Perm Medical Journal最新文献

{"title":"Professional reliability of personnel and corporate wellness programs","authors":"N. N. Malyutina, K. V. Mudraya, S. V. Luzina","doi":"10.17816/pmj41268-79","DOIUrl":"https://doi.org/10.17816/pmj41268-79","url":null,"abstract":"To consider the key aspects of providing professional reliability of the personnel and their connection with the health preservation programs and transformation into corporate wellness programs. The importance of a healthy lifestyle is generally recognized. At the same time motivating employees to a healthy lifestyle is generally considered to be a complex task as well. The need to shift towards a comprehensive approach is noted, the development of corporate well-being programs aimed at supporting and improving the physical and psychological health of employees in particular, as well as enhancing their professional skills and qualities. This becomes a strategic move for the company, aimed at creating a healthy and supportive environment. Moreover, the development of such programs may not only be a business initiative but also align with the trends of the state policy of the Russian Federation. It can be confidently stated that the issue requires further discussion and exploration. \u0000A balanced approach to professional training, motivation, psychological support, and health programs is a key to creating a productive and steady labor potential for the enterprise.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"52 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems of teenage pregnancy: obstetric and perinatal outcomes","authors":"Е. N. Kravchenko, Т. P. Shevlyukovа, G. B. Beznoshchenko, I. А. Bulatovа","doi":"10.17816/pmj41252-60","DOIUrl":"https://doi.org/10.17816/pmj41252-60","url":null,"abstract":"The review describes the problems of teenage pregnancy. A characteristic feature of the course of gestation in adolescents is a significant number of complications accompanying it. The problem of teenage pregnancy should be prevented not only by medical professionals, but also regulated by means of appropriate legal, social and economic measures. \u0000Management of young first-time mothers` pregnancy should be based on earlier consultative follow-up and planned hospitalization for targeted treatment of complications, as well as a thorough risk assessment during gestation and childbirth.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"54 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific dysphoric disorders in epilepsy","authors":"A. G. Malov, A. A. Andrusenko, N. V. Selyanina","doi":"10.17816/pmj41261-67","DOIUrl":"https://doi.org/10.17816/pmj41261-67","url":null,"abstract":"To analyze affective-somatoform (dysphoric) disorders specific to epilepsy. \u0000Dysphoric disorders can be divided into 3 groups: “periictal” disorders, interictal dysphoric disorder and alternative affective-somatoform syndromes. There are 3 groups of risk factors for affective disorders in epilepsy including depressive and dysphoric: those associated with the disease, those associated with the treatment and those associated with psychosocial aspects. Treatment for depression in epilepsy includes medication and psychotherapy. At the first stage of drug therapy, anticonvulsants are corrected, and at the second, an antidepressant is added. Cognitive behavioral therapy is the most effective method of psychotherapy. \u0000Dysphoric disorders in epilepsy are presented by a wide range of conditions, both paroxysmal and non-paroxysmal, and have their own classification and development factors, which must be taken into account when choosing adequate therapy.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"16 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of competence of rural physicians in primary health care in the diagnosis of malignant neoplasms of main localizations","authors":"S. V. Novikova","doi":"10.17816/pmj412112-122","DOIUrl":"https://doi.org/10.17816/pmj412112-122","url":null,"abstract":"Objective. To analize the level of rural PHC doctors` competence on the issues of diagnosis and routing patients with suspected cancer. \u0000Materials and methods. The study was conducted using a survey of medical workers involved in the diagnosis of malignant neoplasms of four main localizations (specialist doctors and paramedics of examination rooms) of the Central District Hospital of five rural municipal districts of the Magnitogorsk oncological cluster of Chelyabinsk region. 35 physicians took part in the study. \u0000Results. The results of the survey were quite negative: the minority of respondents are aware of the exact duration of the mandatory initial diagnostic examination, the period of informing the oncologist about the patient diagnosed with cancer, and the scheme for assigning municipal medical organizations to outpatient oncology centers. \u0000Conclusions. The surveyed contingent is characterized by: low oncological alertness and unsatisfactory competence concerning the initial manifestations of malignancies; inclusion of symptoms of the formed cancer in the number of early manifestations of malignancies, which means that a doctor, unsure of the diagnosis, as if waiting for the appearance of an obvious, from his point of view, symptom of a tumor, and as a result, the patient has an advanced stage of cancer; 3) flawed ideas about the full list of necessary methods for diagnosing malignant neoplasms of leading localizations; unsatisfactory knowledge of regulatory documentation on the routing of patients with suspected cancer.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"97 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory therapy of precancers of the cervix – opinion of medical professionals and students","authors":"E. A. Lykova, E. A. Rosyuk","doi":"10.17816/pmj412104-111","DOIUrl":"https://doi.org/10.17816/pmj412104-111","url":null,"abstract":"Objective. To assess the relevance of immunomodulatory therapy of precancerous diseases of the cervix among medical professionals and students. Precancerous diseases of the cervix combine pathological processes characterized by the structural changes in the epithelium of the cervix. If not treated, they lead to the development of cervical cancer. At present there are no selective drugs for the human papillomavirus. To administer immunotropic medicines it is necessary to know the mechanism of effect on the immune system. \u0000Materials and methods. The study was conducted using an anonymous online questionnaire on the Google Forms platform (https://vk.com/away.php?utf=1to=https%3A%2F%2Fforms.gle%2FRtT7PktnCrLqBB1x8). The questionnaire is presented as part of a one-stage (cross-sectional) study. Data analysis was carried out using Microsoft Excel 2010 graphs and tables. Empirical, sociological and statistical research methods were used. The indicators of the structure of the respondents were calculated, the reliability of the differences was determined by the Student's t-criterion, confidence differences were considered at significance of p 0.05. \u0000Results. The average age of the respondents was 30.4 ± 10.8 years. 46 people (75.4 %) are aware of the possibility of using immunomodulation as therapy for precancerous diseases of the cervix, and 15 people (24.6 %) are not aware of it. 41 respondents (67.2 %) would administer the therapy themselves and their close people; 12 people (19.7 %) find it difficult to answer; 8 respondents (13.1 %) do not agree to administer the therapy. \u0000Conclusions. Medical students have an idea about immunomodulatory therapy in gynecology in 55.9 % of cases. Doctors of different specialties in 100 % of cases are aware of the treatment, see the benefits of prescribing drugs. Students` awareness of the possibilities of immunomodulatory therapy is sufficient, they get additional knowledge from clinical recommendations on the specialty in the practical course.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"21 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of dental mobility in elderly and senile patients with various types of dentition defects","authors":"A. E. Dorofeev, A. V. Sevbitov, A. S. Utiuzh, S. N. Mironov, E. S. Emelina, M. Yu. Kuztetsova","doi":"10.17816/pmj41296-103","DOIUrl":"https://doi.org/10.17816/pmj41296-103","url":null,"abstract":"Objective. To determine the differences in the degree of tooth mobility in elderly patients with various types of dentition defects. To establish and differentiate the degree of tooth mobility in relation to the type of dentition defect in elderly and senile patients. \u0000Materials and methods. 500 patients aged 60 to 75 divided into 4 groups were examined. In the first group of patients, terminal defects were revealed (on one or both sides). The second group consisted of patients with included defects (on one or both sides). The third group was presented by combined defects (included and not included). Patients with single standing teeth constituted the fourth group. Patients with complete absence of teeth were excluded from the study. The assessment of dental mobility was carried out using the Periodotest device. All studies on dental mobility were conducted as part of the initial examination of the patient. To obtain objective data, periotestometry was performed 2 times in each patient. Average periotestometry data were calculated for each patient. The average readings of periotestometry for different groups of patients were determined. \u0000Results. On the basis of the data obtained while comparing the results of periotestometry, in relation to the type of dentition defect, statistically significant differences were established (p 0.001) (method used: the Kraskel – Wallis criteria). The results of periotestometry obtained in patients of group 4 were significantly higher than in representatives of other examined groups. The least mobility according to the results of periotestometry was observed in groups 2 and 3. \u0000Conclusions. The study revealed significant differences in the degree of tooth mobility in relation to the type of dentition defect. In patients with single standing teeth, 2–3 degree of their mobility was determined, while patients with included defects had 1–2 degree of the mobility of existing teeth. The obtained data of periotestometry indicate the need to use unloading dentures in elderly patients, in order to preserve the remaining teeth in patients with single-standing teeth, as well as in patients with terminal defects of the dentition.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"36 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the occurrence of germline mutations BRCA12, PALB2, CHEK2, NBN in patients with pancreatic malignancies. Single-center cohort non-randomized retrospective study","authors":"V. E. Moiseenko, I. G. Kardanova, A. V. Pavlovsky, G. R. Avanesyan, D. A. Granov","doi":"10.17816/pmj41233-41","DOIUrl":"https://doi.org/10.17816/pmj41233-41","url":null,"abstract":"Objective. To analyze the frequency of carriage of BRCA12, PALB2, CHEK2, NBN mutations in patients with malignant neoplasms of pancreas. \u0000Materials and methods. The single-center cohort non-randomized retrospective study is based on the data of 82 patients who were examined and treated in Russian Research Center of Radiology and Surgical Technologies named after academician A.M. Granov from 2020 to 2022. Patients with confirmed ductal adenocarcinoma of pancreas were included into the study group. Screening of mutations in exons 2,10, 18, 19 of BRCA1 gene and exon 11 of BRCA2 gene was performed in these patients. In addition, oncological family histories were studied. \u0000Results. Analysis of medical documentation data showed that 18 (22 %) patients with pancreatic cancer had a hereditary oncological history. In this cohort of patients, 5 (28 %) had relatives with pancreatic cancer, 9 (50 %) had a family history of ovarian cancer, 2 (11 %) female relatives of patients in the study group were diagnosed with breast cancer before the age of 50, also 2 (11 %) patients had a history of more than 2 relatives who suffered from breast cancer and / or prostate cancer. When evaluating the results of revealing the mutations in the entire study group (82 patients), BRCA1 (c.5266dupC) was revealed in 8 patients (9.7 %), PALB-2 (c.1592delT) – in 2 patients (2.4 %), mutations CHEK2, NBN and BRCA2 were not diagnosed in any patient. 5 (6 %) patients who were BRCA1 mutation carriers and one patient with an established PALB2 mutation, according to the analysis of case histories, had no oncological history. None of the patients in the study group was a carrier of the BRCA2, CHEK2 and NBN mutations. \u0000Conclusions. Some patients with pancreatic cancer are carriers of germline mutations. Considering our data on the trend of association between germline mutations and pancreatic cancer, we can make an assumption about the prospect of using this indicator as one of the markers for early detection of pancreatic cancer not only in patients with hereditary risk factors for neoplasia, but also in patients without cancer anamnesis. To obtain the results, further observation of patients in the study group and randomized multicenter studies are required.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"33 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern methods of treatment of anal stenosis","authors":"M. Cherepenin, I. V. Lutkov, V. Gorsky","doi":"10.17816/pmj41211-18","DOIUrl":"https://doi.org/10.17816/pmj41211-18","url":null,"abstract":"Objective. To develop and put into practice a new combined method of anal stenosis surgical treatment based on laser plastic surgery of tissues with a diode laser. Assess the effectiveness of the technique based on the analysis of immediate and long-term results, postoperative complications, peculiarities of technical implementation, and features of the quality of patients` life. \u0000Materials and methods. The study involved 68 patients with anal stricture after the anal and (or) rectal surgery. All patients underwent laser correction of postoperative scar tissue. According to indications, botulinum toxin was injected into the internal sphincter and (or) PRP autoplasma perarectally. Surgery was performed under intravenous anesthesia with the addition of tumescent anesthesia or local anesthesia. Laser radiation from a diode device with a wavelength of 1.56 microns and a power of 10 W was applied. \u0000Results. There are no restrictions on laser correction of anal stenosis regardless of the type and complexity of anal stenosis, it is technically easy to use, minimizes the risk of postoperative complications and relapse of the disease, and has a highly effective treatment result. \u0000Conclusions. The technique is characterized by versatility and ease of use, highly effective results, high quality of patients` life, and it can be used routinely on an outpatient basis.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"52 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding of the etiology and pathogenesis of schizophrenia","authors":"V. V. Vanyukov, I. L. Gulyaeva, Е. R. Ganeeva, О. S. Sukhanova, Е. А. Zhvakina, E. М. Minkhazeva, Т. А. Baluyeva","doi":"10.17816/pmj41242-51","DOIUrl":"https://doi.org/10.17816/pmj41242-51","url":null,"abstract":"The current literature data on the etiology and pathogenesis of schizophrenia were analyzed. The research method is the analysis of scientific papers on this problem over the past 5 years, presented in the databases of eLibrary, National Library of Medicine and electronic versions of the journals “World Psychiatry Journal”, “The Lancet Psychiatry”, “Schizophrenia Bulletin” and others. Genetic, neurotransmitter, psycho-traumatic, sociocultural and other theories of the origin and development of schizophrenia are analyzed in the review. Schizophrenia is a disease difficult to verify and genetically determined. According to modern theories, the occurrence of schizophrenia and the appearance of symptoms can be influenced by metabolic disorders of neurotransmitters, psycho-traumatic factors, socio-cultural aspects of human life, while the anatomical subcortical structures of the brain are damaged.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"59 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary urolithiasis at a young age on the example of a clinical case","authors":"S. Styazhkina, P. G. Sannikov, D. Kuklin, S. G. Gushchin, R. Z. Galieva, G. R. Khaidarova","doi":"10.17816/pmj412123-129","DOIUrl":"https://doi.org/10.17816/pmj412123-129","url":null,"abstract":"To study the clinical features and course of urolithiasis in a young female patient, to suggest the cause of the simultaneous sudden formation of kidney stones in the patient and her mother within a year. \u0000Main provisions: urolithiasis (KSD) is one of the most common diseases of the urinary tract. The relevance of effective treatment of this problem arises from the steady increase in the number of patients around the world, especially in Russia. According to many researchers, this trend is due to the increase in life expectancy, changes in lifestyle and nutrition, as well as changes in the composition of water and climate conditions. Approximately two thirds of patients, develop the disease at the age from 30 to 60. Characteristic features of urolithiasis are repeated recurrence and a high incidence of complex forms, which complicates the treatment of such patients significantly. \u0000Diagnostic algorithm and treatment of urolithiasis are demonstrated in this article on the example of a medical history of a young patient with rapidly progressing urolithiasis. \u0000A similar disease with the same symptoms of urolithiasis was revealed in the patient’s parent a week later, which suggests a hereditary predisposition factor or manifestation of urolithiasis being dependent on the hard drinking water. \u0000The simultaneous sudden formation of kidney stones within a year in a patient at a young age and her mother emphasizes the hereditary nature of the disease. Probably, the peculiarities of national cuisine or the individual preferences of patients played a significant role in the development of the pathology. The composition of drinking water is extremely important. The patient is from the Republic of Bashkortostan, where water hardness is 7.8–8.0, which does not meet the standard.","PeriodicalId":507221,"journal":{"name":"Perm Medical Journal","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}