小肠细菌过度生长的现代概念。

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Current Opinion in Gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI:10.1097/MOG.0000000000001135
Gillian M Barlow, Mark Pimentel
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引用次数: 0

摘要

综述目的:半个多世纪以来,小肠细菌过度生长(SIBO)一直是一种公认的疾病。早期对SIBO的描述是基于结肠细菌“备份”到小肠的概念。这是基于使用无保护的抽吸导管和早期培养技术的技术。呼吸测试、小肠采样、培养技术和下一代测序的最新进展有助于扩大我们对SIBO的理解。最近的发现:“SIBO”现在被理解为包括至少三种不同类型的过度生长,包括SIBO,肠道甲烷菌过度生长(IMO)和肠道硫化物过度生产(ISO)。每一种都有自己独特的微生物特征。此外,下一代测序显示,SIBO不是结肠菌群向小肠的迁移,而是变形菌门(大肠杆菌和克雷伯菌)的两种优势种/菌株的过度生长。最后,下一代粪便和小肠微生物组测序结果验证了呼吸测试作为诊断工具的有效性。总之,这些进展使我们能够识别过度生长综合征中的关键微生物,揭示它们与肠易激综合征等疾病的关系,并为未来开发新的定制治疗方案铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modern concepts of small intestinal bacterial overgrowth.

Purpose of review: Small intestinal bacterial overgrowth (SIBO) has been a recognized condition for more than half a century. Early descriptions of SIBO were based on the concept of colonic bacteria "backing up" into the small intestine. This was based on techniques using unprotected aspiration catheters and earlier culture techniques. Recent advances in breath testing, small bowel sampling, culture techniques, and next generation sequencing have helped expand our understanding of SIBO.

Recent findings: "SIBO" is now understood to encompass at least three different types of overgrowth including SIBO, intestinal methanogen overgrowth (IMO) and intestinal sulfide overproduction (ISO). Each has their own unique microbial profile. In addition, next generation sequencing has revealed that SIBO is not a migration of colonic flora into the small intestine, but rather overgrowth of two predominant species/strains from phylum Proteobacteria ( Escherichia coli and Klebsiella ). Lastly, results from next generation sequencing of the stool and small intestinal microbiomes have validated breath testing as a diagnostic tool.

Summary: Together, these advances have allowed the identification of key microbes in overgrowth syndromes, uncovering their relationships to conditions such as irritable bowel syndrome, and paving the way for the development of novel customized treatment options in the future.

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来源期刊
Current Opinion in Gastroenterology
Current Opinion in Gastroenterology 医学-胃肠肝病学
CiteScore
5.30
自引率
0.00%
发文量
137
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.
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