离子液体胆碱和天竺葵酸介导的局部药物递送在皮肤组织再生和潜在病原体中和中的研究进展

IF 4.2 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2025-06-25 DOI:10.1016/j.coph.2025.102549

Popat Mohite , Shubham Munde , Aarati Budar , Sudarshan Singh , Chuda Chittasupho

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引用次数: 0

摘要

离子液体已经成为药物输送的有前途的载体，胆碱和天竺葵酸（CAGE）在皮肤组织再生和抗菌特性的局部配方中显示出非凡的潜力。CAGE具有独特的物理化学性质，如粘度、高离子电导率和增强的溶解度，有助于增强药物渗透和控制药物释放。CAGE具有固有的抗菌特性，使其成为管理皮肤并发症的理想人选。本文综述了近年来以cage为导向的配方的进展，强调了它们在伤口愈合中的作用，其次是配方策略和关键工艺参数。

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Ionic liquid choline and geranic acid-mediated topical drug delivery in skin tissue regeneration and neutralization of potential pathogens: A review

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Ionic liquid choline and geranic acid-mediated topical drug delivery in skin tissue regeneration and neutralization of potential pathogens: A review

Ionic liquids have emerged as promising vehicles for drug delivery, with choline and geranic acid (CAGE) demonstrating exceptional potential in topical formulation for skin tissue regeneration and antimicrobial properties. CAGE exhibits unique physicochemical properties such as viscosity, high ionic conductivity, and enhanced solubility that contribute to efficacy in enhanced drug permeation with controlled drug release. CAGE possesses the inherent antimicrobial properties, making it an ideal candidate for the management of dermal complications. The review discusses the recent advancements in CAGE-oriented formulations, emphasizing their role in wound healing, followed by formulation strategies and key process parameters.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.