Diagnosis System for COVID-19 Classification from CT Images.","authors":"Behavioural Neurology","doi":"10.1155/2023/9876194","DOIUrl":"https://doi.org/10.1155/2023/9876194","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/2560388.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9876194"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Effects of Acupuncture and Rehabilitation Training on Limb Movement and Living Ability of Patients with Hemiplegia after Stroke.","authors":"Behavioural Neurology","doi":"10.1155/2023/9878720","DOIUrl":"https://doi.org/10.1155/2023/9878720","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/2032093.].</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"9878720"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringin Protects against Tau Hyperphosphorylation in A<i>β</i> _25-35-Injured PC12 Cells through Modulation of ER, PI3K/AKT, and GSK-3<i>β</i> Signaling Pathways.","authors":"Qi Qiu,&nbsp;Xia Lei,&nbsp;Yueying Wang,&nbsp;Hui Xiong,&nbsp;Yanming Xu,&nbsp;Huifeng Sun,&nbsp;Hongdan Xu,&nbsp;Ning Zhang","doi":"10.1155/2023/1857330","DOIUrl":"https://doi.org/10.1155/2023/1857330","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common form of dementia and a significant social and economic burden. Estrogens can exert neuroprotective effects and may contribute to the prevention, attenuation, or even delay in the onset of AD; however, long-term estrogen therapy is associated with harmful side effects. Thus, estrogen alternatives are of interest for countering AD. Naringin, a phytoestrogen, is a key active ingredient in the traditional Chinese medicine Drynaria. Naringin is known to protect against nerve injury induced by amyloid beta-protein (A<i>β</i>) _25-35, but the underlying mechanisms of this protection are unclear. To investigate the mechanisms of naringin neuroprotection, we observed the protective effect on A<i>β</i> _25-35-injured C57BL/6J mice's learning and memory ability and hippocampal neurons. Then, an A<i>β</i> _25-35 injury model was established with adrenal phaeochromocytoma (PC12) cells. We examined the effect of naringin treatment on A<i>β</i> _25-35-injured PC12 cells and its relationship with estrogen receptor (ER), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), and glycogen synthase kinase (GSK)-3<i>β</i> signaling pathways. Estradiol (E₂) was used as a positive control for neuroprotection. Naringin treatment resulted in improved learning and memory ability, the morphology of hippocampal neurons, increased cell viability, and reduced apoptosis. We next examined the expression of ER<i>β</i>, p-AKT (Ser473, Thr308), AKT, p-GSK-3<i>β</i> (Ser9), GSK-3<i>β</i>, p-Tau (Thr231, Ser396), and Tau in PC12 cells treated with A<i>β</i> _25-35 and either naringin or E₂, with and without inhibitors of the ER, PI3K/AKT, and GSK-3<i>β</i> pathways. Our results demonstrated that naringin inhibits A<i>β</i> _25-35-induced Tau hyperphosphorylation by modulating the ER, PI3K/AKT, and GSK-3<i>β</i> signaling pathways. Furthermore, the neuroprotective effects of naringin were comparable to those of E₂ in all treatment groups. Thus, our results have furthered our understanding of naringin's neuroprotective mechanisms and indicate that naringin may comprise a viable alternative to estrogen therapy.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2023 ","pages":"1857330"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}