Transplant International最新文献_第2页

In Vitro and In Vivo Neutralizing Efficacy of Monoclonal Antibodies Against Sars-Cov-2 Variants in Kidney Transplant Recipients 针对肾移植受者 Sars-Cov-2 变异株的单克隆抗体的体外和体内中和效力

Transplant International Pub Date : 2024-07-16 DOI: 10.3389/ti.2024.13272

I. Benotmane, Martin Jungbauer-Groznica, I. Staropoli, Delphine Planas, Océane Dehan, Angela Brisebarre, Etienne Simon-Lorière, S. Fafi-Kremer, Olivier Schwartz, T. Bruel, Sophie Caillard

引用次数: 0

Time Course of High-Energy Phosphate Depletion During Cold Storage of Human Heart Grafts Using the Celsior Solution 使用摄氏溶液冷藏人体心脏移植物期间高能磷酸消耗的时间过程

Transplant International Pub Date : 2024-07-12 DOI: 10.3389/ti.2024.12994

F. Kober, T. Caus, Alberto Riberi, Yann Le Fur, Monique Bernard

{"title":"Time Course of High-Energy Phosphate Depletion During Cold Storage of Human Heart Grafts Using the Celsior Solution","authors":"F. Kober, T. Caus, Alberto Riberi, Yann Le Fur, Monique Bernard","doi":"10.3389/ti.2024.12994","DOIUrl":"https://doi.org/10.3389/ti.2024.12994","url":null,"abstract":"The aim of this study was to provide insight into high-energy phosphate compound concentration dynamics under realistic clinical cold-storage conditions using the Celsior solution in seven heart grafts discarded from transplantation. The hearts of seven local donors (three males, four females, age 37 ± 17 years, height 175 ± 5 cm, weight 75 ± 9 kg) initially considered for transplantation and eventually discarded were submitted to a Magnetic Resonance Spectroscopy observation in a clinical Magnetic Resonance Imaging scanner over at least 9 h. The grafts remained in their sterile container at 4°C during the entire examination. Hence, Phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were recorded non-destructively at a 30-minute interval. With the ischemic time Ti, the concentration ratios decreased at PCr/ATP = 1.68−0.0028·Tis, Pi/ATP = 1.38 + 0.0029·Tis, and intracellular pH at 7.43–0.0012·Tis. ATP concentration remained stable for at least 9 h and did not decrease as long as phosphocreatine was detectable. Acidosis remained moderate. In addition to the standard parameters assessed at the time of retrieval, Magnetic Resonance Spectroscopy can provide an assesment of the metabolic status of heart grafts before transplantation. These results show how HEPC metabolites deplete during cold storage. Although many parameters determine graft quality during cold storage, the dynamics of HEPC and intracellular pH may be helpful in the development of strategies aiming at extending the ischemic time.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"14 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis 弓形虫阳性捐献者的肾移植结果：器官获取与移植网络数据库分析

Transplant International Pub Date : 2024-07-11 DOI: 10.3389/ti.2024.13203

L. Butani, Daniel Tancredi

{"title":"Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis","authors":"L. Butani, Daniel Tancredi","doi":"10.3389/ti.2024.13203","DOIUrl":"https://doi.org/10.3389/ti.2024.13203","url":null,"abstract":"There is a need to reconsider the acceptance of organs from donors considered suboptimal, in the absence of data. Toxoplasma antibody-positive donors (TPD) constitute one such group. The objective of our study was to compare graft survival in deceased donor renal transplant (Tx) recipients, stratified by Toxoplasma IgG status, using the Organ Procurement and Transplantation Network (OPTN) database. A log-linear event history regression model for graft failure categorized by Toxoplasma IgG status, adjusting for confounders was applied to first kidney-only Tx recipients from 2018 to 2022. Of the 51,422 Tx, 4,317 (8.4%) were from TPD. Acute rejection and graft failure (5% each) were similar between groups. Crude graft failure was 7.3 failures per 100 person-years for TPD recipients compared to 6.5 failures per 100 person-years for the Toxoplasma-negative group (p 0.008). The crude failure rate ratio was 1.14 with an adjusted hazard rate ratio of 1.04 (95% CI: 0.94, 1.15, p 0.39). In renal Tx recipients, TPD graft recipients have comparable survival to Tx from Toxoplasma-negative recipients. While caution and close monitoring of recipients post-Tx for surveillance of disseminated toxoplasmosis are still warranted, our study suggests that patients can be successfully managed using TPD organs.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"46 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts: Proof of Concept in an Ovine Experimental Model 捐献心脏的原位左心室压力-容积环路分析：绵羊实验模型的概念验证

Transplant International Pub Date : 2024-07-11 DOI: 10.3389/ti.2024.12982

I. A. Ertugrul, R. A. D. A. Puspitarani, B. Wijntjes, M. Vervoorn, E. M. Ballan, N. van der Kaaij, H. van Goor, B. D. Westenbrink, A. van der Plaats, F. Nijhuis, V. van Suylen, M. E. Erasmus

{"title":"Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts: Proof of Concept in an Ovine Experimental Model","authors":"I. A. Ertugrul, R. A. D. A. Puspitarani, B. Wijntjes, M. Vervoorn, E. M. Ballan, N. van der Kaaij, H. van Goor, B. D. Westenbrink, A. van der Plaats, F. Nijhuis, V. van Suylen, M. E. Erasmus","doi":"10.3389/ti.2024.12982","DOIUrl":"https://doi.org/10.3389/ti.2024.12982","url":null,"abstract":"Ex situ heart perfusion (ESHP) has emerged as an important strategy to preserve donation after brain death (DBD) and donation after circulatory death (DCD) donor hearts. Clinically, both DBD and DCD hearts are successfully preserved using ESHP. Viability assessment is currently based on biochemical values, while a reliable method for graft function assessment in a physiologic working mode is unavailable. As functional assessment during ESHP has demonstrated the highest predictive value of outcome post-transplantation, this is an important area for improvement. In this study, a novel method for ex situ assessment of left ventricular function with pressure-volume loop analyses is evaluated. Ovine hearts were functionally evaluated during normothermic ESHP with the novel pressure-volume loop system. This system provides an afterload and adjustable preload to the left ventricle. By increasing the preload and measuring end-systolic elastance, the system could successfully assess the left ventricular function. End-systolic elastance at 60 min and 120 min was 2.8 ± 1.8 mmHg/mL and 2.7 ± 0.7 mmHg/mL, respectively. In this study we show a novel method for functional graft assessment with ex situ pressure-loop analyses during ESHP. When further validated, this method for pressure-volume assessments, could be used for better graft selection in both DBD and DCD donor hearts.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"46 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies 利用新一代测序技术分析肾移植活检中抗体介导的排斥反应和 T 细胞介导的排斥反应分子特征

Transplant International Pub Date : 2024-07-10 DOI: 10.3389/ti.2024.13043

Esteban Cortes Garcia, A. Giarraputo, M. Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, M. Raynaud, Clément Couderau, F. Mezine, J. Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, F. Halleck, M. Giral, Sophie Brouard, R. Danger, P.A. Gourraud, M. Rabant, Lionel Couzi, M. Le Quintrec, Nassim Kamar, Emmanuel Morelon, François Vrtovsnik, J. Taupin, R. Snanoudj, Christophe Legendre, D. Anglicheau, K. Budde, C. Lefaucheur, A. Loupy, O. Aubert

{"title":"Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies","authors":"Esteban Cortes Garcia, A. Giarraputo, M. Racapé, Valentin Goutaudier, Cindy Ursule-Dufait, Pierre de la Grange, Lucie Adoux, M. Raynaud, Clément Couderau, F. Mezine, J. Dagobert, Oriol Bestard, Francesc Moreso, Jean Villard, F. Halleck, M. Giral, Sophie Brouard, R. Danger, P.A. Gourraud, M. Rabant, Lionel Couzi, M. Le Quintrec, Nassim Kamar, Emmanuel Morelon, François Vrtovsnik, J. Taupin, R. Snanoudj, Christophe Legendre, D. Anglicheau, K. Budde, C. Lefaucheur, A. Loupy, O. Aubert","doi":"10.3389/ti.2024.13043","DOIUrl":"https://doi.org/10.3389/ti.2024.13043","url":null,"abstract":"Recently, interest in transcriptomic assessment of kidney biopsies has been growing. This study investigates the use of NGS to identify gene expression changes and analyse the pathways involved in rejection. An Illumina bulk RNA sequencing on the polyadenylated RNA of 770 kidney biopsies was conducted. Differentially-expressed genes (DEGs) were determined for AMR and TCMR using DESeq2. Genes were segregated according to their previous descriptions in known panels (microarray or the Banff Human Organ Transplant (B-HOT) panel) to obtain NGS-specific genes. Pathway enrichment analysis was performed using the Reactome and Kyoto Encyclopaedia of Genes and Genomes (KEGG) public repositories. The differential gene expression using NGS analysis identified 6,141 and 8,478 transcripts associated with AMR and TCMR. While most of the genes identified were included in the microarray and the B-HOT panels, NGS analysis identified 603 (9.8%) and 1,186 (14%) new specific genes. Pathways analysis showed that the B-HOT panel was associated with the main immunological processes involved during AMR and TCMR. The microarrays specifically integrated metabolic functions and cell cycle progression processes. Novel NGS-specific based transcripts associated with AMR and TCMR were discovered, which might represent a novel source of targets for drug designing and repurposing.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"18 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Vaccine in Lung and Liver Transplant Recipients Exceeds Expectations: An Italian Real-Life Experience on Immunogenicity and Clinical Efficacy of BNT162b2 Vaccine COVID-19 疫苗在肺和肝移植受者中的应用超出预期：意大利 BNT162b2 疫苗免疫原性和临床疗效的真实体验

Transplant International Pub Date : 2024-07-10 DOI: 10.3389/ti.2024.12729

L. Morlacchi, Gianfranco Alicandro, S. U. Uceda Renteria, Nunzio Zignani, Giovanni Giacomel, V. Rossetti, Michele Sagasta, Gaia Citterio, Andrea Lombardi, C. Dibenedetto, Barbara Antonelli, Lorenzo Rosso, Pietro Lampertico, Ferruccio Ceriotti, Francesco Blasi, Maria Francesca Donato

{"title":"COVID-19 Vaccine in Lung and Liver Transplant Recipients Exceeds Expectations: An Italian Real-Life Experience on Immunogenicity and Clinical Efficacy of BNT162b2 Vaccine","authors":"L. Morlacchi, Gianfranco Alicandro, S. U. Uceda Renteria, Nunzio Zignani, Giovanni Giacomel, V. Rossetti, Michele Sagasta, Gaia Citterio, Andrea Lombardi, C. Dibenedetto, Barbara Antonelli, Lorenzo Rosso, Pietro Lampertico, Ferruccio Ceriotti, Francesco Blasi, Maria Francesca Donato","doi":"10.3389/ti.2024.12729","DOIUrl":"https://doi.org/10.3389/ti.2024.12729","url":null,"abstract":"This study assessed humoral and T cell-mediated immune responses to the BNT162b2 vaccine in orthotopic liver transplant (OLT) and lung transplant (LUT) recipients who received three doses of the vaccine from March 2021 at our institution. Serum samples were collected 60 days post-second and third dose to quantify antibodies against the spike region of SARS-CoV-2 while whole blood samples were collected to analyze the SARS-CoV-2-specific T-cell response using an IFN-γ ELISpot assay. We enrolled 244 OLT and 120 LUT recipients. The third dose increased antibody titres in OLT recipients (from a median value of 131 after the second dose to 5523 IU/mL, p < 0.001) and LUT recipients (from 14.8 to 1729 IU/mL, p < 0.001). T-cell response also increased in OLT recipients (from 8.5 to 23 IFN-γ SFU per 250,000 PBMC, p < 0.001) and LUT recipients (from 8 to 15 IFN-γ SFU per 250,000 PBMC, p < 0.001). A total of 128 breakthrough infections were observed: two (0.8%) OLT recipients were hospitalized due to COVID-19 and one died (0.4%); among LUT recipients, seven were hospitalized (5.8%) and two patients died (1.7%). In conclusion, the three-dose schedule of the BNT162b2 vaccine elicited both humoral and T cell-mediated responses in solid organ transplant recipients. The risk of severe COVID-19 post-vaccination was low in this population.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"27 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Volume-Adjustable Artificial Womb for Extremely Preterm Infants 用于早产儿的可调节容积人工子宫

Transplant International Pub Date : 2024-07-09 DOI: 10.3389/ti.2024.12947

J. Heyer, Franziska Schubert, Alexander L. Seitz, Yannick Steinle, J. Arens, Thorsten Orlikowsky, U. Steinseifer, T. Schmitz-Rode, S. Jansen, M. Schoberer

{"title":"A Volume-Adjustable Artificial Womb for Extremely Preterm Infants","authors":"J. Heyer, Franziska Schubert, Alexander L. Seitz, Yannick Steinle, J. Arens, Thorsten Orlikowsky, U. Steinseifer, T. Schmitz-Rode, S. Jansen, M. Schoberer","doi":"10.3389/ti.2024.12947","DOIUrl":"https://doi.org/10.3389/ti.2024.12947","url":null,"abstract":"More than 13 million children are born preterm annually. Prematurity-related mortality accounts for 0.9 million deaths worldwide. The majority of those affected are Extremely Preterm Infants (gestational age less than 28 weeks). Immaturity causes organ failure and specific morbidities like germinal matrix hemorrhage, bronchopulmonary dysplasia, and necrotizing enterocolitis. Artificial womb and placenta technologies address these issues. As a bridge-to-life technology, they provide a liquid environment to allow organ maturation under more physiological conditions. The proposed artificial womb can adapt to fetal growth. Volume adjustment is achieved by removing fluid from the interspace between an inner and outer chamber. Results of the in vitro tests showed a temperature constancy of 36.8°C ± 0.3°C without pressure loss over 7 days. The volume of the inner sac was variable between 3.6 and 7.0 L. We designed a filtration and disinfection system for this particular purpose. This system has proven strong disinfection capabilities, effective filtering of metabolic waste, and the ability to avoid phospholipid washout. The presented artificial womb has sufficient volume variability to adapt to the physiologic growth of an extremely preterm neonate over a 4-week period. We regard this as an important step in the development of this bridge-to-life technology.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"27 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141836065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycolysis Changes in Alloreactive Memory B Cells in Highly Sensitized Kidney Transplant Recipients Undergonig Desensitization Therapy 接受gonig脱敏疗法的高敏肾移植受者体内异活性记忆B细胞的糖酵解变化

Transplant International Pub Date : 2024-07-08 DOI: 10.3389/ti.2024.13029

Johan Noble, Lara Cabezas, A. Truffot, Lucile Dumolard, T. Jouvé, P. Malvezzi, Lionel Rostaing, Céline Dard, Philippe Saas, Paolo Cravedi, Zuzana Macek-Jilkova

{"title":"Glycolysis Changes in Alloreactive Memory B Cells in Highly Sensitized Kidney Transplant Recipients Undergonig Desensitization Therapy","authors":"Johan Noble, Lara Cabezas, A. Truffot, Lucile Dumolard, T. Jouvé, P. Malvezzi, Lionel Rostaing, Céline Dard, Philippe Saas, Paolo Cravedi, Zuzana Macek-Jilkova","doi":"10.3389/ti.2024.13029","DOIUrl":"https://doi.org/10.3389/ti.2024.13029","url":null,"abstract":"Despite the growing use of desensitization strategies, hyperimmune patients remain at high risk of antibody-mediated rejection suggesting that, even when donor-specific antibodies (DSA) are effectively depleted, anti-donor specific B cells persist. We included 10 highly sensitized recipients that underwent desensitization with plasmapheresis and B cell depletion prior to kidney transplantation. We quantified changes in DSA (luminex), total B-cell subsets (flow cytometry), anti-donor HLA B cells (fluorospot), and single-cell metabolism in serially collected samples before desensitization, at the time of transplant, and at 6 and 12 months thereafter. Desensitization was associated with a decrease in DSA and total memory B cell and naive B cell percentage, while plasma cells and memory anti-donor HLA circulating B cells persisted up to 12 months after transplant. At 12-month post-transplantation, memory B cells increased their glycolytic capacity, while proliferative KI67+ plasma cells modified their metabolism by increasing fatty acid and amino acid oxidation capacity and decreasing their glucose dependence. Despite effective DSA depletion, anti-donor B cells persist in kidney transplant recipients. Due to the reliance of these cells on glycolysis, glycolysis-targeting therapies might represent a valuable treatment strategy.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"7 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Early Antibody Mediated Rejection in Antibody Incompatible Living Donor Kidney Transplantation 抗体不相容活体供肾移植中早期抗体介导排斥反应的特征

Transplant International Pub Date : 2024-07-08 DOI: 10.3389/ti.2024.12942

S. Punjala, Maria Ibrahim, Benedict L. Phillips, Jelena Stojanovic, N. Kessaris, O. Shaw, Anthony Dorling, N. Mamode

{"title":"Characteristics of Early Antibody Mediated Rejection in Antibody Incompatible Living Donor Kidney Transplantation","authors":"S. Punjala, Maria Ibrahim, Benedict L. Phillips, Jelena Stojanovic, N. Kessaris, O. Shaw, Anthony Dorling, N. Mamode","doi":"10.3389/ti.2024.12942","DOIUrl":"https://doi.org/10.3389/ti.2024.12942","url":null,"abstract":"Antibody incompatible transplantation (AIT) may be an only option for highly sensitized patients. Severe form of early antibody mediated rejection (AMR) adversely affects graft survival after AIT. The aim of this study was to identify individuals at risk of AMR. We analyzed 213 living donor AITs performed at our center. Among 120 ABOi, 58 HLAi and 35 DSA + FCXM-negative cases, the rates of early AMR were 6%, 31%, and 9%, respectively (p < 0.001). On multivariate analysis for graft loss, early AMR had a HR of 3.28 (p < 0.001). The HLAi group had worse death-censored graft survival (p = 0.003). In the HLAi group, Patients with aggressive variant AMR (AAMR) had greater percentage of C3d complement fixing DSA, higher baseline class I and total DSA MFI levels and B-cell FCXM RMF. C1q and C3d complement fixing DSA and strong positivity of baseline B- or T-cell FXCM as predictors of AAMR had 100% sensitivity. Early AMR is of significant clinical concern in AIT as it results in poor graft survival and is not well described in literature. An aggressive variant is characterized by massive rise in DSA levels at rejection. Baseline DSA, C1q, and C3d and baseline FCXM values can be used to risk-stratify candidates for AIT.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"124 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative Content and Discourse Analysis Comparing the Current Consent Systems for Deceased Organ Donation in Spain and England 定性内容和话语分析：比较西班牙和英国现行的遗体器官捐献同意制度

Transplant International Pub Date : 2024-07-04 DOI: 10.3389/ti.2024.12533

Kate Rees, Leah McLaughlin, D. Paredes-Zapata, Cathy Miller, Nicholas Mays, Jane Noyes

{"title":"Qualitative Content and Discourse Analysis Comparing the Current Consent Systems for Deceased Organ Donation in Spain and England","authors":"Kate Rees, Leah McLaughlin, D. Paredes-Zapata, Cathy Miller, Nicholas Mays, Jane Noyes","doi":"10.3389/ti.2024.12533","DOIUrl":"https://doi.org/10.3389/ti.2024.12533","url":null,"abstract":"England switched to an opt-out system of consent in 2020 aiming to increase the number of organs available. Spain also operates an opt-out system yet has almost twice the organ donations per million population compared with England. We aimed to identify both differences and similarities in the consent policies, documents and procedures in deceased donation between the two countries using comparative qualitative content and discourse analysis. Spain had simpler, locally tailored documents, the time taken for families to review and process information may be shorter, there were more pathways leading to organ donation in Spain, and more robust legal protections for the decisions individuals made in life. The language in the Spanish documents was one of support and reassurance. Documents in England by comparison appeared confusing, since additions were designed to protect the NHS against risk and made to previous document versions to reflect the law change rather than being entirely recast. If England’s ambition is to achieve consent rates similar to Spain this analysis has highlighted opportunities that could strengthen the English system-by giving individuals’ decisions recorded on the organ donor register legal weight, alongside unifying and simplifying consent policies and procedures to support families and healthcare professionals.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0