Best Practice & Research Clinical Obstetrics & Gynaecology最新文献_第9页

Best Practice & Research clinical obstetrics & gynaecology 临床妇产科最佳实践与研究。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-12-15 DOI: 10.1016/j.bpobgyn.2024.102574

Kate Swanson , Mary E. Norton

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引用次数: 0

The clinical relevance of having more than one estrogen in combined hormonal contraception to address the needs of women 在联合激素避孕中使用一种以上雌激素以满足妇女需要的临床意义。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-11-30 DOI: 10.1016/j.bpobgyn.2024.102571

Caroline Frisendahl , Helena Kopp Kallner , Kristina Gemzell-Danielsson

{"title":"The clinical relevance of having more than one estrogen in combined hormonal contraception to address the needs of women","authors":"Caroline Frisendahl , Helena Kopp Kallner , Kristina Gemzell-Danielsson","doi":"10.1016/j.bpobgyn.2024.102571","DOIUrl":"10.1016/j.bpobgyn.2024.102571","url":null,"abstract":"<div><div>This chapter examines the potential of natural estrogens, particularly estradiol and estetrol, in combined hormonal contraceptive pills as alternatives to the widely used synthetic ethinyl estradiol. Current evidence highlights the promise of these natural estrogens in providing effective contraception with improved safety profiles and maintained tolerability.</div></div><div><h3>What we know</h3><div>Estradiol and estetrol exhibit favorable safety and efficacy profiles compared to ethinyl estradiol.</div></div><div><h3>What we think we know</h3><div>Initial studies suggest that estetrol combined with drosperinone provide effective contraception with a predictable bleeding patternand reduced risk for venous thromboembolism compared to ethinyl estradiol containing pills. Such risk may also be further mitigated by non-oral administration of estradiol.</div></div><div><h3>What we do not know</h3><div>Long-term efficacy and safety data are needed to confirm the benefits of natural estrogens and their impact on diverse populations and comorbid conditions. By addressing these gaps, future research can enhance our understanding of natural estrogens in hormonal contraception, ultimately refining their use in clinical practice.</div></div>","PeriodicalId":50732,"journal":{"name":"Best Practice & Research Clinical Obstetrics & Gynaecology","volume":"98 ","pages":"Article 102571"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving access to emergency obstetric care in low- and middle-income countries 改善低收入和中等收入国家获得产科急诊的机会。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1016/j.bpobgyn.2024.102572

Lawrence Chauke

引用次数: 0

Common myths and misconceptions surrounding hormonal contraception 关于激素避孕的常见神话和误解。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1016/j.bpobgyn.2024.102573

Kirsten I. Black , Maxime Vromman , Rebecca S. French

引用次数: 0

Preface: Emergency obstetrics in low- and middle-income countries 前言：低收入和中等收入国家的产科急诊。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-12-19 DOI: 10.1016/j.bpobgyn.2024.102576

Nnabuike Chibuoke Ngene (Dr), Jagidesa Moodley (Emeritus Professor)

引用次数: 0

Fetal imaging, phenotyping, and genomic testing in modern prenatal diagnosis 胎儿成像，表型，和基因组检测在现代产前诊断。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2025-02-01 Epub Date: 2024-12-15 DOI: 10.1016/j.bpobgyn.2024.102575

Matthew A. Shear , Peter N. Robinson , Teresa N. Sparks

引用次数: 0

Chapter 2: Non-invasive prenatal diagnosis 第 2 章：无创产前诊断

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-09-03 DOI: 10.1016/j.bpobgyn.2024.102544

Stephanie K. Allen , Samantha Doyle

{"title":"Chapter 2: Non-invasive prenatal diagnosis","authors":"Stephanie K. Allen , Samantha Doyle","doi":"10.1016/j.bpobgyn.2024.102544","DOIUrl":"10.1016/j.bpobgyn.2024.102544","url":null,"abstract":"<div><p>Non-invasive prenatal diagnosis of monogenic disorders is becoming integrated into routine clinical care for many indications. This is carried out by testing cell-free DNA extracted from the plasma portion of a maternal blood sample. The cell-free DNA is low in concentration, and consists of a mixture of maternal and fetally-derived DNA which are not easy to separate. Methods used therefore need to be rapid, sensitive and specific, including real-time PCR, digital PCR and next generation sequencing with complex algorithms. Testing may be required for pregnancies with an increased chance of a monogenic disorder due to family history or carrier status, or where there are specific abnormalities identified by ultrasound scan. In these situations, testing is considered to be diagnostic and therefore does not require confirmation by invasive testing. With increased access to genomic technologies, and more diagnoses for rare disease patients, future demand for NIPD and possibilities during pregnancy will continue.</p></div>","PeriodicalId":50732,"journal":{"name":"Best Practice & Research Clinical Obstetrics & Gynaecology","volume":"97 ","pages":"Article 102544"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521693424000981/pdfft?md5=67f63cdfe0eec4ee6d24c6e8306e5835&pid=1-s2.0-S1521693424000981-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post pregnancy family planning in Latin America and the Caribbean analysis and strengths in training on immediate contraception post obstetric event by CLAP/PAHO 拉丁美洲及加勒比地区产后计划生育分析和产后立即避孕培训的优势，CLAP/PAHO。

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI: 10.1016/j.bpobgyn.2024.102551

Rodolfo Gómez Ponce de León , Cristian Fabrizio Lombardo , Franco Dilascio , Gabriela Perrotta , Carlos A. León , Suzanne Jacob Serruya

{"title":"Post pregnancy family planning in Latin America and the Caribbean analysis and strengths in training on immediate contraception post obstetric event by CLAP/PAHO","authors":"Rodolfo Gómez Ponce de León , Cristian Fabrizio Lombardo , Franco Dilascio , Gabriela Perrotta , Carlos A. León , Suzanne Jacob Serruya","doi":"10.1016/j.bpobgyn.2024.102551","DOIUrl":"10.1016/j.bpobgyn.2024.102551","url":null,"abstract":"<div><div>Virtual courses developed by the Pan American Health Organization (PAHO) on family planning and immediate contraception post obstetric event (ICPOE) were launched in 2021 as training actions on ICPOE in the region. A total of 89,899 people enrolled in these courses; 36,494 (40.7%) of them enrolled in the course on ICPOE, and almost 60% of participants from Latin America passed the course. Moreover, 37% of participants were nurses, and 36% were physicians; most participants were from 20 to 39 years old. Eighty per cent completed the course in a week, and 89% had finished it by the 15th day. Students who passed the course expressed high overall satisfaction (95%), with ease of taking the course at home (63%) and at the workplace (33%) identified most frequently. Furthermore, practice training sessions (including simulation models) were conducted with 165 candidates to be trainers, physicians, and obstetricians. Approved trainers came from the Dominican Republic, Honduras, Bolivia, and Paraguay.</div></div><div><h3>Conclusion</h3><div>There was evidence of the need for ICPOE training, and the innovative virtual courses developed by PAHO.</div></div>","PeriodicalId":50732,"journal":{"name":"Best Practice & Research Clinical Obstetrics & Gynaecology","volume":"97 ","pages":"Article 102551"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal detection of copy number variants 产前检测拷贝数变异

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-09-07 DOI: 10.1016/j.bpobgyn.2024.102547

Mohamed Wafik , Alice Pendlebury-Watt , Kelly Price , Charlotte Tomlinson , Emma Fowler , Natalie Chandler , Muriel Holder-Espinasse

{"title":"Prenatal detection of copy number variants","authors":"Mohamed Wafik , Alice Pendlebury-Watt , Kelly Price , Charlotte Tomlinson , Emma Fowler , Natalie Chandler , Muriel Holder-Espinasse","doi":"10.1016/j.bpobgyn.2024.102547","DOIUrl":"10.1016/j.bpobgyn.2024.102547","url":null,"abstract":"<div><p>Prenatal detection of copy number variants (CNVs) plays an important role in the diagnosis of fetal genetic abnormalities. Understanding the methods used for prenatal CNV detection and their clinical significance contributes to the implementation of advanced genetic screening techniques in prenatal care; facilitating early identification and management of genetic disorders in fetuses. Some CNVs impose significant genetic counselling challenges; especially those which are associated with uncertain clinical significance, in the context of variable penetrance and/or expressivity or when identified incidentally.</p><p>This chapter focuses on the different techniques used for detecting CNVs, including Single Nucleotide Polymorphism (SNP) arrays, comparative genomic hybridization (CGH) arrays, Non-Invasive Prenatal Testing (NIPT), Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) as well as their advantages and limitations. The tools needed for the classification of CNVs and their clinical relevance are also explored, emphasising the importance of accurate interpretation for appropriate clinical management and genetic counselling.</p></div>","PeriodicalId":50732,"journal":{"name":"Best Practice & Research Clinical Obstetrics & Gynaecology","volume":"97 ","pages":"Article 102547"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal therapies – (Stem cell transplantation; enzyme replacement therapy; in utero genetic therapies) 胎儿疗法--（干细胞移植；酶替代疗法；子宫内遗传疗法）

IF 3.9 2区医学

Best Practice & Research Clinical Obstetrics & Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-09-11 DOI: 10.1016/j.bpobgyn.2024.102542

Rachel Sagar , Anna L. David

{"title":"Fetal therapies – (Stem cell transplantation; enzyme replacement therapy; in utero genetic therapies)","authors":"Rachel Sagar , Anna L. David","doi":"10.1016/j.bpobgyn.2024.102542","DOIUrl":"10.1016/j.bpobgyn.2024.102542","url":null,"abstract":"<div><p>Advances in ultrasound and prenatal diagnosis are leading an expansion in the options for parents whose fetus is identified with a congenital disease. Obstetric diseases such as pre-eclampsia and fetal growth restriction may also be amenable to intervention to improve maternal and neonatal outcomes. Advanced Medicinal Therapeutic Products such as stem cell, gene, enzyme and protein therapies are most commonly being investigated as the trajectory of treatment for severe genetic diseases moves toward earlier intervention. Theoretical benefits include prevention of in utero damage, smaller treatment doses compared to postnatal intervention, use of fetal circulatory shunts and induction of immune tolerance. New systematic terminology can capture adverse maternal and fetal adverse events to improve safe trial conduct. First-in-human clinical trials are now beginning to generate results with a focus on safety first and efficacy second. If successful, these trials will transform the care of fetuses with severe early-onset congenital disease.</p></div>","PeriodicalId":50732,"journal":{"name":"Best Practice & Research Clinical Obstetrics & Gynaecology","volume":"97 ","pages":"Article 102542"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521693424000968/pdfft?md5=3be5e279e0cb3b6beea5aec7f43a200e&pid=1-s2.0-S1521693424000968-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0