Current Opinion in Gastroenterology最新文献_第6页

Idiopathic terminal ileitis: myth or true entity? 特发性末端回肠炎：传说还是真实存在？

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI: 10.1097/MOG.0000000000001011

Nicoletta Nandi, Foong Way David Tai, Mark McAlindon, Reena Sidhu

引用次数: 0

A practical guide to selecting and using new ulcerative colitis therapies. 溃疡性结肠炎新疗法的选择和使用实用指南。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-04-12 DOI: 10.1097/mog.0000000000001023

Tara Nagaraj, John Shinn, Kara De Felice

引用次数: 0

A Practical guide to selecting and using new Crohn's disease therapies. 选择和使用克罗恩病新疗法实用指南》。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-04-12 DOI: 10.1097/mog.0000000000001029

Elizabeth A Scoville, Sara N Horst

引用次数: 0

Towards personalized management of early esophageal adenocarcinoma. 实现早期食管腺癌的个性化治疗。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-04-12 DOI: 10.1097/mog.0000000000001030

Vincent Bos, Man Wai Chan, Roos E Pouw

引用次数: 0

The role of the fibroblast in Barrett's esophagus and esophageal adenocarcinoma. 成纤维细胞在巴雷特食管和食管腺癌中的作用。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-04-12 DOI: 10.1097/mog.0000000000001032

Huili Zhu, Ramon U Jin

引用次数: 0

Advances in endoscopic management of colonic diverticular bleeding. 结肠憩室出血的内窥镜治疗进展。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-04-11 DOI: 10.1097/mog.0000000000001021

Yasutoshi Shiratori, Syed Matthew Kodilinye, Ahmed E Salem

引用次数: 0

Integrins in biliary injury and fibrosis. 胆道损伤和纤维化中的整合素

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1097/MOG.0000000000000995

Johanna R Schaub, Jennifer Y Chen, Scott M Turner

{"title":"Integrins in biliary injury and fibrosis.","authors":"Johanna R Schaub, Jennifer Y Chen, Scott M Turner","doi":"10.1097/MOG.0000000000000995","DOIUrl":"10.1097/MOG.0000000000000995","url":null,"abstract":"Purpose of review: Current treatment options for cholangiopathies are severely limited and there is thus a critical need to identify and develop therapies. This review discusses the role of integrins in biliary injury and fibrosis and their potential as therapeutic targets.Recent findings: There are a diverse set of roles that integrins play in biliary injury and fibrosis. Some integrins activate TGF-β signaling or are involved in sensing of the extracellular matrix, making them attractive targets for biliary fibrosis. In recent work, autoantibodies to α v β 6 were identified in patients with PSC, supporting the relevance of this integrin in the disease. In addition, a role for α 2 β 1 in cyst formation was identified in a mouse model of polycystic liver disease. Leukocyte integrins (e.g. α E β 7 and α 4 β 7 ) contribute to lymphocyte trafficking, making them potential targets for biliary inflammation; however, this has not yet translated to the clinic.Summary: While all members of the same family of proteins, integrins have diverse roles in the pathogenesis of biliary disease. Targeting one or multiple of these integrins may slow or halt the progression of biliary injury and fibrosis by simultaneously impacting different pathologic cells and processes.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"85-91"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micronutrient status and protein-energy malnutrition in free-living older adults: a current perspective. 自由生活的老年人的微量营养素状况和蛋白质-能量营养不良：当前视角。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-04 DOI: 10.1097/MOG.0000000000001000

Maria Del Carmen Alvarez-Nuncio, Thomas R Ziegler

{"title":"Micronutrient status and protein-energy malnutrition in free-living older adults: a current perspective.","authors":"Maria Del Carmen Alvarez-Nuncio, Thomas R Ziegler","doi":"10.1097/MOG.0000000000001000","DOIUrl":"10.1097/MOG.0000000000001000","url":null,"abstract":"Purpose of review: This review addresses the newest findings on micronutrient status and protein-energy malnutrition in the increasingly aging global population; understanding the nutritional challenges they face is vital for healthcare, well being, and public health.Recent findings: The review examines deficiencies in macro- and micronutrients among nonhospitalized, free-living older adults, revealing significant associated health consequences, including frailty, cognitive decline, and reduced quality of life. Deficiencies in fat-soluble vitamins such as A, D, and E, are common in older populations, emphasizing the need for close monitoring for status of these. Furthermore, water-soluble vitamin deficiencies, especially vitamins B12 and C are also common, and pose health risks, including neurological disorders and cognitive decline. Iron and iodine deficiencies contribute to anemia, and neurocognitive disorders. Finally, protein-energy malnutrition is common in older adults living in high-resource countries and may occur concomitant with depletion of one or more micronutrients.Summary: Addressing specific nutritional deficiencies is fundamental to enhancing the wellbeing and quality of life for free-living older adults. Protein-energy malnutrition, impacting over 25% of those aged 65 and above, results in a range of health issues, including poor wound healing, susceptibility to infections, anemia, and delayed convalescence. These concerns are aggravated by inadequate energy, macronutrient, and micronutrient intake, affecting muscle strength and overall health. Future research should focus on tailored appropriate monitoring of at-risk individuals, specific nutritional interventions, and dietary strategies to mitigate these issues and improve health outcomes among older adults.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"99-105"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10872245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional deficiencies in alcohol use disorder/alcohol-associated liver disease. 酒精使用障碍/酒精相关肝病的营养缺乏。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1097/MOG.0000000000000999

Loretta Jophlin, Tzu-Yu Liu, Craig J McClain

{"title":"Nutritional deficiencies in alcohol use disorder/alcohol-associated liver disease.","authors":"Loretta Jophlin, Tzu-Yu Liu, Craig J McClain","doi":"10.1097/MOG.0000000000000999","DOIUrl":"10.1097/MOG.0000000000000999","url":null,"abstract":"Purpose of review: To delineate common and uncommon dietary and nutritional deficiencies in individuals with chronic heavy alcohol use and alcohol use disorder and to highlight important advances in the nutrition field in patients ranging from those with alcohol use disorder (AUD) and no liver disease to those with decompensated alcohol-associated liver disease (ALD).Recent findings: Patients with AUD may have nutritional deficiencies, especially isolated nutrient deficiencies, such as thiamine or zinc deficiencies. This should not be surprising, as alcohol is a major source of \"empty calories.\" It is devoid of critical macronutrients, such as protein, and micronutrients including important vitamins and minerals. Patients with AUD frequently drink much more than often appreciated (10-20 drinks a day). Patients with AUD and early ALD often begin to develop more apparent nutritional deficiencies. Healthcare providers need to be aware of the presenting features of individual nutrient deficiencies, such as thiamine deficiency, and to provide prompt treatment. In patients with more advanced liver disease, malnutrition correlates with severity of liver disease. It is important to understand the value of nutritional support throughout the spectrum of AUD.Summary: We review nutritional deficiencies in the spectrum of patients with AUD and ALD and highlight new information and recommendations.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"112-117"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional deficiencies in children. 儿童营养不良。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1097/MOG.0000000000000998

Farhana Ali, Marialena Mouzaki

引用次数: 0