Circulation Journal最新文献_第9页

The Circulation Journal Official Impact Factor and the Most Frequently Cited Papers in 2024. 流通期刊官方影响因子与2024年最常被引论文。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-07-10 DOI: 10.1253/circj.CJ-66-0241

Kenichi Tsujita

引用次数: 0

Circulating HMGB2 Is Associated With Angiographic Coronary Collateralization in Diabetic Patients With Chronic Total Occlusion and Impairs Vessel Growth via NLRP3. 循环HMGB2与慢性全闭塞糖尿病患者冠脉侧支血管造影相关，并通过NLRP3损害血管生长

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-05-14 DOI: 10.1253/circj.CJ-24-0878

Zhi Ming Wu, Shuai Chen, Yang Dai, Ke Huang, Xiao Qun Wang, Lin Shuang Mao, Chen Die Yang, Fei Fei Li, Le Ying Li, Jing Meng Liu, Yi Xuan Wang, Wen Jia Li, Ruo Sen Yuan, Lin Lu, Rui Yan Zhang, Wei Feng Shen, Ying Shen, Feng Hua Ding

{"title":"Circulating HMGB2 Is Associated With Angiographic Coronary Collateralization in Diabetic Patients With Chronic Total Occlusion and Impairs Vessel Growth via NLRP3.","authors":"Zhi Ming Wu, Shuai Chen, Yang Dai, Ke Huang, Xiao Qun Wang, Lin Shuang Mao, Chen Die Yang, Fei Fei Li, Le Ying Li, Jing Meng Liu, Yi Xuan Wang, Wen Jia Li, Ruo Sen Yuan, Lin Lu, Rui Yan Zhang, Wei Feng Shen, Ying Shen, Feng Hua Ding","doi":"10.1253/circj.CJ-24-0878","DOIUrl":"10.1253/circj.CJ-24-0878","url":null,"abstract":"Background: HMGB2 is reported to be strongly associated with cardiovascular diseases, but its relationship with coronary collateralization is unclear.Methods and results: We determined the serum HMGB2 levels in 322 patients with type 2 diabetes and coronary chronic total occlusion (CTO), and evaluated the degree of coronary collaterals by Rentrop classification (poor collaterals: Rentrop score 0 or 1; good collaterals: Rentrop score 2 or 3). Anti-HMGB2 neutralizing antibody was administered in a diabetic ischemic hindlimb mouse model, followed by laser Doppler perfusion imaging and histological examinations. Human umbilical vein endothelial cells (HUVECs) were treated with HMGB2 to assess the potential mechanisms. Serum HMGB2 decreased stepwise across Rentrop score 0 to 3 (P<0.001), with significantly higher levels in patients with poor collaterals than in those with good collaterals (P<0.001). After adjustment for various confounders, HMGB2 remained an independent factor for poor coronary collateralization (adjusted odds ratio, 1.234; 95% confidence interval, 1.136-1.340; P<0.001). In diabetic mice with hindlimb ischemia, administration of anti-HMGB2 neutralizing antibody increased blood flow restoration. HMGB2 inhibited migration and tube formation of HUVECs in a dose-dependent manner under high-glucose and hypoxic conditions, and promoted NLRP3-mediated pyroptosis.Conclusions: Elevated circulating HMGB2 was associated with poor coronary collateralization in CTO patients with diabetes. HMGB2 impaired angiogenesis and collateral vessel growth in diabetic mice. Such effects are mediated by NLRP3.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1245-1255"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Criteria for Acetylcholine-Provoked Coronary Spasm　- Do We Need Both Symptoms and Ischemic Electrocardiogram Change? 乙酰胆碱诱发性冠状动脉痉挛的诊断标准——我们需要症状和缺血性心电图改变吗？

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-06-12 DOI: 10.1253/circj.CJ-25-0371

Masanobu Ishii, Koichi Kaikita

引用次数: 0

Relative Hyperglycemia and In-Hospital Bleeding Across Glycemic Status in Patients on High-Intensity Antithrombotic Therapy. 高强度抗血栓治疗患者的相对高血糖和院内出血

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-06-06 DOI: 10.1253/circj.CJ-25-0017

Chong Zhang, Junxiang Liu, Wennan Liu, Hangkuan Liu, Pengfei Sun, Yiwen Fang, Jingbo Yang, Haonan Sun, Yongle Li, Roger Sik-Yin Foo, Ching-Hui Sia, Gregg C Fonarow, Qing Yang, Yingwu Liu, Xin Zhou

{"title":"Relative Hyperglycemia and In-Hospital Bleeding Across Glycemic Status in Patients on High-Intensity Antithrombotic Therapy.","authors":"Chong Zhang, Junxiang Liu, Wennan Liu, Hangkuan Liu, Pengfei Sun, Yiwen Fang, Jingbo Yang, Haonan Sun, Yongle Li, Roger Sik-Yin Foo, Ching-Hui Sia, Gregg C Fonarow, Qing Yang, Yingwu Liu, Xin Zhou","doi":"10.1253/circj.CJ-25-0017","DOIUrl":"10.1253/circj.CJ-25-0017","url":null,"abstract":"Background: Relative hyperglycemia, as defined by the stress hyperglycemia ratio (SHR), is linked to death and ischemic events in patients with acute coronary syndrome (ACS). As a modifiable factor, the association between SHR and bleeding risk after percutaneous coronary intervention (PCI) across different glycemic status remains unexplored.Methods and results: In this study, ACS patients treated with PCI were extracted from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) registry and the Tianjin Health and Medical Data Platform (THMDP). SHR was derived from admission fasting blood glucose and hemoglobin A1c. Patients were classified as having diabetes mellitus, pre-diabetes mellitus (Pre-DM), or normal glucose regulation. The primary outcome was in-hospital major bleeding. Among the 33,265 patients in the CCC-ACS cohort, major bleeding was recorded for 437. A high SHR (>1.0) independently predicted major bleeding in the total cohort (adjusted odds ratio [aOR] 1.51; 95% confidence interval [CI] 1.24-1.83), with the highest risk in the Pre-DM group (aOR 1.98; 95% CI 1.34-2.92). These findings were externally validated among 23,423 patients with myocardial infarction in the THMDP cohort. Early guideline-directed medical therapy mitigated the bleeding risk associated with a high SHR.Conclusions: In this study, a high SHR was an independent risk factor for in-hospital major bleeding after PCI, particularly in patients with Pre-DM. Further clinical trials are needed to explore SHR-targeted therapies in Pre-DM.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1228-1237"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Patients With Acute Coronary Syndrome and Lipid Management Status Insights From the Optimal Therapy for All Kagoshima Acute Coronary Syndrome (OK-ACS) Registry. 鹿儿岛急性冠状动脉综合征最佳疗法（OK-ACS）登记册对急性冠状动脉综合征患者特征和血脂管理状况的启示。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-03-29 DOI: 10.1253/circj.CJ-25-0083

Daisuke Kanda, Akihiro Tokushige, Takashi Kajiya, Takashi Arima, Tetsuro Kataoka, Ryo Arikawa, Mitsuru Ohishi

{"title":"Characteristics of Patients With Acute Coronary Syndrome and Lipid Management Status Insights From the Optimal Therapy for All Kagoshima Acute Coronary Syndrome (OK-ACS) Registry.","authors":"Daisuke Kanda, Akihiro Tokushige, Takashi Kajiya, Takashi Arima, Tetsuro Kataoka, Ryo Arikawa, Mitsuru Ohishi","doi":"10.1253/circj.CJ-25-0083","DOIUrl":"10.1253/circj.CJ-25-0083","url":null,"abstract":"Background: With aging of the population, atherosclerotic diseases have increased in Japan, with acute coronary syndrome (ACS) a significant cause of morbidity and mortality. In Kagoshima Prefecture, ACS mortality rates exceed the national average, reflecting challenges in lipid management and access to care.Methods and results: The Optimal Therapy for All Kagoshima Acute Coronary Syndrome (OK-ACS) Registry, initiated in April 2022, enrolled 2,328 ACS patients across Kagoshima. This study evaluated the impact of a standardized lipid management pathway, the \"Kagoshima Style,\" on low-density lipoprotein cholesterol (LDL-C) control and guideline adherence, as well as the regional profile of ACS in Kagoshima. The pathway was implemented at all percutaneous coronary intervention facilities to optimize lipid management and secondary prevention. LDL-C levels decreased significantly (P<0.0001) from admission to discharge and at 3 months (113.3±39.9, 74.6±28.0, and 69.2±25.9 mg/dL, respectively), with no difference according to place of residence. The proportion of patients with LDL-C <70 mg/dL increased from 12% at admission to 59% at 3 months. Maximum tolerated doses of high-intensity statin use increased from 7% at baseline to 9.3% after pathway implementation. Geographic disparities were evident, with patients from isolated islands experiencing delayed treatment access.Conclusions: The Kagoshima Style pathway improved lipid management, reducing LDL-C and enhancing guideline adherence. This interim analysis provides insights into lipid management and regional disparities in patients with ACS across Kagoshima prefecture.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1266-1277"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Discrepancies Between Friedewald and Martin Equations in Predicting Pathogenic Variants of Familial Hypercholesterolemia in Children. Friedewald和Martin方程差异在预测儿童家族性高胆固醇血症致病变异中的应用

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-05-11 DOI: 10.1253/circj.CJ-24-0928

Ryosuke Tani, Keiji Matsunaga, Tomoko Inoue, Katsufumi Nishioka, Kanako Irie, Sonoko Kondo, Takashi Iwase, Hai Ying Fu, Shigeru Ito, Tsuyoshi Sasaki, Sumiko Yoshida, Ichiro Yokota, Yoichi Hoshikawa, Katsunori Yokoyama, Takuji Fujisawa, Hayato Tada, Masayuki Takamura, Takashi Kusaka, Tetsuo Minamino

{"title":"Utility of Discrepancies Between Friedewald and Martin Equations in Predicting Pathogenic Variants of Familial Hypercholesterolemia in Children.","authors":"Ryosuke Tani, Keiji Matsunaga, Tomoko Inoue, Katsufumi Nishioka, Kanako Irie, Sonoko Kondo, Takashi Iwase, Hai Ying Fu, Shigeru Ito, Tsuyoshi Sasaki, Sumiko Yoshida, Ichiro Yokota, Yoichi Hoshikawa, Katsunori Yokoyama, Takuji Fujisawa, Hayato Tada, Masayuki Takamura, Takashi Kusaka, Tetsuo Minamino","doi":"10.1253/circj.CJ-24-0928","DOIUrl":"10.1253/circj.CJ-24-0928","url":null,"abstract":"Background: The Friedewald equation, commonly used to calculate low-density lipoprotein cholesterol (LDL-C), occasionally yields inaccurate estimations for very-low-density lipoprotein cholesterol, suggesting the need for an alternative method such as the Martin equation. In this study, we aimed to evaluate the discrepancies between the Friedewald and Martin equations, particularly in the context of pathogenic variants associated with familial hypercholesterolemia (FH).Methods and results: We evaluated the discrepancies between LDL-C levels calculated using the Friedewald and Martin equations, and for the presence of pathogenic variants of FH in 53 children with hypercholesterolemia detected through universal lipid screening. Genetic testing revealed pathogenic variants of FH in 24 of the 53 children. Chi-squared tests indicated a significant difference in the presence of pathogenic variants of FH between the \"Friedewald ≥ Martin\" and \"Friedewald < Martin\" groups (χ2=11.348, P<0.001). Even in 37 children with LDL-C <180 mg/dL, discrepancies between the equations were still associated with the presence of pathogenic FH variants (Fisher's exact test, P=0.028).Conclusions: Discrepancies in LDL-C levels measured by the Friedewald and Martin equations might serve as a useful predictive marker for identifying pathogenic variants of FH, especially in cases of LDL-C <180 mg/dL, which are often challenging to diagnose.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1190-1196"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life's Essential 8 and All-Cause and Cardiovascular Disease Mortality Among Korean Adults. 韩国成年人的基本生命和全因心血管疾病死亡率。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-05-15 DOI: 10.1253/circj.CJ-24-0922

Yunmin Han, Soomin Lee, Suyeon Kim, Younghwan Choi, Yeon Soo Kim

{"title":"Life's Essential 8 and All-Cause and Cardiovascular Disease Mortality Among Korean Adults.","authors":"Yunmin Han, Soomin Lee, Suyeon Kim, Younghwan Choi, Yeon Soo Kim","doi":"10.1253/circj.CJ-24-0922","DOIUrl":"10.1253/circj.CJ-24-0922","url":null,"abstract":"Background: This study examined the association between Life's Essential 8 (LE8) and the Korean population's risk of all-cause and cardiovascular disease (CVD) mortality.Methods and results: This study included 21,482 adults aged ≥19 years who were enrolled in the Korea National Health and Nutrition Examination Survey. Cardiovascular health (CVH) was assessed using the LE8 score, which comprises the following 8 components: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. The LE8 score ranges from 0 to 100 and was categorized as low (0-49), middle (50-79), high (≥80), with higher scores indicating better CVH. A Cox proportional hazards model was used to estimate hazard ratios, and the population attributable fraction (PAF) was used to determine individual risks associated with each CVH metric. During a median follow-up of 6.3 years, there were 709 all-cause and 122 CVD-related deaths. In the fully adjusted model, compared with low scores, middle and high LE8 scores were associated with 34% and 42% lower risks of all-cause mortality, respectively. A similar reduction in CVD mortality was observed with higher LE8 scores. Physical activity showed the highest PAF, contributing 37% for all-cause mortality and 51% for CVD mortality.Conclusions: Higher LE8 scores were significantly associated with lower all-cause and CVD mortality. Physical activity had the greatest impact on PAF for mortality.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1238-1244"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Impact of Diagnostic Criteria of Intracoronary Acetylcholine Provocation Testing on Clinical Characteristics and Outcomes. 冠状动脉内乙酰胆碱激发试验诊断标准对临床特征和结果的差异影响。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-06-12 DOI: 10.1253/circj.CJ-25-0172

Yoshiyuki Ohnaga, Yuichi Saito, Ken Kato, Kazuya Tateishi, Hideki Kitahara, Yoshio Kobayashi

{"title":"Differential Impact of Diagnostic Criteria of Intracoronary Acetylcholine Provocation Testing on Clinical Characteristics and Outcomes.","authors":"Yoshiyuki Ohnaga, Yuichi Saito, Ken Kato, Kazuya Tateishi, Hideki Kitahara, Yoshio Kobayashi","doi":"10.1253/circj.CJ-25-0172","DOIUrl":"10.1253/circj.CJ-25-0172","url":null,"abstract":"Background: Intracoronary acetylcholine (ACh) provocation testing is a guideline-recommended invasive standard for diagnosing vasospastic angina (VSA)/coronary spastic angina. A positive ACh test is usually defined as significant epicardial vasospasm accompanied by signs of ischemia, namely chest symptoms and/or electrocardiographic (ECG) changes. However, the differential impact of diagnostic ACh test criteria on clinical characteristics and outcomes is unclear.Methods and results: From 2012 to 2024, 973 patients underwent ACh provocation testing for VSA diagnosis. Patients were divided into 3 groups: negative ACh test; and positive ACh test (2 groups), defined as significant epicardial vasospasm with either narrow (both chest symptoms and ECG changes) or broad (chest symptoms or ECG changes) definitions of signs of ischemia. Clinical characteristics and adverse outcomes during ACh testing and follow-up were compared among the 3 groups. In all, 356 (36.6%), 166 (17.1%), and 451 (46.4%) had positive ACh tests with narrow and broad definitions of ischemia and negative ACh tests, respectively. Among patients with positive ACh tests, there were no significant differences in baseline characteristics and adverse outcomes between those with narrow and broad definitions of ischemia.Conclusions: In patients undergoing ACh provocation testing, there were no significant differences in clinical characteristics and outcomes between those diagnosed as having VSA using narrow and broad definitions of signs of ischemia, suggesting that either sign can be used as a criterion of ischemia.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1087-1093"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospitalized Patients, Treatments, and Quality of Care for Cardiovascular Diseases in Japan　- Outline of the Nationwide JROAD Investigation. 日本心血管疾病住院病人、治疗和护理质量--全国 JROAD 调查概要。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2024-11-19 DOI: 10.1253/circj.CJ-24-0704

Masahiro Nishi, Yoshihiro Miyamoto, Yoshitaka Iwanaga, Koshiro Kanaoka, Yoko Sumita, Masaharu Ishihara, Maki Katamura, Shun Kohsaka, Masaharu Nakayama, Koichi Node, Yasuko K Bando, Yu Hirao, Keiichi Fukuda, Tetsuya Matoba, Yoshihiro Fukumoto, Satoaki Matoba

{"title":"Hospitalized Patients, Treatments, and Quality of Care for Cardiovascular Diseases in Japan　- Outline of the Nationwide JROAD Investigation.","authors":"Masahiro Nishi, Yoshihiro Miyamoto, Yoshitaka Iwanaga, Koshiro Kanaoka, Yoko Sumita, Masaharu Ishihara, Maki Katamura, Shun Kohsaka, Masaharu Nakayama, Koichi Node, Yasuko K Bando, Yu Hirao, Keiichi Fukuda, Tetsuya Matoba, Yoshihiro Fukumoto, Satoaki Matoba","doi":"10.1253/circj.CJ-24-0704","DOIUrl":"10.1253/circj.CJ-24-0704","url":null,"abstract":"Cardiovascular diseases (CVD) have imposed a substantial burden on population health and society. In Japan, the National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, grounded in national legislation, seeks to improve the quality of care and standardize treatment for cerebrovascular disease and CVD. The plan emphasizes the need to develop standardized systems for collecting and disseminating medical information, as well as promoting data-driven research. The Japanese Registry Of All cardiac and vascular Diseases (JROAD) was launched by the Japanese Circulation Society to assess the clinical activities of institutions nationwide that have a dedicated cardiovascular inpatient service. Information from participating facilities is accumulated, and a database is constructed by linking Diagnosis Procedure Combination data, which includes patient characteristics and clinical data. Using this real-world data is expected to generate high-quality evidence, leading to a better understanding of CVD, improvements in the quality of care and clinical outcomes, and the implementation of effective health policies, including the appropriate allocation of medical resources and the reduction of medical costs. Ultimately, these efforts aim to extend the life span and healthy life expectancy. This design paper outlines the overall concept of the JROAD investigation in cardiovascular care. In addition, it summarizes representative CVD data, reviews the literature on the quality of care, and describes the prospects of the investigation.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1081-1086"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Arterial Grafting in Patients With Low Left Ventricular Ejection Fraction. 左室射血分数低患者的多动脉移植。

IF 3.1 3区医学

Circulation Journal Pub Date : 2025-07-25 Epub Date: 2025-04-18 DOI: 10.1253/circj.CJ-24-1006

Kohei Hachiro, Noriyuki Takashima, Kenichi Kamiya, Masahide Enomoto, Yasuo Kondo, Fumihiro Miyashita, Hodaka Wakisaka, Tomoaki Suzuki

{"title":"Multiple Arterial Grafting in Patients With Low Left Ventricular Ejection Fraction.","authors":"Kohei Hachiro, Noriyuki Takashima, Kenichi Kamiya, Masahide Enomoto, Yasuo Kondo, Fumihiro Miyashita, Hodaka Wakisaka, Tomoaki Suzuki","doi":"10.1253/circj.CJ-24-1006","DOIUrl":"10.1253/circj.CJ-24-1006","url":null,"abstract":"Background: This study compared postoperative outcomes in patients with a preoperative left ventricular ejection fraction (LVEF) of ≤35% who underwent multiple (MAG) or single (SAG) arterial grafting during off-pump isolated coronary artery bypass grafting.Methods and results: Of 1,627 patients who underwent isolated coronary artery bypass grafting at Shiga University of Medical Science between 2002 and 2023, 176 with a preoperative LVEF ≤35% underwent MAG (n=115) or SAG (n=61). Baseline patient characteristics were comparable in the MAG and SAG groups after adjustment using inverse probability of treatment weighting. The study's mean (±SD) follow-up duration was 4.8±4.7 years. In the MAG and SAG groups, the adjusted estimated 5-year rates of freedom from all-cause death were 71.5% and 69.1%, respectively, while those of cardiac death were 94.1% and 89.5%, respectively. Kaplan-Meier curves showed significant differences in all-cause death (P=0.013) and cardiac death (P=0.001) favoring the MAG group. In a multivariable Cox hazards model, MAG was a predictor of all-cause death (hazard ratio 0.568; P=0.034) and cardiac death (hazard ratio 0.276; P=0.008).Conclusions: Compared with SAG, MAG was associated with significantly lower rates of all-cause death and cardiac death.","PeriodicalId":50691,"journal":{"name":"Circulation Journal","volume":" ","pages":"1145-1152"},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0