Central European Journal of Medicine最新文献_第10页

TRAP (Twin Reversed Arterial Perfusion) sequence TRAP(双动脉反向灌注)序列

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0340-9

A. Doronjski, T. Stojilković, Slobodan D Spasojevic, B. Milanović, V. Stojanović

引用次数: 1

The role of genetic and other biomarkers in NSCLC prognosis 遗传和其他生物标志物在非小细胞肺癌预后中的作用

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0290-2

D. Schveigert, S. Cicėnas, Jaroslav Bublevič, Renatas Aškinis, V. Šapoka, J. Didziapetriene

引用次数: 2

A fetus with meckel-gruber syndrome associated with isomerism 麦克尔-格鲁伯综合症与同分异构体有关的胎儿

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0304-0

T. Kitova, K. Kilova, B. Kitov, A. Masmoudi, D. Milkov, S. Gaigi

{"title":"A fetus with meckel-gruber syndrome associated with isomerism","authors":"T. Kitova, K. Kilova, B. Kitov, A. Masmoudi, D. Milkov, S. Gaigi","doi":"10.2478/s11536-013-0304-0","DOIUrl":"https://doi.org/10.2478/s11536-013-0304-0","url":null,"abstract":"Abstract. Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal malformation. As far as we know, the rate of incidence for the syndrome is 0.02 per 10,000 births. It is estimated that Meckel-Gruber syndrome accounts for 5% of all neural tube defects in Finland. Objective. The aim of this study is to present a case of a fetus with Meckel-Gruber syndrome associated with complete left isomerism. Method. The fetus was obtained after medical interruption of the pregnancy during the fifteenth gestational week. The mother was 36 years old and in a consanguineous marriage. The antenatal ultrasound examination revealed a polymalformative syndrome, leading to a postmortem examination. The fetopathological study of the fetus was conducted at the Centre for Maternity and Neonatology, Tunis, Tunisia, in 2008. Results. The female fetus had a significantly deformed ballooning abdomen, pes equinovarus, flexion of the wrist and a total posterior cleft palate. The central nervous system abnormalities were occipital encephalocele, cystic dilatation of the fourth ventricle, agenesis of corpus callosum and hydrocephalus. The study of the internal organs found dextrocardia, irregular lobulation of the lungs, left isomerism, and polysplenia. The microscopic examination revealed bilateral cystic dilation of the kidneys, fibrous proliferation of the liver and ectasic dilatation of the billiary ducts, representing a ductal plate malformation of the liver. Conclusion. The case is diagnosed with Meckel-Gruber syndrome associated with complete left isomerism, cleft palate and possibly Dandy-Walker syndrome.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"481-484"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0304-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Animal and human dentin microstructure and elemental composition 动物和人类牙本质的微观结构和元素组成

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0295-x

Nina Mlakar, Z. Pavlica, M. Petelin, J. Štrancar, P. Zrimšek, A. Pavlič

{"title":"Animal and human dentin microstructure and elemental composition","authors":"Nina Mlakar, Z. Pavlica, M. Petelin, J. Štrancar, P. Zrimšek, A. Pavlič","doi":"10.2478/s11536-013-0295-x","DOIUrl":"https://doi.org/10.2478/s11536-013-0295-x","url":null,"abstract":"Animal teeth are a common model in studies on dentin adhesive materials. The aim of this study was to compare microstructural parameters (density and diameter of dentinal tubules (DT), peritubular dentin (PTD) thickness, PTD and intertubular dentin (ITD) surface area) and chemical characteristics of canine, porcine, equine, and human root dentin. The middle layers of dentin were harvested just below a cemento-enamel junction from incisors and investigated by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDXS). SEM evaluation of the specimens revealed, that porcine dentin shared most similarities with human dentin. When comparing the density of DTs, canine dentin was also found to be similar to human dentin. Elemental composition of the root dentin did not differ significantly in porcine, equine and human dentin, but in canine dentin higher magnesium value in PTD compared to ITD was found. It is known that microstructural and chemical characteristics affect the strength of the adhesive bonds created among restorative materials and dentin. According to the results of this study, porcine dentin seems to be the most appropriate model to study dental materials to be used in human restorative dentistry.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"468-476"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0295-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Left gastric artery pseudoaneurysm as a sequelae of chronic pancreatitis: recognizing a life-threatening complication 胃左动脉假性动脉瘤作为慢性胰腺炎的后遗症:认识到危及生命的并发症

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0302-2

Deepak J. Pattanshetty, P. Bhat

引用次数: 2

Systemic capillary leak syndrome due to systemic inflammatory response syndrome in infants: a report on 31 patients 婴儿全身性炎症反应综合征致全身毛细血管渗漏综合征31例报告

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0292-0

Chun-yan Yang, P. Xu, Yu-jun Yang, Bao-yun Li, Shiliand Sun, Qiao-zhi Yang, Le-Xin Wang

{"title":"Systemic capillary leak syndrome due to systemic inflammatory response syndrome in infants: a report on 31 patients","authors":"Chun-yan Yang, P. Xu, Yu-jun Yang, Bao-yun Li, Shiliand Sun, Qiao-zhi Yang, Le-Xin Wang","doi":"10.2478/s11536-013-0292-0","DOIUrl":"https://doi.org/10.2478/s11536-013-0292-0","url":null,"abstract":"The aim of this study was to describe the clinical features, management strategies and outcomes of 31 infants with systemic capillary leak syndrome (SCLS) secondary to sepsis or systemic inflammatory response syndrome. There were 23 boys and 8 girls, with an average age 9.6 ± 2.1 days (range, 3.1 to 20 days). The primary disease was pneumonia in 11 patients and sepsis in other 20. Within 72 hrs of admission, all had progressive skin and mucosal edema, septic shock, respiratory distress, oliguria and severe hypoalbuminemia (10–20g/L). Other complications were pulmonary edema or hemorrhage, disseminated intravascular coagulopathy, heart failure, renal or liver dysfunction. All patients were treated with mechanical ventilation with a mean mechanical ventilation time of 19.7± 3.5 days. Intravenous hydroxyethyl starch was also applied at an early stage for 4–12 days, together with broad spectrum antibiotics, plasma and albumin infusion. Twenty one patients (67.0%) were discharged from the neonatal intensive care unit after a median stay of 29 days, and 7 died (37.0%) in the hospital. During a 6.3-month follow-up, 4 patients had hydrocephalus and another 4 had muscle spasm or rigidity in the lower-limbs. We conclude that SCLS is a serious complication of neonatal sepsis with a high rate of in-hospital mortality and post-discharge disability.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"477-480"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0292-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population EGF和p53基因多态性与斯洛伐克人群结直肠癌风险的关系

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0300-4

S. Mahmood, M. Sivoňová, T. Matáková, D. Dobrota, L. Wsólová, A. Dzian, D. Mistuna

{"title":"Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population","authors":"S. Mahmood, M. Sivoňová, T. Matáková, D. Dobrota, L. Wsólová, A. Dzian, D. Mistuna","doi":"10.2478/s11536-013-0300-4","DOIUrl":"https://doi.org/10.2478/s11536-013-0300-4","url":null,"abstract":"During the transformation process single nucleotide polymorphisms (SNPs) of key genes, such as p53 Arg72Pro or EGF A61G, may mediate various cellular processes. These variants may be associated with colorectal cancer risk (CRC), but conflicting findings have been reported. The purpose of this study was to determine the association of the SNPs in 5′ UTR of EGF A61G and p53 Arg72Pro and CRC in the Slovak population. The present case-control study was carried out in 173 confirmed CRC patients and 303 healthy subjects. Genotyping was performed by PCR-RFLP methods. Significant association was observed between age and CRC risk (p=0.001). Lower CRC risk was seen in younger patients carrying genotype p53 Arg72Pro (0.14; 95% CI 0.02–0.99, p=0.049). Gender-stratified analysis showed a significant inverse association of the polymorphism EGF G61G with CRC risk (0.48; 95% CI 0.2–0.9, p=0.04) only in male patients. Tumour site genotype distribution revealed that female patients with localized colon cancer were significantly associated with p53 Pro72Pro genotype (4.0; 95% CI 1.27–12.7, p=0.04) whereas the cancer of rectosigmoid junction was associated with the EGF G61G genotype (4.5; 95% CI 1.2–16.97, p=0.02). Combination of p53 Arg72Pro or EGF A61G polymorphisms were not associated with CRC risk by using logistic regression.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"405-416"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0300-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Orbital Rhabdomyosarcoma with a good life prognosis after surgical treatment in a 14-year-old patient 14岁眼眶横纹肌肉瘤手术治疗后预后良好

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0289-8

C. Nicula, D. Nicula, M. Blidaru, A. Ghiţuică, S. Neamţu, A. Saplonţai-Pop

引用次数: 1

Discharge times for knee arthroscopy in spinal vs. general anesthesia 脊柱与全身麻醉下膝关节镜检查的出院次数

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0303-1

Volker Gebhardt, M. Monnard, C. Weiss, M. Schmittner

{"title":"Discharge times for knee arthroscopy in spinal vs. general anesthesia","authors":"Volker Gebhardt, M. Monnard, C. Weiss, M. Schmittner","doi":"10.2478/s11536-013-0303-1","DOIUrl":"https://doi.org/10.2478/s11536-013-0303-1","url":null,"abstract":"BackgroundSpinal anesthesia (SPA) and general anesthesia (GA) are both safe techniques for knee arthroscopy. In this prospective, single-centre, randomised, clinical trial we compared the discharge times of SPA using 50mg hyperbaric prilocaine 2% and GA with propofol and sufentanil in patients undergoing ambulatory knee arthroscopy.Methods50 patients (18–80 years / American Society of Anaesthesiologists grade I–III) were randomized equally to receive either SPA or GA. The main outcome variable was the time until discharge from the day-surgery centre. Anesthesia related side effects, postoperative analgesics and patient satisfaction were assessed.ResultsTwo of the spinal blocks failed and GA had to be provided. Despite of a faster recovery (unassisted ambulation: SPA: 90 (90–295)min vs. GA: 156 (93–235)min, p=0.0029), spontaneous voiding led to a delayed discharge in the SPA group (SPA: 240 (135–295)min vs. GA: 156 (93–235)min, p<0.0001). There were no differences between the groups regarding other anesthesia related side effects, postoperative demand of analgesics or patient satisfaction.ConclusionSPA with 50mg hyperbaric prilocaine 2% leads to a later discharge than GA with sufentanil and propofol. However, a reevaluation of existing discharge recommendations including obligatory micturition is necessary, to make SPA become even more advantageous for ambulatory surgery.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"30 1","pages":"446-454"},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0303-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68851251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates 新生儿庆大霉素最佳给药方案的临床药代动力学研究

Central European Journal of Medicine Pub Date : 2014-06-01 DOI: 10.2478/s11536-013-0298-7

K. Vučićević, Z. Rakonjac, B. Janković, S. Vezmar Kovačević, B. Miljković, M. Prostran

{"title":"Clinical pharmacokinetics in optimal gentamicin dosing regimen in neonates","authors":"K. Vučićević, Z. Rakonjac, B. Janković, S. Vezmar Kovačević, B. Miljković, M. Prostran","doi":"10.2478/s11536-013-0298-7","DOIUrl":"https://doi.org/10.2478/s11536-013-0298-7","url":null,"abstract":"Gentamicin is readily used for suspected or proven sepsis in neonates, yet it shows considerable inter-individual pharmacokinetic variability, which limits achievements of therapeutic levels. Hence, the aim of this study was to compare peak and trough gentamicin concentrations according to dosing regimen, to evaluate pharmacokinetic parameters, and to consider adjustments of dosing regimen. Babies with infection were treated with 1 h infusion, and daily dose of 5 or 7.5 mg/kg depending on the age. Patients were randomized into two groups: I — dosing interval 12 h (n=8), II — 24 h (n=11). Two steady-state blood samples were obtained. Pharmacokinetic parameters were calculated using one-compartment model. The results showed a difference (p<0.05) in peak gentamicin concentrations between the groups, and tendency of lower trough levels in the group II. Calculated pharmacokinetic parameters included the volume of distribution (Vd) 0.52±0.47 l/kg, clearance (CL) 0.055±0.036 l/hkg and a half-life (t1/2) of 6.89±3.21 h. Based on the method for dosing regimen adjustments, there was a need to extend dosing interval to 36 h in 6 patients","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"9 1","pages":"485-490"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0298-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4