发布求助
文献互助 智能选刊 最新文献

Current Opinion in Pharmacology最新文献

筛选
英文 中文
Targeting the endocannabinoid system for the management of low back pain 针对内源性大麻素系统治疗腰背痛
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-02-23 DOI: 10.1016/j.coph.2024.102438
Mary A. Hopkins , Brian E. McGuire , David P. Finn
{"title":"Targeting the endocannabinoid system for the management of low back pain","authors":"Mary A. Hopkins ,&nbsp;Brian E. McGuire ,&nbsp;David P. Finn","doi":"10.1016/j.coph.2024.102438","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102438","url":null,"abstract":"<div><p>Low back pain (LBP) is a major unmet clinical need. The endocannabinoid system (ECS) has emerged as a promising therapeutic target for pain, including LBP. This review examines the evidence for the ECS as a therapeutic target for LBP. While preclinical studies demonstrate the potential of the ECS as a viable therapeutic target, clinical trials have presented conflicting findings. This review underscores the need for innovative LBP treatments and biomarkers and proposes the ECS as a promising avenue for their exploration. A deeper mechanistic understanding of the ECS in LBP could inform the development of new pain management strategies.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102438"},"PeriodicalIF":4.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000080/pdfft?md5=07597a8c72a12dbf07bf7fe9f395c1f7&pid=1-s2.0-S1471489224000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal issue: Advances in gastrointestinal oncology 胃肠道问题：胃肠道肿瘤学的进展
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-02-23 DOI: 10.1016/j.coph.2024.102437
Jeroen Dekervel, Angelica Petrillo
{"title":"Gastrointestinal issue: Advances in gastrointestinal oncology","authors":"Jeroen Dekervel,&nbsp;Angelica Petrillo","doi":"10.1016/j.coph.2024.102437","DOIUrl":"https://doi.org/10.1016/j.coph.2024.102437","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102437"},"PeriodicalIF":4.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid raft disruption as an opportunity for peripheral analgesia 脂质筏破坏为外周镇痛提供了机会。
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-30 DOI: 10.1016/j.coph.2024.102432
Andrea Kinga Nehr-Majoros , Ágnes Király , Zsuzsanna Helyes , Éva Szőke
{"title":"Lipid raft disruption as an opportunity for peripheral analgesia","authors":"Andrea Kinga Nehr-Majoros ,&nbsp;Ágnes Király ,&nbsp;Zsuzsanna Helyes ,&nbsp;Éva Szőke","doi":"10.1016/j.coph.2024.102432","DOIUrl":"10.1016/j.coph.2024.102432","url":null,"abstract":"<div><p><span><span><span>Chronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential<span> ion channels, opioid receptors, P2X purinoreceptors and </span></span>neurokinin 1 receptor are located in the </span>lipid raft regions of the plasma membrane. Targeting the </span>membrane lipid<span> composition and structure by sphingolipid or cholesterol depletion might open future perspectives for the therapy of chronic inflammatory, neuropathic or cancer pain, most importantly acting at the periphery.</span></p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102432"},"PeriodicalIF":4.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Endocrine and metabolic diseases (2023) 编辑综述：内分泌与代谢疾病》（2023 年）
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-29 DOI: 10.1016/j.coph.2024.102436
Ivana Bjelobaba, Stephanie Constantin
{"title":"Editorial overview: Endocrine and metabolic diseases (2023)","authors":"Ivana Bjelobaba,&nbsp;Stephanie Constantin","doi":"10.1016/j.coph.2024.102436","DOIUrl":"10.1016/j.coph.2024.102436","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102436"},"PeriodicalIF":4.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139579115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: New and revitalized old targets in metabolic disease 编辑综述：代谢性疾病中的新靶点和重获新生的旧靶点
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102434
Jacob B. Hansen, Ivana Novak
{"title":"Editorial overview: New and revitalized old targets in metabolic disease","authors":"Jacob B. Hansen,&nbsp;Ivana Novak","doi":"10.1016/j.coph.2024.102434","DOIUrl":"10.1016/j.coph.2024.102434","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102434"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets” 编辑综述："嘌呤能免疫细胞调控揭示了新的药理靶点
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102435
Wolfgang Junger, Carola Ledderose
{"title":"Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”","authors":"Wolfgang Junger,&nbsp;Carola Ledderose","doi":"10.1016/j.coph.2024.102435","DOIUrl":"10.1016/j.coph.2024.102435","url":null,"abstract":"","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102435"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel treatments for dry eye syndrome 干眼症的新疗法。
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102431
Esther Roucaute , Marcela Huertas-Bello , Alfonso L. Sabater
{"title":"Novel treatments for dry eye syndrome","authors":"Esther Roucaute ,&nbsp;Marcela Huertas-Bello ,&nbsp;Alfonso L. Sabater","doi":"10.1016/j.coph.2024.102431","DOIUrl":"10.1016/j.coph.2024.102431","url":null,"abstract":"<div><p>Dry eye syndrome (DES) is a prevalent and multifactorial disease that leads to a self-perpetuating cycle of inflammation and damage to the ocular surface. This results in symptoms such as redness, burning, and blurred vision, which can negatively affect a patient's quality of life. While treatments are available to manage DES, they only temporarily relieve symptoms. Furthermore, long-term use of certain medications can cause harm to the ocular surface. Therefore, there is a need for safer and effective treatments for DES. This review highlights the latest advancements in DES therapy, providing valuable insights into ongoing efforts to improve patient outcomes.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102431"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analgesic potential of voltage gated sodium channel modulators for the management of pain 电压门控钠通道调节剂治疗疼痛的镇痛潜力
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-25 DOI: 10.1016/j.coph.2024.102433
Jason J. McDougall, Melissa S. O'Brien
{"title":"Analgesic potential of voltage gated sodium channel modulators for the management of pain","authors":"Jason J. McDougall,&nbsp;Melissa S. O'Brien","doi":"10.1016/j.coph.2024.102433","DOIUrl":"10.1016/j.coph.2024.102433","url":null,"abstract":"<div><p>Neuronal electrochemical signals involve the flux of sodium ions through voltage-gated sodium channels (Na<sub>V</sub>) located in the neurolemma. Of the nine sodium channel subtypes, Na<sub>V</sub>-1.7, 1.8, and 1.9 are predominantly located on nociceptors, making them prime targets to control pain. This review highlights some of the latest discoveries targeting Na<sub>V</sub> channel activity, including: (1) charged local anaesthetic derivatives; (2) Na<sub>V</sub> channel toxins and associated small peptide blockers; (3) regulation of Na<sub>V</sub> channel accessory proteins; and (4) genetic manipulation of Na<sub>V</sub> channel function. While the translation of preclinical findings to a viable treatment in humans has remained a challenge, a greater understanding of Na<sub>V</sub> channel physiology could lead to the development of a new stream of therapies aimed at alleviating chronic pain.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"75 ","pages":"Article 102433"},"PeriodicalIF":4.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1471489224000031/pdfft?md5=c9504924cde4ad710a2f60d171f937bb&pid=1-s2.0-S1471489224000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy 在脓毒症心肌病领域，以维持线粒体稳态的铁蛋白沉积为目标
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-18 DOI: 10.1016/j.coph.2023.102430
Hua Ye , Huantao Hu , Xiaoliang Zhou , Maolong Dong , Jun Ren
{"title":"Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy","authors":"Hua Ye ,&nbsp;Huantao Hu ,&nbsp;Xiaoliang Zhou ,&nbsp;Maolong Dong ,&nbsp;Jun Ren","doi":"10.1016/j.coph.2023.102430","DOIUrl":"https://doi.org/10.1016/j.coph.2023.102430","url":null,"abstract":"<div><p><span>Septic cardiomyopathy is one of the predominant culprit factors contributing to the rising mortality in patients with severe </span>sepsis<span><span><span>. Among various mechanisms responsible for the etiology of septic heart anomalies<span>, disruption of mitochondrial homeostasis has gained much recent attention, resulting in myocardial inflammation and even cell death. </span></span>Ferroptosis is a novel category of regulated cell death (RCD) provoked by iron-dependent </span>phospholipid peroxidation through iron-mediated phospholipid (PL) peroxidation, enroute to the rupture of plasma membranes and eventually cell death. This review summarizes the recent progress of ferroptosis in mitochondrial homeostasis during septic cardiomyopathy. We will emphasize the role of mitochondrial iron transport channels and the antioxidant system in ferroptosis. Finally, we will summarize and discuss future research, which should help guide disease treatment.</span></p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"74 ","pages":"Article 102430"},"PeriodicalIF":4.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139487681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-driven GPCR analysis, engineering, and targeting 人工智能驱动的 GPCR 分析、工程和靶向
IF 4 3区 医学
Current Opinion in Pharmacology Pub Date : 2024-01-13 DOI: 10.1016/j.coph.2023.102427
João P.L. Velloso , Aaron S. Kovacs , Douglas E.V. Pires , David B. Ascher
{"title":"AI-driven GPCR analysis, engineering, and targeting","authors":"João P.L. Velloso ,&nbsp;Aaron S. Kovacs ,&nbsp;Douglas E.V. Pires ,&nbsp;David B. Ascher","doi":"10.1016/j.coph.2023.102427","DOIUrl":"https://doi.org/10.1016/j.coph.2023.102427","url":null,"abstract":"<div><p>This article investigates the role of recent advances in Artificial Intelligence (AI) to revolutionise the study of G protein-coupled receptors (GPCRs). AI has been applied to many areas of GPCR research, including the application of machine learning (ML) in GPCR classification, prediction of GPCR activation levels, modelling GPCR 3D structures and interactions, understanding G-protein selectivity, aiding elucidation of GPCRs structures, and drug design. Despite progress, challenges in predicting GPCR structures and addressing the complex nature of GPCRs remain, providing avenues for future research and development.</p></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"74 ","pages":"Article 102427"},"PeriodicalIF":4.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信