Colombia Medica最新文献

{"title":"Internal migration and its association with childhood asthma in Ecuador: a cross-sectional study.","authors":"Alexandro Vinicio Cruz Mariño, Philip Cooper, Martha Chico, Natalia Romero-Sandoval, Alejandro Rodríguez","doi":"10.25100/cm.v55i2.5929","DOIUrl":"10.25100/cm.v55i2.5929","url":null,"abstract":"<p><strong>Background: </strong>Differences in asthma prevalence between urban and rural areas have been observed worldwide. Epidemiological studies in middle- and low-income countries suggest that internal migration processes may partly explain these disparities.</p><p><strong>Objective: </strong>To investigate the association between internal migration and asthma in children living in transitional areas of Ecuador.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using data from a birth cohort of children living in a tropical coastal region in northwestern Ecuador. Asthma indicators included wheezing in the past 12 months, ever wheezing, and asthma diagnosis by a doctor. Internal migration was defined as a change of residence between geographical units: cantonal, parish, and census tract. The relationship between asthma and migration was analyzed using binary logistic regression.</p><p><strong>Results: </strong>Of 2,404 participants, 1,818 children met the inclusion criteria. Among them, 2.8% experienced cantonal migration, 11.9% parish migration, and 24.6% census tract migration. The prevalence of wheezing in the past 12 months, ever wheezing, and asthma diagnosis by a doctor was 13.1%, 33.3%, and 7%, respectively. Children with a history of cantonal migration were more likely to have experienced wheezing compared to those who did not migrate (OR: 1.56; 95%CI: 0.87-2.79).</p><p><strong>Conclusions: </strong>Changes in residence between smaller or adjacent geographic units appeared not to be associated with asthma prevalence. However, cantonal migration may play a role in respiratory health outcomes.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"55 2","pages":"e2035929"},"PeriodicalIF":0.7,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal parasites in children from native communities of Salta, Argentina.","authors":"Carlos Matias Scavuzzo, Micaela Natalia Campero, María Georgina Oberto, Ximena Porcasi, María Victoria Periago","doi":"10.25100/cm.v55i1.5948","DOIUrl":"10.25100/cm.v55i1.5948","url":null,"abstract":"<p><strong>Introduction: </strong>Intestinal parasites particularly affect vulnerable populations, making their management crucial in endemic areas.</p><p><strong>Objective: </strong>To evaluate the relationship between intestinal parasites, socioeconomic characteristics, and anthropometric nutritional status.</p><p><strong>Methods: </strong>This is an observational, cross-sectional study conducted on children aged 1 to 15 years in Tartagal, Argentina, for a year. Intestinal parasitic infections were determined through fecal analysis using sedimentation techniques (Teleman), Kato-Katz, and the Baerman method. Demographic and socioeconomic data were collected using a standardized survey. Height, weight, and mid-upper arm and head circumference were measured in the participants.</p><p><strong>Results: </strong>Of the 588 participants who provided fecal samples, 55.4% had intestinal parasites, with G. lamblia and H. nana being the most prevalent species. Additionally, 31.9% of participants were found to have malnutrition due to excess weight. Risk factors for intestinal parasite presence included age, overcrowding, and walking barefoot, while owning a refrigerator, having an animal corral, adequate water storage, and belonging to the Guaraní ethnic group were protective factors. High vulnerability areas were observed regarding housing conditions and access to public services.</p><p><strong>Conclusions: </strong>An association between socioeconomic conditions and the risk of intestinal parasite presence was observed. However, no association was found between anthropometric nutritional status and the presence of intestinal parasites.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"55 1","pages":"e2025948"},"PeriodicalIF":0.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporadic Creutzfeldt Jakob disease: Case series in Peru.","authors":"Stefany Espinoza, Diego Canales, Cecilia Calderón, David Diaz, Elliot Barreto-Acevedo","doi":"10.25100/cm.v55i1.5821","DOIUrl":"10.25100/cm.v55i1.5821","url":null,"abstract":"<p><strong>Description of the cases: </strong>A series of 6 cases with a probable diagnosis of sporadic CJD, treated in a Peruvian national reference hospital, are presented.</p><p><strong>Clinical findings: </strong>The relevant clinical signs were rapidly progressive dementia and myoclonus, followed by akinetic mutism and pyramidal signs.</p><p><strong>Treatment and results: </strong>Of the cases presented, 80% were men, with an average age of presentation of 65 years and duration from diagnosis to death of 6.5 months. Laboratory tests, images (Brain Resonance) and protein dosage 14.3.3 were performed to support the clinical suspicion. There is no effective treatment at the moment for said pathology.</p><p><strong>Clinical relevance: </strong>Creutzfeldt-Jakob disease (CJD) is a progressive, fatal, neurodegenerative disease of low prevalence and incidence. Great clinical suspicion and the exclusion of other etiologies are required. Currently there is no treatment for this entity and there is a high probability of death before one year.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"55 1","pages":"e2035821"},"PeriodicalIF":0.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with pain sensation in patients with ultrasound-guided prostate biopsy.","authors":"Nihat Turkmen, Kadir Cem Günay","doi":"10.25100/cm.v55i1.5781","DOIUrl":"10.25100/cm.v55i1.5781","url":null,"abstract":"<p><strong>Introduction: </strong>TRUS-guided prostate biopsy is a current method used to obtain the histopathological material necessary to make a definitive diagnosis of prostate cancer.</p><p><strong>Objective: </strong>To investigate patient-related variables affecting the level of pain felt during prostate biopsy to determine what can be done to minimize pain.</p><p><strong>Methods: </strong>The study included 241 patients scheduled for prostate biopsy. Four patients who did not meet the criteria were excluded. Local anesthesia was administered intrarectally 10 minutes before the biopsy to 237 patients, and a conventional 12-core biopsy was performed. The level of pain felt by all patients during the biopsy was measured using the Visual Analog Scale (VAS) score. Pain scores were compared by forming groups according to the selected parameters.</p><p><strong>Results: </strong>The mean age of the 237 included patients was 66.0±7.8 years, the mean serum PSA level was 33.7±197.5 ng/dL, and the mean prostate volume was 33.7±197.5 ml. The mean VAS score was 4.3±1.9. The pain score was higher in patients with positive digital rectal examination findings and lower in patients using 5-alpha reductase inhibitors(5-ARİ). At the same time, no significant difference was found in patients with positive tumor pathology, perineural invasion, alpha-blockers, or combination therapy.</p><p><strong>Conclusion: </strong>Some patient parameters may affect the level of pain felt during TRUS-guided prostate biopsy.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"55 1","pages":"e2045781"},"PeriodicalIF":0.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in scientific writing: What are the ethical boundaries? - A Reflection inspired by the myth of Prometheus.","authors":"Raúl Alberto Aguilera-Eguía, Ángel Roco Videla, Héctor Fuentes-Barria, Cristian Yáñez-Baeza","doi":"10.25100/cm.v54i4.5954","DOIUrl":"10.25100/cm.v54i4.5954","url":null,"abstract":"","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 4","pages":"e7005954"},"PeriodicalIF":0.7,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proprioceptive rehabilitation strategies in posttraumatic wrist injuries. Scoping review.","authors":"Lida J Sánchez-Montoya, Diana P Sánchez, Leidy Tatiana Ordoñez-Mora","doi":"10.25100/cm.v54i4.5709","DOIUrl":"10.25100/cm.v54i4.5709","url":null,"abstract":"<p><strong>Background: </strong>The proprioceptive approach can effectively improve strength, mobility, edema reduction, and pain reduction, which in turn has a positive impact on functionality.</p><p><strong>Objective: </strong>To identify proprioceptive rehabilitation strategies reported in the literature in adults with traumatic wrist injuries.</p><p><strong>Methods: </strong>A scoping review was performed following the parameters of the Prisma ScR strategy. We included research with adult patients diagnosed with posttraumatic wrist injuries who used proprioceptive rehabilitation. Pain, functionality, strength, joint mobility ranges, and edema were evaluated.</p><p><strong>Results: </strong>After removing duplicates and applying the exclusion criteria, a total of 123 articles were found, which left six articles, including 125 patients. Rehabilitation protocols based on proprioceptive neuromuscular facilitation and using sensorimotor tools that promote wrist recovery have been generated. In addition, other approaches have been established, such as motor imagery, which generates a work of identification and organization of movement, improving pain and manual function. However, longer follow-ups, standardization of the instruments used during proprioceptive intervention, and increasing the observed population are needed to generate a recommendation for early intervention and cost-benefit estimates.</p><p><strong>Conclusion: </strong>Proprioceptive rehabilitation has demonstrated benefits in the recovery of the lower limb and hip or back. However, for the rehabilitation of traumatic wrist injuries, it is research pending. Well-described data and good quality designs are needed to routinely propose this strategy in the clinic.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 4","pages":"e3005709"},"PeriodicalIF":0.7,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of central intermittent theta-burst stimulation combined with repetitive peripheral magnetic stimulation on upper limb function in stroke patients.","authors":"Shangrong Jiang, Tingtin Han, Zhijie Zhang, Mingming Wen, Yongping Li","doi":"10.25100/cm.v54i4.5766","DOIUrl":"10.25100/cm.v54i4.5766","url":null,"abstract":"<p><strong>Background: </strong>Intermittent theta-burst stimulation and repetitive peripheral magnetic stimulation can improve motor function in poststroke patients, but the therapeutic effect of this combination remains unclear.</p><p><strong>Objective: </strong>To determine the effects of central intermittent theta-burst stimulation and repetitive peripheral magnetic stimulation on upper limb function.</p><p><strong>Methods: </strong>Fifty-six subacute stroke patients were randomly assigned to three groups: the CMS (n = 18), peripheral magnetic stimulation (PMS) (n = 19) and CPS (n = 19) groups. The CMS group received intermittent theta-burst stimulation and peripheral false stimulation, while the PMS group received repetitive peripheral magnetic stimulation and central false stimulation once a day for five days a week over four weeks. The CPS group received intermittent theta-burst stimulation and repetitive peripheral magnetic stimulation simultaneously once daily for four weeks. The Fugl-Meyer Assessment, Action Research Arm Test, Modified Barthel Index and Modified Ashworth Scale evaluated outcomes before and after four weeks of treatment.</p><p><strong>Results: </strong>The motor function scores of all groups were significantly increased after treatment compared with before treatment, while the Modified Ashworth Scale score showed no significant change. There was a significant difference in the motor function score of the CPS group compared with that of the CMS and PMS groups, but there was no significant improvement in the Modified Ashworth Scale score.</p><p><strong>Conclusion: </strong>Combining the two treatment methods can improve patients' motor function and daily living abilities but cannot improve muscle tone.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 4","pages":"e2005766"},"PeriodicalIF":0.7,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac resynchronization therapy in acute heart failure and left bundle-branch block in a real-life registry.","authors":"Oriol Aguiló, Joan Carles Trullàs, Begoña Espinosa, Pedro López-Ayala, Víctor Gil, María Luisa López-Grima, Pablo Herrero-Puente, Javier Jacob, María Pilar López-Díez, José Manuel Garrido, Javier Millán, Alfons Aguirre, Pascual Piñera, Christian E Müller, Pere Llorens, Òscar Miro","doi":"10.25100/cm.v54i4.5850","DOIUrl":"10.25100/cm.v54i4.5850","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence, characteristics, timing of implementation and prognosis of patients with left bundle branch block (LBBB) and acute heart failure (AHF) treated with cardiac resynchronization therapy (CRT) in a real-life registry.</p><p><strong>Methods: </strong>We analysed the characteristics of patients with AHF and LBBB at the time of inclusion in the EAHFE (Epidemiology Acute Heart Failure Emergency) cohort to determine the indication for CRT, the timing of implementation and its impact on 10-year all-cause mortality.</p><p><strong>Results: </strong>729 patients with a median age of 82 years and there was a high burden of comorbidities and functional dependence. The median left-ventricle ejection fraction (LVEF) was 40%. Forty-six (6%) patients were treated with CRT at some point during follow-up, with a median time of delay for CRT implementation of 960 (IQR=1,147 days) and at least 108 more untreated patients fulfilled criteria for CRT. Patients receiving CRT were younger, had different comorbidities, less functional dependence (higher Barthel index) and lower LVEF values. The median follow-up was 5.7 years (95% CI: 5.6-5.8) and CRT was not associated with changes in 10-year mortality (adjusted HR 1.33, 95% CI: 0.72-2.48; p-value 0.4). When compared with untreated patients fulfilling criteria for CRT, very similar results were observed (adjusted HR 1.34, 95% CI: 0.67-2.68).<b></b></p><p><strong>Conclusions: </strong>CRT implementation was delayed and underused in patients with AHF and LBBB. Under these circumstances, CRT is not associated with a reduction in all-cause mortality in the long term.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 4","pages":"e2015850"},"PeriodicalIF":0.7,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characterization and outcomes of a cohort of colombian patients with AL Amyloidosis.","authors":"Jorge Andrés Lacouture Fierro, Daniel Andrés Ribero Vargas, Juanita Sánchez Cano, Lina Maria Gaviria Jaramillo, Oliver Gerardo Perilla Suarez, Kenny Mauricio Galvez Cárdenas, Sigifredo Ospina Ospina","doi":"10.25100/cm.v54i3.5667","DOIUrl":"https://doi.org/10.25100/cm.v54i3.5667","url":null,"abstract":"<p><strong>Background: </strong>Amyloid light chain (AL) amyloidosis is characterized by amyloid fibril deposition derived from monoclonal immunoglobulin light chains, resulting in multiorgan dysfunction. Limited data exist on the clinical features of AL amyloidosis.</p><p><strong>Objective: </strong>This study aims to describe the clinical characteristics, treatments, and outcomes in Colombian patients with AL amyloidosis.</p><p><strong>Methods: </strong>A retrospective descriptive study was conducted at three high-complexity centers in Medellín, Colombia. Adults with AL amyloidosis diagnosed between 2012 and 2022 were included. Clinical, laboratory, histological, treatment, and survival data were analyzed.</p><p><strong>Results: </strong>The study included 63 patients. Renal involvement was most prevalent (66%), followed by cardiac involvement (61%). Multiorgan involvement occurred in 61% of patients. Amyloid deposition was most commonly detected in renal biopsy (40%). Bortezomib-based therapy was used in 68%, and 23.8% received high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDCT-ASCT). Hematological response was observed in 95% of patients with available data. Cardiac and renal organ responses were 15% and 14%, respectively. Median overall survival was 45.1 months (95% CI: 22.2-63.8). In multivariate analysis, cardiac involvement was significantly associated with inferior overall survival (HR 3.27; 95% CI: 1.23-8.73; <i>p</i>=0.018), HDCT-ASCT had a non-significant trend towards improved overall survival (HR 0.25; 95% CI: 0.06-1.09; <i>p</i>=0.065).</p><p><strong>Conclusions: </strong>In this study of Colombian patients with AL amyloidosis, renal involvement was more frequent than cardiac involvement. Overall survival and multiorgan involvement were consistent with data from other regions of the world. Multivariate analysis identified cardiac involvement and HDCT-AHCT as possible prognostic factors.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 3","pages":"e2025667"},"PeriodicalIF":1.1,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.","authors":"Ana Isabel Giraldo-Rincón, Sara Naranjo Molina, Natalia Gomez-Lopera, Daniel Aguirre Acevedo, Andrea Ucroz Benavidez, Kenny Gálvez Cárdenas, Francisco Cuellar Ambrosí, Jose Domingo Torres, Sigifredo Ospina, Katherine Palacio, Lina Gaviria Jaramillo, Carlos Mario Muñeton, Gonzalo Vasquez Palacio","doi":"10.25100/cm.v54i3.5353","DOIUrl":"10.25100/cm.v54i3.5353","url":null,"abstract":"<p><strong>Background: </strong>Among the chronic myeloproliferative neoplasms (MPNs) not associated with BCR-ABL mutations are polycythemia vera, primary myelofibrosis, and essential thrombocythemia. These diseases are caused by mutations in genes, such as the JAK2, MPL, and CALR genes, which participate in regulating the JAK-STAT signaling pathway.</p><p><strong>Objective: </strong>This study aimed to establish the frequencies of mutations in the JAK2, MPL, and CALR genes in a group of Colombian patients with a negative clinical diagnosis of BCR-ABL chronic myeloproliferative neoplasms.</p><p><strong>Methods: </strong>The JAK2 V617F and MPL W515K mutations and deletions or insertions in exon 9 of the CALR gene were analyzed in 52 Colombian patients with polycythemia vera, primary myelofibrosis, and essential thrombocythemia.</p><p><strong>Results: </strong>The JAK2V617F mutation was carried by 51.9% of the patients, the CALR mutation by 23%, and the MPL mutation by 3.8%; 23% were triple-negative for the mutations analyzed. In these neoplasms, 6 mutation types in CALR were identified, one of which has not been previously reported. Additionally, one patient presented a double mutation in both the CALR and JAK2 genes. Regarding the hematological results for the mutations, significant differences were found in the hemoglobin level, hematocrit level, and platelet count among the three neoplasms.</p><p><strong>Conclusion: </strong>Thus, this study demonstrates the importance of the molecular characterization of the JAK2, CALR and MPL mutations in Colombian patients (the genetic context of which remains unclear in the abovementioned neoplasms) to achieve an accurate diagnosis, a good prognosis, adequate management, and patient survival.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"54 3","pages":"e2035353"},"PeriodicalIF":1.1,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}