Pamukkale Medical Journal最新文献

Evaluation of Knowledge and Attitudes of Female University Students about Ovarian Reserve Awareness and Technologies for Ovarian Reserve: A Cross-Sectional Study 评估女大学生对卵巢储备意识和卵巢储备技术的了解和态度：横断面研究

Pamukkale Medical Journal Pub Date : 2024-07-16 DOI: 10.31362/patd.1480552

Sinem Göral Türkcü, Sevgi Özkan, E. Alataş, Adnan Köksal

{"title":"Evaluation of Knowledge and Attitudes of Female University Students about Ovarian Reserve Awareness and Technologies for Ovarian Reserve: A Cross-Sectional Study","authors":"Sinem Göral Türkcü, Sevgi Özkan, E. Alataş, Adnan Köksal","doi":"10.31362/patd.1480552","DOIUrl":"https://doi.org/10.31362/patd.1480552","url":null,"abstract":"Purpose: The aim of this study was to evaluate the knowledge and attitudes of female university students about ovarian reserve awareness and technologies for ovarian reserve. \u0000Materials and methods: This study was designed as a descriptive and cross-sectional study and was conducted on 660 female university students. The data were collected by using a questionnaire form based on the literature on ovarian reserve and related technologies. The mean, standard deviation and percentage distributions of the data obtained through the WEB page and face-to-face interview technique were analysed in the SPSS programme. \u0000Results: 86.2% of the students wanted to have children in the future and 75.8% planned to have children between the ages of 26-30. 56.7% of the students were aware of the availability of tests related to ovarian reserve and 86.6% of them demanded the development of new tests. In case of low ovarian reserve, 65.6% of the students stated that they could have children earlier, 68% could freeze their eggs, 51.2% could freeze their embryos, 73.8% could adopt a child and 84.7% could continue their work/education. \u0000Conclusion: It is remarkable that the majority of the students did not make any attempt for ovarian reserve evaluation although they wanted to have a child. Among the reasons for this situation, besides the fact that the students are still receiving education, they have false beliefs that their ovarian reserves will be sufficient at the age when they want to have children, that a healthy lifestyle and activity protect the ovarian reserve, and that they can have children with assisted reproductive techniques even if their ovarian reserves are low. It is important to evaluate the ovarian reserves of young women at an early stage in order for them to make a more conscious career and family planning.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"8 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Lithium, Metformin and Everolimus Substances on Cell Growth in 2D and 3D Ishikawa Endometrial Carcinoma Cell Culture 锂、二甲双胍和依维莫司对二维和三维石川子宫内膜癌细胞培养中细胞生长的影响

Pamukkale Medical Journal Pub Date : 2024-07-03 DOI: 10.31362/patd.1490977

Emine Tural, N. Çil, Mücahit Seçme, Gülçin Abban Mete, Hakan Darici, Ayhan Bilir, E. Karaoz

{"title":"The Effects of Lithium, Metformin and Everolimus Substances on Cell Growth in 2D and 3D Ishikawa Endometrial Carcinoma Cell Culture","authors":"Emine Tural, N. Çil, Mücahit Seçme, Gülçin Abban Mete, Hakan Darici, Ayhan Bilir, E. Karaoz","doi":"10.31362/patd.1490977","DOIUrl":"https://doi.org/10.31362/patd.1490977","url":null,"abstract":"Purpose: Our aim is to study the effects of the single and combined treatments of Everolimus, Metformin, and Lithium Chloride in two-dimensional (2D, monolayer) and three-dimensional (3D, spheroid) cell cultures of Ishikawa cells, which comprise the endometrial cancer cell line. \u0000Materials and methods: As part of the study, the effects of single and combined forms of Everolimus, Metformin, and Lithium Chloride were determined on cell viability, invasion, colony formation and apoptosis, and PI3K/AKT/mTOR pathway. Cell viability was assessed using XTT assay. CASP3, CASP8, CASP9, FASL, FADD, TNF, TRADD, BAX, P53, PI3KCA, PI3KCB, PTEN, MTOR, AKT1 genes were evaluated with RT-PCR, apoptosis was evaluated by flow cytometry and 3D spheroid results were evaluated with invert microscope analysis. \u0000Results: Everolimus, metformin, and lithium's IC50 levels were found at 48 hours to be 37.46 nM, 48.59 mM, and 100 µM, respectively. It was determined that the invasive capacities of Ishikawa cells in treatment groups, as well as cell colony formation were significantly reduced. In addition, Ishikawa spheroid cells were significantly suppressed compared with the control groups. RT-PCR results revealed that substances and their combinations affect genes associated with PI3K/AKT/mTOR pathway and apoptosis. Flow cytometry results showed notably increased apoptosis by single and combined treatments. \u0000Conclusion: As a result, the single and combination forms of everolimus, metformin, and lithium have reduced cell proliferation, induced apoptosis, and decreased mTOR activation through various mechanisms in Ishikawa cells.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"81 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do spinopelvic parameters affect the severity of thoracolumbar trauma differently between in-vehicle traffic accidents and falling from a height? 车内交通事故和高空坠落对胸腰椎创伤严重程度的影响不同吗？

Pamukkale Medical Journal Pub Date : 2024-07-03 DOI: 10.31362/patd.1477075

Veysel Kıyak, Sezer Astan

{"title":"Do spinopelvic parameters affect the severity of thoracolumbar trauma differently between in-vehicle traffic accidents and falling from a height?","authors":"Veysel Kıyak, Sezer Astan","doi":"10.31362/patd.1477075","DOIUrl":"https://doi.org/10.31362/patd.1477075","url":null,"abstract":"Objective: Although there is a comprehensive characterization of the impact of spinopelvic parameters on outcomes after degenerative spine surgery, the impact of spinopelvic parameters on thoracolumbar trauma has not yet been defined. In the present study, it was aimed to reveal the correlation between the severity of vertebral fractures developing after trauma according to the mechanism of occurrence and sagittal spinopelvic parameters. \u0000Materials and methods: Patients with thoracolumbar vertebra fractures were evaluated retrospectively. The patients were divided into two groups: in-vehicle traffic accident (sitting group) and fall from height (standing group). The pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS) and vertebral Hounsfield unit (HU) values were measured on computed tomography (CT) scans. \u0000Results: The results of the multivariate logistic regression analysis performed in the study revealed that a one-unit increase in PI reduced the risk of more comminuted fractures (A2 and above) by 0.90 times in sitting position trauma (Hazard ratio (HR): 0.90; 95% CI: 0.84–0.96; p=0.002) and by 0.96 times in standing position trauma (HR: 0.96; 95% CI: 0.93–0.99; p=0.040). \u0000Conclusions: It was observed that in vertebral fractures developed after trauma, the fact that the vertebral column of patients with low PI is more rigid increased the severity of the fracture.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HISTOLOGICAL STRUCTURE AND FUNCTIONAL PROPERTIES OF THE TUNICA ALBUGINEA OF THE OVARY 卵巢白膜的组织结构和功能特性

Pamukkale Medical Journal Pub Date : 2024-07-02 DOI: 10.31362/patd.1467619

Hale Yetgin, Murat Serkant Ünal, C. Kabukçu, A. C. Tufan

{"title":"HISTOLOGICAL STRUCTURE AND FUNCTIONAL PROPERTIES OF THE TUNICA ALBUGINEA OF THE OVARY","authors":"Hale Yetgin, Murat Serkant Ünal, C. Kabukçu, A. C. Tufan","doi":"10.31362/patd.1467619","DOIUrl":"https://doi.org/10.31362/patd.1467619","url":null,"abstract":"Just below the surface epithelium of the ovary is the tunica albuginea, which is a tight irregular connective tissue structure that gives the tissue its white color and contains fibroblast cells. Tunica albuginea, which is more resistant to environmental factors, contains fewer cells and is rich in collagen fibers, is observed as the niche of preantral follicles. It has been observed that fibroblasts forming collagen fibers provide the development of follicles with the paracrine factors and cytokines they secrete and function as a nourishing cell layer. After the graaf follicle forms the corpus luteum, fibroblasts in the adjacent tunica albuginea proliferate and the thickness of this structure increases. The tunica albuginea undergoes frequent renewal due to the corpus luteum structures formed in rats. When the corpus luteum is formed, new capillaries and venules are formed in the adjacent tunica albuginea. This structure may be a suitable model for investigating the migration of cells from the bone marrow to the ovary via vessels. It can be suggested that mesenchymal cells and very small embryonic/epiblast-like stem cells (VSELs), which show pluripotent stem cell characteristics, may migrate from the bone marrow to the tunica albuginea through vascular structures and that the bone marrow may be the source of these cells, which have been previously shown to be present in the ovary. The aim of this review is to examine the effects of the tunica albuginea on the development of follicles and the dynamic structure of the ovary.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141684917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy of percutaneous nephrostomy in managing hematuria following antegrade double j ureteral stent placement 评估经皮肾造瘘术在处理前行双 J 输尿管支架置入术后血尿的疗效

Pamukkale Medical Journal Pub Date : 2024-07-01 DOI: 10.31362/patd.1501235

Muhammet Arslan, H. Aslan, Burak Kurnaz, Kadirhan Alver, Mahmut Demirci, Mehmet Alpua, S. Çelen

{"title":"Evaluating the efficacy of percutaneous nephrostomy in managing hematuria following antegrade double j ureteral stent placement","authors":"Muhammet Arslan, H. Aslan, Burak Kurnaz, Kadirhan Alver, Mahmut Demirci, Mehmet Alpua, S. Çelen","doi":"10.31362/patd.1501235","DOIUrl":"https://doi.org/10.31362/patd.1501235","url":null,"abstract":"Purpose: This study aims to evaluate the clinical outcomes of percutaneous nephrostomy in patients who develop hematuria during percutaneous antegrade double j stent placement. \u0000Materials and methods: We conducted a multicenter retrospective cross-sectional study, reviewing medical records from January 2016 to June 2024, to identify patients who underwent percutaneous antegrade double j stent placement and developed hematuria. Percutaneous antegrade double j stent and nephrostomy procedures were performed under ultrasound and fluoroscopic guidance. \u0000Results: The study included 151 patients with a mean age of 65.9 ± 15.3 years; 46 (30.5%) were female, and 105 (69.5%) were male. Hematuria was observed in 20 (8.9%) of the 225 antegrade double j stent procedures. Hematuria was significantly more common in patients with benign conditions (35%) compared patients with malignant tumors (9.2%) (p=0.003). Postoperative nephrostomy was performed in 118 (52.4%) of the procedures. Among patients who developed hematuria, 11 (55%) received a nephrostomy, compared to 9 (45%) without hematuria, though this difference was not statistically significant (p=0.811). \u0000Conclusion: Percutaneous nephrostomy appears to be an effective intervention for managing hematuria in patients undergoing antegrade double j stent placement. However, the study did not find a statistically significant difference in hematuria incidence with nephrostomy placement, indicating the need for further research with larger sample sizes to confirm these findings and optimize postoperative management strategies.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"731 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of quercetin on oxidative stress in 3T3-L1 mature and hypertrophic cells 槲皮素对 3T3-L1 成熟细胞和肥大细胞氧化应激的影响

Pamukkale Medical Journal Pub Date : 2024-07-01 DOI: 10.31362/patd.1497658

Melek Tunç-ata, Emine Kılıç Toprak, Gizem Akan

{"title":"Effect of quercetin on oxidative stress in 3T3-L1 mature and hypertrophic cells","authors":"Melek Tunç-ata, Emine Kılıç Toprak, Gizem Akan","doi":"10.31362/patd.1497658","DOIUrl":"https://doi.org/10.31362/patd.1497658","url":null,"abstract":"Abstract \u0000 \u0000Purpose: The process of excessive or abnormal accumulation of fat in the body is called obesity, and its prevalence is increasing globally. The imbalance between antioxidants and free radicals, or oxidative stress, can be caused by or result from obesity. Flavonoids with antioxidant potential may help lower the increased oxidative stress associated with obesity. This study aimed to determine how quercetin affected oxidative stress in hypertrophied and mature 3T3-L1 adipocytes. \u0000Materials and methods: After differentiating, 3T3-L1 adipocytes were treated with insulin and a glucose-containing medium to become mature (10 days) and hypertrophic (18 days). The cells were subsequently incubated with 80 µM quercetin for 24 and 48 hours. ELISA was used to determine the levels of total antioxidant capacity/total oxidant capacity (TAS/TOS). Using Oil Red O staining, an accumulation of triglycerides in cells was examined. \u0000Results: It was shown that the quercetin molecule had a prooxidative effect on hypertrophic adipocytes but did not impact on oxidative stress in mature adipocytes. \u0000Conclusion: It is believed that the number and kind of fat cell will determine the appropriate dose and duration of administration for quercetin's antioxidant mechanism of action, which produces numerous beneficial effects.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"47 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence meets medical expertise: evaluating GPT-4's proficiency in generating medical article abstracts 人工智能与医学专业知识的结合：评估 GPT-4 生成医学文章摘要的能力

Pamukkale Medical Journal Pub Date : 2024-06-03 DOI: 10.31362/patd.1487575

Ergin Sağtaş, Furkan Ufuk, H. Peker, A. B. Yağcı

{"title":"Artificial intelligence meets medical expertise: evaluating GPT-4's proficiency in generating medical article abstracts","authors":"Ergin Sağtaş, Furkan Ufuk, H. Peker, A. B. Yağcı","doi":"10.31362/patd.1487575","DOIUrl":"https://doi.org/10.31362/patd.1487575","url":null,"abstract":"Purpose: The advent of large language models like GPT-4 has opened new possibilities in natural language processing, with potential applications in medical literature. This study assesses GPT-4's ability to generate medical abstracts. It compares their quality to original abstracts written by human authors, aiming to understand the effectiveness of artificial intelligence in replicating complex, professional writing tasks. \u0000Materials and Methods: A total of 250 original research articles from five prominent radiology journals published between 2021 and 2023 were selected. The body of these articles, excluding the abstracts, was fed into GPT-4, which then generated new abstracts. Three experienced radiologists blindly and independently evaluated all 500 abstracts using a five-point Likert scale for quality and understandability. Statistical analysis included mean score comparison inter-rater reliability using Fleiss' Kappa and Bland-Altman plots to assess agreement levels between raters. \u0000Results: Analysis revealed no significant difference in the mean scores between original and GPT-4 generated abstracts. The inter-rater reliability yielded kappa values indicating moderate to substantial agreement: 0.497 between Observers 1 and 2, 0.753 between Observers 1 and 3, and 0.645 between Observers 2 and 3. Bland-Altman analysis showed a slight systematic bias but was within acceptable limits of agreement. \u0000Conclusion: The study demonstrates that GPT-4 can generate medical abstracts with a quality comparable to those written by human experts. This suggests a promising role for artificial intelligence in facilitating the abstract writing process and improving its quality.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"30 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141270824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Apoptotic and Cell Cycle Effects of Sorafenib and Doxorubicin on URG4/URGCP in Leukemia Cells 索拉非尼和多柔比星对白血病细胞中 URG4/URGCP 的凋亡和细胞周期效应的研究

Pamukkale Medical Journal Pub Date : 2024-05-24 DOI: 10.31362/patd.1476105

Y. Dodurga, L. Elmas, Mücahit Seçme, Nazlı Demirkıran, Ç. BİRAY AVCI, G. Bagci, Sevda Sağ, Lale Şatıroğlu Tufan

{"title":"Investigation of the Apoptotic and Cell Cycle Effects of Sorafenib and Doxorubicin on URG4/URGCP in Leukemia Cells","authors":"Y. Dodurga, L. Elmas, Mücahit Seçme, Nazlı Demirkıran, Ç. BİRAY AVCI, G. Bagci, Sevda Sağ, Lale Şatıroğlu Tufan","doi":"10.31362/patd.1476105","DOIUrl":"https://doi.org/10.31362/patd.1476105","url":null,"abstract":"Leukemia, characterized by abnormal proliferation of blood cells, primarily affects leukocytes but can also impact other blood cells. Treatment typically involves stem cell transplants, radiotherapy, and chemotherapy, although chemotherapy can cause significant damage to healthy cells while targeting cancer cells. The effects of anti-cancer drugs like Sorafenib (SOR) and Doxorubicin (DOX) in leukemia treatment have been studied. Sorafenib, impacting various cellular signaling pathways, has proven effective in cancer therapy. On the other hand, Doxorubicin interacts with DNA to halt cell replication, leading to cell death. The impact of these drugs on apoptosis and the cell cycle in leukemia cells has been investigated. The study aims to examine the effects of DOX and SOR on URG4/URGCP mRNA levels in K562 and HL-60 leukemia cells, elucidating their impact on apoptosis and the cell cycle. This research seeks to understand the cellular effects of drugs used in leukemia treatment, contributing valuable insights to drug development processes in leukemia therapy.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"33 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Ultrasound Screening Method and Prevalence for Developmental Hip Dysplasia In The Central Anatolia 评估安纳托利亚中部地区发育性髋关节发育不良的超声波筛查方法和患病率

Pamukkale Medical Journal Pub Date : 2024-05-20 DOI: 10.31362/patd.1412442

Oğuzhan Pekince, Ferhat Sayar, E. Ercan, Özkan Köse

{"title":"Evaluation of Ultrasound Screening Method and Prevalence for Developmental Hip Dysplasia In The Central Anatolia","authors":"Oğuzhan Pekince, Ferhat Sayar, E. Ercan, Özkan Köse","doi":"10.31362/patd.1412442","DOIUrl":"https://doi.org/10.31362/patd.1412442","url":null,"abstract":"Objectives:This study aimed to assess the frequency and subsequent results of developmental dysplasia of the hip (DDH) in newborns in Central Anatolia who were admitted to Konya City Hospital and evaluate the efficiency of the existing screening and treatment methods in detecting and managing DDH in infants. \u0000Methods: Total of 10,650 infants were evaluated who had Graf USG screening in Konya City Hospital. İnfants born at or after 38 weeks of gestation were included, while premature infants were excluded. Additionally, we included infants who underwent USG screening between 30 and 90 days after birth, and whose hip development physiology was adequately visualized and assessed during the USG examination. \u0000Results: The study examined 8,695 term infants (52.5% male, 47.5% female) who underwent USG screening between 2020 and 2022. Participants mean gestational age at the time of the first USG examination was 7.94±2.07 weeks. Graf type 1 was higher in males (%97-96,5) and graf type 2 was higher in females (%7,2-7,8). Radiologists prefer to re-examine after 1 month for type 2a(%84,49-82,02) but orthopaedic consultation for type Type-2B, 2C, and type-3. The majority of infants (93.6%) underwent only one USG screening. No patients who continued regular USG control and treatment required surgical treatment requiring osteotomy. \u0000Conclusion: USG is an early diagnostic method for developmental hip dysplasia (DDH), which allows for simple treatment options and prevention of complications. It is a simple, inexpensive, and non-invasive method. Our study supports that regular USG screenings in infants eliminate the need for surgical procedures requiring osteotomy.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"79 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Ema, Töllner and Rodwell scores in the diagnosis of neonatal sepsis 评估新生儿败血症诊断中的埃玛评分、托尔纳评分和罗德维尔评分

Pamukkale Medical Journal Pub Date : 2024-05-14 DOI: 10.31362/patd.1457265

Ö. Özdemir, Büşra Erdal, Musa Turgut

{"title":"Evaluation of Ema, Töllner and Rodwell scores in the diagnosis of neonatal sepsis","authors":"Ö. Özdemir, Büşra Erdal, Musa Turgut","doi":"10.31362/patd.1457265","DOIUrl":"https://doi.org/10.31362/patd.1457265","url":null,"abstract":"Introduction: There are no specific signs, symptoms and rapid laboratory tests to definitively diagnose sepsis in the neonatal period. This makes it difficult to diagnose sepsis in newborns in a timely manner and initiate appropriate treatment, or causes babies without sepsis to receive unnecessary antibiotics. \u0000Purpose: Therefore, in this study, we planned to investigate the clinical adequacy and reliability of EMA (European Medicines Agency), Töllner and Rodwell hematological scoring in the early diagnosis of neonatal sepsis. \u0000Method: EMA, Töllner and Rodwell hematological scoring was performed on each patient. Complete blood count, peripheral smear, C-reactive protein, procalcitonin, blood gas and blood sugar values of newborn babies with suspected sepsis were recorded, blood culture, urine culture and cerebrospinal fluid examination and cultures taken when necessary were evaluated. Using statistical analysis, the 'Positive Expected Value and Negative Expected Values' ratios of the scores were obtained, and the performance results were examined. \u0000Results: 95 newborns with a preliminary clinical diagnosis of sepsis were included in the study. These babies were divided into two groups: clinical (n:71) and proven sepsis (n:24) according to blood culture results. Positive and negative predictive values of scoring systems in definitive sepsis diagnosis; for EMA respectively; 21.5%, 56.3% for Töllner; It was determined as 31.3%, 77.8%, and 100%, 77.8% for Rodwell. \u0000Conclusion: Our study showed that clinician opinion and standard laboratory tests are limited in the diagnosis of neonatal sepsis, and Rodwell hematological scoring is more prominent in recognizing proven sepsis compared to the other two scores .","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0