Clinical Implant Dentistry and Related Research最新文献

{"title":"Current State of Evidence for Implant Placement and Loading in Partially Edentulous Patients: A Systematic Review","authors":"German O. Gallucci, Adam Hamilton, Samuel Akhondi, Kevser Pala, Juan Francisco Peña-Cardelles","doi":"10.1111/cid.70120","DOIUrl":"10.1111/cid.70120","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To systematically review the updated evidence for the clinical outcome of fixed implant prostheses treated with different combinations of implant placement and loading protocols in partially edentulous patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An electronic search was performed in Medline, Embase, and Central to identify studies of implants subjected to immediate placement + immediate restoration/loading (Type 1A), immediate placement + early loading (Type 1B), immediate placement + conventional loading (Type 1C), early placement + immediate restoration/loading (Type 2–3A), early placement + early loading (Type 2–3B), early placement + conventional loading (Type 2–3C), late placement + immediate restoration/loading (Type 4A), late placement + early loading (Type 4B), late placement + conventional loading (Type 4C) with implant-supported fixed dental prostheses (IFDPs) in partially edentulous patients. A cumulative survival rate for each type of the implant placement and loading protocols was weighted by the duration of follow-up and number of implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 11 427 records, 140 studies (42 RCTs; 98 CCTs/cohort studies) encompassing 10 456 implants met the criteria. Weighted cumulative survival rates for each protocol were: 98.0% (Type 1A), 91.6% (Type 1B), 95.0% (Type 1C), 97.8% (Type 2–3A), 100% (Type 2–3B), 94.0% (Type 2–3C), 97.2% (Type 4A), 97.9% (Type 4B), 97.5% (Type 4C). Protocols 1A, 1C, 2–3C, 4A, 4B, and 4C satisfy scientific and/or clinical validation thresholds, whereas 1B and 2–3B remain insufficiently documented despite high numeric survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In immediate placement, Type 1C shows strong survival rates. It is considered scientifically and clinically validated, while Type 1A also meets the criteria for a scientifically and clinically validated protocol with high survival rates. Meanwhile, Type 1B continues to show lower and more variable survival rates—being clinically documented—underscoring the need for careful case selection. Regarding early placement, Type 2–3C is recognized as a scientifically and clinically validated protocol. Type 2–3A, which was previously underreported, now demonstrates similarly validated survival rates that expand the evidence for early implant placement with immediate loading. Although Type 2–3B is clinically documented, it still lacks sufficient evidence. All late implant placement protocols are considered scientifically and clinically validated: T","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Clinical Risk Factors and Patient-Reported Outcomes of Full-Arch Implant-Supported Prostheses","authors":"Xinyue Zhang,&nbsp;Yinlin Wang,&nbsp;Kexin Yang,&nbsp;Xiaoping Qin,&nbsp;Jiakang Yang,&nbsp;Tianle Chen,&nbsp;Shan Yang,&nbsp;Huiming Wang,&nbsp;Baixiang Wang","doi":"10.1111/cid.70119","DOIUrl":"10.1111/cid.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate clinical outcomes, marginal bone loss (MBL) trends, risk factors, and patient-reported outcomes (PROs) of immediate full-arch implant restoration to guide clinical decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on 50 patients with 256 implants who underwent immediate restoration. Clinical and imaging data, implant survival rates, and mechanical complications were analyzed. MBL was measured at five time points using cone beam computed tomography (CBCT): T0 (immediately post-implantation), T1 (6 months), T2 (1 year), T3 (2 years), and T4 (3–5 years). PROs were assessed using the Oral Health Impact Profile-14 (OHIP-14) and the European Five-Dimensional Health Inventory-5 L (EQ-5D-5L).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The implant survival rate was 98%, with an average follow-up of 42 ± 16.36 months. Mechanical complications occurred in 46% of cases. MBL was most rapid between T0 and T2 and slowed from T2 to T4. Significant risk factors for increased MBL included smoking, maxillary implants, female gender, and advanced age. Furthermore, 30° angled multi-unit abutments on posterior implants were associated with greater MBL compared to straight (0°) angled abutments. Overall, patients reported high satisfaction with the immediate restoration, as reflected by the OHIP-14 and EQ-5D-5L scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Immediate restoration with full-arch implants yields excellent clinical outcomes and improves Oral Health-Related Quality of Life (OHRQoL). While bone levels tend to stabilize after 2 years, the high incidence of prosthetic complications underscores the critical need for rigorous long-term maintenance protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Survival of Dental Implants in Post-Menopausal Women Receiving Denosumab: A Retrospective Cohort Study","authors":"Junghye Hwang,&nbsp;Youngjae Yoon,&nbsp;Garam Byun,&nbsp;Byung-Joon Choi,&nbsp;Joo-Young Ohe,&nbsp;Baek-Soo Lee,&nbsp;Junho Jung","doi":"10.1111/cid.70122","DOIUrl":"10.1111/cid.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the effects of anti-resorptive drugs (ARD), including denosumab, on dental implant survival in post-menopausal women with osteoporosis, compared with those receiving non-ARD, and to identify risk factors associated with ARD that may influence implant outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This retrospective cohort study examined 1694 implants placed in 806 women aged 55 years or older with at least of follow-up of 12 months. Implants were categorized according to exposure to anti-resorptive drugs (ARD), including bisphosphonates or denosumab, or assignment to a non-ARD control group. The assessed variables included demographic, ARD-related, implant/prosthesis-related factors, and marginal bone loss. Propensity score matching was used to balance group characteristics. Statistical analyses included Firth logistic regression with patient-level clustering and a linear mixed model for longitudinal bone changes. Kaplan–Meier curves were illustrated to describe implant survival trends among the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Implant survival rates were 99.13% (bisphosphonates), 98.08% (denosumab), and 98.24% (control), with no significant differences in implant failure or marginal bone loss between the groups. However, diabetes mellitus, alcohol consumption, and overdenture prosthesis were associated with a significantly increased risk of implant failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Implant-based prosthetic rehabilitation is also feasible in post-menopausal women receiving ARD for osteoporosis. Although the implant survival rate was comparable to non-ARD users, caution is advised for patients on high doses of ARD or undergoing long-term therapy due to their pharmacological effects compromising bone metabolism. Additionally, the risk of failure associated with invasive procedures needs to be further evaluated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Remove or Not Remove Non-Conventional Dental Implants? Eleven-Year Retrospective Study on Implant Outcomes","authors":"Yifat Manor,&nbsp;Michael V. Joachim,&nbsp;Itay Oz,&nbsp;Refael Amir Braun,&nbsp;Guy Ronen,&nbsp;Gil Ben-Izhack","doi":"10.1111/cid.70112","DOIUrl":"10.1111/cid.70112","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;p&gt;Dental implants have become the gold standard for tooth replacement, and there are various designs for them. However, mechanical and biologic complications can necessitate implant removal.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess the challenges of dental implant removal according to implant designs through 11 years of data collected via a single-center study.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A retrospective study of patients that required dental implant removal between the years 2014 and 2024. Individuals with non-conventional implant designs, like subperiosteal, blade (basal), and broken root-form implants, were selected for the case series description. The analysis included details regarding the mechanical and biological determinants of the implant removal and the rehabilitation following the removal.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Two hundred and sixty-four patients (mean age 66.78 years [Range 32–87, SD 9.85]) were screened, and 503 implants were removed between the years 2014 and 2024—among which 40 were non-conventional designs. Broken osseointegrated implants are among the most challenging to remove. Case series of the removal of these non-conventional designs are described. There are substantial bone defect consequences in cases of basal implants, and the possibility for reimplantation is low. Cases demonstrating the preservation of zygomatic implants with complications are also presented.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The removal of broken osseointegrated dental implants, particularly screw-type implants, poses significant challenges due to their integration with the surrounding bone tissue. Similarly, non-conventional implant designs such as zygomatic implants, which are larger in size and located near vital anatomical structures, carry a heightened risk of complications during removal. The preservation of zygomatic implants is recommended due to the bone defects that could result from their removal. Therefore, it is crucial for clinicians to carefully consider the selection of implant designs and sizes prior to implantation. This decision-making process should be informed by an understanding of the potential difficulties and risks associated with implant removal in the event of failure.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Clinical Relevance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In everyday dental practice, clinic","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Light- and Non-Light Occlusion on Clinical Outcomes: A Retrospective Study","authors":"Bolin Li,&nbsp;Jing Wang,&nbsp;Jiayu Gao,&nbsp;Xuemei Tang,&nbsp;Lin Xiang,&nbsp;Yili Qu,&nbsp;Yi Man","doi":"10.1111/cid.70110","DOIUrl":"10.1111/cid.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate longitudinal occlusal alterations in implant-supported fixed prostheses (ISFPs) with light contact or non-light contact design and to analyze their clinical outcomes observed over a 5-year follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study categorized implants into two groups based on initial occlusal design: light occlusion group (12 μm articulating film removable at maximum intercuspal position [MIP] between ISFPs and opposing dentition) and non-light occlusion group (12 μm articulating film could not be removed). All participants were evaluated at 6–12 months, 1–3 years, and 3–5 years after ISFPs delivery. Occlusal patterns at MIP and during eccentric movements were monitored using articulating papers of different colors (blue/red) and thicknesses (12 μm/100 μm). Proximal contact loss rates, marginal bone loss, and technical complication rates were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 46 patients with 63 implants were included in this study. ISFPs in both groups exhibited rapid occlusal changes at MIP, characterized by reduced occlusal clearance, increased occlusal contact area, and stabilizing overtime regardless of initial design. Eccentric occlusion showed minimal alterations. Proximal contact loss rates, marginal bone loss, and technical complication rates revealed no significant intergroup differences. Multivariate regression analysis identified initial occlusal design, edentulous type, and implant systems as significant factors influencing the occlusal variation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Light occlusion on ISFPs was not stable over time, and the occlusal status of ISFPs showed a similar development trend in both groups. Compared with non-light occlusion, the light contact design did not significantly affect the long-term success of ISFPs.</p>\u0000 \u0000 <p><b>Trial Registration:</b> This study was registered in a clinical trial registry (www.chictr.org.cn, no: ChiCTR2400080874)</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dental Anxiety and Pain Perception in Patients Receiving Dental Implants: An Observational Study","authors":"Chunqin Liu,&nbsp;Shumin Nie,&nbsp;Xiaoli Ren,&nbsp;Xiaohua Liu","doi":"10.1111/cid.70118","DOIUrl":"10.1111/cid.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Previous studies have identified an association between dental anxiety and pain perception; however, the nature of this relationship in the context of oral implant surgery, particularly with respect to pain perception across multiple time points, remains unclear. This study aimed to examine the association between dental anxiety and peak pain perception following oral implant surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a prospective observational study involving 332 patients undergoing oral implant surgery. Pain perception was evaluated using a Visual Analogue Scale at five time points: preoperatively (T0), intraoperatively (T1), and at 6 h (T2), 24 h (T3), and 7 days postoperatively (T4). Dental anxiety was assessed with the Modified Dental Anxiety Scale. Logistic regression analysis was conducted to investigate the association between dental anxiety and peak pain perception. A generalized additive model was used to identify nonlinear associations, and a segmented logistic regression model was employed to identify break points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean score for pain perception increased from 0.26 ± 0.87 at T0 to 4.36 ± 1.70 at T2, then gradually decreased to 2.55 ± 1.34 at T3 and 0.55 ± 0.80 at T4, where T2 was the time point of peak pain intensity. Logistic regression analysis revealed that the odds ratio (OR) for the association between dental anxiety and pain perception was 1.38 (95% CI: 1.26, 1.53), indicating a 38% increase in the likelihood of pain perception for each one-unit increase in dental anxiety score. A nonlinear relationship was observed, with a break point identified at a dental anxiety score of 14.01. Below this threshold, the odds of pain perception increased substantially with increasing anxiety (OR = 1.51, 95% CI: 1.34, 1.69; <i>p</i> &lt; 0.001). However, beyond this point, the level of anxiety was not associated with pain perception risk (OR = 0.91, 95% CI: 0.76, 1.07; <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A nonlinear relationship was observed between dental anxiety and pain perception following oral implant surgery. Even at subclinical levels, elevated anxiety was associated with an increased likelihood of pain perception. These findings highlight the importance of early identification and management of dental anxiety to improve postoperative pain control. Further research is warranted to evaluate the clinical utility of integrating anxiety assessment into preoperative care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Bone Level Changes in Implant-Supported Fixed Prostheses in a Retrospective Study: A Multifactorial Analysis","authors":"Wilawan Chaiyaporn,&nbsp;Teerawut Tangsathian,&nbsp;Kakanang Supanimitkul,&nbsp;Navawan Sophon,&nbsp;Tharntip Suwanwichit,&nbsp;Attawood Lertpimonchai,&nbsp;George Pelekos,&nbsp;Sirikarn P. Arunyanak,&nbsp;Kajorn Kungsadalpipob","doi":"10.1111/cid.70115","DOIUrl":"10.1111/cid.70115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify the site-related, implant characteristic-related, prosthetic, and patient-related factors associated with marginal bone level around dental implant-supported fixed prostheses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This cross-sectional study analyzed clinical and radiographic data obtained during maintenance visits. The interproximal radiographic bone levels were selected at the site showing the greatest bone loss. The implants were classified as having a bone level ≥ 2 mm (BL group) or &lt; 2 mm (NBL group). Multivariate multilevel logistic regression was used to assess the association between multiple factors and bone level ≥ 2 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 196 subjects with 404 implants were included, with a mean follow-up period of 5.21 years. Implementing multifactorial analysis, the results demonstrated that probing depth ≥ 6 mm (odds ratios [OR] 5.39; 95% confidence intervals [CI] 1.21–24.06; <i>p</i> = 0.027), absence of keratinized mucosa (OR 3.54; 95% CI 1.11–11.28; <i>p</i> = 0.033), presence of an implant abutment microgap (OR 2.82; 95% CI 1.12–7.12; <i>p</i> = 0.028), transmucosal height &lt; 2 mm (OR 4.79; 95% CI 1.85–12.41; <i>p</i> = 0.001), and a history of periodontitis (OR 2.80; 95% CI 1.08–7.24; <i>p</i> = 0.034) exhibited a significantly higher risk of marginal bone level ≥ 2 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Marginal bone level around implant-supported prostheses was influenced by the interplay of multiple factors consisting of deep probing depth, absence of keratinized mucosa, inadequate transmucosal height, microgap configuration, and history of periodontitis. These findings emphasized the need for comprehensive peri-implant assessment, which included monitoring probing depths and soft tissue quality. Additionally, it was crucial to ensure that prostheses were well-designed and had the appropriate transmucosal height. Patients with a history of periodontitis were advised to follow a strict maintenance program. Further prospective studies are needed to confirm the causality for ongoing investigation into the specific aspects and mechanisms involved.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconceptualizing Peri-Implantitis: Dual-Factor Inflammation and Its Role in Advancing Biomaterial Coatings","authors":"Daniela Moreira Cunha,&nbsp;Amanda Paino Santana,&nbsp;Mariana Martins Guerreiro,&nbsp;Akhilanand Chaurasia,&nbsp;Anton Sculean,&nbsp;Rafael Scaf de Molon,&nbsp;Erica Dorigatti de Avila","doi":"10.1111/cid.70108","DOIUrl":"10.1111/cid.70108","url":null,"abstract":"&lt;p&gt;There is no doubt that peri-implantitis is an inflammatory condition affecting the tissues surrounding dental implants, driven by a complex interplay between microbial dysbiosis and the host immune response [&lt;span&gt;1&lt;/span&gt;]. Subclinical interactions between the dysbiotic biofilm and the host immune system are initiated largely by components of anaerobic Gram-negative bacteria, most notably lipopolysaccharide (LPS), which predominates at diseased peri-implant sites. LPS engages toll-like receptor 4 (TLR4) on epithelial and immune cells, activating transcriptional pathways that upregulate proinflammatory mediators and establish a permissive environment for leukocyte recruitment [&lt;span&gt;2&lt;/span&gt;]. Neutrophils, macrophages, and dendritic cells are rapidly mobilized and amplify tissue destruction through the release of cytokines and extracellular matrix-degrading enzymes. Among these innate immune cells, macrophages play a particularly central role in peri-implant disease pathogenesis, exhibiting a pronounced shift toward an M1-dominant phenotype [&lt;span&gt;3, 4&lt;/span&gt;]. Interestingly, macrophage polarization has also been implicated as a key pathogenic mechanism across a broad spectrum of chronic inflammatory diseases, including cancer, diabetes, atherosclerosis, and periodontitis [&lt;span&gt;5, 6&lt;/span&gt;] supporting the notion that peri-implantitis may share pathogenic pathways with, and potentially associate with, other local and systemic inflammatory conditions. M1-polarized macrophages produce RANKL, reactive oxygen species, and matrix metalloproteinases, thereby promoting osteoclastogenesis and accelerating bone resorption. Neutrophils further contribute through membrane-bound RANKL expression and heightened sensitivity to microbial cues. As disease progresses, adaptive immunity becomes similarly dysregulated, with helper T-cells (CD4&lt;sup&gt;+&lt;/sup&gt; T)-cell subsets, including Th1, Th2, Th17 cells, and regulatory T cells (Tregs), sustaining chronic inflammation and driving interleukin (IL-)17-mediated neutrophil recruitment and osteoclast activation. Tregs, characterized by expression of transcription factor forkhead box p3 (FOXP3), cluster of differentiation (CD)25, and the IL-2 receptor, are markedly elevated in peri-implantitis lesions and are typically associated with the production of IL-10, tgf beta growth factor (TGF)-β1, and IL-35. While IL-10 and TGF-β1 function as baseline homeostatic anti-inflammatory mediators, IL-35 is induced under intense inflammatory pressure. The observed imbalance with elevated FOXP3 and IL-35 coupled with reduced TGF-β1 suggests a dysfunctional or unstable Treg phenotype unable to effectively restrain inflammation, thereby contributing to the progressive soft- and hard-tissue destruction characteristic of peri-implantitis [&lt;span&gt;7&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In simple terms, a dysbiotic biofilm, an imbalanced and pathogenic microbial community adhered to the implant surface, acts as the primary trigger, initiating an inflammatory casc","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of ZAGA Classification on the Accuracy of 150 Digitally Planned Zygomatic Implants Placement","authors":"Francesco Zingari,&nbsp;Francesco Gallo,&nbsp;Riccardo Finamore,&nbsp;Selene Barone,&nbsp;Amerigo Giudice","doi":"10.1111/cid.70117","DOIUrl":"10.1111/cid.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This 3D analysis assessed the accuracy of zygomatic implant (ZI) placement using a static surgical guide in correlation with ZAGA classification and the rehabilitation type.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pre-surgical CT scans were used to create a virtual surgical plane, exported as .stl files, and to define the ZAGA classification of each implant. A CT scan was taken 6 months post-surgery, and segmentation of the zygomatic implants was performed. The 3D analysis on 3DSlicer software compared planned and placed zygomatic implants, measuring linear and angular displacements at the apex and base of each model. Displacements were correlated with the ZAGA classification and the type of rehabilitation (if quad, twin, or mono zygomatic implant).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 45 patients and 150 zygomatic implants, all placed using bone-supported surgical guides with no bone modifications. The implant survival rate was 100% at 6 months. Most patients received quad rehabilitation with 4 implants, and there was strong overlap between planned and placed implants. The mean surface displacement was 0.43 mm on the right and 0.45 mm on the left. The angular deviation between the planned and placed implant orientations was lower than 1° for both the anterior and posterior implants. According to ZAGA classification, surface displacement increased from class 0 to 4. No significant differences were found among the type of rehabilitation (<i>p</i> &gt; 0.289).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study highlights the accuracy of fully guided surgery for zygomatic implant placement, recommending its consideration in clinical decision-making. It also shows greater accuracy in lower ZAGA classes and no significant difference across rehabilitation types.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Osteomeatal Complex Variations and Maxillary Sinus Membrane Thickness: A CBCT Study","authors":"Damla Eda Yapıcı Gulbey,&nbsp;Abdussamet Batur,&nbsp;Seyit Ali Kayis,&nbsp;Guliz Nigar Guncu,&nbsp;Sema S. Hakki","doi":"10.1111/cid.70121","DOIUrl":"10.1111/cid.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Perforation is the most common complication of sinus floor elevation (SFE) surgery, and is closely associated with the thickness of the maxillary sinus membrane. This study aimed to evaluate the relationship between maxillary sinus membrane thickness and anatomical variations in the osteomeatal complex (OMC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cone beam computed tomography scans were retrospectively analyzed, encompassing 1957 sinuses. Mucosal thickness (MT) and mucosal appearance (MA) were classified as normal, flat thickening, polypoid thickening, or ostium obstruction. Ostium width (OW), infundibulum length (IL), and ethmoidal bulla diameter (EBD) were measured. The presence of Haller cells (HC), concha bullosa (CB), and superior attachment of the uncinate process (UPSA) was recorded. Kruskal–Wallis, Mann–Whitney U, Chi-square, and GEE models were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mucosal thickening was observed in 54% of the sinuses, with flat thickening (23.5%) being the most prevalent pattern. A significant association was found between ostium obstruction and MT greater than 10 mm. MT, IL, OW, and EBD values were significantly higher in men than in women. Significant correlations were also identified between MT and IL, OW, EBD, and HC. No significant relationship was found between CB and MT. However, UPSA types 3, 4, and 6 were significantly associated with polypoid thickening and ostium obstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings demonstrate that anatomical variations in the OMC influence maxillary sinus membrane thickness. A comprehensive evaluation of these variations should be performed before planning for SFE procedures. Dentists should be proficient in identifying and assessing the osteomeatal region during routine radiographic examinations to prevent potential complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}