International Journal of Research in Medical Sciences最新文献_第3页

A prospective observational study on bolus administration of high-dose nitroglycerin in treating sympathetic collapsing acute pulmonary edoema 栓注大剂量硝酸甘油治疗交感神经塌陷性急性肺水肿的前瞻性观察研究

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233994

C. Marndi, Ashok Kumar Behera, Gopabandhu Patra, Saubhagya Chhotaray

{"title":"A prospective observational study on bolus administration of high-dose nitroglycerin in treating sympathetic collapsing acute pulmonary edoema","authors":"C. Marndi, Ashok Kumar Behera, Gopabandhu Patra, Saubhagya Chhotaray","doi":"10.18203/2320-6012.ijrms20233994","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233994","url":null,"abstract":"Background: Sympathetic crashing causes sudden cardiac failure in minutes or hours. Early diagnosis and treatment may avoid acute heart failure fatalities. Sympathetic crashing reduces afterload, shifting fluid into the pulmonary circulation and causing pulmonary edema. The usual strategy of progressively increasing vasodilator dosage has increased preload. Treating SCAPE with large doses of nitroglycerin and non-invasive breathing is helpful. High doses of nitroglycerin boost afterload and eliminate ICU admissions. In this study, a standard protocol for the treatment of patients with sympathetic crashing acute pulmonary edema is assessed for its effectiveness. Methods: An observational study was conducted prospectively at Bhima Bhoi Medical College and Hospital in Balangir, Odisha, India over the course of a year. The patients presenting with SCAPE symptoms were treated according to standard protocol. The outcomes were subjected to statistical analysis to derive a correlation between treatment and response. Results: The mean initial bolus given to all the patients was 836 µg. The total cumulative dose of nitroglycerin used in each patient was 36 mg. The symptoms of most of the patients resolved within the first 6 hours of treatment. Conclusions: The standard protocol developed at the institute, which included a high dose of nitroglycerine along with non-invasive ventilation, was efficient in treating acute heart failure due to sympathetic crashing and acute pulmonary edema. Nitroglycerin, along with non-invasive ventilation, should be used in the management of sympathetic crashing pulmonary edema and acute heart failure.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"26 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derangement of liver function tests in dengue patients 登革热病人的肝功能检测异常

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233973

Ram Dev Chaudhary, Siddhi Datri Jha, Vijay Kumar Sah, R. N. Mandal, Manish Pandey, Bipin Kumar Yadav, Tarkeshwor Mahato, Kirti Kumari Sah, Abhijeet Sah, Ram Prabodh Chaudhary

{"title":"Derangement of liver function tests in dengue patients","authors":"Ram Dev Chaudhary, Siddhi Datri Jha, Vijay Kumar Sah, R. N. Mandal, Manish Pandey, Bipin Kumar Yadav, Tarkeshwor Mahato, Kirti Kumari Sah, Abhijeet Sah, Ram Prabodh Chaudhary","doi":"10.18203/2320-6012.ijrms20233973","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233973","url":null,"abstract":"Background: Changes in the liver function test may serve as an early marker for timely diagnosis and identification of patients who may develop severe dengue. The purpose of this study was to examine the link between dengue fever severity and liver function test. Methods: This prospective observational study was conducted in the Department of General Medicine, Madhesh Institute of health sciences, provincial hospital, Janakpurdham in which we included dengue positive patients (aged 18 years or more) based on NS1 antigen or high titer on IgM/IgG testing from July 2023 till August 2023. We excluded patients with diseases like malaria, cirrhosis of liver, enteric fever, viral hepatitis or any other disease or taking any medication which can derange LFT. Results: We included 96 patients fulfilling the study criteria. Of these, 71% had DF, 22% had DHF and 7% had DSS. Among liver enzymes, mean AST of the patients was significantly higher in DSS group of patients (775.19±39.65 U/l), as compared to those in the DF and DHF group of patients, p value <0.01. Similarly, mean ALT of the patients was significantly higher in DSS group of patients (387.8±18.6 U/l), as compared to those in the DF and DHF group of patients, p value<0.01. On the contrary, mean alkaline phosphatase levels were similar between the three patient groups. Conclusions: Based on the results our study, we conclude that raised AST and ALT levels were significantly associated with severity of DSS and DHF. Patients with dengue infection should have a baseline liver function test and subsequent LFT monitoring to detect early hepatic impairment.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"62 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tale of spontaneous passage of large proximal ureteric calculus in a male patient 一名男性输尿管近端大结石自发通过的故事

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234019

Shivendra Agrawal, N. Srinath, Prathvi

{"title":"Tale of spontaneous passage of large proximal ureteric calculus in a male patient","authors":"Shivendra Agrawal, N. Srinath, Prathvi","doi":"10.18203/2320-6012.ijrms20234019","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234019","url":null,"abstract":"Ureteric stones are very notorious. Sometimes a very small stone may require a surgical removal and sometimes a large stone might pass spontaneously. We report a case of a 43 years old male patient who presented to our department with complaint of right flank pain of 1-week duration. This patient was diagnosed with right proximal ureteric calculus (11×6 mm) at L3 level. He was planned for ureterorenoscopy lithotripsy (URSL)/push back percutaneous nephrolithotomy (PCNL). Patient needed time for getting financially prepared for the surgery. Meanwhile we prescribed him an alpha blocker once daily at bedtime, oral analgesia SOS and advised to take adequate hydration. On 10th day of first presentation, to our surprise, the patient came with a stone in his hand, which he has passed spontaneously, and was confirmed by a radiograph. The likelihood of a ureteric stone spontaneously passing during expectant treatment is influenced by various factors, including its size, location, and orientation within the ureter. 11×6 mm proximal ureteric stone is the largest stone passed spontaneously in a male patient in our institute and most probably in literature.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"325 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate effect of sciatic neurodynamic slider and tensioner technique on hamstring flexibility and postural balance in healthy adults: a randomized control trial 坐骨神经动力滑块和拉力器技术对健康成年人腿筋灵活性和姿势平衡的立竿见影效果：随机对照试验

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233985

Dharmita Yogeshwar, Tapaswini Sahoo

{"title":"Immediate effect of sciatic neurodynamic slider and tensioner technique on hamstring flexibility and postural balance in healthy adults: a randomized control trial","authors":"Dharmita Yogeshwar, Tapaswini Sahoo","doi":"10.18203/2320-6012.ijrms20233985","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233985","url":null,"abstract":"Background: Inadequate hamstring muscle flexibility leads to impaired balance in healthy individuals. So, the present study is conducted to evaluate the immediate effect of neurodynamic slider and tensioner technique on hamstring muscle flexibility and balance in healthy individuals. Method: Total 42 healthy individuals both male and female age between 18-26 with AKE <70 degree participated in the study. 42 individuals were randomly assigned in two groups. Group A received neurodynamic slider technique followed by group B received tensioner technique. AKE angle was immediately examined before and after the intervention to evaluate hamstring flexibility. Results: Results is concluded that both slider and tensioner technique are equally effective to improve hamstring muscle flexibility (p<0.05) and balance in healthy individuals within the group but. As the findings of between the group shows that both the techniques are equally effective not superior on one another (p>0.05). Conclusions: This study concludes that both the neural slider and tensioner techniques were equally effective in immediately increasing the hamstring flexibility and dynamic postural balance in healthy individuals.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absceded abdominal wall desmoid tumor: a case report 腹壁脱失性蝶形瘤：病例报告

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234008

Ana Karen Mena Zenteno, Aldo Olvera, Cynthia Sánchez, Jorge A. Montero

{"title":"Absceded abdominal wall desmoid tumor: a case report","authors":"Ana Karen Mena Zenteno, Aldo Olvera, Cynthia Sánchez, Jorge A. Montero","doi":"10.18203/2320-6012.ijrms20234008","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234008","url":null,"abstract":"Desmoid tumor is a rare type of tumor dependent on a well-differentiated fibroblastic monoclonal proliferation with a high capacity for non-metastatic local invasion, it constitutes <3% of soft tissue neoplasms, an annual incidence of 5-6 cases per million is reported, its etiology is unknown and its clinical presentation depends on the location of the tumor. We presented a case of a 53-year-old female patient who presented to the emergency department with clinical characteristics of abdominal wall abscess with no significant history of its appearance. Abscess drainage plus biopsy of muscle tissue in the anterior region of the abdominal wall was performed, histopathology report compatible with desmoid tumor, radical surgical treatment was decided in a second intervention. Desmoid tumor is rare, since its diagnosis and treatment require a multidisciplinary approach; Active surveillance is currently the treatment of choice for patients who have DD in noncritical locations, and at least 1 to 2 years of active surveillance is now recommended because of its likelihood of spontaneous regression. The main objective of all existing therapies is to preserve or improve the quality of life of the patient.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"46 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathophysiology and pathology of SARS-CoV-2 infection SARS-CoV-2 感染的病理生理学和病理学

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234029

O. Olaofe

{"title":"The pathophysiology and pathology of SARS-CoV-2 infection","authors":"O. Olaofe","doi":"10.18203/2320-6012.ijrms20234029","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234029","url":null,"abstract":"SARS-CoV-2 infection is a major pandemic that has involved all continents in the world. It has caused almost seven million deaths since its onset. SARS-CoV-2 commonly enters cells by binding to angiotensin-converting enzyme 2 (ACE2) molecules on the surface of cells in the human body. SARS-CoV-2 infection, although mild in many patients, has the potential to cause dysfunction of many organ systems in the body. The body response to the internalisation of the virus in the epithelial cells of the lungs can lead to alveolar epithelial inflammation, commonly referred to as the exudative phase of acute respiratory distress syndrome (ARDS). Cardiac symptoms shown by patients infected with SARS-CoV-2 include chest tightness/pain and palpitations. These features can be because of newly developed or worsening ischaemic heart disease and arrythmias, respectively. SARS-CoV-2 infection is known to cause a clinical condition known as COVID-19-associated nephropathy (COVAN), a disease quite similar to HIV-associated nephropathy (HIVAN). Like HIVAN, COVAN is relatively more common in people of African descent and is associated with the APOL1 variant gene. Researchers have not identified unique morphological changes that could be used to identify the infection in tissues. Hence, the use of RT-PCR for diagnosis is still very important.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical profiles and proximate analysis of n-hexane extract of Terminalia catappa kernel from Nigeria 尼日利亚鸡枞核仁正己烷提取物的化学成分和近似物分析

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233971

Nimisoere Peace Batubo, O. Ogbu, Dapper Datonye Victor

{"title":"Chemical profiles and proximate analysis of n-hexane extract of Terminalia catappa kernel from Nigeria","authors":"Nimisoere Peace Batubo, O. Ogbu, Dapper Datonye Victor","doi":"10.18203/2320-6012.ijrms20233971","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233971","url":null,"abstract":"Background: Terminalia catappa is a traditionally consumed edible plant used for various health conditions. This study aimed to characterise the phytochemical profile, nutritional composition, and acute oral toxicity of the n-hexane extract of Terminalia catappa nuts. Methods: Gas chromatography-mass spectrometry (GC-MS) analysis was conducted to determine the phytochemical profile of the n-hexane extract of Terminalia catappa nuts. Proximate analysis was performed to evaluate the nutritional composition. Acute oral toxicity testing was carried out in Wistar rats as per OECD Guideline 425 to assess safety. Results: The phytochemical analysis identified 19 bioactive compounds in the Terminalia catappa nut extract. The major components were cis-vaccenic acid (24.493%), propyleneglycol monoleate (23.783%), and mitotane (14.186%). Proximate analysis revealed the nuts to be rich sources of fat (56.71%) and protein (26.30%). The median lethal dose (LD50) of the n-hexane extract in rats was greater than 5000 mg/kg, indicating a high margin of safety. Conclusions: This work provides valuable insights into the nutritional potential and safety profile of Terminalia catappa nuts. Phytochemical characterisation corroborates traditional uses, while the acute toxicity data establishes the relative safety of the n-hexane extract when consumed at high doses.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"46 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlative study of sonological appearance of BI-RADS 4 and above breast lumps with histopathology and immunohistochemistry markers BI-RADS 4 及以上乳腺肿块声学外观与组织病理学和免疫组化标记物的相关性研究

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234001

Vijaya Narayana Holla K., Tara H., Veena K.

{"title":"Correlative study of sonological appearance of BI-RADS 4 and above breast lumps with histopathology and immunohistochemistry markers","authors":"Vijaya Narayana Holla K., Tara H., Veena K.","doi":"10.18203/2320-6012.ijrms20234001","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234001","url":null,"abstract":"Background: Breast cancer is clinically categorized into 4 major subtypes, ER (+), PR (+), Her2 (+), and TNBC. Although the correlation between sonographic features of breast cancer and immunohistochemistry markers expression is found, it is not still very clear; thus, this study aimed to investigate the ultrasound features of breast cancer and analyze the correlation between them. Methods: This was a prospective study, in which patients with breast lumps were sonologically categorized as BI-RADS 4 and above. Percutaneous biopsy was done. Histopathology and immunohistochemistry markers were correlated with ultrasound findings. Results: ER (+), PR (+) tumors were associated with irregular shape. ER (+), PR (+), and Her2 (+) tumors were associated with indistinct margin. TNBC tumor was associated with microlobulated margin. TNBC cases had more posterior acoustic enhancement. Conclusions: Young female with ultrasound features of oval/round shape, micro-lobulated margin, abrupt tumor interface, showing posterior acoustic enhancement, absence of microcalcification was significantly associated with TNBC. Tumor with an irregular shape, indistinct margin, hyperechoic halo, no change in posterior acoustic feature, and presence of microcalcification were significantly associated with ER (+) cancers. Tumor with irregular shape, indistinct margin, and no change in the posterior acoustic feature was significantly associated with PR (+) cancers. Tumour with indistinct margin, and hyperechoic halo is significantly associated with Her2 (+) cancers. Tumor with irregular shape, indistinct margin, hyperechoic halo, and no posterior acoustic feature was associated with NTNBC.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"43 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What to do in case of an endoscopic image of gastric necrosis or ischaemia post-funduplication? A case report 如果内镜图像显示胃溃疡后出现胃坏死或缺血，该怎么办？病例报告

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234004

Ricardo-Raziel Peña, Ricardo H. Gallo, Carlo A. Tristán-Tenorio, Saúl E. J. Ruelas, Williams O. Ramírez-Miguel, F. Higuera-Hidalgo, Agustín Etchegaray-Dondé

引用次数: 0

Total leucocyte count and platelet indices: novel, early diagnostic markers of acute appendicitis 白细胞总数和血小板指数：急性阑尾炎的新型早期诊断指标

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233987

Rithu Ravikkumar, K. Vaidya, Aashish Sharma, Sukesh

{"title":"Total leucocyte count and platelet indices: novel, early diagnostic markers of acute appendicitis","authors":"Rithu Ravikkumar, K. Vaidya, Aashish Sharma, Sukesh","doi":"10.18203/2320-6012.ijrms20233987","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233987","url":null,"abstract":"Background: Among the plethora of causes for patients presenting with an acute abdomen, appendicitis is the most common conclusive diagnosis. Known being controversial for its etiology and pathogenesis, diagnosis of acute appendicitis has been challenging despite the development of various clinical and laboratory studies. Inflammatory markers of hematological origin-total leucocyte count (TLC), platelet indices viz. mean platelet count (MPV), plateletcrit (PCT), and platelet distribution width (PDW), have long been preferred as rudimentary diagnostic parameters for acute appendicitis despite being contentious. Methods: An analytical and cross-sectional study among 100 individuals. Statistical evaluation of TLC, MPV, PCT and PDW of 21 appendicitis cases and 70 healthy individuals were complied. Results: Compared to the control group, cases showed significantly higher values of TLC and MPV while the PCT and PDW were normally distributed and showed no significant statistics. The sensitivity of TLC and MPV was determined to be 95.2%, 71.4%, and specificity 100%, 73.8% respectively. Conclusions: With equitable results, the routine and cost-effective TLC and MPV play a novel role in the early diagnosis of acute appendicitis.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"210 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0