Kupffer cells are central to mitigating intravascular infections.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-07-30 DOI:10.1097/MOG.0000000000001128

Filipe Rodolfo Moreira Borges Oliveira, Paul Kubes

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Abstract

Purpose of review: Kupffer cells (KCs), the resident liver macrophages, are absolutely critical in immune surveillance and intravascular pathogen eradication. This mini-review highlights KCs' contributions to host protection of intravascular infections.

Recent findings: KCs, uniquely originated and self-renewing, demonstrate remarkable functional plasticity and trained immunity. KCs are frontline responders in infections: they phagocytose microorganisms but can succumb to certain infections. We highlight some of the recent findings in this regard.

Summary: Understanding KCs' complex interactions with diverse pathogens is key to improving treatment modalities in infection. Future research, needs to focus on how certain pathogens evade KCs and how we can aid these macrophages in eradicating microbes. A move towards humanized KC models in vivo and in vitro incorporating key environmental factors such as shear flow and unique sinusoidal components will be essential to unravel their comprehensive roles.

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库普弗细胞是缓解血管内感染的核心。

综述目的：库普弗细胞（KCs）是常驻肝巨噬细胞，在免疫监视和血管内病原体根除中起着至关重要的作用。这篇综述强调了KCs在血管内感染的宿主保护中的作用。最近研究发现：KCs具有独特的起源和自我更新能力，具有显著的功能可塑性和训练免疫能力。KCs是感染的一线反应者：它们吞噬微生物，但可能屈服于某些感染。我们强调在这方面最近的一些发现。摘要：了解KCs与多种病原体的复杂相互作用是改善感染治疗方式的关键。未来的研究需要关注某些病原体如何逃避KCs，以及我们如何帮助这些巨噬细胞根除微生物。将剪切流和独特正弦分量等关键环境因素纳入体内和体外的人源化KC模型对于揭示其综合作用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Gastroenterology 医学-胃肠肝病学

CiteScore

5.30

自引率

0.00%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.