International Journal of Research in Medical Sciences最新文献_第4页

Expression of isocitrate dehydrogenase-1 in glioblastoma, Bangladesh perspective 异柠檬酸脱氢酶-1 在胶质母细胞瘤中的表达，孟加拉国的视角

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233977

Ratim Mir, M. A. Islam, Nowfel Islam, M. N. Islam, Reba Das, Enamul Kabir

{"title":"Expression of isocitrate dehydrogenase-1 in glioblastoma, Bangladesh perspective","authors":"Ratim Mir, M. A. Islam, Nowfel Islam, M. N. Islam, Reba Das, Enamul Kabir","doi":"10.18203/2320-6012.ijrms20233977","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233977","url":null,"abstract":"Background: Glioblastoma is the most frequent malignant brain tumor in adults. Various studies have identified IDH (isocitrate dehydrogenase) mutation as a hallmark genetic alteration in glial tumors. The World Health Organization (WHO) has classified glioblastoma based on IDH mutation status, including IDH-mutant glioblastoma, IDH-wildtype glioblastoma along with its variants and glioblastoma, NOS (not otherwise specified) (where IDH mutation status cannot be evaluated). Methods: It was a cross-sectional observational study, conducted on 35 histologically diagnosed cases of glioblastoma, within the period of March, 2018 to December 2019. Results: Among the 35 glioblastoma cases, 6 (17.14%) were found to be IDH-mutant (positive for IDH1 immunostain), while the remaining 29 cases were negative for IDH1 immunostain (therefore designated as IDH-wildtype glioblastoma). In the IDH-mutant group, 3 out of 6 patients were in the younger age group (≤40 years). On the other hand, IDH-wildtype glioblastoma was more common in elderly and most frequent was in the age group of 51-60 years (11 out of 29 cases). Conclusions: In this study, IDH1 expression was observed in 17.14% of all glioblastoma cases (designated as IDH-mutant glioblastoma). Whereas, most (~82.86%) of the glioblastoma cases did not express IDH1 (designated as IDH-wildtype).","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"51 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical profile of diabetic ketoacidosis in type 2 diabetes patients at a tertiary care centre 一家三级医疗中心 2 型糖尿病患者糖尿病酮症酸中毒的临床概况

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233996

Hardik More, Dilip Patil, Chahat Singh

{"title":"Clinical profile of diabetic ketoacidosis in type 2 diabetes patients at a tertiary care centre","authors":"Hardik More, Dilip Patil, Chahat Singh","doi":"10.18203/2320-6012.ijrms20233996","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233996","url":null,"abstract":"Background: The present study was undertaken to analyse the clinical profile of type 2 diabetes patients presenting with diabetic ketoacidosis at the time of presentation, owing to dearth of scientific enquiry into this research query. Methods: The present study was an analytical, cross-sectional study conducted over the period of two years. All the type 2 diabetes patients with diabetic ketoacidosis admitted during the study period constituted the study population, after being subjected to prefixed selection criteria. Detailed clinical history was recorded and thorough physical examination was conducted of all the participants, along with basic relevant blood parameters. Results: Out of the total 60 type 2 DM patients with DKA studied, 53.3% patients belonged to 51 to 60 years age group and 55% were males. All the patients had fruity breath odour at the presentation. Obesity was present in 48.3% and Kussmaul breathing observed in 90% of patients. Poor compliance to treatment (51.7%) was the biggest precipitating factor of DKA in type 2 DM patients. Around 2/3rd (68.3%) was on oral hypoglycemic agents (OHA), 10% were on OHA and insulin, while 21.7% were newly diagnosed at the time of presentation. Mean RBS in type 2 DM patients with DKA was 510.8±153.5 mg/dl and mean HbA1C was 9.15±0.78%. Conclusions: Stricter compliance to the treatment will go a long way in avoiding occurrence of the dreaded complication in type 2 diabetes patients.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"52 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of periodontal health with physical and emotional well-being among pre and postmenopausal women in Bangalore: a cross sectional study 班加罗尔绝经前后妇女牙周健康与身心健康的关系：一项横断面研究

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233989

Angelin Mary L., Namita D. Shanbhag, M. Puranik

{"title":"Association of periodontal health with physical and emotional well-being among pre and postmenopausal women in Bangalore: a cross sectional study","authors":"Angelin Mary L., Namita D. Shanbhag, M. Puranik","doi":"10.18203/2320-6012.ijrms20233989","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233989","url":null,"abstract":"Background: Menopausal transition is frequently accompanied by physical, emotional as well as periodontal health changes in pre and postmenopausal women due to the decline in circulating blood oestrogen levels. Aim was to investigate the association of periodontal health with physical and emotional well-being among pre and postmenopausal women aged 35-65 years. Methods: A cross sectional study was conducted among 150 pre and 150 postmenopausal women in Bangalore urban district Women Health Questionnaire was used to assess physical and emotional well-being. WHO Oral Health Assessment form for adults 2013 along with plaque and gingival indexes were used to assess the periodontal health status. Descriptive, bivariate, multiple linear regression analysis were carried out. A p<0.05 was considered statistically significant. Results: The mean age among pre and postmenopausal women were 40.09±2.24 years and 55.42±5.7 (p<0.001). The mean scores of depression/anxiety mood; somatic symptoms; memory/concentration; vasomotor symptoms; sleep problem was significantly higher in postmenopausal compared to premenopausal group (p<0.001). The mean number of teeth with gingival bleeding (12.93±8.0 and 6.94±5.68); deep periodontal pocket (2.05±1.61 and 0.44±0.97) were higher in postmenopausal group in comparison to the other group respectively (p<0.001). Depression was significantly associated with periodontal health of women in both the groups. Conclusions: Women after menopause experienced more physical and emotional changes. Periodontal health status was found to be poor among postmenopausal women compared to premenopausal women.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"37 13‐14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autopsy study of road traffic accident cases at tertiary care center, Mandya, Karnataka 卡纳塔克邦曼迪亚市三级医疗中心对道路交通事故病例的尸检研究

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20233991

Rakshitha B. M., Chinmayi Y., Vijay Kumar, Kumar U.

{"title":"An autopsy study of road traffic accident cases at tertiary care center, Mandya, Karnataka","authors":"Rakshitha B. M., Chinmayi Y., Vijay Kumar, Kumar U.","doi":"10.18203/2320-6012.ijrms20233991","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233991","url":null,"abstract":"Background: Road traffic accidents represent a pervasive global crisis resulting in the loss of millions of lives and countless injuries annually. According to the world health organization (WHO), over 1.3 million people die in road traffic accident every year, and an additional 20-50 million are injured or disabled. Objective was to study the demographic patterns in these cases of RTA in and around AIMS B. G. Nagar, India. Methods: It was a cross sectional study of all medico legal necropsies of road traffic accidents, Data was collected between January 2022 to June 2023 at the mortuary of the department of forensic medicine and toxicology, AIMS, B. G. Nagar, and Karnataka, India. Collected data was analysed. Results: During the study period 117 (40.20%) were road traffic accidents, according to this study road traffic accidents were more 30 (25.64%) in old age groups and males 105 (89.74%) were majorly affected. Majority of the accidents 41 (35%) predominantly occurred during evening to midnight hours on highways 65 (55.55%), light vehicles (37.61%) were most frequently engaged in road traffic accident and the most common site of injury was head 98 (83.76%), and cause of death was due to intracranial hemorrhages (49.57%) and among the pattern of intracranial hemorrhage we observed high number of (32.47%) combination of subdural hemorrhages and sub-arachnoid hemorrhages. Conclusions: Through this study we want to create awareness and deploy safety measures to prevent RTA.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of magnetic port finder for metallic foreign body extraction in hand 使用磁性端口探测器提取手部金属异物

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234010

Osvaldo I. Guevara Valmaña, Sebastian Triguieros-Guzman, Omar S. Fattel-Servin, Valentina Prieto-Vargas, Katia Balderas-Ruiz, Armando Apellaniz-campo, Daniela Tellez-Placios

引用次数: 0

Utility of cystoscope sheath in percutaneous nephrolithotomy- a case report 膀胱镜鞘在经皮肾镜碎石术中的应用--一份病例报告

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234013

Kasi V. Gali, A. Choudhary, Anshuman Singh, Abhijit Shah

引用次数: 0

A case report of multisystemic sarcoidosis with extracardiac shunt 伴有心外分流的多系统肉样瘤病病例报告

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234018

Faris K. Shamsudeen

引用次数: 0

Drug induced iatrogenic Cushing’s syndrome 药物诱发的先天性库欣综合征

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234026

Regina G. G. Arroyo, Hannia I. P. Belmontes, Marlene de J. G. Torres, Brizza M. R. Mendoza, Begoña E. Gonzalez, Natalia C. Bonilla, Aran A. R. Ceja, G. G. Santiago

引用次数: 0

Bartholin gland cyst and abscess: an updated scenario 巴氏腺囊肿和脓肿：最新情况

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234030

Shreyasee Das, Rahul Shil, Dhanpal H. N.

{"title":"Bartholin gland cyst and abscess: an updated scenario","authors":"Shreyasee Das, Rahul Shil, Dhanpal H. N.","doi":"10.18203/2320-6012.ijrms20234030","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234030","url":null,"abstract":"Bartholin glands are greater vestibular glands and are located on either side of the vaginal opening. They are mainly homologous to the bulbourethral or cowper’s gland in males. These two pea-sized glands secrets mucus which is essential for vaginal lubrication. Bartholin gland cysts are one of the most frequent fluid-filled masses developing in the vulval area. They may develop as cysts first without symptoms, but if left untreated, they can be infectious and can lead to surgical corrections. The incidence rate of Bartholin gland cysts and abscesses is 0.5 per 1000 people per year. In women, it mainly affects aging between 35 and 50 years. The cysts formed due to blockage of the Bartholin gland duct, which further causes retention and cystic dilation. Mainly, the disease happens due to sexually transmitted infections. Needle aspiration, incision, and drainage are the easiest and most reliable treatment options, but they are not carried out due to their high recurrence rate. This Bartholin gland cyst can interfere with the quality of life as the person can suffer discomfort in walking, difficulty in sitting and walking, and discomfort during intercourse. Most of the Bartholin’s gland cysts are also caused by the microorganisms that infect the perineal area. However, Bartholin’s cyst occurs in nulliparous women of childbearing age. Women in the reproductive age group should get counselling regarding the disease to take better precautionary measures to tackle the condition.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional recovery in a rare case of an adult patient with leucodystrophy 一例罕见的成人白质营养不良症患者的功能恢复

International Journal of Research in Medical Sciences Pub Date : 2023-12-28 DOI: 10.18203/2320-6012.ijrms20234021

Suvarna S. Ganvir, Simran M. Jethani, Stuti N. Gaikwad, Maheshwari Harishchandre

引用次数: 0