Pamukkale Medical Journal最新文献

{"title":"Traumatic knee dislocation","authors":"Mert Bektaş, Harun Güngör, Kadir Gem","doi":"10.31362/patd.1421027","DOIUrl":"https://doi.org/10.31362/patd.1421027","url":null,"abstract":"Dear Editor, \u0000We would like to thank aouthors for their invaluable comments on our article.These types of complicated injuries are challenging traumas that can be overcome with the cooperation of orthopedics and traumatology and physical therapy and rehabilitation units.Physical therapy is at least as important as surgery in restoring the patient's previous movement function, especially in the postoperative period. With this awareness, we aimed to restore the pre-injury functions of the patients by receiving the necessary support from our physical therapy and rehabilitation unit in the patients we included in our study. We have seen that early stage physical therapy and rehabilitation, especially after surgery, reduces the limitation of function. In addition, we concluded that physical therapy and rehabilitation specific to the patient and the type of injury will be more effective. \u0000In conclusion, as you mentioned in your article, such injuries with high morbidity are injuries that many medical departments can overcome by working together. Physical therapy and rehabilitation is the most important building block of the postoperative process.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"57 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary pseudotumor cerebri in the pediatric population: clinical features, treatment, and prognosis","authors":"Olcay Güngör, Emine Ün, Osman Parça, Beste Kipcak","doi":"10.31362/patd.1372956","DOIUrl":"https://doi.org/10.31362/patd.1372956","url":null,"abstract":"Purpose: Pseudotumor cerebri syndrome (PTSC) is characterized by elevated intracranial pressure (ICP) without intracranial mass, hydrocephalus, or abnormalities in cerebrospinal fluid composition. In secondary PTSC (sPTSC), there is a reason that increases the CSF pressure. The aim of this study is to evaluate the diagnosis, treatment, and follow-up of pediatric patients diagnosed with secondary PTC. \u0000Materials and methods: This is a retrospective study conducted in a single-center tertiary pediatric hospital. We included patients aged 1-17 years who were diagnosed with sPTSC in a tertiary hospital between 2018 and 2023 and met the current diagnostic criteria for PTSC. We evaluated the complaints, etiology, ophthalmological evaluations, and treatment results of the cases. \u0000Results: Seventeen patients with a diagnosis of PTCS were included in the study. The mean age was 9.82(±4.6). Of the patients, 9(56.2%) were male and 8(43.7%) were female. The most common symptoms were headache in 10 patients(62.5%), nausea/vomiting in 6 patients(37.5%), and double vision in 5 patients(31.2%). All patients had papilledema and 7(43.7%) patients had sixth nerve palsy. Recurrence was observed in 3(16%) patients. Optic nerve fenestration was performed in three patients as a second-line treatment. \u0000Conclusion: In cases that do not respond to medical treatment, optic nerve sheath fenestration may be a good treatment option. \u0000Keywords: optic nerve, child, pseudotumor cerebri","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"109 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Konjenital Adrenal Hiperplazili Hastalarda Final Boyun Değerlendirilmesi","authors":"Burçin Kurti̇pek, Melikşah Keski̇n, Elvan Bayramoglu, Zehra Aycan","doi":"10.31362/patd.1366476","DOIUrl":"https://doi.org/10.31362/patd.1366476","url":null,"abstract":"Purpose : Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease that occurs as a result of deficiency of any of the enzymes required for the synthesis of glucocorticoid, mineralocorticoid and sex steroid from cholesterol in the adrenal cortex .In this study, we aimed to evaluate the final height in patients with CAH due to 21-hydroxylase and 11 Beta hydroxylase deficiency and to investigate the factors affecting it. \u0000Material-method: The anthropometric, clinical and laboratory findings of the patients who were diagnosed with CAH in the Pediatric Endocrinology Clinic were evaluated retrospectively. A total of 39 patients with CAH who had regular controls, who did not have precocious puberty and no additional disease during their follow-up, and who reached the final height were included in the study. \u0000Results: The final height was 158.2±5.46 cm in female cases and 168.8±11.67 cm in male cases with classic simple virilizing CAD due to 21 hydroxylase deficiency, and it was 152.2±5.94 cm in salt-wasting female cases and 156.5±6.2 cm in salt-wasting male cases. It was found to be 155.9±7.59 cm in non-classic female cases and 157 cm in 1 non-classic male case. The final height of all classic type CAH cases is SD - 1.41±1.45 SD, and it was calculated as -0.81±1.12 (-2,30 - 0,80) in cases with simple virilizing type classic CAH and -1.79±1.53 (-3.70 - 0.70) in cases with salt-wasting type classic CAD. In non-classic CAH cases, final height SD was calculated as -1.65±1.69 SD. When patients with salt-wasting CAH and simple virilizing CAH were compared in terms of final height SD and genetically adjusted height SD, the final heights of patients with simple virilizing CAH were significantly longer (p","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"141 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139604519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of DNA damage and inflammatory marker profile in patients after bariatric surgery","authors":"T. Sari, S. Yilmaz, M. Aykota, Doç.dr Selda Şi̇mşek, İ. Açikbaş, B. Er Urganci","doi":"10.31362/patd.1408756","DOIUrl":"https://doi.org/10.31362/patd.1408756","url":null,"abstract":"Abstract \u0000Purpose: Obesity is a significant risk factor in the development of many serious diseases. The most prominent ones among them are diabetes and coronary heart disease. Elevated blood sugar levels in obese individuals lead to increased susceptibility to infections due to the suppression of the immune response. Moreover, fatty skin folds can cause topical infections, ulcers, and delayed/impaired wound healing. Therefore, inflammatory and pro-inflammatory markers in the serum have gained importance in diseases such as diabetes and obesity. Furthermore, in obesity, reactive oxygen species (ROS) lead to DNA damage. 8-oxo-dG, which is the primary product of DNA oxidation, can be detected in the serum, saliva, and urine, making it an ideal biological marker for DNA damage in large population-based studies. The Comet assay analysis is a method used to demonstrate the double-strand breaks in DNA. Induction of γ-H2AX in tissue indicates the initiation of a well-regulated mechanism to reverse double-strand breaks in DNA. Potential benefits of monitoring the genomic health in obesity include creating a sense of urgency for personalized intervention measures and evaluating their progress. DNA damage in obesity is believed to be a reversible condition. Chronic inflammation is an etiological factor known to support DNA damage and neoplastic transformations in cells. Cytokines secreted from adipose tissue, especially TNF-alpha, IL-6, and IL-1β, promote the accumulation of various cells, including neutrophils, macrophages, and dendritic cells, and it indicates the initiation of an inflammatory process. In this project, it was aimed to investigate possible changes in inflammation markers and DNA damage in individuals undergoing bariatric surgery, who were beginning to improve endocrine and metabolic syndrome markers. \u0000Materials and methods: For this purpose, blood and urine samples were collected from 45 obese patients, who had undergone bariatric surgery and 45 healthy volunteers matched for age and gender. The levels of inflammatory markers (IL-1β, IL-6, IL-8, and TNF-α) and the DNA damage marker γ-H2AX in serum, as well as the amount of 8-oxo-dG in urine, were determined using ELISA. Additionally, the percentage of DNA damage was determined using the Comet assay analysis. \u0000Results: Weight control achieved through bariatric surgery and the subsequent reduction in fat tissue resulted in a significant decrease in the levels of γ-H2AX and 8-oxo-dG, as well as a parallel significant reduction in the percentage of DNA damage in the Comet assay results. The significant decrease in inflammatory markers IL-1β, IL-6, IL-8, and TNF-α levels indicated that bariatric surgery also affects inflammation indirectly. \u0000Conclusion: Although there are numerous studies in the literature on individual parameters related to DNA damage in various diseases and obesity, it is believed that the present study determining DNA damage, oxidation, and repair mechanisms simultaneously ","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"72 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic knee dislocation","authors":"Uğur Ertem","doi":"10.31362/patd.1413990","DOIUrl":"https://doi.org/10.31362/patd.1413990","url":null,"abstract":"I would like to share my opinions on the article “Traumatic knee dislocation”. First of all, I would like to thank the authors for contributions to the science of a subject that is of great concern to physicians interested in the musculoskeletal system and whose treatment and rehabilitation is very difficult. I will try to contribute to such an important issue as a physical medicine and rehabilitation physician.","PeriodicalId":506150,"journal":{"name":"Pamukkale Medical Journal","volume":"15 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}