急性髓性白血病CAR - T细胞靶标鉴定的新方法

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2025-04-08 DOI:10.1016/j.coph.2025.102524

Gordon Victor Hoffmann , Adrian Gottschlich , Marion Subklewe , Sebastian Kobold

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引用次数: 0

摘要

由于疾病的复杂性和与正常造血重叠，在急性髓性白血病（AML）中确定安全有效的CAR - T细胞靶点具有挑战性。本文综述了AML靶点发现的进展，强调了创新方法。结构表面组学识别肿瘤特异性蛋白质构象，而人工智能驱动的单细胞RNA测序整合了多源数据，以确定最佳靶点。精细化的细胞表面捕获技术绘制AML表面体，而不依赖于预定义的抗体。这些策略增强了CAR - T细胞的特异性，最大限度地减少了肿瘤外效应，为更安全、更有效的AML治疗和更广泛的癌症治疗提供了有希望的途径。

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Novel approaches to CAR T cell target identification in acute myeloid leukemia

Identifying safe and effective CAR T cell targets in acute myeloid leukemia (AML) is challenging due to the disease’s complexity and overlap with normal hematopoiesis. This review highlights advances in target discovery for AML, emphasizing innovative approaches. Structural surfaceomics identifies tumor-specific protein conformations, while AI-driven single-cell RNA sequencing integrates multi-source data to pinpoint optimal targets. Refined cell surface capture technology maps the AML surfaceome without relying on predefined antibodies. These strategies enhance CAR T cell specificity and minimize off-tumor effects, offering promising pathways for safer and more effective AML treatments and broader cancer therapies.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.