Current Opinion in Pharmacology最新文献

TMEM16A regulates MUC5AC production in airway diseases: A comprehensive review TMEM16A调控MUC5AC在气道疾病中的产生：一项全面的综述

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1016/j.coph.2025.102603

Jintao Gan , Xiaochun Huang , Danli Zhu , Jing Jia

引用次数: 0

Oxytocin for chronic pain and acupuncture analgesia 催产素用于慢性疼痛和针刺镇痛。

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.coph.2026.102608

Jinyu Wu , Kaiwen Zhang , Shuyou Wang , Hanlai Zhang , Jianliang Zhang

引用次数: 0

Transcutaneous electrical nerve stimulation and opioid analgesia: Exploring a potential synergistic relationship 经皮神经电刺激和阿片镇痛：探讨潜在的协同关系。

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.coph.2026.102606

Chaoran Li , Ruocheng Xu , Yunjing Qiu , Weibo Sun , Tiansong Yang

{"title":"Transcutaneous electrical nerve stimulation and opioid analgesia: Exploring a potential synergistic relationship","authors":"Chaoran Li , Ruocheng Xu , Yunjing Qiu , Weibo Sun , Tiansong Yang","doi":"10.1016/j.coph.2026.102606","DOIUrl":"10.1016/j.coph.2026.102606","url":null,"abstract":"<div><div>Clinical analgesia requires balancing effective pain relief against opioid-related risks. Transcutaneous electrical nerve stimulation (TENS), a nonpharmacological and noninvasive modality, demonstrates synergistic potential with opioids, which may enhance analgesia, reduce opioid consumption, and minimize adverse effects. This review synthesizes evidence on TENS-opioid synergy, categorizes TENS modalities and parameters, and examines their interactive mechanisms. We discuss optimization strategies, including early TENS application, parameter individualization, and a “TENS + low-dose opioid” regimen. This combination represents a promising multimodal approach integrating pharmacological and nonpharmacological therapies, potentially improving outcomes while reducing opioid-related harms. Future work should prioritize rigorous pharmacological studies to confirm synergy, alongside multicenter trials, parameter optimization, development of intelligent personalized systems, and further mechanistic research to advance precision pain medicine.</div></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"87 ","pages":"Article 102606"},"PeriodicalIF":4.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting strategies and immune regulatory mechanisms of CAR-macrophages in the treatment of osteosarcoma car -巨噬细胞治疗骨肉瘤的靶向策略和免疫调节机制

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2025-12-22 DOI: 10.1016/j.coph.2025.102602

Rongrong Chai

{"title":"Targeting strategies and immune regulatory mechanisms of CAR-macrophages in the treatment of osteosarcoma","authors":"Rongrong Chai","doi":"10.1016/j.coph.2025.102602","DOIUrl":"10.1016/j.coph.2025.102602","url":null,"abstract":"<div><div>Osteosarcoma (OS), the most common primary malignant bone tumor, poses significant clinical challenges owing to its high metastatic potential and resistance to chemotherapy. Although Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) has made significant progress in treating hematologic malignancies, its efficacy remains limited in solid tumors, such as OS. Chimeric antigen receptor macrophages (CAR-MΦ) represent an emerging cell therapy. It possesses potent phagocytic killing capabilities and inherent immune–modulatory properties. It has the unique potential to reshape the immunosuppressive microenvironment of OS. This review systematically outlines the target selection of CAR-MΦ in OS, its dual mechanisms of direct killing and indirect immune modulation, and thoroughly explores strategies to overcome tumor heterogeneity and immune suppression using CAR-MΦ approaches. Finally, it highlights the current challenges and future development directions. This emphasizes that CAR-MΦ therapy holds promise as a key breakthrough in overcoming the treatment bottleneck for OS. It is a key driver of the shift in the therapeutic paradigm from targeting cell toxicity to reshaping the immune microenvironment.</div></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"87 ","pages":"Article 102602"},"PeriodicalIF":4.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CPX-351: From preclinical studies to future directions CPX-351：从临床前研究到未来发展方向

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-08 DOI: 10.1016/j.coph.2026.102605

A. Sperotto , G. Ciotti , M. Basso , M. Gottardi

引用次数: 0

Auricular stimulation therapy: An evidence-based practice strategy for depression 耳穴刺激疗法：抑郁症的循证实践策略

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.coph.2026.102607

Jin Gao , Yulong Liang , Peijing Rong , Yu Wang , Hao Chen

引用次数: 0

Pharmacological silence: Revisiting the clinical and molecular impact of inactive metabolites 药理学沉默：重新审视非活性代谢物的临床和分子影响。

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.coph.2026.102609

Ahmed M. Abd-Eldayem

{"title":"Pharmacological silence: Revisiting the clinical and molecular impact of inactive metabolites","authors":"Ahmed M. Abd-Eldayem","doi":"10.1016/j.coph.2026.102609","DOIUrl":"10.1016/j.coph.2026.102609","url":null,"abstract":"<div><div>The conventional binary classification of drug metabolites as either pharmacologically active or inert has created a persistent blind spot in drug development and toxicology. By disproportionately emphasizing parent compounds, this paradigm relegates so-called ‘inactive’ derivatives to the margins of mechanistic inquiry, thereby obscuring the true complexity of drug action. Therefore, this review challenges the reductionist framework, consolidating compelling evidence that these ostensibly silent metabolites function as contextual modulators with biologically significant consequences. Emerging data implicate them in time-dependent inhibition (TDI) of cytochrome P450 enzymes, amplification of oxidative stress cascades through chemically reactive intermediates, and subtle modulation of neuroimmune and apoptotic thresholds. Moreover, their cumulative impact is magnified under conditions of chronic dosing, polypharmacy, or impaired metabolic clearance, where low–affinity interactions with secondary receptors and signaling pathways can reshape pharmacodynamic and pharmacokinetic outcomes. We propose reframing ‘inactive’ metabolites not as inert byproducts but as mechanistic amplifiers and modulators whose influence contributes to unforeseen toxicological profiles, idiosyncratic adverse reactions, and drug–drug interactions. Recognizing this overlooked dimension of metabolite biology is essential for advancing molecular screening, refining therapeutic drug monitoring, and improving the safety and efficacy profiles of both established and novel chemical entities.</div></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"87 ","pages":"Article 102609"},"PeriodicalIF":4.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in targeted therapies for acute myeloid leukemia 急性髓系白血病靶向治疗的进展

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-04-01 Epub Date: 2025-12-30 DOI: 10.1016/j.coph.2025.102604

Matthew P. Connor, Adam Barsouk, Omar Elghawy, Catherine Lai

引用次数: 0

Nutritional composition of diets for inducing and maintaining remission in inflammatory bowel diseases: from bedside to plate 诱导和维持炎症性肠病缓解的饮食营养成分：从床边到餐盘。

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.coph.2025.102587

L. Godny , T. Pfeffer-Gik , S. Elial-Fatal , S. Shakhman , I. Dotan

{"title":"Nutritional composition of diets for inducing and maintaining remission in inflammatory bowel diseases: from bedside to plate","authors":"L. Godny , T. Pfeffer-Gik , S. Elial-Fatal , S. Shakhman , I. Dotan","doi":"10.1016/j.coph.2025.102587","DOIUrl":"10.1016/j.coph.2025.102587","url":null,"abstract":"<div><div>There is growing interest in the role of dietary therapies in the management of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC). This narrative review synthesizes current evidence on the nutritional composition and clinical implications of diets evaluated for IBD across different disease stages and phenotypes. In active CD, dietary strategies commonly focus on the exclusion of specific components believed to promote inflammation, such as food additives and ultra processed foods. This is in contrast to exclusive enteral nutrition or Crohn’s disease exclusion diet (CDED) + partial enteral nutrition (PEN), which, despite containing food additives such as emulsifiers, remains the main established and efficacious dietary therapies for active CD. Some diets also restrict gluten and lactose during their initial phases. In active UC, dietary approaches emphasize the modulation of microbial metabolism, particularly by reducing colonic sulfide production and enhancing the production of short-chain fatty acids through reduced intake of animal-based foods and increased consumption of fermentable fibers and resistant starch. For maintenance of remission in both CD and UC, data supporting specific dietary approaches are currently limited. However, the emphasis shifts toward sustainability, favoring flexible, plant-based, minimally processed dietary patterns, such as the Mediterranean diet (MED). Future well-designed, adequately powered clinical trials are required to confirm efficacy, clarify long-term outcomes, and establish disease-specific dietary recommendations. Personalized dietary counseling by trained IBD dietitians, as part of the multidisciplinary team, remains central to integrating these approaches into care, optimizing adherence, and ensuring nutritional adequacy and optimal quality of life.</div></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"86 ","pages":"Article 102587"},"PeriodicalIF":4.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electro-microbial interplay in the gut–brain axis: An emerging paradigm for gut microbiota modulation via vagus nerve stimulation 电-微生物在肠-脑轴上的相互作用：通过迷走神经刺激调节肠道微生物群的一个新兴范例

IF 4.2 3区医学

Current Opinion in Pharmacology Pub Date : 2026-02-01 Epub Date: 2025-11-15 DOI: 10.1016/j.coph.2025.102588

Jingwen Liang , Xiunan Li , Chunyang Mao , Zhen Qin , Rui Wang

{"title":"Electro-microbial interplay in the gut–brain axis: An emerging paradigm for gut microbiota modulation via vagus nerve stimulation","authors":"Jingwen Liang , Xiunan Li , Chunyang Mao , Zhen Qin , Rui Wang","doi":"10.1016/j.coph.2025.102588","DOIUrl":"10.1016/j.coph.2025.102588","url":null,"abstract":"<div><div>The treatment of central nervous system disorders remains a clinical challenge, highlighting an urgent need for innovative therapeutic strategies. The gut-brain axis represents a complex bidirectional communication network between the gastrointestinal tract and the brain, with the vagus nerve serving as a critical pathway for signal transmission. Vagus nerve stimulation (VNS), an established therapy for drug-resistant epilepsy and depression, has been shown to modulate the composition and functional output of gut microbiota, which in turn influences disease progression. Concurrently, gut microbiota and their metabolites such as short-chain fatty acids can regulate vagal activity through feedback mechanisms. This bidirectional interaction operates through neural, immune and metabolic pathways. This review provides a systematic review of the mechanisms through which VNS influences gut microbiota, and how microbial products feedback to regulate vagus nerve activity and the integrated pathways underlying this cross-talk, for the sake of providing insights into novel therapeutic approaches targeting the gut-brain interface.</div></div>","PeriodicalId":50603,"journal":{"name":"Current Opinion in Pharmacology","volume":"86 ","pages":"Article 102588"},"PeriodicalIF":4.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0