Circulation Journal最新文献_第9页

Evolving Paradigms in Home Left Ventricular Assist Device Therapy　- Reducing Caregiver Burden in the Era of Advanced Technology. 家庭左心室辅助装置治疗的发展模式-在先进技术时代减轻照顾者的负担。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-02-08 DOI: 10.1253/circj.CJ-24-0766

Shunsuke Saito, Ryohei Matsuura, Chizu Kamon, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Shin Yajima, Yusuke Misumi, Kotaro Yoshida, Yudai Muratsuji, Kaori Kubota, Takashi Yamauchi, Shigeru Miyagawa

{"title":"Evolving Paradigms in Home Left Ventricular Assist Device Therapy　- Reducing Caregiver Burden in the Era of Advanced Technology.","authors":"Shunsuke Saito, Ryohei Matsuura, Chizu Kamon, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Shin Yajima, Yusuke Misumi, Kotaro Yoshida, Yudai Muratsuji, Kaori Kubota, Takashi Yamauchi, Shigeru Miyagawa","doi":"10.1253/circj.CJ-24-0766","DOIUrl":"10.1253/circj.CJ-24-0766","url":null,"abstract":"Background: In Japan, caregiver presence 24 h/day, 7 days a week is required for patients with left ventricular assist devices (LVADs) during the first 6 months after discharge, with ongoing cohabitation recommended thereafter. This study evaluated the incidence of LVAD pump stoppages during home care, the role of caregivers in preventing adverse events, and the need for continuous caregiver support.Methods and results: A retrospective analysis was conducted on 264 patients who underwent LVAD implantation between 2010 and 2023 and were managed at home. In all, 116 power loss incidents were documented, with 65 leading to pump stoppages. Notably, no stoppages occurred in patients using the EVAHEART or HeartMate 3 devices, which are equipped with backup battery systems. Of the 65 stoppages, 83% were resolved by patients and only 6% required caregiver intervention. The Zarit Burden Interview revealed a mean caregiver burden score of 30.1, comparable to that of caregivers for patients with severe brain damage.Conclusions: The burden experienced by caregivers of LVAD patients is substantial, but with the advent of advanced devices like the HeartMate 3, the need for caregiver support 24 h/day, 7 days a week may be reconsidered. The findings of this study suggest that continuous caregiver presence may not be essential for all LVAD patients, potentially easing the burden on caregivers.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"479-484"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Frailty Assessed by the Kihon Checklist Upon the Readmission of Older Patients With Heart Failure. 用 Kihon 检查表评估的虚弱程度与老年心力衰竭患者再入院的关系

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-02-21 DOI: 10.1253/circj.CJ-24-0908

Kazuhisa Tsurumoto, Kenta Kamisaka, Eisaku Nakane, Moriaki Inoko, Kazuki Uemura

{"title":"Association of Frailty Assessed by the Kihon Checklist Upon the Readmission of Older Patients With Heart Failure.","authors":"Kazuhisa Tsurumoto, Kenta Kamisaka, Eisaku Nakane, Moriaki Inoko, Kazuki Uemura","doi":"10.1253/circj.CJ-24-0908","DOIUrl":"10.1253/circj.CJ-24-0908","url":null,"abstract":"Background: Frailty is highly prevalent and associated with a poor prognosis in older patients with heart failure (HF). In this study, we investigated the association between frailty, as assessed by the Kihon Checklist (KCL), and readmissions in older patients with HF.Methods and results: We performed a retrospective cohort study of all consecutive older patients hospitalized for HF aged ≥65 years between September 2016 and March 2018. The KCL was based on the health condition and living situation of each patient prior to hospitalization and was categorized into 4 groups based on quartiles of the total score (Q1-4). The primary outcome was readmission due to HF within 2 years post-discharge. A total of 244 patients (111 males; mean age, 81.7 years [6.9]) were included. During 2 years of follow-up post-discharge, 71 patients (29.1%) experienced an adjudicated readmission for acute HF. Multivariable Cox regression analysis revealed that Q2-4 of the KCL were associated with an increased hazard ratio (HR) for HF readmission when compared with Q1 (Q2; HR [95% confidence interval (CI)]: 9.54 [2.78-32.66], P<0.001; Q3; 8.28 [2.37-28.84], P<0.001; Q4; 9.12 [2.51-33.11], P<0.001).Conclusions: Our findings revealed an association between frailty, as assessed by the KCL, and readmissions for HF within 2 years of discharge in older patients with HF.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"457-462"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Journey to Transthyretin Cardiac Amyloidosis Diagnosis　- A Japanese Claims Database Study. 转甲状腺素心脏淀粉样变性诊断的患者旅程-日本索赔数据库研究。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-01-29 DOI: 10.1253/circj.CJ-24-0666

Masatoshi Minamisawa, Hiroaki Konishi, Yoshinobu Kitano, Hajime Abe, Kanae Togo, Yasuhiro Izumiya

{"title":"Patient Journey to Transthyretin Cardiac Amyloidosis Diagnosis　- A Japanese Claims Database Study.","authors":"Masatoshi Minamisawa, Hiroaki Konishi, Yoshinobu Kitano, Hajime Abe, Kanae Togo, Yasuhiro Izumiya","doi":"10.1253/circj.CJ-24-0666","DOIUrl":"10.1253/circj.CJ-24-0666","url":null,"abstract":"Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an under-recognized cause of heart failure (HF) in older adults. Delayed ATTR-CM diagnosis may result in more advanced symptoms. This study describes the journey of Japanese patients with ATTR-CM.Methods and results: This retrospective non-interventional study used the DeSC Healthcare database. Patients aged ≥18 years at the index date (date when ATTR-CM was first diagnosed or date of first tafamidis 80 mg prescription, whichever was earlier) and who had received ≥1 tafamidis 80 mg prescription or ≥1 specific ATTR-CM diagnosis, excepting \"suspected diagnosis\", at any time between April 1, 2014 and August 31, 2021 were included. The median age of patients was 79.0 years, and 79.9% (n=239) were male. The most frequently observed comorbidities defined as indicating the onset of ATTR-CM were HF (87.9%), atrial fibrillation/atrial flutter (50.2%), and conduction disorders (17.2%), with a median time from onset to index date of 15.5, 14.0, and 9.0 months for each comorbidity, respectively. Lumbar spinal stenosis (23.9%), neuropathy (13.0%), and carpal tunnel syndrome (7.5%) were common extracardiac symptoms, with a median time from the appearance of these symptoms to index date of 19.0, 5.0, and 18.0 months, respectively.Conclusions: There was a delay between the appearance of cardiac and extracardiac comorbidities of ATTR-CM and its diagnosis in real-world Japanese clinical settings, emphasizing the need for early diagnosis of ATTR-CM.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"432-441"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic Valve Stenosis-Like Symptoms Caused by Pseudoaneurysm Following Total Arch Replacement. 全弓置换术后假性动脉瘤引起的主动脉瓣狭窄样症状。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-01-31 DOI: 10.1253/circj.CJ-24-0918

Kazuhiro Ueno, Takashi Shuto, Kaoru Uchida, Shinji Miyamoto

引用次数: 0

Impact of High-Sensitivity Cardiac Troponin T on Clinical Outcomes in Patients With Cardiac Sarcoidosis. 高敏感性心肌肌钙蛋白T对心肌结节病患者临床预后的影响

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-02-07 DOI: 10.1253/circj.CJ-24-0801

Yoichi Takaya, Koji Nakagawa, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Kazufumi Nakamura, Shinsuke Yuasa

{"title":"Impact of High-Sensitivity Cardiac Troponin T on Clinical Outcomes in Patients With Cardiac Sarcoidosis.","authors":"Yoichi Takaya, Koji Nakagawa, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Kazufumi Nakamura, Shinsuke Yuasa","doi":"10.1253/circj.CJ-24-0801","DOIUrl":"10.1253/circj.CJ-24-0801","url":null,"abstract":"Background: The prognostic utility of high-sensitivity cardiac troponin T (hs-cTnT) on clinical outcomes in cardiac sarcoidosis (CS) remains unknown, so we evaluated hs-cTnT in the chronic phase of CS.Methods and results: We enrolled 92 consecutive patients with CS in the chronic phase after medical therapies. Patients were divided into 2 groups according to hs-cTnT level: 0.014 ng/mL: high hs-cTnT (n=37); normal hs-cTnT (n=55). The primary endpoint was cardiac death and the secondary endpoint was cardiac death, ventricular tachyarrhythmias, or hospitalization for heart failure. The mean age of patients was 63±11 years, and 75 received steroid treatment. During a median follow-up of 63 months, there were 9 cardiac deaths: 7 (19%) patients with high hs-cTnT and 2 (4%) patients with normal hs-cTnT. The rate of cardiac death was higher in patients with high hs-cTnT than in those with normal hs-cTnT (log-rank, P<0.01). Cox proportional hazard analysis showed that hs-cTnT was an independent predictor of cardiac death. The events rate was higher in patients with high hs-cTnT than in those with normal hs-cTnT (log-rank, P<0.01): cardiac death, ventricular tachyarrhythmias or hospitalization for heart failure occurred in 24 (65%) patients with high hs-cTnT and 11 (20%) patients with normal hs-cTnT.Conclusions: Elevated hs-cTnT was linked with adverse outcomes in CS patients, suggesting it is an effective prognostic biomarker.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"442-449"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality Metrics for Heart Failure　- A Guideline-Driven Indicator Development Using a Modified Delphi Process and Its Applicability to Contemporary Japanese Practice. 心力衰竭的质量度量-使用改进的德尔菲过程的指南驱动指标开发及其对当代日本实践的适用性。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-02-14 DOI: 10.1253/circj.CJ-24-0971

Takahiro Suzuki, Takeshi Kitai, Takashi Kohno, Shun Kohsaka, Atsushi Mizuno

引用次数: 0

Establishing Cross-Specialty Expert Consensus on the Optimal Management of Hyperkalemia in Patients With Heart Failure and Chronic Kidney Disease. 建立心力衰竭和慢性肾脏疾病患者高钾血症最佳管理的跨专业专家共识。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-25 Epub Date: 2025-03-12 DOI: 10.1253/circj.CJ-24-0844

Takeshi Kitai, Shoichi Maruyama, Koichiro Kuwahara, Kouichi Tamura, Koichiro Kinugawa, Naoki Kashihara

{"title":"Establishing Cross-Specialty Expert Consensus on the Optimal Management of Hyperkalemia in Patients With Heart Failure and Chronic Kidney Disease.","authors":"Takeshi Kitai, Shoichi Maruyama, Koichiro Kuwahara, Kouichi Tamura, Koichiro Kinugawa, Naoki Kashihara","doi":"10.1253/circj.CJ-24-0844","DOIUrl":"10.1253/circj.CJ-24-0844","url":null,"abstract":"Background: Patients with both heart failure (HF) and chronic kidney disease (CKD) are often treated with renin-angiotensin-aldosterone system inhibitors (RAASi), but these drugs can cause hyperkalemia, which may lead to their reduction or discontinuation, resulting in the loss of their beneficial effects. Approaches to managing RAASi-induced hyperkalemia are discordant, so in this study we aimed to establish a cross-specialty consensus on the optimal approach to managing hyperkalemia in patients with HF and CKD.Methods and results: The study used a modified Delphi methodology. A steering committee of Japanese cardiologists and nephrologists drafted 26 consensus statements, which were used to create a survey, distributed across Japan. A total of 250 responses were received. Consensus, defined as 75% agreement, was achieved for 21/26 (81%) statements. Respondents agreed on the importance of effective hyperkalemia management based on serum potassium levels and supported the use of potassium binders (PBs), particularly novel PBs such as sodium zirconium cyclosilicate, to treat hyperkalemia while maintaining RAASi therapy. However, when potassium levels exceed 6.0 mEq/L, reduction or discontinuation of RAASi may be considered based on individual risk factors.Conclusions: This consensus provides proposals that may help support the optimal management of RAASi-induced hyperkalemia in Japanese patients with HF and CKD. It highlights the importance of treating hyperkalemia alongside optimal RAASi therapy.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"470-478"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Anthracyclines on Pericardial Adipose Tissue Assessed by Magnetic Resonance Imaging　- An Animal Experiment. 磁共振成像评估蒽环类药物对心包脂肪组织的影响-动物实验。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-22 DOI: 10.1253/circj.CJ-24-0794

Mengxi Li, Xingyuan Kou, Xue Zheng, Xi Guo, Wanyin Qi, Cao Li, Jing Chen

{"title":"Effects of Anthracyclines on Pericardial Adipose Tissue Assessed by Magnetic Resonance Imaging　- An Animal Experiment.","authors":"Mengxi Li, Xingyuan Kou, Xue Zheng, Xi Guo, Wanyin Qi, Cao Li, Jing Chen","doi":"10.1253/circj.CJ-24-0794","DOIUrl":"https://doi.org/10.1253/circj.CJ-24-0794","url":null,"abstract":"Background: Anthracyclines are widely used in cancer treatment, yet their potential for anthracycline-induced cardiotoxicity (AIC) limits their clinical utility. Despite the significant anatomical relevance of pericardial adipose tissue (PeAT) to cardiovascular disease, its response to anthracycline exposure remains poorly understood.Methods and results: Male New Zealand White rabbits (n=17) received weekly doxorubicin injections and underwent magnetic resonance imaging (MRI) scans biweekly for 10 weeks. PeAT volumes (total, left paraventricular, right paraventricular) were measured together with ventricular function. Histopathological evaluations were also conducted. A mixed linear model identified the earliest timeframe for detectable changes in PeAT volume and left ventricular function. Total PeAT volume decreased from the 6th week (1.17±0.06, P<0.05) and continued to decrease until the 8th week (0.96±0.06, P<0.05) and left paraventricular adipose tissue volume decreased significantly, but no changes were observed in right paraventricular adipose tissue volume. The volume of PeAT exhibited a positive correlation with left ventricular ejection fraction (LVEF) (r=0.43, P<0.05), which declined below 50% by the 8th week, and a negative correlation with myocardial cell injury scores (r=-0.595, P<0.05).Conclusions: Anthracycline administration led to an early reduction in PeAT volume, particularly in the left paraventricular region, detectable by MRI as early as the 6th week. Changes in PeAT volume preceded alterations in LVEF and were associated with declines in cardiac function and myocardial cell damage.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble Guanylate Cyclase Stimulator Vericiguat Attenuates Angiotensin II-Induced Oxidative Stress and Cardiac Remodeling. 可溶性鸟苷酸环化酶刺激剂Vericiguat减轻血管紧张素ii诱导的氧化应激和心脏重塑。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-20 DOI: 10.1253/circj.CJ-24-0659

Taisuke Harada, Hidekazu Kondo, Kodai Nakamura, Yu He, Shunsuke Goto, Masaki Takahashi, Hirochika Yamasaki, Naoki Matsuda, Masayuki Takano, Ichitaro Abe, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Kunio Yufu, Hirotaka Shibata, Naohiko Takahashi

{"title":"Soluble Guanylate Cyclase Stimulator Vericiguat Attenuates Angiotensin II-Induced Oxidative Stress and Cardiac Remodeling.","authors":"Taisuke Harada, Hidekazu Kondo, Kodai Nakamura, Yu He, Shunsuke Goto, Masaki Takahashi, Hirochika Yamasaki, Naoki Matsuda, Masayuki Takano, Ichitaro Abe, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Kunio Yufu, Hirotaka Shibata, Naohiko Takahashi","doi":"10.1253/circj.CJ-24-0659","DOIUrl":"https://doi.org/10.1253/circj.CJ-24-0659","url":null,"abstract":"Background: Vericiguat, an oral soluble guanylate cyclase stimulator, is a novel therapeutic agent for patients with heart failure with reduced ejection fraction; however, the detailed cardioprotective mechanism remains unclear. We aimed to explore the mechanism of the effect of vericiguat on the myocardium, particularly focusing on oxidative stress, using in vivo and in vitro experiments.Methods and results: Male 8-week-old mice were divided into a control group, angiotensin II (AngII) infusion group, and AngII infusion with low- or high-dose vericiguat treatment group. After 14 days of treatment, vericiguat did not affect the systolic or diastolic blood pressure increase caused by AngII infusion. AngII-induced cardiac hypertrophy and fibrosis in the left ventricle (LV) were significantly ameliorated by high-dose vericiguat treatment. AngII-induced O2-overproduction and upregulation of messenger RNA levels of Nppa, Nppb, Myh7, Col1a1, Col3A1, and Tgfb1 in the LV were significantly attenuated by vericiguat in a dose-dependent manner. Incubation of neonatal rat cardiomyocytes using vericiguat and AngII revealed that preceding incubation with vericiguat directly reduced AngII-induced cardiomyocyte O2-production and cardiac hypertrophy-associated gene expression. In addition, AngII-induced phosphorylation of ERK 1/2 or p38 MAPK was significantly attenuated by the incubation with vericiguat.Conclusions: Our study demonstrated that vericiguat suppresses myocardial oxidative stress via the regulation of ERK 1/2 or p38 MAPK signaling, leading to antihypertrophic/fibrotic effects.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Mass Index Affects Hospital-Associated Disability and Economic Burden in Elective Cardiovascular Surgery　- JROAD/JROAD-DPC Database. 体重指数影响择期心血管手术的医院相关残疾和经济负担- JROAD/JROAD- dpc数据库

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-03-18 DOI: 10.1253/circj.CJ-24-0901

Masato Ogawa, Kodai Ishihara, Yuji Kanejima, Naofumi Yoshida, Koshiro Kanaoka, Yoko Sumita, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Yoshitada Sakai, Ken-Ichi Hirata, Kazuhiro P Izawa

{"title":"Body Mass Index Affects Hospital-Associated Disability and Economic Burden in Elective Cardiovascular Surgery　- JROAD/JROAD-DPC Database.","authors":"Masato Ogawa, Kodai Ishihara, Yuji Kanejima, Naofumi Yoshida, Koshiro Kanaoka, Yoko Sumita, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Yoshitada Sakai, Ken-Ichi Hirata, Kazuhiro P Izawa","doi":"10.1253/circj.CJ-24-0901","DOIUrl":"https://doi.org/10.1253/circj.CJ-24-0901","url":null,"abstract":"Background: Both underweight and overweight are recognized as important factors influencing outcomes in patients undergoing cardiovascular surgery. This study investigated the effects of body mass index (BMI) on hospital-associated disability (HAD) and hospitalization costs in patients undergoing elective cardiovascular surgery (coronary artery bypass grafting, valve surgery, aortic surgery) by analyzing data from the Japanese Registry of All Cardiac and Vascular Diseases - Diagnosis Procedure Combination (JROAD-DPC) database.Methods and results: All patients in the JROAD-DPC database were categorized into 5 groups according to the World Health Organization BMI criteria for Asians. HAD was defined as a decrease of ≥5 points in the Barthel Index from admission to discharge. The primary outcome was the prevalence of HAD, and the secondary outcome was hospitalization costs. Among the 228,891 patients included in the study, the median BMI was 23.2 kg/m2. The prevalence of HAD was 8.7%, with a U-shaped relationship between BMI and HAD, indicating that both extremely low and high BMIs were associated with a higher incidence of HAD. Hospitalization costs also showed a U-shape relationship with BMI, with higher costs for patients with HAD.Conclusions: Low BMI in any age group was associated with HAD, and older people with a BMI considered too high also had HAD. BMI could be an important risk stratification tool for functional outcomes and economic burden in patients undergoing elective cardiovascular surgery.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0