Transplant International最新文献

Donor Evaluation Tool: A New Technology Improves Donor Enrolment on ICU 捐献者评估工具：新技术提高了重症监护病房的捐献者登记率

Transplant International Pub Date : 2024-07-26 DOI: 10.3389/ti.2024.12227

Chiara Imbimbo, Marcus Nauwerk, Tizian Cammarota, Franziska Beyeler, Nathalie Krügel, Andreas Elmer, Thomas F. Mueller, F. Immer

{"title":"Donor Evaluation Tool: A New Technology Improves Donor Enrolment on ICU","authors":"Chiara Imbimbo, Marcus Nauwerk, Tizian Cammarota, Franziska Beyeler, Nathalie Krügel, Andreas Elmer, Thomas F. Mueller, F. Immer","doi":"10.3389/ti.2024.12227","DOIUrl":"https://doi.org/10.3389/ti.2024.12227","url":null,"abstract":"Uncertainties on the intensive care unit (ICU) regarding the eligibility of a patient to be a potential deceased organ donor may prevent their referral and enrolment in the pathway for organ donation. Healthcare staff may exclude potential donors for medical reasons, which are no longer applicable. Hence, Swisstransplant implemented a digital donor evaluation tool (DET) in 2021, which allows the local hospital’s organ donation coordinator to send a direct request to medical advisors (MA) of the organ procurement organization before excluding potential donors. All 156 requests entered in 2022 were analyzed. 117 patients (75.0%) were primarily accepted by the MA as potential donors. Of those 60 patients (51.3%) became actual organ donors. Main reasons for using the DET were questions regarding malignancies (n = 33, 21.2%), infectious diseases (n = 35, 22.4%) and age/co-morbidities (n = 34, 21.8%). The average age of the actual “DET donor” compared to the regularly enrolled, actual “Non-DET donor” was 65.3 ± 15.8 vs. 56.8 ± 17.5 years, respectively (p = 0.008). On average 1.9 ± 1.1 organs compared to 3.2 ± 1.3 organs were retrieved from DET vs. Non-DET donors. In summary, this new digital donor evaluation tool supports reporting and facilitates eligibility decisions in uncertain, complex donor cases, potentially increasing the number of organ donations.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes 对干细胞衍生胰岛移植治疗 2 型糖尿病持谨慎乐观态度

Transplant International Pub Date : 2024-07-26 DOI: 10.3389/ti.2024.13358

Hanne Scholz, V. Sordi, L. Piemonti

引用次数: 0

Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection 肺部排斥的组织学诊断与分子诊断的治疗反应

Transplant International Pub Date : 2024-07-26 DOI: 10.3389/ti.2024.12847

A. Zajacova, M. Mackova, K. Halloran, P. Gauthier, J. Balko, M. Guney, D. Rakita, M. Svorcova, J. Kolařík, J. Vachtenheim, J. Pozniak, J. Simonek, L. Fila, R. Lischke, P. Halloran, J. Havlín

{"title":"Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection","authors":"A. Zajacova, M. Mackova, K. Halloran, P. Gauthier, J. Balko, M. Guney, D. Rakita, M. Svorcova, J. Kolařík, J. Vachtenheim, J. Pozniak, J. Simonek, L. Fila, R. Lischke, P. Halloran, J. Havlín","doi":"10.3389/ti.2024.12847","DOIUrl":"https://doi.org/10.3389/ti.2024.12847","url":null,"abstract":"Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue transcriptomics could improve biopsy interpretation. This single-center, retrospective cohort study evaluated discrepancies between the histology of transbronchial biopsies (TBBs) with no rejection (NR) and T-cell mediated rejection (TCMR) by molecular diagnosis. The accuracy of diagnosis was assessed based on response to treatment. 54 TBBs from Prague Lung Transplant Program obtained between December 2015 and January 2020 were included. Patients with acute cellular rejection (ACR) grade ≥ 1 by histology received anti-rejection treatment. Response to therapy was defined as an increase in FEV1 of ≥ 10% 4 weeks post-biopsy compared to the pre-biopsy value. Among the 54 analyzed TBBs, 25 (46%) were concordant with histology, while 29 (54%) showed discrepancies. ACR grade 0 was found in 12 TBBs (22%) and grade A1 ≥ 1 in 42 TBBs (78%). Treatment response was present in 14% in the NR group and in 50% in the TCMR group (p = 0.024). Our findings suggest that low-grade acute cellular rejection is less likely to be associated with molecular TCMR, which might better identify lung transplant recipients who benefit from therapy.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"60 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Utility of the Vasoactive-Inotropic Score and Its Nomogram in Guiding Postoperative Management in Heart Transplant Recipients 血管活性-肌张力评分及其提名图在指导心脏移植受者术后管理中的实用性

Transplant International Pub Date : 2024-07-25 DOI: 10.3389/ti.2024.11354

Tixiusi Xiong, Wai Yen Yim, Jiangyang Chi, Yixuan Wang, Hongwen Lan, Jing Zhang, Yong-feng Sun, Jiawei Shi, Si Chen, N. Dong

{"title":"The Utility of the Vasoactive-Inotropic Score and Its Nomogram in Guiding Postoperative Management in Heart Transplant Recipients","authors":"Tixiusi Xiong, Wai Yen Yim, Jiangyang Chi, Yixuan Wang, Hongwen Lan, Jing Zhang, Yong-feng Sun, Jiawei Shi, Si Chen, N. Dong","doi":"10.3389/ti.2024.11354","DOIUrl":"https://doi.org/10.3389/ti.2024.11354","url":null,"abstract":"In the early postoperative stage after heart transplantation, there is a lack of predictive tools to guide postoperative management. Whether the vasoactive-inotropic score (VIS) can aid this prediction is not well illustrated.In total, 325 adult patients who underwent heart transplantation at our center between January 2015 and December 2018 were included. The maximum VIS (VISmax) within 24 h postoperatively was calculated. The Kaplan-Meier method was used for survival analysis. A logistic regression model was established to determine independent risk factors and to develop a nomogram for a composite severe adverse outcome combining early mortality and morbidity.VISmax was significantly associated with extensive early outcomes such as early death, renal injury, cardiac reoperation and mechanical circulatory support in a grade-dependent manner, and also predicted 90-day and 1-year survival (p < 0.05). A VIS-based nomogram for the severe adverse outcome was developed that included VISmax, preoperative advanced heart failure treatment, hemoglobin and serum creatinine. The nomogram was well calibrated (Hosmer-Lemeshow p = 0.424) with moderate to strong discrimination (C-index = 0.745) and good clinical utility.VISmax is a valuable prognostic index in heart transplantation. In the early post-transplant stage, this VIS-based nomogram can easily aid intensive care clinicians in inferring recipient status and guiding postoperative management.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"44 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function 肾移植后副肿瘤综合征：频率、风险因素、与原肾肾小球肾炎副肿瘤性发生的差异以及对肾移植长期功能的影响

Transplant International Pub Date : 2024-07-25 DOI: 10.3389/ti.2024.12969

Izabela Zakrocka, Gayatri Nair, Maria Jose Soler, K. Jhaveri, Andreas Kronbichler

{"title":"Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function","authors":"Izabela Zakrocka, Gayatri Nair, Maria Jose Soler, K. Jhaveri, Andreas Kronbichler","doi":"10.3389/ti.2024.12969","DOIUrl":"https://doi.org/10.3389/ti.2024.12969","url":null,"abstract":"Posttransplant malignancies are an important complication of solid organ transplantation. Kidney transplant recipients are at particularly high risk of cancer development. The most relevant risk factors of carcinogenesis are the use of immunosuppressive agents and oncogenic viral infections. Additionally, immune dysregulation caused by these factors may predispose to various types of organ damage. Paraneoplastic glomerular diseases are one of the most interesting and understudied cancer manifestations. The appropriate diagnosis of paraneoplastic glomerular damage can be challenging in kidney transplant recipients, due to factors inherent to concomitant medication and common comorbidities. Recent advances in the field of molecular and clinical nephrology led to a significant improvement in our understanding of glomerular diseases and their more targeted treatment. On the other hand, introduction of novel anticancer drugs tremendously increased patients’ survival, at the cost of kidney-related side effects. Our review aims to provide insights into diagnosis and treatment of paraneoplastic glomerular diseases, with a special attention to kidney transplant recipients.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"55 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor Fractions of Cell-Free DNA Are Elevated During CLAD But Not During Infectious Complications After Lung Transplantation 肺移植术后出现感染并发症时，CLAD 期间的供体细胞游离 DNA 分数会升高，而感染并发症期间则不会

Transplant International Pub Date : 2024-07-24 DOI: 10.3389/ti.2024.12772

Mirza Novo, R. Nordén, Johan Westin, Göran Dellgren, Jens Böhmer, A. Ricksten, Jesper M. Magnusson

{"title":"Donor Fractions of Cell-Free DNA Are Elevated During CLAD But Not During Infectious Complications After Lung Transplantation","authors":"Mirza Novo, R. Nordén, Johan Westin, Göran Dellgren, Jens Böhmer, A. Ricksten, Jesper M. Magnusson","doi":"10.3389/ti.2024.12772","DOIUrl":"https://doi.org/10.3389/ti.2024.12772","url":null,"abstract":"During the last few years, cell-free DNA (cfDNA) has emerged as a possible non-invasive biomarker for prediction of complications after lung transplantation. We previously published a proof-of-concept study using a digital droplet polymerase chain reaction (ddPCR)-based method for detection of cfDNA. In the current study, we aimed to further evaluate the potential clinical usefulness of detecting chronic lung allograft dysfunction (CLAD) using three different ddPCR applications measuring and calculating the donor fraction (DF) of cfDNA as well as one method using the absolute amount of donor-derived cfDNA. We analyzed 246 serum samples collected from 26 lung transplant recipients. Nine of the patients had ongoing CLAD at some point during follow-up. All four methods showed statistically significant elevation of the measured variable in the CLAD samples compared to the non-CLAD samples. The results support the use of ddPCR-detected cfDNA as a potential biomarker for prediction of CLAD. These findings need to be validated in a subsequent prospective study.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"17 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SElf-Care After REnal Transplantation Study: A Retrospective Evaluation of a Home-Monitoring Program Implemented as Standard Care 肾移植后护理研究：对作为标准护理实施的家庭监测计划的回顾性评估

Transplant International Pub Date : 2024-07-22 DOI: 10.3389/ti.2024.13192

B. Hezer, M. E. J. Reinders, M. W. F. van den Hoogen, M. Tielen, J. van de Wetering, D. A. Hesselink, E. K. Massey

{"title":"The SElf-Care After REnal Transplantation Study: A Retrospective Evaluation of a Home-Monitoring Program Implemented as Standard Care","authors":"B. Hezer, M. E. J. Reinders, M. W. F. van den Hoogen, M. Tielen, J. van de Wetering, D. A. Hesselink, E. K. Massey","doi":"10.3389/ti.2024.13192","DOIUrl":"https://doi.org/10.3389/ti.2024.13192","url":null,"abstract":"After transplantation self-management is essential for graft survival and optimal quality of life. To address the need for home-based support in self-management, we implemented the “SelfCare after Renal Transplantation” (SeCReT) box, containing home-monitoring equipment combined with a smartphone application that was linked to the electronic patient records. This study investigated the uptake and continuation, protocol adherence, and subjective evaluation of this home-monitoring program. All “de novo” kidney recipients who received the SeCReT-box in the study period (Aug 2021–Dec 2022) were eligible for inclusion. Protocol adherence was defined as ≥75%. Subjective evaluation was assessed with a 5-item questionnaire. Of the 297 recipients transplanted, 178 participants (60%) were included in the analysis. Protocol adherence was 83%, 73%, 66%, and 57% respectively at 5, 10, 20, and 40 weeks of the protocol. With regard to continuation, 135 participants were still in the program at the end of the study period (75% retention rate). Regarding subjective evaluations, 82% evaluated the program positively, and 52% reported lower care needs due to home-monitoring. Results are positive among those who entered and continued the program. Qualitative research is needed on barriers to entering the program and facilitators of use in order to promote optimal implementation.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"40 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed Graft Function After Kidney Transplantation: The Role of Residual Diuresis and Waste Products, as Oxalic Acid and Its Precursors 肾移植后移植功能延迟：残余利尿和废物（如草酸及其前体）的作用

Transplant International Pub Date : 2024-07-19 DOI: 10.3389/ti.2024.13218

Gideon Post Hospers, Wesley J. Visser, J. Verhoeven, M. Laging, Sara J. Baart, Ingrid R. A. M. Mertens zur Borg, D. Hesselink, Anneke M. E. de Mik-van Egmond, M. Betjes, M. van Agteren, D. Severs, J. van de Wetering, R. Zietse, Michel J. Vos, I. Kema, M. Kho, M. Reinders, J. Roodnat

{"title":"Delayed Graft Function After Kidney Transplantation: The Role of Residual Diuresis and Waste Products, as Oxalic Acid and Its Precursors","authors":"Gideon Post Hospers, Wesley J. Visser, J. Verhoeven, M. Laging, Sara J. Baart, Ingrid R. A. M. Mertens zur Borg, D. Hesselink, Anneke M. E. de Mik-van Egmond, M. Betjes, M. van Agteren, D. Severs, J. van de Wetering, R. Zietse, Michel J. Vos, I. Kema, M. Kho, M. Reinders, J. Roodnat","doi":"10.3389/ti.2024.13218","DOIUrl":"https://doi.org/10.3389/ti.2024.13218","url":null,"abstract":"Delayed graft function (DGF) after kidney transplantation heralds a worse prognosis. In patients with hyperoxaluria, the incidence of DGF is high. Oxalic acid is a waste product that accumulates when kidney function decreases. We hypothesize that residual diuresis and accumulated waste products influence the DGF incidence. Patients transplanted between 2018–2022 participated in the prospective cohort study. Pre-transplant concentrations of oxalic acid and its precursors were determined. Data on residual diuresis and other recipient, donor or transplant related variables were collected. 496 patients were included, 154 were not on dialysis. Oxalic acid, and glyoxylic acid, were above upper normal concentrations in 98.8%, and 100% of patients. Residual diuresis was ≤150 mL/min in 24% of patients. DGF occurred in 157 patients. Multivariable binary logistic regression analysis demonstrated a significant influence of dialysis type, recipient BMI, donor type, age, and serum creatinine on the DGF risk. Residual diuresis and glycolic acid concentration were inversely proportionally related to this risk, glyoxylic acid directly proportionally. Results in the dialysis population showed the same results, but glyoxylic acid lacked significance. In conclusion, low residual diuresis is associated with increased DGF incidence. Possibly accumulated waste products also play a role. Pre-emptive transplantation may decrease the incidence of DGF.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"102 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review 肝移植中的胆管细胞器官组织；全面回顾

Transplant International Pub Date : 2024-07-19 DOI: 10.3389/ti.2024.12708

C. Rejas, H. Junger

{"title":"Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review","authors":"C. Rejas, H. Junger","doi":"10.3389/ti.2024.12708","DOIUrl":"https://doi.org/10.3389/ti.2024.12708","url":null,"abstract":"Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss. The low availability of organs and high demand for transplantation motivate scientists to find novel interventions. Organoids, as three-dimensional cell cultures derived from adult cells or induced pluripotent cells, may help to address this problem. Different types of organoids have been described, from which cholangiocyte organoids offer a high level of versatility and plasticity for a deeper study of liver disease mechanisms. Cholangiocytes can be obtained from different segments of the biliary tree and have shown a remarkable capacity to adapt to new environments, presenting an effective system for studying cholangiopathies. Studies using cholangiocyte organoids show promising results for disease modeling, where organoids offer fundamental features to recapitulate the complexities of tissues in vitro and uncover fundamental pathological pathways to potentially reveal therapeutic strategies for personalized medicine. Organoids could hold the potential for regeneration of injured livers, representing tools of clinical impact in regenerative medicine when tissue damage is already present.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Impacts of Allograft Biopsy in Renal Transplant Recipients 10 Years or Longer After Transplantation 肾移植受者移植后 10 年或更长时间异体活检的临床影响

Transplant International Pub Date : 2024-07-18 DOI: 10.3389/ti.2024.13022

Tomoko Namba-Hamano, Takayuki Hamano, Yohei Doi, Atsuko Hiraoka, Hiroaki Yonishi, Shinsuke Sakai, Atsushi Takahashi, Masayuki Mizui, S. Nakazawa, K. Yamanaka, Yoichi Kakuta, R. Imamura, Norio Nonomura, Yoshitaka Isaka

{"title":"Clinical Impacts of Allograft Biopsy in Renal Transplant Recipients 10 Years or Longer After Transplantation","authors":"Tomoko Namba-Hamano, Takayuki Hamano, Yohei Doi, Atsuko Hiraoka, Hiroaki Yonishi, Shinsuke Sakai, Atsushi Takahashi, Masayuki Mizui, S. Nakazawa, K. Yamanaka, Yoichi Kakuta, R. Imamura, Norio Nonomura, Yoshitaka Isaka","doi":"10.3389/ti.2024.13022","DOIUrl":"https://doi.org/10.3389/ti.2024.13022","url":null,"abstract":"We aimed to investigate the clinical value of allograft biopsy performed long after renal transplantation. We retrospectively evaluated 99 allograft biopsies in recipients with transplantation vintages of 10 years or longer. Mixed-effects model showed that 1-year estimated glomerular filtration rate (eGFR) slopes after biopsy were significantly greater than those before biopsy [−3.13, −4.42 mL/min/1.73 m2/year, p = 0.01]. Renal biopsy changed the treatment strategies in more than half of the patients. Improvement in eGFR slopes was pronounced in 51 patients with treatment modification based on the biopsy results [2.27 (95% confidence interval (CI): 0.66, 3.89) mL/min/1.73 m2/year], whereas no improvement was observed in those without [0.33 (95% CI: −1.05, 1.71) mL/min/1.73 m2/year, Pinteraction = 0.001]. Among the treatment modifications, enhancement of immunosuppression (IS) led to the most remarkable improvement in eGFR slope. Patients with g scores ≥2 were more likely to receive IS enhancement than those with g scores = 0 [odds ratio; 15.0 (95% CI: 1.65, 136)]. Patients with active glomerulitis (g ≥ 1) without chronicity (cg ≤ 1) showed the most significant improvement in eGFR slope. Given the prevalence of active glomerulitis (g ≥ 1, 21%), which is responsive to treatment even long after transplantation, and the observed magnitude of eGFR slope improvement, renal biopsy can indeed improve allograft prognosis.","PeriodicalId":506324,"journal":{"name":"Transplant International","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0