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Current Opinion in Pharmacology最新文献

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From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling 从 "禁忌症 "到 "一线治疗"--当前超越典型β受体信号转导的机理认识
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-04-17 DOI: 10.1016/j.coph.2024.102458
Theresa Brand , Ann-Kathrin Lukannek , Valérie Jahns , Roland Jahns , Kristina Lorenz
{"title":"From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling","authors":"Theresa Brand ,&nbsp;Ann-Kathrin Lukannek ,&nbsp;Valérie Jahns ,&nbsp;Roland Jahns ,&nbsp;Kristina Lorenz","doi":"10.1016/j.coph.2024.102458","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102458","url":null,"abstract":"<div><p>β-blockers are a solid pillar in the treatment of cardiovascular diseases. However, they are highly discussed regarding effectiveness for certain indications and side-effects. Even though there are up to 20 licensed compounds, only four are used for heart failure (HF) therapy. On the receptor level several key characteristics seem to influence the clinical outcome: subtype selectivity, antagonistic vs (inverse/biased) agonistic properties and -in particular- ancillary capacities. On a molecular level, divergent and novel signaling patterns are being identified and extra-cardiac effects on e.g. inflammation, metabolism and oxidative stress are highlighted. This review discusses different well-known and newly discovered characteristics that need to be considered for HF therapy and in the context of co-morbidities.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"76 ","pages":"Article 102458"},"PeriodicalIF":4.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000286/pdfft?md5=79cdbcebcc1144f5a8184b3d624ad690&pid=1-s2.0-S1471489224000286-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140607315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis 补体途径是新生血管性老年黄斑变性介导的视网膜下纤维化的治疗靶点
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-03-30 DOI: 10.1016/j.coph.2024.102448
Heping Xu , Caijiao Yi , Mei Chen
{"title":"The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis","authors":"Heping Xu ,&nbsp;Caijiao Yi ,&nbsp;Mei Chen","doi":"10.1016/j.coph.2024.102448","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102448","url":null,"abstract":"<div><p>Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in the elderly in developed countries. Intravitreal injection of VEGF inhibitors is the mainstream therapy for nAMD, although nearly 50% of the patients do not respond or respond poorly to the therapy. One of the main reasons for the poor outcome of the therapy is the development of subretinal macular fibrosis, a process of excessive deposition of extracellular matrix proteins around the diseased blood vessels. Currently, there is no medication to prevent or treat the condition. Here, we discussed recent advances in the pathogenesis of nAMD-mediated macular fibrosis, with a focus on the role of the complement system. We further proposed approaches to target the complement system for the management of macular fibrosis and highlighted the area of further research for future clinical applications of complement-based therapy.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"76 ","pages":"Article 102448"},"PeriodicalIF":4.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000183/pdfft?md5=fbf295b621546072e3f80c3a7d39177b&pid=1-s2.0-S1471489224000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside 靶向 TRP 通道缓解疼痛：从临床到床边的现有证据综述
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-03-11 DOI: 10.1016/j.coph.2024.102447
Ari-Pekka Koivisto , Thomas Voets , Michael J. Iadarola , Arpad Szallasi
{"title":"Targeting TRP channels for pain relief: A review of current evidence from bench to bedside","authors":"Ari-Pekka Koivisto ,&nbsp;Thomas Voets ,&nbsp;Michael J. Iadarola ,&nbsp;Arpad Szallasi","doi":"10.1016/j.coph.2024.102447","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102447","url":null,"abstract":"<div><p>Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102447"},"PeriodicalIF":4.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000171/pdfft?md5=e71d630d360072b78e623fcc3092cb04&pid=1-s2.0-S1471489224000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration 雌激素相关受体α：老年性黄斑变性的潜在调节剂
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-03-05 DOI: 10.1016/j.coph.2024.102439
Fatima Massare Somers , Goldis Malek
{"title":"Estrogen related receptor alpha: Potential modulator of age-related macular degeneration","authors":"Fatima Massare Somers ,&nbsp;Goldis Malek","doi":"10.1016/j.coph.2024.102439","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102439","url":null,"abstract":"<div><p>To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed. The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor that regulates several AMD-associated pathogenic pathways. However, it has not been investigated in detail in the ocular posterior pole during aging or in AMD. This review delves into the literature highlighting the significance of ESRRA as a molecular target that may be important in the pathobiology of AMD, and discusses data available supporting the targeting of this receptor signaling pathway as a therapeutic option for AMD.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102439"},"PeriodicalIF":4.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the endocannabinoid system for the management of low back pain 针对内源性大麻素系统治疗腰背痛
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-02-23 DOI: 10.1016/j.coph.2024.102438
Mary A. Hopkins , Brian E. McGuire , David P. Finn
{"title":"Targeting the endocannabinoid system for the management of low back pain","authors":"Mary A. Hopkins ,&nbsp;Brian E. McGuire ,&nbsp;David P. Finn","doi":"10.1016/j.coph.2024.102438","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102438","url":null,"abstract":"<div><p>Low back pain (LBP) is a major unmet clinical need. The endocannabinoid system (ECS) has emerged as a promising therapeutic target for pain, including LBP. This review examines the evidence for the ECS as a therapeutic target for LBP. While preclinical studies demonstrate the potential of the ECS as a viable therapeutic target, clinical trials have presented conflicting findings. This review underscores the need for innovative LBP treatments and biomarkers and proposes the ECS as a promising avenue for their exploration. A deeper mechanistic understanding of the ECS in LBP could inform the development of new pain management strategies.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102438"},"PeriodicalIF":4.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000080/pdfft?md5=07597a8c72a12dbf07bf7fe9f395c1f7&pid=1-s2.0-S1471489224000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal issue: Advances in gastrointestinal oncology 胃肠道问题：胃肠道肿瘤学的进展
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-02-23 DOI: 10.1016/j.coph.2024.102437
Jeroen Dekervel, Angelica Petrillo
{"title":"Gastrointestinal issue: Advances in gastrointestinal oncology","authors":"Jeroen Dekervel,&nbsp;Angelica Petrillo","doi":"10.1016/j.coph.2024.102437","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102437","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102437"},"PeriodicalIF":4.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid raft disruption as an opportunity for peripheral analgesia 脂质筏破坏为外周镇痛提供了机会。
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-30 DOI: 10.1016/j.coph.2024.102432
Andrea Kinga Nehr-Majoros , Ágnes Király , Zsuzsanna Helyes , Éva Szőke
{"title":"Lipid raft disruption as an opportunity for peripheral analgesia","authors":"Andrea Kinga Nehr-Majoros ,&nbsp;Ágnes Király ,&nbsp;Zsuzsanna Helyes ,&nbsp;Éva Szőke","doi":"10.1016/j.coph.2024.102432","DOIUrl":"10.1016/j.coph.2024.102432","url":null,"abstract":"<div><p><span><span><span>Chronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential<span> ion channels, opioid receptors, P2X purinoreceptors and </span></span>neurokinin 1 receptor are located in the </span>lipid raft regions of the plasma membrane. Targeting the </span>membrane lipid<span> composition and structure by sphingolipid or cholesterol depletion might open future perspectives for the therapy of chronic inflammatory, neuropathic or cancer pain, most importantly acting at the periphery.</span></p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102432"},"PeriodicalIF":4.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Endocrine and metabolic diseases (2023) 编辑综述：内分泌与代谢疾病》（2023 年）
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-29 DOI: 10.1016/j.coph.2024.102436
Ivana Bjelobaba, Stephanie Constantin
{"title":"Editorial overview: Endocrine and metabolic diseases (2023)","authors":"Ivana Bjelobaba,&nbsp;Stephanie Constantin","doi":"10.1016/j.coph.2024.102436","DOIUrl":"10.1016/j.coph.2024.102436","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102436"},"PeriodicalIF":4.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139579115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: New and revitalized old targets in metabolic disease 编辑综述：代谢性疾病中的新靶点和重获新生的旧靶点
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102434
Jacob B. Hansen, Ivana Novak
{"title":"Editorial overview: New and revitalized old targets in metabolic disease","authors":"Jacob B. Hansen,&nbsp;Ivana Novak","doi":"10.1016/j.coph.2024.102434","DOIUrl":"10.1016/j.coph.2024.102434","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102434"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets” 编辑综述："嘌呤能免疫细胞调控揭示了新的药理靶点
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102435
Wolfgang Junger, Carola Ledderose
{"title":"Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”","authors":"Wolfgang Junger,&nbsp;Carola Ledderose","doi":"10.1016/j.coph.2024.102435","DOIUrl":"10.1016/j.coph.2024.102435","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102435"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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