Central European Journal of Medicine最新文献_第9页

Leiomyosarcoma of inferior vena cava complicated by Budd-Chiari syndrome and disseminated intravascular coagulation — case report 下腔静脉平滑肌肉瘤合并Budd-Chiari综合征及弥散性血管内凝血1例

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0291-1

Małgorzata Krakowska-Stasiak, J. Kosałka, K. Wójcik, B. Sokołowska, J. Szpor, I. Grys, J. Musial

引用次数: 0

Multiple endocrine neoplasia type 1: a case report and review of the literature 1型多发性内分泌肿瘤1例报告及文献复习

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0297-8

A. Šileikis, E. Kildušis, R. Janavicius, K. Strupas

{"title":"Multiple endocrine neoplasia type 1: a case report and review of the literature","authors":"A. Šileikis, E. Kildušis, R. Janavicius, K. Strupas","doi":"10.2478/s11536-013-0297-8","DOIUrl":"https://doi.org/10.2478/s11536-013-0297-8","url":null,"abstract":"Multiple endocrine neoplasia syndrome, type 1 (MEN1) is an underdiagnosed autosomal dominant inherited cancer predisposition syndrome with inter- and intrafamilial variability without a known genotype-phenotype correlation. Disease is caused by mutations in the MEN1 gene located on chromosome 11, but other genes (CDKN1B, AIP) and mechanisms might be involved too. We performed retrospective case series study of MEN1 syndrome patient and his family and present our experience of management of genetically confirmed 9 MEN1 syndrome large family members from Lithuania with novel MEN1 gene mutation (MEN1 exon 6 — c. 879delT (p.Pro293Profs*76)) and delineate its clinical phenotype. At present the diagnosis of MEN1 syndrome must be established by direct mutation testing. MEN1 syndrome patients, their relatives and patients suspected of MEN1 are eligible for mutation testing. Patients with MEN1 have a shorter life expectancy than the general population. MEN1 patients and mutation carriers should be subjected to periodic screening in order to detect manifestations in an early stage. Early genetic diagnosis and subsequent periodic screening is associated with less morbidity and mortality at follow-up. Our study confirmed the absence of genotype-phenotype correlation and showed high intrafamilial clinical expression variability of the MEN1 syndrome.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0297-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Amiodarone neurotoxicity: the other side of the medal 胺碘酮神经毒性:奖牌的另一面

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0306-y

G. Galassi, E. Georgoulopoulou, A. Ariatti

{"title":"Amiodarone neurotoxicity: the other side of the medal","authors":"G. Galassi, E. Georgoulopoulou, A. Ariatti","doi":"10.2478/s11536-013-0306-y","DOIUrl":"https://doi.org/10.2478/s11536-013-0306-y","url":null,"abstract":"The efficacy of amiodarone is tempered by its toxicity, with 50% of long-term users discontinuing the drug. The non-cardiac side effects of amiodarone may involve central and peripheral nervous system. We studied two patients treated with amiodarone for 46 and 15 months respectively. Both patients exhibited progressive distal extremity weakness, impaired perception, loss of deep reflexes. Electrophysiology identified a widespread, sensorimotor polyneuropathy with features of axonal loss and demyelination. Visual evoked potentials (VEPs) showed prolonged P100 latency bilaterally in absence of visual symptoms or brain magnetic resonance imaging (MRI) abnormalities. Extensive laboratory examinations excluded known causes of peripheral neuropathies. At 21 months after amiodarone withdrawal, P100 latency of case 1 VEPs returned to normal, whereas polyneuropathy continued to progress. In the second patient neuropathy has worsened similarly over 2 years whereas P100 latency of VEPs recovered to normal within 7 months after withdrawal of amiodarone. These findings may suggest different mechanisms of toxicity, which could be due to amiodarone pharmacokinetic and its metabolite effects on the peripheral nerves, as opposed to the optic nerve. We emphasize that use of amiodarone needs monitoring of patients at risk of development side effects.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0306-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Severe renal vascular hypertension caused by upper left branch renal artery stenosis complicated with multiple thrombosis and cardiac hypertrophy 肾动脉左上支狭窄并发多发性血栓形成及心脏肥厚所致严重肾血管高血压

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0299-6

D. Milošević, D. Batinic, Sonja Hodžić, Maja Lemac, M. Spajić, D. Turudić, Ana-Meyra Potkonjak

引用次数: 0

Accuracy of general practitioners’ readings of ECG in primary care 全科医生在初级保健中心电图读数的准确性

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0288-9

Paulo Santos, Paulo Pessanha, Manuel Viana, M. Campelo, J. Nunes, A. Hespanhol, F. Macedo, Luciana Couto

{"title":"Accuracy of general practitioners’ readings of ECG in primary care","authors":"Paulo Santos, Paulo Pessanha, Manuel Viana, M. Campelo, J. Nunes, A. Hespanhol, F. Macedo, Luciana Couto","doi":"10.2478/s11536-013-0288-9","DOIUrl":"https://doi.org/10.2478/s11536-013-0288-9","url":null,"abstract":"BackgroundThe electrocardiogram (ECG) is a diagnostic test commonly used in daily Primary Care practice. General Practitioners (GP) often feel unsure about their interpretation of ECGs, so they engage external services to provide it.AimTo evaluate accuracy of ECG readings done by GPs by comparison with those done by a cardiologist as the gold standard.MethodsWe studied 195 ECGs collected consecutively during first semester of 2010 in an urban Health Centre of Portugal. Each ECG was read by each physician and inter-observer agreement was evaluated. After coding by Novacode, sensitivity and specificity of GP’s readings were calculated.ResultsInter-observer agreement between GP readings was “good” with an intraclass correlation coefficient of 0.727 (CI 95%: 0.670–0.779). When compared with gold standard, GP achieved a “good” agreement with an intraclass correlation coefficient of 0.712 (CI 95%: 0.659–0.762). The overall accuracy of GP for detecting abnormalities was 81.0% (95%CI: 75.7–85.6%), with a sensitivity of 84.8% (95%CI: 77.3–90.6%) and a specificity of 77.5% (95%CI: 69.7–84.2%). For normal tests, accuracy was 79.9% (95%CI: 74.7–84.3). In the most prevalent classes of abnormalities, accuracy was higher than 90%.ConclusionGP showed good skills in reading ECGs in their practice of Primary Care. Better attention should be given to ischemic abnormalities present on ECGs. Key message: General Practitioners demonstrate good skills for reading the ECGs of patients on a primary care centre when compared to the gold standard defined by a cardiologist reading.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0288-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Delayed diagnosis of an isolated partial anomalous pulmonary venous connection 孤立性部分肺静脉连接异常的延迟诊断

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0312-0

S. Glaveckaitė, Karolina Lušaitė, V. Grabauskienė, N. Valevičienė, A. Laucevičius

引用次数: 2

Simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in quetiapine overdose case 静脉脂肪乳剂与木炭血液灌流同时应用于喹硫平过量病例

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0305-z

Shasine B. Veli, V. Atanasov, Jordan S. Angelov, K. Kanev

引用次数: 1

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0294-y

R. Bužgová, M. Bužga, P. Holéczy

{"title":"Health-related quality of life in morbid obesity: the impact of laparoscopic sleeve gastrectomy","authors":"R. Bužgová, M. Bužga, P. Holéczy","doi":"10.2478/s11536-013-0294-y","DOIUrl":"https://doi.org/10.2478/s11536-013-0294-y","url":null,"abstract":"Our aim in this prospective study was to determine the impact of laparoscopic sleeve gastrectomy on the quality of life of patients with morbid obesity in comparison with population standards. The study evaluated 76 morbidly obese patients who underwent laparoscopic sleeve gastrectomy. The short version of the World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was used to evaluate quality of life in the following four areas: physical health, mental health, social relations, and environment. Patients completed the questionnaire before their planned operation and again 3 and 6 months after surgery. Compared with the population standard, patients with morbid obesity had significantly lower quality of life scores in the physical and mental health domains, including on independent questions related to of overall health and quality of life (p<0.001). Women scored lower on indicators of mental health than men. Three and 6 months following surgery a significant trend of body mass index (BMI) reduction was seen, as well as increased quality of life in all indicated areas (p<0.001). Laparoscopic sleeve gastrectomy treatment in morbidly obese patients reduced BMI on a long-term basis, a change seen as early as 3 months after surgery. By 6 months after surgery, patients had the same quality of life scores as the reference population.","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/s11536-013-0294-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68850493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

TRAP (Twin Reversed Arterial Perfusion) sequence TRAP(双动脉反向灌注)序列

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0340-9

A. Doronjski, T. Stojilković, Slobodan D Spasojevic, B. Milanović, V. Stojanović

引用次数: 1

The role of genetic and other biomarkers in NSCLC prognosis 遗传和其他生物标志物在非小细胞肺癌预后中的作用

Central European Journal of Medicine Pub Date : 2014-07-08 DOI: 10.2478/s11536-013-0290-2

D. Schveigert, S. Cicėnas, Jaroslav Bublevič, Renatas Aškinis, V. Šapoka, J. Didziapetriene

引用次数: 2