Clinical Implant Dentistry and Related Research最新文献

{"title":"Clinical and Histologic Outcomes of Biologically Oriented Alveolar Ridge Preservation: A Prospective Observational Study","authors":"Antonio Rapani,&nbsp;Leonardo Tonegato,&nbsp;Paolo Savadori,&nbsp;Rebecca Martini,&nbsp;Riccardo Pasquali,&nbsp;Matteo Zotti,&nbsp;Vanessa Nicolin,&nbsp;Federico Berton,&nbsp;Claudio Stacchi","doi":"10.1111/cid.70048","DOIUrl":"https://doi.org/10.1111/cid.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study aimed to evaluate the efficacy of Biologically oriented Alveolar Ridge Preservation (BARP) in minimizing post-extraction ridge modifications compared with unassisted socket healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective controlled observational study was conducted involving 30 patients requiring single-rooted upper premolar extractions. Patients were divided into two groups: the test (15 patients), which underwent a ridge preservation procedure combining absorbable collagen sponge in the middle and apical third of the socket and collagenated xenogeneic bone substitute in the most coronal part (BARP), and the control (15 patients), which healed spontaneously. Soft tissue contour changes after 6 months were analyzed using digital impressions. Moreover, histomorphometric analysis of the regenerated tissue was performed in the test group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BARP significantly reduced post-extractive mucosal ridge modifications compared to the control group. Mean vertical shrinkage at the mid-buccal part of the edentulous site was 1.61 ± 0.61 mm (BARP) vs. 2.51 ± 0.64 mm (control; <i>t</i>-test, df = 28, <i>p</i> &lt; 0.001), and mean horizontal reduction was 3.37 ± 0.63 mm (BARP) vs. 4.34 ± 0.48 mm (control; <i>t</i>-test, df = 28, <i>p</i> &lt; 0.001). Histomorphometric analysis of the regenerated tissue showed 39.7% ± 9.1% newly formed bone with minimal residual graft material (5.0% ± 5.4%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>BARP technique effectively minimizes post-extractive soft tissue contour modifications and supports natural bone regeneration, resulting in adequate bone dimensions for implant rehabilitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Workflow and Guided Surgery in Implant Therapy—Literature Review and Practical Tips to Optimize Precision","authors":"Chia-Sheng Chen,&nbsp;Hsin Hsu,&nbsp;Yun-Wen Kuo,&nbsp;Hsin-Yu Kuo,&nbsp;Chin-Wei Wang","doi":"10.1111/cid.70038","DOIUrl":"https://doi.org/10.1111/cid.70038","url":null,"abstract":"<div>\u0000 \u0000 <p>The application of digital technology in implant dentistry refines prosthetically-driven treatment planning by integrating virtual facial and intraoral models with cone-beam computed tomography (CBCT) images. This integration enables the development of more personalized treatment plans, ensures precise implant positioning, and strengthens communication between clinicians and patients, thereby reducing potential errors and risks. Computer-aided implant surgery consists of two primary approaches: static-guided surgery, which uses a physical surgical stent to guide the osteotomy based on the preoperatively planned virtual implant position, and dynamic-guided surgery, which employs an optical tracking system with a real-time monitor display for the visualization of implant osteotomy inside the alveolar bone. Each approach offers distinct advantages and poses unique clinical challenges. This paper provides an overview of the current applications and literature on digital treatment planning and computer-aided implant surgery, discussing the advantages and limitations of each approach. Clinical cases are presented to illustrate the digital workflow and highlight key considerations for implementing these methods. Currently, the use of digital workflow in implant dentistry is rising, and it is essential to strike a balance between precision and practicality. The future is promising, with generalized adoption anticipated.</p>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reliability of CBCT to Assess Quality of Augmented Bone After Lateral Sinus Floor Elevation With Xenografts: A Retrospective Analysis","authors":"Xixuan Wang,&nbsp;Wenyan Zhao,&nbsp;Menglin Liao,&nbsp;Yunfei Liu,&nbsp;Chengzhe Ban,&nbsp;Gang Fu,&nbsp;Qingqing Wu","doi":"10.1111/cid.70029","DOIUrl":"https://doi.org/10.1111/cid.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objetives</h3>\u0000 \u0000 <p>This study aimed to explore the reliability of cone beam computed tomography (CBCT) in evaluating the quality of augmented bone after lateral sinus floor elevation (LSFE) with xenografts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-six patients with lost maxillary molars were included, with half of whom received LSFE with xenografts and staged implant placement, and the other half showed no vertical bone defects and underwent implant placement directly. A total of 36 implants were included, with 18 implants in each group. A CBCT exam was taken before implant placement to acquire data on mineral quality at the future implant site, including bone mineral density (BMD), various microstructure indices, and gray values (GVs) within different threshold ranges. Augmented bone biopsies were collected during implant preparation. The microstructure indices and histological characteristics of the biopsies were evaluated by micro computed tomography (μCT) and histological staining. An implant-oriented volume of interest for CBCT analysis was established to co-locate the CBCT-measured data and the biopsy-related data using 3DSlicer. A Spearman rank correlation test was used to analyze the relationship between CBCT-measured data and the biopsy-related data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>μCT-measured microstructure indices of the augmented bone (BV/TV and Tb.Th) were significantly correlated with new bone area (BV/TV, <i>p</i> = 0.035, <i>r</i> = 0.498; Tb.Th, <i>p</i> = 0.027, <i>r</i> = 0.520). No correlation was found between the CBCT-measured and μCT-measured microstructure indices. CBCT-measured BMD and microstructure indices hardly showed any correlation with histological indices (<i>p</i> &gt; 0.05). When the threshold was set from 0 to 50, the mean GVs were significantly, positively correlated with new bone area (<i>p</i> = 0.041, <i>r</i> = 0.486), and bone substitute area was positively correlated to the mean GVs of higher threshold (range 60–255, <i>p</i> = 0.048, <i>r</i> = 0.472; range 70–255, <i>p</i> = 0.009, <i>r</i> = 0.593).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CBCT without bone substitute segmentation was not reliable for evaluating the quality of xenogenic augmented bone after LSFE. The influence of the xenogenic substitute on CBCT analysis can be reduced by setting a low GV threshold. The bone substitute segmentation strategy may present a new way to increase the reliability of CBCT in evaluating xenogenic augmented bone.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Anterior Immediate Versus Delayed Implant Placement With an Autonomous Robotic System: A Retrospective Study","authors":"Danhong Zhou,&nbsp;Zichun Xia,&nbsp;Yunxuan Chen,&nbsp;Jin He,&nbsp;Danji Zhu,&nbsp;Yinhuan Zhou,&nbsp;Zhiwei Jiang,&nbsp;Guoli Yang","doi":"10.1111/cid.70047","DOIUrl":"https://doi.org/10.1111/cid.70047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to compare the accuracy of an autonomous robotic system for anterior immediate and delayed implant placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included patients who underwent anterior dental implant surgery from September 2022 to March 2025 using an autonomous robotic system. Osteotomies performed with the autonomous robotic system in this study were modified by using precision and side-cutting drills, along with repeated lifting of drills to minimize deviations. Linear and angular deviations in two- and three-dimensional space were assessed by matching preoperative planning with postoperative cone beam computed tomography. Postoperative pain and surgical satisfaction were recorded using a 100-mm visual analog scale. The Shapiro–Wilk test, Student's <i>t</i>-test, Mann–Whitney <i>U</i>-test, Pearson's Chi-Square test, and Fisher's exact test were used, and <i>p</i> &lt; 0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This retrospective study included 53 patients (65 implants) who underwent anterior dental implant surgery with the autonomous robotic system (immediate implant placement group: 19 patients, 21 implants; delayed implant placement group: 34 patients, 44 implants). Comparison of deviations in immediate and delayed implantation using the autonomous robotic system showed a mean (± SD) coronal deviation of 0.57 ± 0.19 mm versus 0.49 ± 0.20 mm (<i>p</i> = 0.129), a mean apical deviation of 0.57 ± 0.19 mm versus 0.52 ± 0.21 mm (<i>p</i> = 0.373), and a mean angular deviation of 0.53° ± 0.18° versus 0.61° ± 0.28° (<i>p</i> = 0.742). Postoperative pain and surgical satisfaction were not significantly different between the two groups (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The autonomous robotic system demonstrated high and comparable accuracy in both anterior immediate and delayed implantation, with overall patient satisfaction. This could reduce the technical sensitivity of anterior immediate implant placement, enhance precision, and broaden the clinical applications of the autonomous robotic system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"","doi":"10.1111/cid.70045","DOIUrl":"https://doi.org/10.1111/cid.70045","url":null,"abstract":"<p>The cover image is based on the article <i>Clinical Outcomes of Bone-Level and Tissue-Level Short Implants Placed in Posterior Maxilla: A Case–Control Study</i> by Teresa Lombardi et al., https://doi.org/10.1111/cid.13428.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to a Letter to the Editor: A Randomized Controlled Trial on the Timing of Soft Tissue Augmentation in Immediate Implant Placement","authors":"Thibault Struys,&nbsp;Véronique Christiaens,&nbsp;Thomas De Bruyckere,&nbsp;Jeremy Pitman,&nbsp;Pieter-Jan Van Hove,&nbsp;Jan Cosyn","doi":"10.1111/cid.70039","DOIUrl":"https://doi.org/10.1111/cid.70039","url":null,"abstract":"","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of Cement Materials and Isolation Techniques for the Effective Removal of Residual Cement in the Cementation","authors":"Süha Kuşçu,&nbsp;Yeliz Hayran","doi":"10.1111/cid.70040","DOIUrl":"https://doi.org/10.1111/cid.70040","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to investigate the impact of different cement and cement isolation techniques used in implant-supported restorations on eliminating residual cement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study employed two distinct cement isolation methods: rubber dam and polytetrafluoroethylene tape. The study comprised three primary groups comprising 30 samples, categorized based on the isolation methods and control group. The cement excess was removed with a dental explorer probe for the control group. Moreover, three different cement materials were used: polycarboxylate, temporary implant, and resin cement. Each primary group was subdivided into three subgroups according to the type of cement used, leading to 10 samples per subgroup. Cobalt-chromium superstructures, intended to be cemented onto the implant analog-abutment complex, were fabricated using the direct metal laser sintering method. The crowns were filled with cement, and after the cementation process, any excess cement was subsequently removed using the designated isolation method. After removal, images of the cement residues at the gingival margin of the crown-abutment complex and occlusal surface of the gingiva around the implant were captured. These images were then analyzed using Adobe Photoshop CC2018, wherein excess cement was marked using the Lasso Tool to quantify the total area. The excess cement data was analyzed using IBM SPSS Statistics Version 23 software.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The results of the three-way ANOVA showed a difference in excess cement amounts between the isolation methods and cement materials (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). In evaluating the isolation methods, the rubber dam was identified as the most suitable for temporary cement, while polytetrafluoroethylene tape was determined as the most suitable method for resin cement. Using a dental probe resulted in the highest amount of residual cement across all cement materials. Among the cement types, polycarboxylate cement exhibited the highest residual cement amount, followed by temporary implant cement and resin cement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The amount of excess cement was influenced by the isolation method and the type of cement used. The rubber dam emerged as the most effective method for minimizing cement residues. The most significant amount of residual cement was identified for polycarboxylate, whereas the lowest amount was observed for resin cement. The appropriate isolation method should be selected ","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Analysis of Peri-Implant Soft Tissue Gain With Collagen Matrix and Connective Tissue Graft: A Randomized Control Trial","authors":"Igor Ashurko,&nbsp;Svetlana Tarasenko,&nbsp;Mary Magdalyanova,&nbsp;Maxim Balyasin,&nbsp;Anna Galyas,&nbsp;Sabina Kazumyan,&nbsp;Nadiya Safi,&nbsp;Alexey Unkovskiy","doi":"10.1111/cid.70043","DOIUrl":"https://doi.org/10.1111/cid.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the efficacy of the connective tissue graft (SCTG) and the collagen matrix (VXCM) in terms of soft tissue gain at the buccal site around a single implant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was designed as a randomized, controlled clinical trial. This trial was registered in ClinicalTrial.gov with the identifier NCT05870774 and is accessible under the following link: https://clinicaltrials.gov/study/NCT05870774?term=NCT05870774&amp;rank=1. This clinical trial was not registered prior to participant recruitment and randomization. Patients with a single tooth gap and horizontal soft tissue thickness deficiency were enrolled in the study. Sites were randomly allocated to the control (SCTG) or test group (VXCM: Geistlich Fibro-Gide, Geistlich Pharma AG, Wolhusen, Switzerland) to augment buccal soft tissue thickness. The primary outcome was soft tissue gain 3 months post-op. Secondary outcomes included soft tissue gain 6 months post-op, the pink aesthetic score (PES), and patient-reported outcome measures (PROMs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients' recruitment started on 28 October 2021 and ended on 25 December 2022. Thirty-two patients were enrolled and subjected to intervention. Sixteen patients were included per group. Three months post-op, soft tissue gain at the buccal site was 1.77 ± 0.61 mm in the VXCM group and 1.26 ± 0.41 mm in the SCTG group (<i>p</i> = 0.0003). Six months post-op, soft tissue gain was 1.11 ± 0.44 mm in the VXCM group and 1.43 ± 0.81 mm in the SCTG group (<i>p</i> = 0.0459). PROMs, including pain perception, favored the VXCM group. SCTG demonstrated favored results in PES.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SCTG remains the gold standard for increasing soft tissue thickness in terms of the clinical result.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Hyaluronic Acid on Prefabricated CAD CAM Bone Blocks for Ridge Augmentation: A Split Mouth Study","authors":"Mohamed Hamdy Helal,&nbsp;Mona S. Sheta,&nbsp;Aya Anwar Alsherif,&nbsp;Mai Atef Hassan,&nbsp;Moustafa Nabil Aboushelib,&nbsp;Rehab F. Ghouraba","doi":"10.1111/cid.70035","DOIUrl":"https://doi.org/10.1111/cid.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Alveolar ridge augmentation has been one of the most accepted treatments for restoring bone volume. Various products are available in particle forms, which have limitations, especially related to controlling the expected volume gain. A prefabricated computer-aided design and computer-aided manufacturing (CAD-CAM) allogenic bone block could provide a good alternative.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A split-mouth randomized clinical trial included 10 patients with the bilateral posterior atrophic mandible (20 sides), who were randomly assigned to two groups with an allocation ratio of 1:1. Group I: the ridge was augmented using prefabricated CAD-CAM allogenic bone block hydrated using hyaluronic acid, and group II was hydrated using saline. Blinding was limited to the patients and the investigator responsible for data analysis (double blinding). Six months after grafting surgery, a core biopsy was taken for histological analysis, and implants were inserted into the augmented ridge. The amount of bone gain was evaluated radiographically using CBCT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All ridges in both groups revealed a successful bone gain in CBCT. However, the mean bone gain in group I (3.975 ± 0.31) was significantly higher than in group II (2.497 ± 0.66). Histologically, both groups showed osteointegration and new bone formation, with group I being superior. VEGF, OPN, and Cox 2 expressions were more intense in group I than in group II. The histomorphometric analysis revealed that group I had a considerably higher surface area of new bone formation than group II (<i>p</i>-value &lt; 0.001). Immunohistochemical staining for VEGF revealed a significant difference between groups I (15.04 ± 0.47) and II (11.41 ± 0.54).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this study, the addition of HA to prefabricated CAD-CAM allogenic block enhanced its osteogenic properties and guaranteed adequate integration of the graft for implant insertion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This clinical trial was not registered before the participants' recruitment and randomization (https://clinicaltrials.gov/study/NCT06395818<span>)</span>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Yuhuan Jiang,&nbsp;Yujia Yang,&nbsp;Liya Chen,&nbsp;Weikai Zhou,&nbsp;Yi Man,&nbsp;Jing Wang","doi":"10.1111/cid.70032","DOIUrl":"https://doi.org/10.1111/cid.70032","url":null,"abstract":"<p>The cover image is based on the article Digitally Guided Aspiration Technique for Maxillary Sinus Floor Elevation in the Presence of Cysts: A Case Series by Yuhuan Jiang et al., https://doi.org/10.1111/cid.70009.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50679,"journal":{"name":"Clinical Implant Dentistry and Related Research","volume":"27 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cid.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}