Current Opinion in Gastroenterology最新文献

Kupffer cells are central to mitigating intravascular infections. 库普弗细胞是缓解血管内感染的核心。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-07-30 DOI: 10.1097/MOG.0000000000001128

Filipe Rodolfo Moreira Borges Oliveira, Paul Kubes

引用次数: 0

Advances in diagnosis and therapy for upper gastrointestinal Crohn's disease. 上消化道克罗恩病的诊断和治疗进展。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-08-01 DOI: 10.1097/MOG.0000000000001129

Laura Sahyoun, Jill K J Gaidos

{"title":"Advances in diagnosis and therapy for upper gastrointestinal Crohn's disease.","authors":"Laura Sahyoun, Jill K J Gaidos","doi":"10.1097/MOG.0000000000001129","DOIUrl":"10.1097/MOG.0000000000001129","url":null,"abstract":"Purpose of review: Crohn's disease is a chronic, relapsing and remitting inflammatory process that can involve the entire length of the gastrointestinal tract. Upper gastrointestinal involvement (UGI) in Crohn's disease is present in up to 15% of patients and can present as a diagnostic challenge given nonspecific symptoms and overlapping disease entities. This review provides an update on diagnosing and risk stratifying UGI-CD.Recent findings: Literature suggests the use of imaging modalities (such as video capsule endoscopy, cross-sectional imaging and intestinal ultrasound) to help identify proximal inflammation when clinical suspicion for UGI involvement exists based on symptoms and patient factors. Additionally, proximal disease involvement has been associated with increased disease severity, a higher prevalence of strictures and an increased risk for surgery. First-line therapies are corticosteroids and antitumor necrosis factor therapies if systemic treatment is needed based on disease severity. For stricturing disease, endoscopic balloon dilation, strictureplasty, surgical resection or bypass can be considered for medically refractory or recurrent disease.Summary: As the prevalence and progression of UGI-CD is still understudied due to its variable definition, presentation and incidence, the development of a standardized approach to diagnosis could aid in determining the overall prevalence and most effective treatments.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"426-431"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing care in malignant gastric outlet obstruction: a contemporary review of management strategies. 推进恶性胃出口梗阻的护理：当代管理策略回顾。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-04-23 DOI: 10.1097/MOG.0000000000001101

Adrianna Wierzbicka, Tilak Shah

{"title":"Advancing care in malignant gastric outlet obstruction: a contemporary review of management strategies.","authors":"Adrianna Wierzbicka, Tilak Shah","doi":"10.1097/MOG.0000000000001101","DOIUrl":"10.1097/MOG.0000000000001101","url":null,"abstract":"Purpose of review: The aim of this review is to summarize the most pertinent data on management of malignant gastric outlet obstruction (MGOO), with an emphasis on recent updates.Recent findings: Traditionally, options to restore luminal patency in patients with MGOO were surgical gastrojejunostomy (SGJ) and endoscopic insertion of an enteral stent. The latter was reserved for patients with poor performance status or anticipated survival less than 2 months. Endoscopic gastroenterostomy (EUS-GE) is a newer technique that aims to mimic a SGJ and involves placement of a lumen apposing metal stent (LAMS) from the stomach directly into the jejunum. In a recent randomized trial of EUS-GE vs. enteral stent, the former was associated with reduced re-interventions, improved stent patency, and improved patient reported eating habits. Recent publications suggest that EUS-GE may offer substantial advantages over S-GJ; a randomized trial is currently underway. Venting gastrostomy may be the most suitable option for patients with markedly impaired gastric motility or with multiple luminal obstructions.Summary: MGOO is a debilitating late complication of advanced upper gastrointestinal malignancies, resulting from blockage or mechanical compression of the distal stomach, pyloric antrum or duodenum. Various modalities are currently available, and should be tailored to patient's expectations, underlying cause, life expectancy, and functional status.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"409-415"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern concepts of small intestinal bacterial overgrowth. 小肠细菌过度生长的现代概念。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI: 10.1097/MOG.0000000000001135

Gillian M Barlow, Mark Pimentel

{"title":"Modern concepts of small intestinal bacterial overgrowth.","authors":"Gillian M Barlow, Mark Pimentel","doi":"10.1097/MOG.0000000000001135","DOIUrl":"10.1097/MOG.0000000000001135","url":null,"abstract":"Purpose of review: Small intestinal bacterial overgrowth (SIBO) has been a recognized condition for more than half a century. Early descriptions of SIBO were based on the concept of colonic bacteria \"backing up\" into the small intestine. This was based on techniques using unprotected aspiration catheters and earlier culture techniques. Recent advances in breath testing, small bowel sampling, culture techniques, and next generation sequencing have helped expand our understanding of SIBO.Recent findings: \"SIBO\" is now understood to encompass at least three different types of overgrowth including SIBO, intestinal methanogen overgrowth (IMO) and intestinal sulfide overproduction (ISO). Each has their own unique microbial profile. In addition, next generation sequencing has revealed that SIBO is not a migration of colonic flora into the small intestine, but rather overgrowth of two predominant species/strains from phylum Proteobacteria ( Escherichia coli and Klebsiella ). Lastly, results from next generation sequencing of the stool and small intestinal microbiomes have validated breath testing as a diagnostic tool.Summary: Together, these advances have allowed the identification of key microbes in overgrowth syndromes, uncovering their relationships to conditions such as irritable bowel syndrome, and paving the way for the development of novel customized treatment options in the future.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"399-408"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potassium-competitive acid blockers. 钾竞争性酸阻滞剂。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-07-23 DOI: 10.1097/MOG.0000000000001127

Trevor A Davis, C Prakash Gyawali

{"title":"Potassium-competitive acid blockers.","authors":"Trevor A Davis, C Prakash Gyawali","doi":"10.1097/MOG.0000000000001127","DOIUrl":"10.1097/MOG.0000000000001127","url":null,"abstract":"Purpose of review: Acid suppression is the mainstay of management of common foregut disorders, including gastroesophageal reflux disease (GERD), peptic ulcer disease and Helicobacter pylori infection. Drawbacks of standard management with proton pump inhibitors (PPIs) include acid lability requiring enteric coating, slow onset of effect, lack of suppression of nocturnal acid breakthrough, and need for administration before meals.Recent findings: Potassium-competitive acid blockers (PCABs) are a novel class of acid suppressants that are effective in the management of symptomatic and erosive GERD, peptic ulcer disease and H. pylori infection. Administration before meals is not needed, and these agents achieve profound acid suppression right from the first dose, with control of daytime as well as nocturnal acid. In randomized controlled trials, PCABs are noninferior and often superior to PPIs, especially in healing of advanced grade esophagitis and eradication of treatment-naive as well as refractory H. pylori. The safety profile of PCABs over 10 years of use is reassuring, although profound acid suppression may contribute to hypergastrinemia and increased risk of gastrointestinal infections.Summary: As PCABs become available in many countries around the globe, real-world use will allow further research to determine the clinical niche of these acid-suppressive agents.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"389-398"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates in endoscopic hemostasis for nonvariceal gastroduodenal bleeding. 内镜下止血治疗非静脉曲张胃十二指肠出血的最新进展。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1097/MOG.0000000000001133

Himesh B Zaver, Mary S McGrath, Andrew Y Wang

引用次数: 0

Stomach and duodenum: what's current in 2025. 胃和十二指肠：2025年的样子。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-10-02 DOI: 10.1097/MOG.0000000000001130

Tilak U Shah

引用次数: 0

All in my head or all in my gut? An update on irritable bowel syndrome. 全在脑子里还是全在肚子里？肠易激综合征的最新进展。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-10-23 DOI: 10.1097/MOG.0000000000001141

Amy T Woods, Alexander C Ford, Christopher J Black

{"title":"All in my head or all in my gut? An update on irritable bowel syndrome.","authors":"Amy T Woods, Alexander C Ford, Christopher J Black","doi":"10.1097/MOG.0000000000001141","DOIUrl":"https://doi.org/10.1097/MOG.0000000000001141","url":null,"abstract":"Purpose of review: Irritable bowel syndrome (IBS) has a considerable impact on patients and healthcare systems. IBS is a disorder of brain-gut interaction with numerous biopsychosocial factors involved, including early life experiences, previous gastrointestinal infections, and coexisting mood disorders. An understanding of the role of the gut-brain axis in symptom generation is vital to enable delivery of holistic care.Recent findings: We explore psychological mechanisms, such as coexisting anxiety and depression, adverse life experiences, and somatisation and how these impact symptom severity. There is evidence for psychological therapies, such as cognitive behavioural therapy or gut-directed hypnotherapy, in IBS. We go on to summarise gut-based mechanisms, such as abnormal motility, visceral hypersensitivity, inflammation, and dysbiosis. Efficacious treatments targeting these include antidiarrhoeals, laxatives, antispasmodics, drugs acting on ion channels or serotonin, gut-brain neuromodulators, and treatments targeting the microbiota or inflammation. Finally, we consider emerging evidence from models describing distinct IBS phenotypes and their potential to facilitate a more integrated approach to identify best treatment options.Summary: For many patients with IBS, both brain and gut mechanisms must be considered within the context of the biopsychosocial model to enable effective delivery of holistic and personalised care.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of techniques of third space endoscopy for gastrointestinal tumors. 胃肠肿瘤第三空间内镜检查技术综述。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI: 10.1097/MOG.0000000000001113

Zaheer Nabi, D Nageshwar Reddy

{"title":"A review of techniques of third space endoscopy for gastrointestinal tumors.","authors":"Zaheer Nabi, D Nageshwar Reddy","doi":"10.1097/MOG.0000000000001113","DOIUrl":"10.1097/MOG.0000000000001113","url":null,"abstract":"Purpose of review: This review explores the evolving landscape of third-space endoscopy (TSE) techniques for the management of gastrointestinal (GI) tumors. With rapid technological advances and accumulating evidence, there is a pressing need to synthesize current knowledge and clarify the comparative utility of approaches like submucosal tunneling endoscopic resection (STER) and tunneling endoscopic submucosal dissection (ESD).Recent findings: STER is safe and effective for resection of subepithelial lesions, offering mucosal preservation, high en bloc resection rates, and reduced recovery time compared to ESE, ESD, and endoscopic full-thickness resection. Piecemeal STER is a potential alternative to surgery in managing large esophageal sub-epithelial lesions without compromising outcomes. For early epithelial neoplasms, pocket-creation and tunneling variants of ESD improve dissection speed and reduce adverse events, especially in large lesions. Comparative studies across esophagus, stomach, and colon confirm these benefits. Additionally, risk scoring systems and resection algorithms may guide personalized technique selection.Summary: STER and tunneling ESD represent significant advances in minimally invasive management of GI tumors. Incorporating these techniques into practice can enhance safety and efficacy, especially when guided by risk stratification tools. Ongoing innovation, including artificial intelligence and robotics, is likely to further refine third-space interventions in near future.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"327-332"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic ultrasound in hepatology: ushering a new era in liver disease management. 内窥镜超声在肝病中的应用：引领肝病治疗的新时代。

IF 2.5 3区医学

Current Opinion in Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI: 10.1097/MOG.0000000000001115

Andrada Seicean, Irina Dragomir, Bogdan Procopet

{"title":"Endoscopic ultrasound in hepatology: ushering a new era in liver disease management.","authors":"Andrada Seicean, Irina Dragomir, Bogdan Procopet","doi":"10.1097/MOG.0000000000001115","DOIUrl":"10.1097/MOG.0000000000001115","url":null,"abstract":"Purpose of review: This review aims to provide an up-to-date overview of the expanding role of endoscopic ultrasound (EUS) in endohepatology, highlighting its potential to transform the diagnostic and therapeutic landscape for liver diseases. Given the increasing complexity of liver disease management, this review discusses both established and emerging applications of EUS in liver parenchyma assessment, portal hypertension diagnosis and related complications treatment and liver biopsy techniques.Recent findings: Recent studies demonstrate that EUS can accurately assess liver fibrosis, detect focal lesions, and evaluate portal hypertension, with significant advancements in EUS-guided liver biopsy and treatment of gastric varices. Key findings include improved diagnostic accuracy with EUS-FNB over traditional methods and the potential for endoscopic ultrasound portal pressure gradient (EUS-PPG) in portal pressure measurements.Summary: EUS holds significant promise in diagnosing and treating liver diseases, with applications in assessing liver fibrosis, identifying focal liver lesions, and managing portal hypertension. Future research will likely focus on enhancing EUS's role in therapeutic procedures, such as managing portal vein thrombosis and creating intrahepatic portosystemic shunts, offering a new avenue for minimally invasive treatment options.","PeriodicalId":50607,"journal":{"name":"Current Opinion in Gastroenterology","volume":" ","pages":"298-305"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0