Pamukkale Medical Journal最新文献

{"title":"Can Emergency Department Blood Parameters Predict Coronary Artery Occlusion in Acute Myocardial Infarction?","authors":"Hülya YILMAZ BAŞER, Alkame Akgümüş, A. Balun","doi":"10.31362/patd.1423299","DOIUrl":"https://doi.org/10.31362/patd.1423299","url":null,"abstract":"Purpose: The aim of this study is to assess the detectability of coronary artery stenosis in patients evaluated for acute myocardial infarction (AMI) in the emergency department and undergoing coronary angiography, based on blood parameters examined in the emergency setting. \u0000Materials and Methods: In our single-center prospective observational study, patients diagnosed with AMI in the Emergency Department between September 1 and October 31, 2023, and those who underwent coronary angiography by a single cardiologist were included. The blood parameters applied during routine assessment in the Emergency Department were recorded, and parameters with predictive effects based on the percentages of vessel stenosis after angiography were evaluated. \u0000Results: A total of 64 patients (44 males and 20 females) who met the study criteria were included in our research. Following the evaluation based on the highest percentage of stenosis in any coronary artery after coronary angiography, patients were divided into two groups. Group 1 consisted of 15 patients with mild stenosis (stenosis","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noonan syndrome: molecular and clinical findings in individuals with PTPN11 pathogenic variants","authors":"Derya Karaer, T. Durak, Kadri Karaer","doi":"10.31362/patd.1438458","DOIUrl":"https://doi.org/10.31362/patd.1438458","url":null,"abstract":"Purpose: RASopathies encompass a spectrum of disorders resulting from pathogenic variants in genes associated with the Ras/mitogen-activated protein kinase (RAS/MAPK) pathway, critical for cellular functions like proliferation, differentiation and survival. Noonan syndrome (NS), the most prevalent form of RASopathies, presents with a myriad of clinical features including characteristic facial dysmorphisms, congenital heart defects, and developmental delays. Despite its clinical recognition, molecular confirmation remains elusive in a notable percentage of cases. In this study, we aimed to investigate the clinical and molecular profiles of six patients diagnosed with NS, focusing on the role of PTPN11 gene mutations. \u0000Materials and methods: Molecular evaluation was performed using PTPN11 gene sequence analysis and whole gene sequencing methods in six patients who were thought to have typical NS phenotypes based on clinical evaluations. \u0000Results: Molecular screening in patients identified four different pathogenic variants in the PTPN11 gene. These variants, all heterozygous, were classified as pathogenic according to established criteria. \u0000Conclusion: Our findings contribute to understanding the genetic landscape of NS and underscore the significance of molecular analysis in confirming diagnoses.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"52 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of first and sixth year medical faculty students towards sexual assault victims: A cross-sectional study","authors":"Fatih Turan, Volkan Zeybek","doi":"10.31362/patd.1447964","DOIUrl":"https://doi.org/10.31362/patd.1447964","url":null,"abstract":"Purpose: \u0000Sexual violence encompasses a range of coercive behaviors, from verbal harassment to forced penetration, and includes from social pressure and intimidation to the application of physical force. Sexual violence has numerous mental and physical health consequences on the individual. Although physicians recognize their crucial role in caring for sexual violence victims, various attitudes and behaviors hinder their fulfillment of these roles. In our study, the aim was to determine the attitudes of first and sixth-year medical faculty students towards sexual assault victims and the socio-demographic factors influencing these attitudes. \u0000Materials and methods: \u0000A total of 370 voluntary first- and sixth-year students enrolled in the 2021-2022 academic year at Manisa Celal Bayar University Faculty of Medicine were administered a questionnaire comprising socio-demographic characteristics, the \"Social Attitudes Scale Towards Sexual Assault Victims,\" and questions assessing their knowledge of forensic medicine regarding sexual assault. \u0000Results: \u0000Our study found that 55.9% of the medical faculty students who participated were female, with an average age of 20.83±2.85 years. 56.5% were first-year students. 18.9% reported that they or someone close to them had been subjected to behavior considered as sexual assault. The average score of the participants in the Social Attitudes Scale towards Sexual Assault Victims was determined to be 95.29. It was statistically significant that women aged between 17-22 and those with a high monthly family income had higher average scores on the scale. It was found that 17.3% of the participants answered all six forensic medical questions correctly. The total scores of female students on the Social Attitudes Scale Towards Sexual Assault Victims and the scores of the behavior and thought sub-dimensions were found to be statistically significantly higher than those of male students. \u0000Conclusion: \u0000It was determined that participants generally held a positive attitude towards sexual assault victims. Factors contributing to this positive attitude included higher parental education levels, the influence of education received during medical school and preceding periods, and social environments.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"55 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric Analysis of Pain Centers in Migraine Patients","authors":"Orkhan Mammadkhanlı, Kaan Yağmurlu, S. Kehaya, Erdi Şensöz, A. Akıncı, Osman Şimşek","doi":"10.31362/patd.1462085","DOIUrl":"https://doi.org/10.31362/patd.1462085","url":null,"abstract":"Purpose: To investigate patterns of abnormalities in pain centers among patients with chronic pain, particularly those with migraines. The study aims to explore the potential correlation with pain duration and migraine types, and to propose new interventions for managing chronic pain \u0000Methods: Radiologic data of 32 migraine patients and 28 healthy controls underwent three-dimensional iso T1-weighted brain MRI between 2019 and 2023 at our university hospital were examined. Structured questionnaires collected data on age, gender, disease duration since migraine diagnosis, average pain intensity, and medication use. Patients with a minimum migraine duration of 3 years were included and divided into two groups based on the absence (Group 1) or presence (Group 2) of aura. Furthermore, patients were categorized into groups according to migraine attacks (episodic and chronic). Volumetric analysis, including cortical and subcortical pain-related structures, was performed using volBrain software. \u0000Results: Significant differences were observed in grey matter (p=0.037), cortical grey matter (p=0.022), cerebrum grey matter (p=0.026), anterior cingulate cortex (ACC) (p=0.017), middle cingulate cortex (MCC) (p=0.014), and posterior cingulate cortex (PCC) (p=0.008) volumes among the groups. Group comparisons revealed significant differences in the ACC, MCC, and PCC between Groups 0 and 1 (p=0.047, p=0.040, and p=0.047, respectively) and PCC between Groups 0 and 2 (p=0.026), possibly related to aura pathogenesis. Patients without aura exhibited non-significantly thinner postcentral gyrus (p=0.079), suggesting potential cortical involvement. \u0000Conclusions: This study provides insights into pain center abnormalities in migraine patients and their potential relevance to pain duration and migraine type.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence Of Anti-Musk-Positive Bulbar Myasthenia Gravis And Myotonic Dystrophy Type 1: The First Case Report from Turkey","authors":"Esra Demir Ünal","doi":"10.31362/patd.1434678","DOIUrl":"https://doi.org/10.31362/patd.1434678","url":null,"abstract":"Muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) is an acute-onset subtype of MG that primarily affects the fasciobulbar muscles and begins with progressive velopharyngeal and respiratory symptoms such as early respiratory crises, swallowing, and speaking difficulties. Myotonic dystrophy Type 1 (DM1) is an autosomal dominantly inherited autoimmune neuromuscular disease characterized by distal-dominant muscle weakness, cardiovascular pathologies, and corneal disorders. In this case report, we discussed 42-year-old female patient with a previous diagnosis of DM1, and diagnosed with MuSK-MG as a result of electroneuromyographic and antibody tests upon the development of bulbar symptoms and thymus hyperplasia. The patient underwent video-assisted thymectomy, and medical treatment was started with a combination of pyridostigmine and methylprednisolone. The coexistence of anti-MuSK positive MG with thymoid hyperplasia and DM 1 has not been reported so far, and it has been predicted that both diseases may trigger each other through neuroinflammatory mechanisms on an autoimmunergic basis.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140705458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between salivary flow rate, oral health, and malnutrition in the elderly: a cross-sectional study “about”","authors":"Deniz Mut Sürmeli","doi":"10.31362/patd.1462337","DOIUrl":"https://doi.org/10.31362/patd.1462337","url":null,"abstract":"I would like to write regarding the article titled \"The relationship between salivary flow rate, oral health, and malnutrition in the elderly: a cross-sectional study,\" published in the Pamukkale Medical Journal. The authors have conducted a study that involved considerable effort, and as a geriatrician, I extend my gratitude to them for their valuable contribution to this significant area of geriatrics. The relationship between salivary flow rate, oral/dental health, and the presence of malnutrition in older adults had been evaluated in this study. The study excluded individuals with diseases that could affect salivary flow rate and those who received radiotherapy to the head and neck region. However, the comorbidities or medications of the individuals were not inquired about or recorded. This was an important concern for me because the use of drugs with anticholinergic side effects could potentially affect salivary flow rates. n this letter, I aimed to highlight the impact of medications with anticholinergic effects on salivary glands and suggest alternative study designs for future research.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"154 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of short-term radiographic outcomes of medial parapatellar, mini-midvastus, and subvastus surgical approaches in fast-track total knee arthroplasty","authors":"Hakan Zora, Harun Güngör, G. Bayrak","doi":"10.31362/patd.1438157","DOIUrl":"https://doi.org/10.31362/patd.1438157","url":null,"abstract":"Purpose: Due to the difficulties in accessing the knee joint, correct prosthesis placement is of great importance during the implementation of total knee arthroplasty (TKA). This study aimed to compare short-term radiographic X-ray outcomes in patients who underwent fast-track TKA with medial parapatellar (MPP), mini-midvastus (mMV), or subvastus (SV) surgical approaches. \u0000Materials and methods: Between 2018 and 2020, 93 patients operated with MPP, mMV, and SV surgical approaches and who had complete data of radiographic outcomes before and sixth-week postoperative were retrospectively analyzed and patients divided into three groups: MPP (n=31), mMV (n=31), and SV (n=31). The alignments of preoperative and sixth-week postoperative X-ray images of the surgical approaches were measured. The operative time of fast-track TKA implementation with MPP, mMV, and SV surgical approaches was recorded. \u0000Results: The MPP group had higher preoperative lateral distal femoral angle than the mMV group and a higher preoperative lateral proximal femoral angle than SV group (p=0.018 and p=0.027, respectively). The mMV group had higher postoperative proximal medial tibial angle than SV group (p=0.011). In the postoperative sixth week, the MPP and mMV groups had a lower posterior tibial slope angle than SV group (p=0.001). The MPP approach had significantly shorter operative time than mMV and SV approaches (p=0.001). \u0000Conclusion: The outcomes indicate that MPP, mMV, and SV surgical approaches are preferable and feasible in obtaining a satisfactory prosthesis alignment during fast-track TKA. The MPP approach may be preferable because of its shorter operative time and potential advantage in minimizing surgical complication risks.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"81 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140747240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering self-management: exploring self-care practices in heart failure patients","authors":"Işık Tekin, İpek Büber","doi":"10.31362/patd.1411566","DOIUrl":"https://doi.org/10.31362/patd.1411566","url":null,"abstract":"Background and Aim: Heart failure (HF) is a complex clinical syndrome in which ventricular filling and beating functions are impaired. HF also causes psychosocial and economic problems and is a significant public health problem affecting the quality of life. Effective self-care (SC) is a non-pharmacological method that contributes to treatment, improves the patient's quality of life, and reduces repeated hospitalizations and economic burdens. Our study aimed to evaluate self-care in HF patients and to determine the factors affecting SC. \u0000 \u0000Materials and methods: A total of 100 patients with HF, including 36 women and 64 men, were included in the study. Data were collected by using the Descriptive Information Form and the European Heart Failure Self-Care Behavior Scale in one-on-one interviews with patients under appropriate physical conditions. \u0000 \u0000Results: Our findings indicate that a range of factors, including age, hypertension, educational status, the total number of comorbid diseases, and the use of certain medications such as SGLT-2 inhibitors, differently impact SC behaviors. SC behaviors were found to be adequate in the study population \u0000 \u0000Conclusion: We identified essential factors that affect SC in HF patients. We have identified critical factors such as age, educational status, hypertension, comorbidity, and particularly the use of SGLT2 inhibitors, as key influencers of SC practices. For this reason, patient-centered healthcare models should be developed and considered by medical practitioners.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"917 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140749197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daratumumab enhances the overall response to multiple myeloma therapy as the number of cycles increases","authors":"Özde Elver, Nevin Alayvaz Aslan, Veysel Erol, İsmail Can Kendir, Nil Guler","doi":"10.31362/patd.1427969","DOIUrl":"https://doi.org/10.31362/patd.1427969","url":null,"abstract":"Objective: New medicines employed in recent years have resulted in significant increases in survival rates for Multiple Myeloma (MM). Daratumumab is utilized in both first-line myeloma treatment and relapsed/refractory illness. Our study aims to assess the clinical features, response to treatment and factors influencing response to treatment in patients who received daratumumab monotherapy or combination therapy at our center. \u0000Patients and Methods: 21 multiple myeloma patients who were followed up in the hematology clinic at Pamukkale University Faculty of Medicine and treated with daratumumab were retrospectively examined. \u0000Results: The patients median age was 65±9.7 years (42-80), with a female/male ratio of 11/10. Daratumumab was utilized after two lines of treatment in 13 patients (61.9%), first line treatment in 5 patients, and second line treatment in 3 patients. The average number of cycles was 4.05±5.06 (1-18). Daratumumab was used as a single agent in one patient, in 13 patients in combination with bortezomib, immunomodulatory medications, cyclophosphamide, and/or melphalan, and in 7 patients in combination with chemotherapy. At the completion of therapy evaluation, 38.1% (n:8) of the patients were lost, 38.1% (n:8) continued treatment with VGPR or better, and 23.8% (n:5) continued treatment with PR. Three (42.9%) of the seven patients who received daratumumab along with chemotherapy died. The number of cycles increased the rate of complete reaction (CR), which was statistically significant (p=0.026). \u0000Conclusion: Daratumumab-containing therapy regimens improve treatment success in multiple myeloma patients, and complete response rates rise as treatment duration increases.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"157 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAW264.7 hücrelerinde Odoroside A'nın immün transformasyondaki rolü","authors":"Fatma Seçer Çelik, Canan Eroğlu Güneş","doi":"10.31362/patd.1433389","DOIUrl":"https://doi.org/10.31362/patd.1433389","url":null,"abstract":"Amaç: Makrofajlar bağışıklık sisteminin en önemli unsurlarından biridir ve inflamasyonda ikili rol oynamaktadır. Hem ortamda immün yanıtın oluşumunu hem de baskılanmasını düzenlemektedir. Kanser mikroçevresindeki bu sinyalleme, kanserin ilerlemesini etkiler. Bu kanseri teşvik eden veya kanseri ortadan kaldıran süreç makrofajlar tarafından yönetilmektedir. Proinflamatuar sitokin genlerinin ifadesindeki artış, ortamdaki tümör hücrelerinin baskılanmasını sağlar. Bu çalışmada Odoroside A'nın makrofaj dönüşümüne etkisinin araştırılması amaçlanmıştır. \u0000Gereç ve yöntem: Makrofaj hücrelerinde öldürücü olmayan Odoroside A dozu CCK-8 analizi ile belirlenmiştir. Daha sonra RAW264.7 hücrelerinde sitokin genlerinin ve yüzey belirteçlerinin qRT-PCR kullanılarak gen ekspresyon analizi yapılmıştır. Gen ekspresyonu analizinde anlamlı çıkan sitokinlerin protein düzeyleri ELISA yöntemi kullanılarak incelenmiştir. \u0000Bulgular: Odoroside A, RAW264.7 hücrelerinde IL1 ve IL6 genlerinin ekspresyonunu önemli ölçüde artırırken, IL10 geninin ekspresyonunu önemli ölçüde azaltmıştır. IL4 ve TGFβ gen ifadelerinde anlamlı bir değişiklik olmamıştır. İstatistiksel olarak anlamlı artış gösteren IL1 ve IL6 gen ekspresyonlarının protein düzeyinde de anlamlı düzeyde arttığı belirlenmiştir. \u0000Sonuç: Tüm veriler birlikte değerlendirildiğinde Odoroside A'nın RAW264.7 hücrelerinde proinflamatuar yanıtı arttırdığı, dolayısıyla M1 tip makrofaj dönüşümünü sağladığı gözlenmiştir. Bu, Odoroside A'nın, tümör nişindeki makrofaj aracılı oluşan proinflamatuar ortamın tümörün ortadan kaldırılmasında etkili olabileceğini düşündürmektedir.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"408 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}