Clinical Imaging最新文献

{"title":"Ultrasonographic assessment of the risk of free-floating thrombus detachment in the lower extremity deep veins in patients with fracture","authors":"Yang Xu ,&nbsp;Jing Lin ,&nbsp;Jin-Mei Gao ,&nbsp;Yu Yuan","doi":"10.1016/j.clinimag.2024.110302","DOIUrl":"10.1016/j.clinimag.2024.110302","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the ultrasonographic features and influencing factors of free-floating thrombus (FFT) detachment in the lower extremity deep veins (LEDVs) of patients with fractures.</div></div><div><h3>Methods</h3><div>Clinical data of patients diagnosed with FFT in the LEDVs and implanted with an inferior vena cava filter (IVCF) in our hospital between July 2021 and August 2023 were retrospectively analysed. The patients were divided into the thrombus detachment group (the experimental group, <em>n</em> = 92) and the non-thrombus detachment group (the control group, <em>n</em> = 103) based on the presence of detached thrombus in the IVCF. The effects of thrombus echogenicity, floating degree, thrombus location, thrombin time, D-dimer and fibrinogen on thrombus shedding were analysed. The nomogram method was used to establish the model and predict the probability of delayed postoperative recovery.</div></div><div><h3>Results</h3><div>The proportions of patients with extremely hypoechoic thrombus and medium and high floating degrees increased in the experimental group compared with those in the control group, and the differences between the two groups were statistically significant (<em>P</em> &lt; 0.05). Extremely hypoechoic thrombus (<em>P</em> = 0.021, 95 % <em>CI:</em> 1.109–13.748) and high (<em>P</em> = 0.001, 95 % <em>CI:</em> 3.854–28.573) and medium floating degrees (<em>P</em> = 0.004, 95 % <em>CI:</em> 1.792–13.453) were risk factors for deep veins FFT (DV FFT) detachment. The results of receiver operating characteristic curve analysis showed that the area under the curve of the model was 0.893, with a 95 % CI of 0.856–0.937, indicating a high prediction accuracy.</div></div><div><h3>Conclusion</h3><div>Ultrasonographic parameters, including thrombus echogenicity and floating degree, are valuable in predicting DV FFT detachment in patients with traumatic fractures, providing references for IVCF implantation.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110302"},"PeriodicalIF":1.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899707124002328/pdfft?md5=d4056d1e4a75a361b939a9c840e5d508&pid=1-s2.0-S0899707124002328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geniculate ganglion diverticulum: a potential imaging marker in patients with idiopathic intracranial hypertension","authors":"Sachin Chitalkar ,&nbsp;Dipak Thakor ,&nbsp;Ali Sheikhy ,&nbsp;Jamie Cole ,&nbsp;Sarah Fangmeyer ,&nbsp;Fatemeh Nasri ,&nbsp;Abdelmonem Ahmed ,&nbsp;Ashkan Monfared ,&nbsp;Md Reza Taheri","doi":"10.1016/j.clinimag.2024.110278","DOIUrl":"10.1016/j.clinimag.2024.110278","url":null,"abstract":"<div><h3>Purpose</h3><p>The diagnosis of idiopathic intracranial hypertension (IIH) is often challenging in patients who do not present with classic symptoms. Brain MRI can play a pivotal role, as several imaging findings, such as an empty sella appearance (ESA), have been shown to be associated with IIH. Yet, none of the MRI signs have been shown to have a high sensitivity and specificity. In this study, we tested the hypothesis that presence of a geniculate ganglion diverticulum (GGD) is a potential imaging marker for the detection of IIH.</p></div><div><h3>Materials and methods</h3><p>This is an IRB-approved, single-institution, retrospective, observational study. Brain MRI examinations of patients referred to Radiology by Otology clinic over a period of 10 years were reviewed. 244 MRI exams fulfilling inclusion and exclusion criteria were independently screened for the presence of GGD and ESA by two Neuroradiology fellows. Electronic medical records (EMR) of patients in this study were reviewed for presence of clinical manifestations of IIH. Receiver operator characteristic (ROC) curves were generated to estimate the accuracy of each covariate in diagnosing IIH. The area under each ROC curve (AUC) was calculated to identify an accurate prognostic covariate. Statistical analysis was done using R programming language V 4.2.2.</p></div><div><h3>Results</h3><p>GGD was identified in MRI exams of 51 patients. A 2:1 propensity score (PS) matching for age, gender, and Body Mass Index (BMI) was used to select non-GGD control group for comparison with the GGD group. There was strong agreement between the 2 reviewers (kappa = 0.81, agreement = 95 %). Twelve patients in this study were diagnosed with IIH. There was a high incidence of GGD (OR = 12.19, 95 % CI (2.56, 58.10)) and ESA (OR = 4.97, 95 % CI (1.47, 16.74)) in IIH patients. The AUC observed in GGD for predicting IIH was 0.771 (0.655–0.888), specificity = 0.709 (0.638–0.780), and sensitivity = 0.833 (0.583–1). The AUC observed for ESA in predicting IIH was 0.682 (0.532–0.831), specificity = 0.780 (0.709–0.844), and sensitivity = 0.583 (0.333–0.833).</p></div><div><h3>Conclusion</h3><p>GGD is potentially a novel imaging marker of IIH with sensitivity higher than and specificity comparable to that of ESA.</p></div><div><h3>Clinical relevance statement</h3><p>Presence of GGD should raise the possibility of IIH.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110278"},"PeriodicalIF":1.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the O-RADS scoring system for the differentiation of different types of ovarian neoplasms: A modified approach with non-DCE-MRI","authors":"Tong Chen ,&nbsp;Xujun Qian ,&nbsp;Zhi Zhu ,&nbsp;Yueyue Zhang ,&nbsp;Chaogang Wei ,&nbsp;Xiaohong Shen ,&nbsp;Caiyuan Zhang ,&nbsp;Junkang Shen","doi":"10.1016/j.clinimag.2024.110285","DOIUrl":"10.1016/j.clinimag.2024.110285","url":null,"abstract":"<div><h3>Purpose</h3><div>The O-RADS MRI score stratifies adnexal mass risk with characteristics of T1-weighted, T2-weighed and dynamic contrast-enhanced (DCE) images. We explored a modified approach to evaluate the value of incorporation DWI/ADC with non-DCE-MRI in ORADS scoring system, and to assess the diagnostic performance and interreader consistency in differentiating ovarian neoplasm with different types.</div></div><div><h3>Methods</h3><div>This retrospective study included 218 women who underwent pelvic MRI with 221 ovarian tumors between January 2017 and December 2021. Two radiologists independently assessed each lesion using the original and modified O-RADS approach (incorporating DWI/ADC with non-DCE). Cohen's weighted-kappa and ROC analyses were employed to assess interreader consistency and diagnostic efficiency across all lesions and three ovarian neoplasms categories.</div></div><div><h3>Results</h3><div>The area under the ROC curve (AUC) of the original protocol was 0.945 for all lesions and 0.947, 0.992, and 0.758 for the epithelial cell, germ cell and sex cord-stromal neoplasms. The modified approach achieved AUCs of 0.959 for all lesions and 0.962, 0.997, and 0.837 for the three categories. The interreader agreement was ‘excellent’ for all lesions and ‘good’ for the subgroups with the original protocol, improving to ‘excellent’ for all categories with the modified approach.</div></div><div><h3>Conclusion</h3><div>A modified O-RADS incorporating DWI/ADC with non-DCE MRI yields high diagnostic performance in differentiation of different types of ovarian neoplasms. It further improves consistency in subgroup interpretation. The modified approach can serve as an effective diagnostic tool without DCE, further promoting its adoption in primary hospitals.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110285"},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating synergy between beta-blockers and transarterial chemoembolization in the treatment of hepatocellular carcinoma: preliminary data from a propensity matched analysis","authors":"Martin B.G. Mutonga ,&nbsp;Annabella Shewarega ,&nbsp;Moritz Gross ,&nbsp;Vinzent H. Kahl ,&nbsp;David C. Madoff","doi":"10.1016/j.clinimag.2024.110283","DOIUrl":"10.1016/j.clinimag.2024.110283","url":null,"abstract":"<div><h3>Purpose</h3><p>Favorable clinical outcomes have been reported with the adjunct use of beta-blockers in cancer treatment, hypothetically secondary to their anti-angiogenic/anti-proliferative effects. Hereby, we investigate whether there is synergy between beta-blockers and TACE in the treatment of HCC.</p></div><div><h3>Methods</h3><p>36 HCC patients on beta-blockers (mean dose of 48 mg daily) at the time of first-line treatment with TACE at our institution were retrospectively identified out of a cohort of 221 patients between 2008 and 2019. Using propensity scoring, a matched cohort of 36 patients not exposed to beta-blockers was generated based on age, gender, ethnicity, etiology of liver disease, BCLC, child Pugh score, PS/ECOG, cirrhosis, largest mass treated, type of TACE and treated liver segments. Tumor response was assessed at 1st and 2nd post-TACE imaging timepoints (1.4 and 4.1 months on average respectively). Variables were compared using chi-square test and Student's <em>t</em>-test. Kaplan-Meier transplant-free survival plots were generated using IBM® SPSS® software. Cox regression analysis was used to evaluate survival predictors. A <em>p</em> values &lt; 0.05 was considered significant.</p></div><div><h3>Results</h3><p>Comparing the control and beta-blocker cohorts, there were no differences in baseline characteristics, post-TACE imaging timepoints, tumor response or transplant free survival (<em>p</em> &gt; 0.05). Tumor size was found to be a predictor of survival when the two cohorts were combined (<em>p</em> = 0.03).</p></div><div><h3>Conclusion</h3><p>Transplant-free survival and HCC response to first-line TACE treatment were similar in the control and beta-blocker groups. Large tumor sizes were associated with higher mortality in combined analysis of the cohorts.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110283"},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI implementation: Radiologists' perspectives on AI-enabled opportunistic CT screening","authors":"Adam E.M. Eltorai ,&nbsp;Dominick J. Parris ,&nbsp;Mary Jo Tarrant ,&nbsp;William W. Mayo-Smith ,&nbsp;Katherine P. Andriole","doi":"10.1016/j.clinimag.2024.110282","DOIUrl":"10.1016/j.clinimag.2024.110282","url":null,"abstract":"<div><h3>Objective</h3><p>AI adoption requires perceived value by end-users. AI-enabled opportunistic CT screening (OS) detects incidental clinically meaningful imaging risk markers on CT for potential preventative health benefit. This investigation assesses radiologists' perspectives on AI and OS.</p></div><div><h3>Methods</h3><p>An online survey was distributed to 7500 practicing radiologists among ACR membership of which 4619 opened the emails. Familiarity with and views of AI applications were queried and tabulated, as well as knowledge of OS and inducements and impediments to use.</p></div><div><h3>Results</h3><p>Respondent (n = 211) demographics: mean age 55 years, 73 % male, 91 % diagnostic radiologists, 46 % in private practice. 68 % reported using AI in practice, while 52 % were only somewhat familiar with AI. 70 % viewed AI positively though only 46 % reported AI's overall accuracy met expectations. 57 % were unfamiliar with OS, with 52 % of those familiar having a positive opinion. Patient perceptions were the most commonly reported (25 %) inducement for OS use. Provider (44 %) and patient (40 %) costs were the most common impediments. Respondents reported that osteoporosis/osteopenia (81 %), fatty liver (78 %), and atherosclerotic cardiovascular disease risk (76 %) could be well assessed by OS. Most indicated OS output requires radiologist oversight/signoff and should be included in a separate “screening” section in the Radiology report. 28 % indicated willingness to spend 1–3 min reviewing AI-generated output while 18 % would not spend any time. Society guidelines/recommendations were most likely to impact OS implementation.</p></div><div><h3>Discussion</h3><p>Radiologists' perspectives on AI and OS provide practical insights on AI implementation. Increasing end-user familiarity with AI-enabled applications and development of society guidelines/recommendations are likely essential prerequisites for Radiology AI adoption.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110282"},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encouragement vs. liability: How prompt engineering influences ChatGPT-4's radiology exam performance","authors":"Daniel Nguyen ,&nbsp;Allison MacKenzie ,&nbsp;Young H. Kim","doi":"10.1016/j.clinimag.2024.110276","DOIUrl":"10.1016/j.clinimag.2024.110276","url":null,"abstract":"<div><p>Large Language Models (LLM) like ChatGPT-4 hold significant promise in medical application, especially in the field of radiology. While previous studies have shown the promise of ChatGTP-4 in textual-based scenarios, its performance on image-based response remains suboptimal. This study investigates the impact of prompt engineering on ChatGPT-4's accuracy on the 2022 American College of Radiology In Training Test Questions for Diagnostic Radiology Residents that include textual and visual-based questions. Four personas were created, each with unique prompts, and evaluated using ChatGPT-4. Results indicate that encouraging prompts and those disclaiming responsibility led to higher overall accuracy (number of questions answered correctly) compared to other personas. Personas that threaten the LLM with legal action or mounting clinical responsibility were not only found to score less, but also refrain of answering questions at a higher rate. These findings highlight the importance of prompt context in optimizing LLM responses and the need for further research to integrate AI responsibly into medical practice.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110276"},"PeriodicalIF":1.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mentee of many, now a mentor to all: RSNA Gold Medalist Dr. Yoshimi Anzai's story of people, principles, and what lies beyond","authors":"Tracy J. Kao ,&nbsp;Gregory E. Punch","doi":"10.1016/j.clinimag.2024.110284","DOIUrl":"10.1016/j.clinimag.2024.110284","url":null,"abstract":"","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110284"},"PeriodicalIF":1.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899707124002146/pdfft?md5=37863cea3962ab97648a600bf1311268&pid=1-s2.0-S0899707124002146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system involvement in Erdheim-Chester disease: a magnetic resonance imaging study","authors":"Aryan Zahergivar ,&nbsp;Fatemeh Dehghani Firouzabadi ,&nbsp;Fatemeh Homayounieh ,&nbsp;Mahshid Golagha ,&nbsp;Fahimul Huda ,&nbsp;Nadia Biassou ,&nbsp;Ritu Shah ,&nbsp;Moozhan Nikpanah ,&nbsp;Mojdeh Mirmomen ,&nbsp;Faraz Farhadi ,&nbsp;Rahul H. Dave ,&nbsp;Skand Shekhar ,&nbsp;William A. Gahl ,&nbsp;Juvianee I. Estrada-Veras ,&nbsp;Ashkan A. Malayeri ,&nbsp;Kevin O'Brien","doi":"10.1016/j.clinimag.2024.110281","DOIUrl":"10.1016/j.clinimag.2024.110281","url":null,"abstract":"<div><h3>Purpose</h3><p>To characterize brain MR imaging findings in a cohort of 58 patients with ECD and to evaluate relationship between these findings and the <em>BRAF</em>^{<em>V600E</em>} pathogenic variant.</p></div><div><h3>Methods</h3><p>ECD patients of any gender and ethnicity, aged 2–80 years, with biopsy-confirmed ECD were eligible to enroll in this study. Two radiologists experienced in evaluating ECD CNS disease activity reviewed MRI studies. Any disagreements were resolved by a third reader. Frequencies of observed lesions were reported. The association between the distribution of CNS lesions and the <em>BRAF</em>^{<em>V600E</em>}pathogenic variant was evaluated using Fisher's exact test and odd ratio.</p></div><div><h3>Results</h3><p>The brain MRI of all 58 patients with ECD revealed some form of CNS lesions, most likely due to ECD. Cortical lesions were noted in 27/58 (46.6 %) patients, cerebellar lesions in 15/58 (25.9 %) patients, brain stem lesions in 17/58 cases (29.3 %), and pituitary lesions in 10/58 (17.2 %) patients. Premature cortical atrophy was observed in 8/58 (13.8 %) patients. <em>BRAF</em>^{<em>V600E</em>} pathogenic variant was significantly associated with cerebellar lesions (<em>p</em> = 0.016) and bilateral brain stem lesions (<em>p</em> = 0.043). A trend toward significance was noted for cerebral atrophy (<em>p</em> = 0.053).</p></div><div><h3>Conclusion</h3><p>The study provides valuable insights into the brain MRI findings in ECD and their association with the <em>BRAF</em>^{<em>V600E</em>} pathogenic variant, particularly its association in cases with bilateral lesions. We are expanding our understanding of how ECD affects cerebral structures. Knowledge of MRI CNS lesion patterns and their association with mutations such as the BRAF variant is helpful for both prognosis and clinical management.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110281"},"PeriodicalIF":1.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging finding of renal masses associated with pathogenic variation in succinate dehydrogenase subunit B gene","authors":"Aditi Chaurasia ,&nbsp;Evrim B. Turkbey ,&nbsp;Fatemeh Dehghani Firouzabadi ,&nbsp;Shiva Singh ,&nbsp;Safa Samimi ,&nbsp;Nikhil Gopal ,&nbsp;Corina Millo ,&nbsp;Mark W. Ball ,&nbsp;W. Marston Linehan ,&nbsp;Ashkan A. Malayeri","doi":"10.1016/j.clinimag.2024.110280","DOIUrl":"10.1016/j.clinimag.2024.110280","url":null,"abstract":"<div><h3>Purpose</h3><p>Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a newly defined, rare subtype of renal cancer, associated with pathogenic variations in the Succinate Dehydrogenase Subunit B (SDHB) gene. Our aim is to investigate the imaging findings of SDHB-associated renal tumors, utilizing cross-sectional and FDG-PET imaging in patients with pathogenic variations in SDHB gene, to facilitate accurate tumor characterization.</p></div><div><h3>Methods</h3><p>Twenty SDH-deficient tumors from 16 patients with pathogenic variations in SDHB gene were retrospectively evaluated using cross-sectional and FDG-PET imaging. Clinical findings such as demographics, family history, extra-renal findings and metastases were recorded. Tumor imaging characteristics on CT/MRI included were laterality, size, homogeneity, morphology, margins, internal content, T1/T2 signal intensity, enhancement features, and restricted diffusion.</p></div><div><h3>Results</h3><p>Sixteen patients (median age 31 years, IQR 19–41, 8 males) were identified with 68.8 % of patients having a known family history of SDHB variation. 81.3 % of lesions were solitary and majority were solid (86.7 % on CT, 87.5 % on MRI) with well-defined margins in &gt;62.5 % of lesions, without evidence of internal fat, calcifications, or vascular invasion. 100 % of lesions demonstrated restricted diffusion and avid enhancement, with degree &gt;75 % for most lesions on CT and MRI. On FDG-PET, all renal masses showed increased radiotracer uptake. 43.8 % of patients demonstrated extra-renal manifestations and 43.8 % had distant metastasis.</p></div><div><h3>Conclusion</h3><p>SDHB-associated RCC is predominantly noted in young patients with no gender predilection. On imaging, SDH-deficient RCC are frequently unilateral, solitary, and solid with well-defined margins demonstrating avid enhancement with variability in enhancement pattern and showing restricted diffusion.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"115 ","pages":"Article 110280"},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899707124002109/pdfft?md5=9777a538918010a1747f5de1376a4c84&pid=1-s2.0-S0899707124002109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of dual-energy CT in detecting bone marrow edema in lower limb joint injuries: a meta-analysis","authors":"Yong Wang ,&nbsp;Kai Huang ,&nbsp;Qiaofeng Guo ,&nbsp;Hongtao Hou","doi":"10.1016/j.clinimag.2024.110273","DOIUrl":"10.1016/j.clinimag.2024.110273","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to evaluate the diagnostic performance of dual-energy computed tomography (DECT) in detecting bone marrow edema (BME) in patients with lower limb joint injuries.</p></div><div><h3>Methods</h3><p>A thorough literature search was conducted across the PubMed, Embase, and Web of Science databases to identify relevant studies up to April 2024. Studies examining the diagnostic performance of DECT in detecting BME in lower limb joint injuries patients were included. Sensitivity and specificity were evaluated using the inverse variance method and transformed via the Freeman-Tukey double arcsine transformation. Furthermore, the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was utilized to evaluate the methodological quality of the included studies.</p></div><div><h3>Results</h3><p>This meta-analysis included 17 articles involving 625 patients. The pooled sensitivity, specificity, and AUC for DECT in detecting BME in lower limb joint injuries patients were 0.82 (95 % CI: 0.76–0.87), 0.95 (95 % CI: 0.92–0.97), and 0.95 (95 % CI: 0.93–0.97), respectively. The pooled sensitivity of DECT for detecting BME in knee, hip, and ankle joint injuries was 0.80, 0.84, and 0.80, with no significant difference among these joints (<em>P</em> = 0.55). The pooled specificity for knee, hip, and ankle injuries was 0.95, 0.97, and 0.89. Specificity differed significantly among the joints (<em>P</em> &lt; 0.01), with the highest specificity in hip injuries.</p></div><div><h3>Conclusions</h3><p>Our meta-analysis indicates that DECT demonstrates high diagnostic performance in detecting BME in patients with lower limb joint injuries, with the highest specificity observed in hip joint injuries. To validate these findings, further larger prospective studies are necessary.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"114 ","pages":"Article 110273"},"PeriodicalIF":1.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}