eneuro最新文献

筛选

英文中文

Locus Ceruleus Dynamics Are Suppressed during Licking and Enhanced Postlicking Independent of Taste Novelty 舔食过程中神经节动力受抑制，舔食后动力增强，与味觉新奇性无关

eneuro Pub Date : 2024-04-01 DOI: 10.1523/ENEURO.0535-23.2024

Will Fan, Christopher B. Engborg, Natale R. Sciolino

{"title":"Locus Ceruleus Dynamics Are Suppressed during Licking and Enhanced Postlicking Independent of Taste Novelty","authors":"Will Fan, Christopher B. Engborg, Natale R. Sciolino","doi":"10.1523/ENEURO.0535-23.2024","DOIUrl":"https://doi.org/10.1523/ENEURO.0535-23.2024","url":null,"abstract":"Attending to salient sensory attributes of food, such as tastes that are new, displeasing, or unexpected, allows the procurement of nutrients without food poisoning. Exposure to new tastes is known to increase norepinephrine (NE) release in taste processing forebrain areas, yet the central source for this release is unknown. Locus ceruleus norepinephrine neurons (LC-NE) emerge as a candidate in signaling salient information about taste, as other salient sensory stimuli (e.g., visual, auditory, somatosensation) are known to activate LC neurons. To determine if LC neurons are sensitive to features of taste novelty, we used fiber photometry to record LC-NE activity in water-restricted mice that voluntarily licked either novel or familiar substances of differential palatability (saccharine, citric acid). We observed that LC-NE activity was suppressed during lick bursts and transiently activated upon the termination of licking and that these dynamics were independent of the familiarity of the substance consumed. We next recorded LC dynamics during brief and unexpected consumption of tastants and found no increase in LC-NE activity, despite their responsiveness to visual and auditory stimuli, revealing selectivity in LC's responses to salient sensory information. Our findings suggest that LC activity during licking is not influenced by taste novelty, implicating a possible role for non-LC noradrenergic nuclei in signaling critical information about taste.","PeriodicalId":506486,"journal":{"name":"eneuro","volume":"347 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring Changes in TMS-Evoked EEG and EMG Activity During 1 Hz rTMS of the Healthy Motor Cortex 监测健康运动皮层 1 赫兹经颅磁刺激期间经颅磁刺激诱发的脑电图和肌电图活动变化

eneuro Pub Date : 2024-04-01 DOI: 10.1523/ENEURO.0309-23.2024

S. Schoisswohl, Carolina Kanig, M. Osnabruegge, D. Agboada, B. Langguth, Roman Rethwilm, T. Hebel, M. Abdelnaim, Wolfgang Mack, Wolfgang Seiberl, Manuel Kuder, M. Schecklmann

{"title":"Monitoring Changes in TMS-Evoked EEG and EMG Activity During 1 Hz rTMS of the Healthy Motor Cortex","authors":"S. Schoisswohl, Carolina Kanig, M. Osnabruegge, D. Agboada, B. Langguth, Roman Rethwilm, T. Hebel, M. Abdelnaim, Wolfgang Mack, Wolfgang Seiberl, Manuel Kuder, M. Schecklmann","doi":"10.1523/ENEURO.0309-23.2024","DOIUrl":"https://doi.org/10.1523/ENEURO.0309-23.2024","url":null,"abstract":"Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique capable of inducing neuroplasticity as measured by changes in peripheral muscle electromyography (EMG) or electroencephalography (EEG) from pre-to-post stimulation. However, temporal courses of neuromodulation during ongoing rTMS are unclear. Monitoring cortical dynamics via TMS-evoked responses using EMG (motor-evoked potentials; MEPs) and EEG (transcranial-evoked potentials; TEPs) during rTMS might provide further essential insights into its mode of action – temporal course of potential modulations. The objective of this study was to first evaluate the validity of online rTMS-EEG and rTMS-EMG analyses, and second to scrutinize the temporal changes of TEPs and MEPs during rTMS. As rTMS is subject to high inter-individual effect variability, we aimed for single-subject analyses of EEG changes during rTMS. Ten healthy human participants were stimulated with 1,000 pulses of 1 Hz rTMS over the motor cortex, while EEG and EMG were recorded continuously. Validity of MEPs and TEPs measured during rTMS was assessed in sensor and source space. Electrophysiological changes during rTMS were evaluated with model fitting approaches on a group- and single-subject level. TEPs and MEPs appearance during rTMS was consistent with past findings of single pulse experiments. Heterogeneous temporal progressions, fluctuations or saturation effects of brain activity were observed during rTMS depending on the TEP component. Overall, global brain activity increased over the course of stimulation. Single-subject analysis revealed inter-individual temporal courses of global brain activity. The present findings are in favor of dose-response considerations and attempts in personalization of rTMS protocols.","PeriodicalId":506486,"journal":{"name":"eneuro","volume":"72 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Takagishi et al., “Protein Nanoparticles Modified with PDGF-B as a Novel Therapy after Acute Cerebral Infarction” 勘误：Takagishi 等人，"用 PDGF-B 修饰的蛋白质纳米粒子作为急性脑梗塞后的新型疗法"。

eneuro Pub Date : 2024-04-01 DOI: 10.1523/ENEURO.0143-24.2024

Soh Takagishi, K. Arimura, Masaharu Murata, K. Iwaki, Tomohiro Okuda, Keisuke Ido, A. Nishimura, S. Narahara, T. Kawano, Koji Iihara

引用次数: 0

首页上一页